Les maladies infectieuses animales et tout particulièrement les maladies virales porcines telles que le syndrome reproducteur et respiratoire porcin, les maladies associées au circovirus porcin et la grippe porcine. Certains projets de recherche du Dr Gagnon ciblent: 1) le développement de vaccin et 2) l'étude de la pathogenèse des infections animales mixtes (bactéries-virus, virus-virus) et donc qui étudient les interactions pathogènes-pathogènes. De plus, en tant que directeur du seul laboratoire universitaire québécois de diagnostic des maladies infectieuses animales vétérinaires, le Dr Gagnon réalise divers projets de caractérisation de nouveaux virus et de virus réémergents.

Publications récentes du chercheur:

1. C. Savard, F. Alvarez, C. Provost, Y. Chorfi, S. D’Allaire, M.-O. Benoit-Biancamano, C.A. Gagnon. Fostera^TM PRRS modified live vaccine efficacy against a Canadian heterologous virulent field strain of porcine reproductive and respiratory syndrome virus (PRRSV). Can J Vet Res 2016; 80(1):1-11. PMID: 26732457
2. C. Bellehumeur, O. Nielsen, L. Measures, L. Harwood, T. Goldstein, B. Boyle and C.A. Gagnon. Herpesviruses including novel gammaherpesviruses are widespread among phocid seal species in Canada. J Wildlife Diseases 2016;52(1):70-81. PMID: 26555112
3. J.A. Ferreira Barbosa, J. Labrie, F. Beaudry, C.A. Gagnon, M. Jacques. Actinobacillus pleuropneumoniae induces SJPL cell cycle arrest in G2/M-phase and inhibits porcine reproductive and respiratory syndrome virus replication Virology Journal 2015. Nov 14;12(1):188. PMID: 26577697C.
4. Bellehumeur, B. Boyle, S.J. Charette, J. Harel, Y. L’Homme, L. Masson, C.A. Gagnon. Propidium monoazide (PMA) and ethidium bromide monoazide (EMA) improve DNA array and high-throughput sequencing of porcine reproductive and respiratory syndrome virus identification. J Virol Methods 2015;222:182-191. PMID: 26129867
5. C. Savard, C.A. Gagnon, Y. Chorfi. Deoxynivalenol (DON) naturally contaminated feed impairs the immune response induced by porcine reproductive and respiratory syndrome virus (PRRSV) live attenuated vaccine. Vaccine 2015;33:3881–3886. PMID: 26117152
6. C. Savard, C. Provost, F. Alvarez, V. Pinilla, N. Music, M. Jacques, C.A. Gagnon, Y. Chorfi. Effects of deoxynivalenol (DON) mycotoxin on in vivo and in vitro porcine circovirus type 2 infections. Vet Microbiol. 2015;176(3-4):257-67. PMID: 25717015
7. C. Bellehumeur, S. Lair, C.H. Romero, C. Provost, O. Nielsen, C.A. Gagnon. Identification of a novel herpesvirus associated with a penile proliferative lesion in a beluga (Delphinapterus leucas). 2015. J. Wildlife Diseases. 2015;51(1):244-9. PMID: 25375944
8. S. Chénier, M. Boulianne, C.A. Gagnon. Post-vaccinal reovirus infection with high mortality in breeder chicks. Avian diseases. 2014;58(4):659-665. PMID: 25619015
9. C. Lévesque, C. Provost, J. Labrie, Y. Hernandez Reyes, J.A Burciaga Nava; C.A Gagnon, M. Jacques. Actinobacillus pleuropneumoniae possesses an antiviral activity against porcine reproductive and respiratory syndrome virus. PLoS One 2014 May 30;9(5):e98434. PMID:24878741
10. Y. Wang, C.A. Gagnon, C. Savard, N. Music, M. Srednik, M. Segura, C. Lachance, C. Bellehumeur, M. Gottschalk. Capsular sialic acid of Streptococcus suis serotype 2 binds to swine influenza virus and enhances bacterial interactions with virus-infected tracheal epithelial cells. Infection and Immunity 2013; 81(12):4498-4508.
11. C. Bellehumeur, B. Boyle, I. Mandeville and C.A. Gagnon. High-throughput sequencing revealed the presence of an unforeseen parvovirus species in Canadian swine: the porcine partetravirus. Can Vet J 2013;54(8):787-789.
12. C. Provost, J.J. Jia, N. Music, C. Lévesque, M.-È. Lebel, J.R.E. del Castillo, M. Jacques and C.A. Gagnon. Identification of a new cell line permissive to porcine reproductive and respiratory syndrome virus infection and replication which is phenotypically distinct from MARC-145 cell line. Virol J. 2012 Nov 13;9:267.
13. D. Tremblay, V. Allard, J.-F. Doyon, C. Bellehumeur, J.G. Spearman, J. Harel, and C.A. Gagnon. Emergence of a new swine H3N2 and pandemic (H1N1) 2009 influenza A virus reassortant in two Canadian animal populations, mink and swine. J Clin Microbiol 2011; 49(12):4386–4390.
14. C.A. Gagnon, N. Music, G. Fontaine, D. Tremblay, J. Harel. Emergence of a new type of porcine circovirus (PCV) in swine: a type 1 and type 2 PCV recombinant. Vet Microbiol 2010;144:18-23.

Le Dr Carl A. Gagnon est vétérinaire diplômé de la Faculté de médecine vétérinaire (FMV) de l’Université de Montréal, promotion 1994.  Par la suite, il a poursuivi des études graduées en virologie et immunologie et obtenu sont doctorat (PhD) en 2001 à l’INRS Institut-Armand-Frappier.  Après avoir été agent de recherche dans la même institution, il a été directeur du Centre de biologie expérimentale de l’INRS (Animalerie de recherche répondant aux normes BPL) de 2003 à 2004. 

Depuis 2004, Carl A. Gagnon est professeur à la FMV, ses activités de recherche ciblant principalement la virologie porcine.  En tant que directeur scientifique du Laboratoire de diagnostic virologique vétérinaire (LDVV) et directeur scientifique du Laboratoire de diagnostic moléculaire (LDM) de la FMV, il est très impliqué au niveau du diagnostic des maladies virales animales (porcin, bovin, aviaire, équin, vison, animaux de zoo, etc.). Ces travaux de recherche ciblent des pathogènes viraux responsables de pertes économiques importantes pour l'agriculture tels que le virus du syndrome reproducteur et respiratoire porcin, et le circovirus porcin.

Depuis juillet 2014, Carl A. Gagnon est le directeur du Centre de recherche en infectiologie porcine et avicole (CRIPA).

Membre de l'Ordre des médecins vétérinaires du Québec (OMVQ).

Membre de l'Association canadienne des médecins vétérinaires (ACMV).

Carolina Kist Traesel (2013-2014). Boursière FRQNT et CNPq. Projet: Identification des mécanismes d’action de l’activité antivirale du surnageant d’App envers le virus du SRRP.

Christian Bellehumeur (2011-2014). Projet: Utilisation de la technologie des biopuces et de séquençage à haut débit pour la détection et l'identification des maladies infectieuses animales.

Christian Savard (2010-2014). Boursier FRQNT et CCSP. Projet: Effet des mycotoxines sur la susceptibilité des infections virales.

Chantale Provost (2010-2013). Boursière CCSP. Projet: Étude de la pathogèneses du PCV et VSRRP à l’aide de nouvelles lignées cellulaire et infection mixtes.

1. C. Savard, F. Alvarez, C. Provost, Y. Chorfi, S. D’Allaire, M.-O. Benoit-Biancamano, C.A. Gagnon. Fostera^TM PRRS modified live vaccine efficacy against a Canadian heterologous virulent field strain of porcine reproductive and respiratory syndrome virus (PRRSV). Can J Vet Res 2016; 80(1):1-11. PMID: 26732457
2. C.A. Gagnon, V. Allard, G. Cloutier. Canine parvovirus type 2b is the most prevalent genomic variant strain found in parvovirus antigen positive diarrheic dog feces samples across Canada. Can Vet J 2016;57(1):29-31. PMID: 26740694
3. C. Bellehumeur, O. Nielsen, L. Measures, L. Harwood, T. Goldstein, B. Boyle and C.A. Gagnon. Herpesviruses including novel gammaherpesviruses are widespread among phocid seal species in Canada. J Wildlife Diseases 2016;52(1):70-81. PMID: 26555112
4. J.A. Ferreira Barbosa, J. Labrie, F. Beaudry, C.A. Gagnon, M. Jacques. Actinobacillus pleuropneumoniae induces SJPL cell cycle arrest in G2/M-phase and inhibits porcine reproductive and respiratory syndrome virus replication Virology Journal 2015. Nov 14;12(1):188. PMID: 26577697
5. C. Bellehumeur, B. Boyle, S.J. Charette, J. Harel, Y. L’Homme, L. Masson, C.A. Gagnon. Propidium monoazide (PMA) and ethidium bromide monoazide (EMA) improve DNA array and high-throughput sequencing of porcine reproductive and respiratory syndrome virus identification. J Virol Methods 2015;222:182-191. PMID: 26129867
6. C. Savard, C.A. Gagnon, Y. Chorfi. Deoxynivalenol (DON) naturally contaminated feed impairs the immune response induced by porcine reproductive and respiratory syndrome virus (PRRSV) live attenuated vaccine. Vaccine 2015;33:3881–3886. PMID: 26117152
7. M. Lessard, C. Savard, K. Deschene, K. Lauzon, V. Pinilla, C.A.Gagnon, J Lapointe, F. Guay and Y. Chorfi. Impact of deoxynivalenol (DON) contaminated feed on intestinal integrity and immune response in swine. Food and Chemical Toxicology. 2015;80:7-16. PMID: 25701311
8. M. Jacques, D. Grenier, J. Labrie, C. Provost, C.A. Gagnon. Persistence of porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2) in bacterial biofilms. J. Swine Health Produc. 2015;23(3):132-36.
9. C. Savard, C. Provost, F. Alvarez, V. Pinilla, N. Music, M. Jacques, C.A. Gagnon, Y. Chorfi. Effects of deoxynivalenol (DON) mycotoxin on in vivo and in vitro porcine circovirus type 2 infections. Vet Microbiol. 2015;176(3-4):257-67. PMID: 25717015
10. C. Bellehumeur, S. Lair, C.H. Romero, C. Provost, O. Nielsen, C.A. Gagnon. Identification of a novel herpesvirus associated with a penile proliferative lesion in a beluga (Delphinapterus leucas). 2015. J. Wildlife Diseases. 2015;51(1):244-9. PMID: 25375944
11. J. Baroch, C.A. Gagnon, S. Lacouture and M. Gottschalk. Exposure of US feral swine (Sus scrofa) to selected pathogens. Can J Vet Res. 2015;79:74–78. PMID: 25673913
12. S. Chénier, M. Boulianne, C.A. Gagnon. Post-vaccinal reovirus infection with high mortality in breeder chicks. Avian diseases. 2014;58(4):659-665. PMID: 25619015
13. C. Savard, V. Pinilla, C. Provost, C.A. Gagnon, Y. Chorfi. In vivo effect of deoxynivalenol (DON) naturally contaminated feed on porcine reproductive and respiratory syndrome virus (PRRSV) infection. Vet Microbiol. 2014. Dec 5;174(3-4):419-26. PMID: 25465662
14. C. Lévesque, C. Provost, J. Labrie, Y. Hernandez Reyes, J.A Burciaga Nava; C.A Gagnon, M. Jacques. Actinobacillus pleuropneumoniae possesses an antiviral activity against porcine reproductive and respiratory syndrome virus. 2014. PLoS One May 30;9(5):e98434. PMID:24878741
15. Y. Dang, C. Lachance, Y. Wang, C.A Gagnon, C. Savard, M. Segura, D. Grenier and M. Gottschalk. Transcriptional approach to study porcine tracheal epithelial cells individually or dually infected with swine influenza virus and Streptococcus suis. BMC Veterinary Research 2014. Apr 7;10(1):86. PMID: 24708855
16. C. Savard, V. Pinilla, C. Provost, M. Segura, C.A. Gagnon and Y. Chorfi. In vitro effect of deoxynivalenol (DON) mycotoxin on porcine reproductive and respiratory syndrome virus (PRRSV). Food and Chemical Toxicology 2014;65:219-26. PMID:24394488
17. Charlebois, A., C. Marois-Créhan, P. Hélie, C.A. Gagnon, M. Gottschalk, M. Archambault. Genetic diversity of Mycoplasma hyopneumoniae isolates of abattoir pigs. Vet Microbiol 2014;168(2-4):348-56. PMID:24345410
18. Wang, Y., C.A. Gagnon, C. Savard, N. Music, M. Srednik, M. Segura, C. Lachance, C. Bellehumeur, M. Gottschalk. Capsular sialic acid of Streptococcus suis serotype 2 binds to swine influenza virus and enhances bacterial interactions with virus-infected tracheal epithelial cells. Infection and Immunity 2013; 81(12):4498-4508. PMID:24082069
19. M. Shi, P. Lemey, M. Singh Brar, M.A. Suchard, M.P. Murtaugh, S. Carman, S. D’Allaire, B. Delisle, M.-È. Lambert, C.A. Gagnon, L. Ge, D. Yoo, E.C. Holmes, F. Chi-Ching Leung. The Spread of Type 2 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) in North America: a Phylogeographic Approach. Virology 2013;447(1-2):146–154. PMID:24210109
20. C. Bellehumeur, B. Boyle, I. Mandeville and C.A. Gagnon. High-throughput sequencing revealed the presence of an unforeseen parvovirus species in Canadian swine: the porcine partetravirus. Can Vet J 2013;54(8):787-789. PMID:24155481
21. É. Roques, A. Girard, C.A. Gagnon and D. Archambault. Antibody responses induced in mice immunized with recombinant adenovectors expressing chimeric proteins of various porcine pathogens. Vaccine 2013;31(24):2698-704. PMID:23583895
22. P. Ward, E. Poitras, D. Leblanc, C.A. Gagnon, D. Plante, J. Brassard and A. Houde. Comparison of different RT-qPCR assays for the detection of human and bovine group A rotaviruses and characterization by sequences analysis of genes encoding VP4 and VP7 capsid proteins. J Applied Microbiol 2013;114(5):1435-48. PMID:23421708
23. É. Roques, A. Girard, M.-C. St-Louis, B. Massie, C.A. Gagnon, M. Lessard and D. Archambault. Immunogenic and protective properties of codon-optimized GP5 and M structural proteins of porcine reproductive and respiratory syndrome virus expressed from replicating but nondisseminating adenovectors. Vet Res 2013;44:17. PMID:23497101
24. C. Provost, J.J. Jia, N. Music, C. Lévesque, M.-È. Lebel, J.R.E. del Castillo, M. Jacques and C.A. Gagnon. Identification of a new cell line permissive to porcine reproductive and respiratory syndrome virus infection and replication which is phenotypically distinct from MARC-145 cell line. Virol J. 2012 Nov 13;9:267. PMID:23148668
25. B. Delisle, C.A. Gagnon, M.-È. Lambert and S. D’Allaire. Porcine reproductive and respiratory syndrome virus diversity of Eastern Canada swine herds in a large sequence dataset reveals two hypervariable regions under positive selection. Infection, Genetics and Evolution 2012;12:1111–1119. PMID:22484762
26. D. Tremblay, V. Allard, J.-F. Doyon, C. Bellehumeur, J.G.Spearman, J. Harel, and C.A. Gagnon. Emergence of a new swine H3N2 and pandemic (H1N1) 2009 influenza A virus reassortant in two Canadian animal populations, mink and swine. J Clin Microbiol 2011; 49(12):4386–4390. PMID:22012020
27. C.A. Gagnon, J. Tremblay, D. Larochelle, N. Music and D. Tremblay. Identification of a novel herpesvirus associated with cutaneous ulcers in a fisher (Martes pennanti). J Vet Diagn Invest 2011;23(5):986-990. PMID:21908360
28. W. Van Breedam, S. Costers, M. Vanhee, C.A. Gagnon, I.M. Rodríguez-Gómez, M. Geldhof, M. Verbeeck J. Van Doorsselaere, U. Karniychuk, H.J. Nauwynck. Porcine reproductive and respiratory syndrome virus (PRRSV)-specific mAbs: supporting diagnostics and providing new insights into the antigenic properties of the virus. Vet Immunol and Immunopathol 2011;141(3-4):246-257. PMID:21470695
29. R. Drolet, F. Cardinal, A. Houde, C.A. Gagnon. Unusual central nervous system lesions in slaughter-weight pigs with porcine circovirus type 2 systemic infection. Can Vet J 2011;52:394-397. PMID:21731092
30. C.A. Gagnon, O. Allam, R. Drolet, D. Tremblay. Quebec :Detection of bovine lymphotropic herpesvirus DNA in tissues of a bovine aborted fetus. Can Vet J 2010;51(9):1021-1022. PMID:21119872
31. N. Music, C.A. Gagnon. The role of porcine reproductive and respiratory syndrome virus (PRRSV) structural and non-structural proteins in virus pathogenesis. Animal Health Res Reviews 2010;11(02):135-163. PMID:20388230
32. F.R. Okamba, M. Arella, N. Music, J.J. Jia, M. Gottschalk, C.A. Gagnon.  Potential use of a recombinant replication-defective adenovirus vector carrying the C-terminal portion of the P97 adhesin protein as a vaccine against Mycoplasma hyopneumoniae in swine. Vaccine 2010;28(30):4802-4809. PMID:20472025
33. C.A. Gagnon, N. Music, G. Fontaine, D. Tremblay, J. Harel. Emergence of a new type of porcine circovirus (PCV) in swine: a type 1 and type 2 PCV recombinant. Vet Microbiol 2010;144:18-23. PMID :20097492
34. D.W. Silversides, N. Music, M. Jacques, C.A. Gagnon, R. Webby. Investigation of the species origin of the St. Jude porcine lung epithelial cell line (SJPL) made available to researchers. J. Virol. 2010;84(10):5454-5455. PMID :20200241
35. D. Verreault, V. Létourneau. L. Gendron, D. Massé, C.A. Gagnon, C. Duchaine. Airborne porcine circovirus in Canadian swine confinement buildings. Vet Microbiol 2010;141:224-230. PMID:19773132
36. C.A. Gagnon, G. Spearman, A. Hamel, D.L. Godson, A. Fortin, G. Fontaine, D. Tremblay. Characterization of a Canadian mink H3N2 influenza A virus isolate genetically related to triple reassortant swine influenza virus. J Clin Microbiol 2009;47:796-799. PMID:19116358
37. C.A. Gagnon, J. del Castillo, N. Music, G. Fontaine, J. Harel, D. Tremblay. 2008. Development and use of a multiplex real-time quantitative polymerase chain reaction assay for detection and differentiation of Porcine circovirus-2 genotypes 2a and 2b in an epidemiological survey. J Vet Diagn Invest, 20:545-558. PMID:18776085
38. S. Carman, H. Cai, J. DeLay, Sameh Y.B. McEwen, C.A. Gagnon, D. Tremblay, M. Hazlett, P. Lusis, J. Fairles, H. Alexander and T. van Dreumel. 2008. The emergence of a new strain of porcine circovirus-2 with PCR restriction fragment length polymorphism type 321 in Ontario and Quebec swine and its association with severe porcine circovirus associated disease – 2004-2006. Can J Vet Res 72:259-268. PMID:18505190
39. C.A. Gagnon, S. M. Elahi, D. Tremblay, N. A. Bryant, D. M. Elton, J.-P. Lavoie, S. Carman and J. Elsener. 2007. Cross Canada Disease Report - Genetic relatedness of recent Canadian equine influenza virus isolates with vaccine strains used in the field.  Can. Vet. J. 48(10):1028-1030. PMID:17987964
40. C.A. Gagnon, D. Tremblay, P. Tijssen, M.-H. Venne, A. Houde and S.M. Elahi. 2007. The emergence of porcine circovirus 2b genotype (PCV-2b) in swine in Canada.  Can. Vet. J. 48(8):811-819. PMID:17824323