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Martine Raymond

Biologie moléculaire de la levure

Professeure titulaire

Faculté de médecine - Département de biochimie et médecine moléculaire

Roger-Gaudry

514 343-6746

martine.raymond@umontreal.ca

Professeure/chercheuse titulaire

IRIC - Direction générale

Pavillon Marcelle-Coutu, room 3306-17

martine.raymond@umontreal.ca

Secondary number: 514 343-6843 (Télécopieur)

Media

 - © IRIC

Profile

Research expertise

Our research focuses on the molecular biology of Candida albicans, an opportunistic yeast that causes systemic or mucosal infections in immunocompromised individuals (such as HIV patients, patients undergoing chemotherapy or organ transplant). Our laboratory uses genetic, genomic and molecular biology approaches to understand the mechanisms responsible for C. albicans multidrug resistance and virulence. In particular, we are interested in understanding the function of multidrug transporters of the ATP-binding cassette family which export antifungal drugs out of the cells. Using functional genomics (DNA microarrays), we work at identifying the transcriptional networks controlling multidrug resistance and virulence in C. albicans. Finally, our laboratory is part of a CIHR multidisciplinary team on fungal pathogenesis grouping several Montreal-based researchers whose objective is to discover new C. albicans target proteins or small non-coding RNAs for antifungal drug development.

Affiliations and responsabilities

Teaching and supervision

Student supervision

Theses and dissertation supervision (Papyrus Institutional Repository)

Projects

Research projects

2017 - 2022

Analyses génétiques, génomiques et protéomiques du rôle de la chromatine dans la réponse des champignons aux antifongiques

Lead researcher : Martine Raymond , Hugo Wurtele
Funding sources: FRQNT/Fonds de recherche du Québec - Nature et technologies (FQRNT)
Grant programs: PV113724-(PR) Projets de recherche en équipe (et possibilité d'équipement la première année)
2015 - 2020

UNE APPROCHE CHIMIO- ET PROTEO-GENOMIQUE EN MEDECINE PERSONNALISEE POUR LA LEUCEMIE MYELOIDE AIGUE

Lead researcher : Guy Sauvageau
Funding sources: FCI/Fondation canadienne pour l'innovation
Grant programs: PVXXXXXX-Fonds d'innovation
2013 - 2019

MOLECULAR MECHANISMS OF FUNGAL QUORUM SENSING

Lead researcher : Martine Raymond
Funding sources: CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs: PVX20965-(RGP) Programme de subvention à la découverte individuelle ou de groupe
2009 - 2016

MOLECULAR MECHANISMS OF ANTIFUNGAL DRUG RESISTANCE IN CANDIDA ALBICANS

Lead researcher : Martine Raymond
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXX5647-(MOP) Subvention de fonctionnement incluant les subventions de fonctionnement programmatiques (général)
2008 - 2014

MOLECULAR MECHANISMS OF ANTIFUNGAL DRUG RESISTANCE IN CANDIDA ALBICANS

Lead researcher : Martine Raymond

Outreach

Publications and presentations

Publications

  • Znaidi, S., Weber, S. Zin Al-Abdin, O., Bomme, P., Saidane, S., Drouin, S., Lemieux, S., De Deken, X., Robert, F. and Raymond, M.  2008.  Genome-wide location analysis of Candida albicans Upc2p, a regulator of sterol metabolism and azole drug resistance.  Eukaryotic Cell. 7:836-847.
  • Liu, T.T., Znaidi, S., Barker, K.S., Xu, L., Homayouni, R., Saidane, S., Morschhäuser, J., Nantel, A., Raymond, M., and Rogers, P.D.  2007.  Genome-wide expression and location analyses of the Candida albicans Tac1p regulon.  Eukaryotic Cell. 6:2122-2138.
  • Znaidi, S., De Deken, X., Weber, S., Rigby, T., Nantel, A. and Raymond, M.  2007.  The zinc finger transcription factor Tac1p regulates PDR16 expression in Candida albicans.  Mol. Microbiol. 66:440-452.
  • Saidane, S., Weber, S., De Deken, X., St-Germain, G., and Raymond, M.  2006.  PDR16-mediated clinical azole resistance in Candida albicans.Mol. Microbiol. 60:1546-1562.
  • Gauthier, C., Weber, S., Alarco, A.-M., Alqawi, O., Daoud, R., Georges, E. and Raymond, M. 2003. Functional similarities and differences between the Candida albicans Cdr1p and Cdr2p transporters.  Antimicrob. Agents Chemother. 47:1543-1554.

Disciplines

  • Molecular Biology
  • Genetics
  • Microbiology

Areas of expertise

  • Development of Drug Delivery Systems
  • Yeasts