Homéostasie de la longueur des télomères et instabilité génomique
- Professeure titulaire
Faculté de médecine - Département de médecine
Lea Harrington and her colleagues pursue the mechanisms by which chromosome ends, telomeres, are maintained and protected from degradation and recombination. The activity of an enzyme responsible for new telomere addition in most eukaryotes, telomerase, is increased in many cancers and conversely is decreased in many somatic tissues. Since critically short telomeres that elicit a DNA damage response are incompatible with cell viability, the regulation of telomerase activity and dosage is thus a critical determinant of normal and cancer cell proliferation.
Affiliations and responsabilities
Teaching and supervision
Theses and dissertation supervision (Papyrus Institutional Repository)
Cycle : Master's
Grade : M. Sc.
Cycle : Doctoral
Grade : Ph. D.
Exploiting the synthetic-lethal vulnerabilities of stem cells and cancer cells with eroded telomeres
Genetic and chemical ablation of senescent cells that result from age-dépendent telomere erosion
Telomere instability transforms differentiated stem cells into teratomas: implications for aging and disease
TELOMERE INTEGRITY AND STABILITY OF THE DIFFERENTIATED STATE
UNE APPROCHE CHIMIO- ET PROTEO-GENOMIQUE EN MEDECINE PERSONNALISEE POUR LA LEUCEMIE MYELOIDE AIGUE
INVESTIGATION OF NOVEL METHODS OF TELOMERE MAINTENANCE IN CELLULAR SENESCENCE, AGING AND CANCER
Publications and presentations