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Health Sciences; Life Sciences

David Williamson

Professeur titulaire de clinique

Faculté de pharmacie

Pavillon Jean Coutu, room 2181

514 343-6111 #1924

david.williamson@umontreal.ca

Secondary numbers: 514 338-2222 #2666 (Travail 1) 514 343-6120 (Télécopieur)

Profile

education

  • 2014 — Ph.D — Sciences cliniquesUniversité de Sherbrooke
  • 1997 — M.Sc. (pharmacothérapie avancée) — PharmacieUniversité de Montréal
  • 1996 — B.Pharm — PharmacieUniversité de Montréal

Affiliations and responsabilities

Projects

Research projects

2022 - 2026

Large reductions in arterial CARbon dioxide and development of acute Brain Injury in invasively mechanically ventilated patients with acute respiratory failure (CARBI)

Lead researcher : Yiorgos Alexandros Cavayas
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet
2020 - 2026

A prospective translational model of the therapeutic potential of cannabidiol in reducing acute pain symptoms and opioid usage following traumatic injury.

Lead researcher : Louis De Beaumont
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-Subvention d'équipe
2021 - 2025

Adverse Drug Events and Medication Errors in adult Intensive Care Units

Lead researcher : Nadezhda Roumeliotis
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet
2021 - 2024

Prise en charge pharmacothérapeutique des conséquences physiques, comportementales et cognitives des lésions cérébrales traumatiques aiguës

Lead researcher : David Williamson
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Bourse de chercheur-boursier clinicien : Junior 2
2018 - 2024

Quantity of Opioids for Acute Pain and Limit Unused Medication (OPUM study)

Lead researcher : Raoul Daoust
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet
2018 - 2021

Implantation des meilleures pratiques de gestion de la douleur à l'unité des soins intensifs de traumatology: un travail d'équipe.

Lead researcher : Céline Gélinas
Co-researchers : Marc Perreault , Manon Choinière , David Williamson , Francis Bernard
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Volet 3 - Consortium pour le développement de la recherche en traumatologie
2018 - 2021

Identifier les patients à risque de douleur chronique après un traumatisme craniocérébral modéré/sévère dès les premiers jours d'hospitalisation aux soins intensifs

Lead researcher : Caroline Arbour
Co-researchers : Louis De Beaumont , David Williamson , Francis Bernard
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Volet 1 - Consortium pour le développement de la recherche en traumatologie
2018 - 2020

Sedatives newly prescribed following intensive care unit admission among sedative-naïve elderly patients: Understanding the risk of falls and determining targets for deprescribing (SNOW-FALL)

Lead researcher : Lisa Denise Burry
Co-researchers : David Williamson
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet
2016 - 2020

Agitation et délirium en traumatologie et aux soins intensifs

Lead researcher : David Williamson
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Bourse de chercheur-boursier clinicien : Junior 1
2016 - 2020

PROSPECT: Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial

Lead researcher : Jennie Johnstone
Co-researchers : David Williamson , Emmanuel Charbonney
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs:
2017 - 2019

Revue systématique et méta-analyse sur les agents sédatifs en traumatisme crânien

Lead researcher : David Williamson
Funding sources: Fondation NeuroTrauma Marie-Robert
Grant programs:
2016 - 2019

Agitation et délirium en traumatologie et aux soins intensifs

Lead researcher : David Williamson
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Établissement de jeunes chercheurs Juniors 1
2016 - 2018

Traitement des hémorragies intracrâniennes chez les patients anticoagulés ayant subi un traumatisme crânien léger : Revue systématique et méta-analyse

Lead researcher : Jean Marc Chauny
Co-researchers : Martin Albert , David Williamson , Natalie Le Sage
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Volet 4 - Consortium pour le développement de la recherche en traumatologie
2016 - 2017

Managing Pain In Collaboration in the Intensive Care Unit (MPIC-ICU): A Stepped Wedge Cluster Randomized Trial.

Lead researcher : Céline Gélinas
Co-researchers : Manon Choinière , David Williamson , Emmanuel Charbonney , Francis Bernard
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet
2015 - 2017

Interventions pharmacologiques pour le contrôle du délirium et de l'agitation suite à un traumatisme cranio-cérébral: une revue systématique de données cliniques et précliniques

Lead researcher : David Williamson
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Volet 4 - Consortium pour le développement de la recherche en traumatologie

Outreach

Publications and presentations

Publications

Publications des 5 dernières années

  1. Marsolais P, Larouche G, Lagacé AM, Williams V, Bernard F, Rico P, Frenette AJ, Williamson D, Albert M, Charbonney E. The feasibility of potential organ donors using real case-scenarios; do we need to create a “donor board” process for donors perceived as unlikely feasible? Transplant International 2022; March 15. Epub ahead of print.
  2. Duong A, Thirion DJG, Williamson D, Simard C, Marsot A. Aminoglycosides' dosing and monitoring practices in critically ill patients in Quebec hospitals. J Chemother. 2022 Mar 3:1-4. Epub ahead of print.

  3. Chan K, Burry LD, Tse C, Wunsch H, De Castro C, Williamson DR. Impact of Ketamine on Analgosedative Consumption in Critically Ill Patients: A Systematic Review and Meta-Analysis. Ann Pharmacother. 2022 Jan 26:10600280211069617.

  4. Daoust R, Paquet J, Marquis M, Chauny JM,Williamson D,Huard V, Arbour C, Émond M, Cournoyer A. Evaluation of Interventions to Reduce Opioid Prescribing for Patients Discharged From the Emergency Department: A Systematic Review and Meta-analysis. JAMA Netw Open. 2022;5(1):e2143425. doi:10.1001/jamanetworkopen.2021.43425

  5. Martineau-Lessard, C., Arbour, C., Germélus, N-É., Williamson, D., De Beaumont, L., Bernard, F. Pupil light reflex for the assessment of analgesia in critically ill sedated patients with traumatic brain injury: A preliminary study. Journal of Neuroscience Nursing (ePub Dec 8th)

  6. Daoust R, Paquet J, Huart V, Chauny JM, Lavigne G, Williamson D, Choiniere M, Lang E, Yan JW, Perry JJ, Emond M, Gosselin S, Cournoyer A. Association Between Fentanyl Treatment for Acute Pain in the Emergency Department and Opioid Use Two Weeks After Discharge. Am J Emerg Med (ePub Dec 4th)

  7. Johnstone J, Meade M, Lauzier F, Marshall J, Duan E, Dionne J, Arabi Y, Heels-Ansdell D; Thabane L, Lamarche D; Surette M; Zytaruk N, Mehta S, Dodek, P, Mcintyre L, English S; Rochwerg B,Karachi T, Henderson W, Wood G, Ovakim D, Herridge M, Granton J, Wilcox E, Gioffi A, Stelfox H; Niven D, Muscedere, J, Lamontagne F, D'Aragon, F, St-Arnaud C, Ball I, Nagpal D, Girard M, Aslanian P, Charbonney E, Williamson D, Sligl W, Friedrich J, Adhikari N; Marquis F, Archambault P, Khwaja K, Kristof A, Kutsiogiannis J, Zarychanski R, Paunovic, B, Reeve B, Lellouche F, Hosek P, Tsang J, Binnie A, Trop S, Loubani O, Hall R, Cirone R, Reynolds S, Lysecki P, Golan E, Carten Ceba R, Taylor R, Cook D. Lactobacillus Rhamnosus GG in Critical Illness: A Randomized Trial. JAMA 2021;326:1024-33.

  8. Burry L, Chen W, Williamson D, Guenette M, Hutton B, Mehta S, Egerod I, Kanji S, Adhikari NK, Moher D, Martin C, Rose L. Intensive Care Med 2021;47:943-60.

  9. Saavedra Mitjans M, David PM, Frenette AJ, Arbour C, Perreault MM, Williams V, Bernard F, Williamson DR. EXperienceS and aTtitudes towards Agitated behaviors in Tbi ICu patients (EXSTATIC): a protocol for an interprofessional mixed-method study. BMJ Open 2021; 11(7):e045816

  10. Duceppe MA, Kanji S, Ruo N, Do A, Cavayas YA, Robert-Halabi M, Albert M, Zavalkoff S, Samoukovic G, Williamson DR. Alterations in the pharmacokinetics and pharmacodynamics of commonly used antimicrobials in critical care patients during extracorporeal membrane oxygenation: A systematic review. Drugs. 2021;81:1307-1329.

  11. Morris JL, Bernard F, Bérubé M, Dubé JN, Houle J, Laporta D, Morin SN, Perreault M, Williamson D, Gélinas C. Determinants of Pain Assessment Documentation in Intensive Care Units. Can J Anaesth. 2021;68:1176-1184

  12. Duong A, Simard C, Wang YL, Williamson D, Marsot A. Aminoglycosides in the intensive care unit: what’s new in population PL modeling. Antibiotics (Basel) 2021;10:507.

  13. Williamson DR, Kanji S, Burry LD. Advanced Pharmacist Practitioner Series – Clinician scientist. Can J Hosp Pharm 2021;74:130-4.

  14. Bilodeau V, Saavedra Mitjans M, Frenette AJ, Burry L, Albert M, Bernard F, Williamson DR. . J Clin Pharm Ther 2021;46:1020-26.

  15. Bendayan M, Mardigyan V, Williamson D, Chen-Tournoux A, Eintracht S, Rudski L, MacNamara E, Blostein M, Afilalo M, Afilalo J. Association of Muscle Mass With Direct Oral Anticoagulant Activity in Older Adults. J Am Geriatr Soc 2021;69:1012-1018.

  16. Williamson DR, Cherifa S, Saavedra Mitjans M, Arbour C, Frenette AJ, Charbonney E, Blais L, Burry LD, Mehta S, Bernard F. A pilot feasibility cohort study of agitated behaviors in critically traumatic brain injury patients. Pilot and feasibility Studies 2020;6:193.

  17. Gagnon A, Laroche M, Williamson DR, Giguère JF, Giroux M, Bernard F. Incidence and characteristics of cerebral hypoxia after craniectomy in brain injured patients: a cohort study. J Neurosurgery (ePub 5 nov 2020)

  18. Flynn F, Richard G, Dobrescu MA, Bouchard J, Williamson DR, Brindamour D, Charbonney E, Dupuis S. Refractory dabigatran-induced hemorrhage despite multiple idarucizumab administration and renal replacement therapy. J Pharm Pract (ePub 28 septembre)

  19. Frenette AJ, Williamson DR, Rochwerg B, Weiss MJ, Ball I, D’Aragon F, Serri K, Brindamour D, Meade M, Charbonney E.Worldwide management of donors after neurological death: a systematic review and narrative synthesis of guidelines. Can J Anesth 2020;67:1839-1857

  20. Cavayas YA, Noël A, Brunette V, Williamson DR, Bellemare P, Lagrenade-Verdant C, LeGuillan S, Levesque E, Frenette AJ, Lamarche Y, Giasson M, Rico P, Beaulieu Y, Marsolais P, Serri K, Bernard F, Albert M. Early experience with critically ill patients with COVID-19 in Montreal. Can J Anaesth. 2021;68:204-213.

  21. Burry LD, Barletta J, Williamson D, , Kanji S, Maves RC, Dichter J, Christian MD, Geiling J, Erstad B. Chest. 2020;158:2414-2424

  22. Jutras M, Williamson DR, Chassé M, Leclair G. Development and validation of a liquid chromatography coupled to tandem mass spectrometry method for the simultaneous quantification of five analgesics and sedatives, and six of their active metabolites in human plasma: Application to a clinical study on the determination of neurological death in the intensive care unit. J Pharm Biomed Anal. 2020;190:113521

  23. Sneyers B, Duceppe MA, Frenette AJ, Burry LD, Rico P, Lavoie A, Gélinas C, Mehta S, Dagenais M, Williamson DR, Perreault MM Drugs 2020 Jun 26:1-23.

  24. Kanji S, Burry L, Williamson D, Pittman M, Dubinsky S, Patel D, Natarajan S, MacLean R, Huh JH, Scales D, Neillipovitz D. 2020 Oct;67(10):1405-1416

  25. Burry L, Hutton B, Williamson DR, Mehta S, Adhikari NKJ, Cheng W, Ely EW, Egerod I, Fergusson DA, Rose L. Pharmacological interventions for the treatment of delirium in critically ill adults. Cochrane Database of Systematic Reviews 2019, Issue 8. Art. No.: CD011749. DOI: 10.1002/14651858.CD011749.pub2.

  26. Capilnean A, Martone A, Sandu PR, Rosu VA, Murgoi P, Frenette AJ, Williamson DR, Lecavalier A, Javaraman D, Rico P, Bellemare P, Gelinas C, Perreault MM. Withdrawal assessment in the adult ICU population. Am J Crit Care 2019; 28:361-369.

  27. Frenette AJ, Veillette C, Poulin F, Albert M, Marsolais P, Bernard F, D’Aragon F, Williamson D, Charbonney E, Serri K. Evaluation of left and right heart function by echocardiography in potential heart donors: a cohort study. J Crit Care 2019; 15;54:37-41

  28. Williamson DR, Frenette AJ, Perreault MM, Burry LD, Charbonney E, Lamontagne F, Potvin MJ, Giguère JF, Mehta S, Bernard F. Pharmacological interventions for agitation and delirium in traumatic brain injury: a systematic review. BMJ Open 2019; 9;9(7):e029604.

  29. Fortier M, Ferreira V, Pinsonneault M, Pistre P, Meideros Charbonneau J, Buisson A, Proulx C, Guenette S, Bally M, Williamson DR, Ang A. Impact of a pharmacist antimicrobial checklist on hospital antimicrobial use: A patient-level interrupted time series study. J Hosp infection 2019; 103:251-258.

  30. Sokoloff C, Williamson D, Serri K, Albert M, Odier C, Charbonney E and Bernard F. Trans-cranial Doppler as an Inference Tool of Cerebral Hypoxic Episodes Early after Moderate and Severe TBI. Neurocritical Care  (ePub 19 juin)

  31. Frenette AJ, Williamson DR, Williams V, Lagacé AM, Charbonney E Serri K. Efficacy and safety of levothyroxine on cardiac function in brain dead organ donors: a pilot study. Prog Transplant 29(3):261-268.

  32. Daoust R, Paquet J, Cournoyer A, Piette E, Morris J, Lessard J, Castonguay V, Williamson D, Chauny JM. Opioid Induced Side Effects, Including Constipation, For The Acute Pain of Emergency Department Discharged Patients. Am J Emerg Med (ePub 5 juin)

  33. Frenette AJ, Charbonney E, D’Aragon F, Serri K, Marsolais P, Chassé M, Meade M, Williamson DR. A Canadian Survey of Deceased organ donor’s management centered on hemodynamic and hormonal aspects. Can J Anesth 2019; 66:1162-1172.

  34. Dupuis S, Brind’amour D, Karzon S, Bellemare P, Charbonney E, Frenette AJ, Burry L, Perreault MM, Williamson DR. Pharmacological interventions used to facilitate mechanical ventilation weaning in difficult to wean patients: a systematic review and meta-analysis. Can J Anesth 2019;66(3) :318-327

  35. Duceppe MA, Perreault MM, Frenette AJ, Burry LD, Rico P, Lavoie A, Gélinas C, Mehta S, Dagenais M, Williamson DR. Frequency, risk factors and symptomatology of iatrogenic withdrawal from opioids and benzodiazepines in critically Ill neonates, children and adults: A systematic review of clinical studies. J Clin Pharm Ther 2019; 44:148-156.

  36. Dellazizzio L, Demers SP, Charbonney E, Williams V, Serri K, Albert M, Williamson DR, Bernard F. Minimal PaO2 threshold after Traumatic Brain Injury and clinical utility of a novel Brain Oxygenation Ratio (BOx Ratio). J Neurosurg (Published online November 2, 2018; DOI: 10.3171/2018.5.JNS18651)

  37. Wang HT, Williamson DR, Francispillai M, Richard-Denis A, Albert M. Pneumonia as a modifiable risk factor of mechanical ventilation and prolonged mechanical ventilation in cervical spinal chord injuries. Can Journal of Respiratory, Critical Care, and Sleep Medicine 2018;2:213-217

  38. Chartrand M, Martineau J, Brouillette D, Williamson DR, Côté S, Landry J, Huot R, White-Guay B, Hudon E, Perreault S, Kano G, Martin E, Gagnon MM, Lalonde L. Quality indicators for community pharmacist management of anticoagulation. J Manag Care Pharm 2018; 24(4):357-365

  39. Turchet C, Canfield A, Williamson DR, Fan-Lun C, Tabbara N; Mantas I, Guenette M, Sinha S, Burry L. Delirium Detection in Hospitalized Older Adults: An Audit of Practice. J Pharm Tech 2018; 34:91–98.

  40. Wang PP, Huang E, Feng X, Bray CA, Perreault MM, Rico P, Bellemare P, Murgoi P, Gélinas C, Lecavalier A, Jayaraman D, Frenette AJ, Williamson DR. Iatrogenic Withdrawal Syndrome due to Opioids in Critically Ill Patients: a Multicenter Prospective Cohort Study. Ann Intensive Care 2017;7:88.

  41. Ada Chiu, Lisa Burry, Jennifer Korman, Marc Perreault, David Williamson, Sangeeta Mehta. Opioid Withdrawal in Critically Ill Patients: Frequency, Risk Factors, and A Review of Current Assessment Tools. Ann Pharmacother 2017; 51:1099-1111.

  42. Burry L, Williamson D, Perreault MM, Smith O, Mantas I, Fergusson DA, Mehta S, Rose L. Delirium and exposure to psychoactive medications in critically ill adults: A multi-centre observational study. J Crit Care. 2017;42:268-274

  43. Arnold DM, Lauzier F, Albert M, Williamson D, Li N, Zarychanski R, Doig C, McIntyre L, Freitag A, Crowther M, Saunders L, Clarke F, Cooper J, Qushmaq I, Lopes RD, Heels-Ansdell D, Webert K, Cook D. The Association Between Platelet Transfusions and Bleeding in Critically Ill Patients with Thrombocytopenia. Res Pract Thromb Haemost. 2017;103–111.

  44. Doré M, San Juan A, Frenette AJ, Williamson DR. Clinical importance of monitoring the unbound valproic acid concentration in patients with hypoalbuminemia. Pharmacotherapy 2017; 37(8):900-907.

  45. Burry  L, Dryden  L, Rose  L, Williamson  DR, Adhikari  NKJ, Turgeon  AF, Golan  E, Dewhurst  N, Fergusson  DA, Hutton  B, Mehta  S. Sedation for moderate‐to‐severe traumatic brain injury in adults: a network meta‐analysis. Cochrane Database of Systematic Reviews 2017, Issue 4. Art. No.: CD012639. DOI: 10.1002/14651858.CD012639.

  46. Burry LD, Scales D,Williamson DR, Mehta S, Wilcox E, Bernard F, Azad A, Fan E, Rose L. for Prevention of in Critically Ill Patients (MELLOW-1) – Study protocol. BMJ Open 2017 Mar 30;7(3):e015420.

  47. Duceppe MA*,Williamson D*, Elliott A, Para M, Poirier MC, Delisle MS, Frenette AJ, Deckelbaum D, Razek T, Desjardins M, Bertrand JC,Bernard F, Rico P, Burry L, Perreault MM. Modifiable risk factors for delirium in critically ill trauma patients: a multicenter prospective study. J Intensive Care Med E-Pub (24 mars 2017)

  48. Chapdelaine A, Doré M, Troyanov Y, Williamson DR, Mansour AM. Metabolite monitoring to guide thiopurine therapy in systemic autoimmune diseases. Clin Rheumatol 2017;36 :1341-8.

  49. Albert M, Corsilli D, Williamson DR, Brosseau M, Bellemare P, Delisle S, Nguyen AQN, Varin F. Comparison of inhaled milrinone, nitric oxide and prostacyclin in acute respiratory distress syndrome. World J Crit Care Med 2017; 2017 Feb 4;6:74-78.

Areas of expertise

  • Axe : Médicament et santé des populations
  • Pharmacothérapie (maladies thromboemboliques)
  • Pharmacothérapie (complications hématologiques)
  • Pharmacothérapie (soins critiques)
  • Clinical research
  • Recherche épidémiologique