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Health Sciences; Natural Sciences and Engineering

Léa Harrington

Homéostasie de la longueur des télomères et instabilité génomique

Professeure titulaire

Faculté de médecine - Département de médecine

lea.harrington@umontreal.ca

Profile

Research expertise

Lea Harrington and her colleagues pursue the mechanisms by which chromosome ends, telomeres, are maintained and protected from degradation and recombination. The activity of an enzyme responsible for new telomere addition in most eukaryotes, telomerase, is increased in many cancers and conversely is decreased in many somatic tissues. Since critically short telomeres that elicit a DNA damage response are incompatible with cell viability, the regulation of telomerase activity and dosage is thus a critical determinant of normal and cancer cell proliferation.

Affiliations and responsabilities

Teaching and supervision

Student supervision

Theses and dissertation supervision (Papyrus Institutional Repository)

2021

The role of the human INO80 complex in telomere maintenance

Graduate : Henry, Danielle
Cycle : Master's
Grade : M. Sc.
2021

Genome-wide CRISPR screens for the interrogation of genome integrity maintenance networks

Graduate : Benslimane, Yahya
Cycle : Doctoral
Grade : Ph. D.

Projects

Research projects

2021 - 2028

Exploiting the synthetic-lethal vulnerabilities of stem cells and cancer cells with eroded telomeres

Lead researcher : Léa Harrington
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet
2019 - 2024

Genetic and chemical ablation of senescent cells that result from age-dépendent telomere erosion

Lead researcher : Léa Harrington
Co-researchers : Michael David Tyers
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXX5647-(MOP) Subvention de fonctionnement incluant les subventions de fonctionnement programmatiques (général)
2016 - 2023

Telomere instability transforms differentiated stem cells into teratomas: implications for aging and disease

Lead researcher : Léa Harrington
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet
2014 - 2021

TELOMERE INTEGRITY AND STABILITY OF THE DIFFERENTIATED STATE

Lead researcher : Léa Harrington
Co-researchers : Dean Betts
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXX5647-(MOP) Subvention de fonctionnement incluant les subventions de fonctionnement programmatiques (général)
2015 - 2020

UNE APPROCHE CHIMIO- ET PROTEO-GENOMIQUE EN MEDECINE PERSONNALISEE POUR LA LEUCEMIE MYELOIDE AIGUE

Lead researcher : Guy Sauvageau
Funding sources: FCI/Fondation canadienne pour l'innovation
Grant programs: PVXXXXXX-Fonds d'innovation
2011 - 2014

INVESTIGATION OF NOVEL METHODS OF TELOMERE MAINTENANCE IN CELLULAR SENESCENCE, AGING AND CANCER

Lead researcher : Léa Harrington
Funding sources: FCI/Fondation canadienne pour l'innovation
Grant programs:

Outreach

Publications and presentations

Disciplines

  • Biochemistry