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Rami Al Batran

Professeur adjoint

Faculté de pharmacie

Pavillon Jean Coutu, local 3216

Autre numéro : 514 343-6111 #14500 (Travail 1)
Autre courriel : rami.al.batran@umontreal.ca (Travail)

Portrait

Biographie

Dr Al Batran has extensive expertise in the areas of obesity and energy metabolism, as well as animal models of diabetes and cardiovascular disease. His ongoing research program primarily focusing on how obesity-induced alterations in energy metabolism, and how targeting energy metabolism may be a novel approach to counteract obesity-related diseases such as type 2 diabetes and cardiovascular disease.

Prix et distinctions


Research Scholars Junior 1 - Fonds de recherche du Québec - Santé (FRQS)


KRESCENT New Investigator Award - A Joint Program Between KFC and CIHR


Post-Doctoral Fellowship - Canadian Institutes of Health Research (CIHR / IRSC)


Post-Doctoral Fellowship - Diabetes Canada

Affiliations et responsabilités

Affiliations de recherche

Enseignement et encadrement Ce professeur recrute

Recrutement en recherche Ce professeur recrute

PhD Position in Energy Metabolism

About the Lab

The Al Batran lab is looking for an enthusiastic and highly motivated PhD candidate who has a degree in Molecular Biology and/or Biotechnology. The laboratory is located at the Faculty of Pharmacy, University of Montreal, and the Lab offers an attractive and friendly research environment, provides state-of-the-art instrumentation and techniques.

Project Description

This position is available in the laboratory headed by Dr. Rami Al Batran. The project goal is focused on understanding how alterations in ketone body metabolism at the cellular and molecular levels contribute to obesity-related metabolic disorders including insulin resistance, type 2 diabetes, and diabetic kidney disease.

Qualification Requirements

  • Applicants must hold a master’s degree in Molecular Biology and/or Biotechnology.
  • To have obtained at least 3.3 out of 4 GPA of during his/her undergraduate studies.
  • Background and experience in some of the following areas is required: biochemistry, animal studies and cell culture.
  • Fluent oral and written communication skills in English and French.

Personal skills

The successful candidate will be:

  • Highly motivated to do world class research.
  • Self-driven and enthusiastic.
  • Able to work independently and in a structured manner.
  • Willing to learn new skills.
  • Proactive in solving problems.

How to apply

The application must include

  • Cover letter statement of motivation and research interests.
  • CV (summarizing education and list of laboratory experience).
  • Copies of educational certificates (academic transcripts only).
  • A complete list of publications and academic works.
  • List of reference persons: 2-3 references (name, relation to candidate, and e-mail).

These documents must be submitted before September 1, 2021. Only shortlisted candidates will be contacted during September 2021.

Contact information

Applicants should submit their files in one PDF to Dr. Rami Al Batran for further details.

Faculty of Pharmacy

University of Montreal 

E-mail: rami.al.batran@umontreal.ca

Website: https://www.albatranlab.com

Enseignement

Projets

Projets de recherche

2024 - 2031

Exploring the Hepatoprotective Actions of Sodium-glucose Cotransporter 2 (SGLT2) Inhibitors

Chercheur principal : Rami Al Batran
Sources de financement : IRSC/Instituts de recherche en santé du Canada
Programmes de subvention : PVXXXXXX-(PJT) Subvention Projet
2023 - 2026

Investigating the Short- and Long-term Effects of Ketogenic Diet on Atherosclerosis

Chercheur principal : Rami Al Batran
Sources de financement : FMCC/Fondation des maladies du coeur du Canada
Programmes de subvention : PVXX7979-Subvention pour projet de recherche et de développement
2022 - 2026

Cibler le métabolisme des corps cétoniques dans l'obésité et le syndrome métabolique

Chercheur principal : Rami Al Batran
Sources de financement : FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Programmes de subvention : PVXXXXXX-Établissement de jeunes chercheurs Juniors 1
2022 - 2026

Cibler le métabolisme des corps cétoniques dans l'obésité et le syndrome métabolique

Sources de financement : FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Programmes de subvention : PVXXXXXX-Bourse de chercheur-boursier : Junior 1
2020 - 2026

Medium Chain Triglycerides and Ketogenesis

Chercheur principal : Rami Al Batran
Sources de financement : CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Programmes de subvention : PVXXXXXX-(DGECR) Tremplin vers la découverte
2020 - 2026

Medium Chain Triglycerides and Ketogenesis

Chercheur principal : Rami Al Batran
Sources de financement : CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Programmes de subvention : PVX20965-(RGP) Programme de subvention à la découverte individuelle ou de groupe
2022 - 2025

Investigating the Role of Ketone Body Metabolism in Diabetic Kidney Disease

Chercheur principal : Rami Al Batran
Sources de financement : KRESCENT Program The Kidney Foundation of Canada
Programmes de subvention :
2021 - 2025

Pharmacothérapie du métabolisme du corps cétonique dans l'obésité

Chercheur principal : Rami Al Batran
Sources de financement : FCI/Fondation canadienne pour l'innovation
Programmes de subvention : PVXXXXXX-Fonds d'exploitation des infrastructures (FEI)
2021 - 2024

Could a Ketogenic Diet Slow the Progression of Diabetic Kidney Disease?

Chercheur principal : Rami Al Batran
Sources de financement : Fondation canadienne du rein
Programmes de subvention :
2021 - 2024

Réseau de recherche en santé cadiométabolique, diabète et obésité CMDO / Quantitative fluxomics of ketone bodies in diabetic kidney disease (the identified trainee is Abdualrahman Abdualkader and the intercenter collaborator is Dr. Matthieu Ruiz (IRCM)).

Sources de financement : FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Programmes de subvention : PVXXXXXX-Réseaux thématiques de recherche
2022 - 2023

Branched-Chain Amino Acids and Insulin Resistance

Chercheur principal : Rami Al Batran
Sources de financement : Diabète Québec
Programmes de subvention :
2022 - 2023

Investigating the Role of Ketone Body Metabolism in Diabetic Kidney Disease

Chercheur principal : Rami Al Batran
Sources de financement : KRESCENT Program The Kidney Foundation of Canada
Programmes de subvention :
2020 - 2022

Pharmacothérapie du métabolisme du corps cétonique dans l'obésité

Chercheur principal : Rami Al Batran
Sources de financement : FCI/Fondation canadienne pour l'innovation
Programmes de subvention : PVXXXXXX-Fonds des leaders

Rayonnement

Publications et communications

Publications

Selected Publications:

Al Batran R, Gopal K, Capozzi ME, Chahade JJ, Saleme B, Tabatabaei-Dakhili SA, Greenwell AA, Niu J, Almutairi M, Byrne NJ, Masson G, Kim R, Eaton F, Mulvihill EE, Garneau L, Masters AR, Desta Z, Velázquez-Martínez CA, Aguer C, Crawford PA, Sutendra G, Campbell JE, Dyck JRB, and Ussher JR. Pimozide Alleviates Hyperglycemia in Diet-Induced Obesity by Inhibiting Skeletal Muscle Ketone Oxidation. Cell Metabolism. 2020 https://doi.org/10.1016/j.cmet.2020.03.017

Eshreif A, Al Batran R, Jamieson KL, Darwesh AM, Gopal K, Greenwell AA, Zlobine I, Aburasayn H, Eaton F, Mulvihill EE, Campbell JE, Seubert JM, Ussher JR. L-citrulline supplementation improves glucose and exercise tolerance in obese mice. Exp Physiol. 2019 Dec 5. doi: 10.1113/EP088109.

Uddin GM, Zhang L, Shah S, Fukushima A, Wagg CS, Gopal K, Al Batran R, Pherwani S, Ho KL, Boisvenue J, Karwi QG, Altamimi T, Wishart DS, Dyck JRB, Ussher JR, Oudit GY, Lopaschuk GD. Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure. Cardiovasc Diabetol. 2019 Jul 5;18(1):86.

Ho KL, Zhang L, Wagg C, Al Batran R, Gopal K, Levasseur J, Leone T, Dyck JRB, Ussher JR, Muoio DM, Kelly DP, and Lopaschuk GD. Increased ketone body oxidation provides additional energy for the failing heart without improving cardiac efficiency. Cardiovasc Res. 2019 Feb 18. pii: cvz045.

Al Batran R, Gopal K, Aburasayn H, Eshreif A, Almutairi M, Greenwell AA, Campbell SA, Saleme B, Court EA, Eaton F, Light PE, Sutendra G, Ussher JR. The antianginal ranolazine mitigates obesity-induced hepatic steatosis and increases hepatic dehydrogenase activity. JCI Insight. 2019 Jan 10;4(1). pii: 124643.

Al Batran R, Gopal K, Martin MD, Ho KL, Almutairi M, Aburasayn H, Eaton F, Campbell JE, Ussher JR. Skeletal muscle-specific Cre recombinase expression, controlled by the human α-skeletal actin promoter, improves glucose tolerance in mice fed a high-fat diet. Diabetologia. 2018 Aug;61(8):1849-1855.

Gopal K, Almutairi M, Al Batran R, Eaton F, Gandhi M, Ussher JR. Cardiac-specific deletion of pyruvate dehydrogenase impairs glucose oxidation rates and induces diastolic dysfunction. Front Cardiovasc Med. 2018 Mar 6; 5:17.

Al Batran R, Almutairi M, Ussher JR. Glucagon-like peptide-1 receptor mediated control of cardiac energy metabolism. Peptides. 2018 Feb;100:94-100.

Aburasayn H, Al Batran R, Gopal K, Almutairi M, Eshreif A, Eaton F, Ussher JR. Female offspring born to obese and insulin-resistant dams are not at increased risk for obesity and metabolic dysfunction during early development. Can J Physiol Pharmacol. 2018 Jan;96(1):97-102.

Al Batran R, & Ussher JR. Revisiting protein acetylation and myocardial fatty acid oxidation. Am J Physiol Heart Circ Physiol. 2017 Sep 1;313(3):H617-H619

Gopal K, Saleme B, Al Batran R, Aburasayn H, Eshreif A, Ho KL, Ma WK, Almutairi M, Eaton F, Gandhi M, Park EA, Sutendra G, Ussher JR. FoxO1 regulates myocardial glucose oxidation rates via transcriptional control of pyruvate dehydrogenase kinase 4 expression. Am J Physiol Heart Circ Physiol. 2017 Sep 1;313(3):H479-H490.  

Aburasayn H, Al Batran R, Ussher JR. Targeting ceramide metabolism in obesity. Am J Physiol Endocrinol Metab. 2016 Aug 1;311(2):E423-35.

Disciplines

  • Pharmacie
  • Pharmacologie

Champ d’expertise

  • Obésité
  • Diabète
  • Pharmacologie métabolique
  • Pharmacologie cardiovasculaire
  • Axe : Découverte et validation de cibles thérapeutiques

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