cryo-microscopie electronique, virologie, biologie structurale

• D.Phil (U.Frankfurt)

Fussner-Dupas E^‡, Li R, Strauss M^‡, Correlative Electron spectroscopic Imaging (ESI) and electron tomography of chromatin, Methods in Molecular Biology - Histones: Methods and Protocols, 2025. 

Alanagh HR, Sánchez-Sánchez MG, Wozny MR, Habibi Y, Jarade C, Sprules T, Strauss M, Mittermaier A, Hendricks AG^‡, Harrington MJ^‡, pH-sulfate synergy regulates processing and mechanics of mussel byssus protein condensates, Chem Mater (2025) 37, 3, 925–938. 

Clusiau S, Piché N, Brodusch N, Strauss M, Gauvin R, Workflow automation of SEM acquisitions and feature tracking, Ultramicroscopy (2025), 269, 114093. 

Dinesh NEH, Rousseau J, Mosher DF, Strauss M, Mui J, Campeau PM^‡, Reinhardt DR^‡, Mutations in fibronectin dysregulate chondrogenesis in skeletal dysplasia, Cell Mol Life Sci (2024), 81(1):419. 

Clusiau S, Piché N, Provencher B, Strauss M; Gauvin R, Optimizing SEM parameters for segmentation with AI – Part 1: Generating a training set, Comp Mater Sci (2024), 245, 113255. 

Clusiau S, Piché N, Provencher B, Strauss M; Gauvin R, Optimizing SEM Parameters for segmentation with AI – Part 2: Designing and training a regression model, Comp Mater Sci (2024), 245, 113283. 

Wozny MR*, Nelea V*, Siddiqui IFS, Wanga S, de Waard V, Strauss M^‡, Reinhardt DP^‡, Microfibril-associated glycoprotein 4 forms octamers that mediate interactions with elastogenic proteins and cells, Nat Commun (2024) 15:4015. 

Markus LMD, Sharon I, Munro K, Grogg M, Hilvert D, Strauss M^‡, Schmeing TM^‡, Structure and function of a hexameric cyanophycin synthetase 2, Protein Sci (2023) 32(7): e4685. 

Jayawardena N, McCarthy C, Wang I, Waqqar S, Burga LN, Strauss M^‡, Bostina M^‡, Characterisation of a Seneca Valley virus thermostable mutant, Virology (2022) 575:74-82. 

Wang I, Gupta SK, Ems G, Jayawardena N, Strauss M^‡, Bostina M^‡, Cryo-EM structure of a possum enterovirus, Viruses (2022) 14(2), 318. 

Fortinez CMA, Bloudoff K, Harrigan C, Sharon I, Strauss M, Schmeing TM, Structures and function of a tailoring oxidase in complex with a nonribosomal peptide synthetase module. Nat Commun 13, 548 (2022). 

Gomez-Blanco J*, Kaur S*, Strauss M, Vargas J, Hierarchical autoclassification of cryo-EM samples and macromolecular energy landscape determination, Comput Methods Programs Biomed (2022) 216, 106673. 

Gupta TK, Klumpe S, Gries K, Heinz S, Wietrzynski W, Ohnishi N, Niemeyer J, Schaffer M, Rast A, Strauss M, Plitzko JM, Baumeister W, Rudack T, Sakamoto W, Nickelsen J, Schuller JM, Schroda M, Engel BD. Structural basis for VIPP1 oligomerization, nucleotide hydrolysis, and lipid interaction. Cell (2021) 184(14): p3643-59. 

Bartlett JD, Smith CE, Hu Y, Ikeda A, Strauss M, Liang T, Hsu YH, Trout AH, McComb DW, Freeman RC, Simmer JP, Hu JCC. MMP20-generated amelogenin cleavage products prevent formation of fan-shaped enamel malformations. Sci Rep (2021) 11(1): p1-18. 

Jehle F, Priemel T, Strauss M, Fratzl P, Bertinetti L, Harrington MJ. Collagen Pentablock Copolymers form smectic liquid crystals as precursors for mussel byssus fabrication. ACS Nano (2021) 15(4): 6829-38. 

Karunatilaka KS, Filman DJ, Strauss M, Loparo JJ, Hogle JM. Real-time imaging of polioviral RNA translocation across a membrane. mBio (2021) Feb 23;12(1):e03695-20. 

Smith CE, Hu Y, Strauss M, Hu JCC, Simmer JP. The spatial distribution of focal stacks within the inner enamel layer of mandibular mouse incisors. J Anat (2021) 238(4): p970-85; e13352. 

Shah PNM, Filman DJ, Karunatilaka KS, Hesketh EL, Groppelli E, Strauss M, Hogle JM. Cryo-EM structures reveal two distinct conformational states in a picornavirus cell entry intermediate. PLoS Pathog (2020) 16(9): e1008920. 

Finogenova K, Bonnet J, Poepsel S, Schäfer IB, Finkl K, Schmid K, Litz C, Strauss M, Benda C, Müller J, Structural basis for PRC2 decoding of active histone methylation marks H3K36me2/3, eLife (2020) Nov19; e61964. 

Huang WC, Zhou S, He X, Chiem K, Mabrouk MT, Nissly RH, IBird IM, Strauss M, Sambhara S, Ortega J, Wohlfert EA, Martinez-Sobrido L, Kuchipudi SV, Davidson BA, Lovell JF. SARS- CoV-2 RBD Neutralizing antibody induction is enhanced by particulate vaccination. Adv Mater (2020) 32: 2005637. 

Gutmann T, Schäfer IB, Poojari C, Brankatschk B, Vattulainen I^‡, Strauss M^‡, Coskun Ü^‡, Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain, J Cell Biol (2020) Jan 6;219(1). 

Leijten ZJWA, Wirix MJM, Strauss M, Plitzko JM, de With G, Friedrich H, Low-dose (S)TEM elemental analysis of water and oxygen uptake in beam sensitive materials, Ultramicroscopy (2020) Jan;208:112855. 

Gat Y, Schuller J, Lingaraju M, Bonneau F, Strauss M, Murray P, Weyher E, Conti E. IP6 binding to PIKK kinases revealed by the cryo-EM structure of a SMG1-SMG8-SMG9 complex. Nat Struct Mol Biol (2019) Dec 26(12):1089-1093. 

Filman DJ, Marino SF, Ward JE, Yang L, Mester Z, Bullitt E, Lovley DR, Strauss M, Cryo-EM reveals the structural basis of long-range electron transport in a cytochrome-based bacterial nanowire, Commun Biol (2019) 2: 219. 

Schäfer I, Yamashita M, Schuller JM, Schüssler S, Reichelt P, Strauss M, Conti E, Molecular Basis for poly(A) RNP architecture and recognition by the Pan2-Pan3 deadenylase, Cell (2019) May 16, 2019.

Schlauderer, F, Seeholzer, T, Desfosses, A, Gehring, T, Strauss, M, Gutsche, I, Hopfner, KP, and Krappmann, D, Lammens, K, Molecular architecture and regulation of BCL10-MALT1 filaments, Nature Commun (2018) 9:4041. 

Balchin, D, Miličić, G, Strauss, M, Hayer-Hartl, M, Hartl, F.U, Pathway of actin folding directed by the eukaryotic chaperonin TRiC, Cell (2018) 174(6): 1507-21. 

Bilokapic S, Strauss M, Halic M. Cryo-EM of nucleosome core particle interactions in trans, Sci Rep (2018) 8(1): 7046. 

Eustermann S, Schall K, Kostrewa D, Lakomek K, Strauss M, Moldt M, Hopfner KP. Structural basis for ATP-dependent chromatin remodelling by the INO80 complex, Nature (2018) 556(7701): 386-390. 

Bilokapic S, Strauss M, Halic M.  Structural rearrangements of the histone octamer translocate DNA, Nature Commun (2018) 9(1): 1330. 

Strauss, M, Jayawardena, N, Sun, E, Easingwood, R.A, Burga, L.N, Bostina, M, (2018). Cryo-electron microscopy structure of Seneca Valley virus procapsid, J Virology 92(6) e01927-17. 

Bilokapic S, Strauss M, Halic M. Histone octamer rearranges to adapt to DNA unwrapping, Nat Struct Mol Biol (2018) 25(1): 101-108. 

Freeman Rosenzweig ES, Xu B, Kuhn Cuellar L, Martinez-Sanchez A, Schaffer M, Strauss M, Cartwright HN, Ronceray P, Plitzko JM, Förster F, Wingreen NS, Engel BD, Mackinder LCM, Jonikas MC, The eukaryotic CO2-concentrating organelle is liquid-like and exhibits dynamic reorganization, Cell (2017) 171(1): 148-162.e19. 

Strauss M, Schotte L, Filman DJ, and Hogle JM, CryoEM structures of expanded poliovirus with VHHs sample the conformational repertoire of the expanded state, J Virology (2017),92(3):e01443-16. 

Groppelli E, Levy H, Sun E, Strauss M, Nico, C, Gold S, Zhuang X, Tuthill TJ, Hogle JM, Rowlands DJ, PicornaVirus RNA is protected from cleavage by ribonuclease during virion uncoating and transfer across cellular and model membranes, PLoS Pathog (2017), 13(2):1-21. 

Nasr ML, Baptista D, Strauss M, Sun ZJ, Grigoriu S, Huser S, Plückthun A, Hagn F, Walz T, Hogle JM, Wagner G, Covalently circularized nanodiscs for studying membrane proteins and viral entry, Nat Methods (2017), 14:49-52. 

Strauss M*, Schotte L*, Thys B, Filman DJ, and Hogle JM, Five of five VHHs neutralizing poliovirus bind the receptor-binding site, J Virology (2016), 90(7): 3496-3505. 

Azhari H, Strauss M, Hook S, Boyd BJ, Rizwan SB, Stabilising cubosomes with Tween 80 as a step towards targeting lipid nanocarriers to the blood–brain barrier, Eur J of Pharm Biopharm (2016) 104:148-55. 

Schotte L, Thys B, Strauss M, Filman DJ, Rombout B, Hogle JM, Characterization of poliovirus neutralization escape mutants of single-domain antibody fragments (VHHs), Antimicrob Agents Chemother (2015), 59(8):4695-706. 

Strauss M, Filman DJ, Cheng N, Noel RT, Belnap DM, Hogle JM, Nectin-like interactions between poliovirus and its receptor trigger conformational changes associated with cell entry, J Virology (2015), 89(8):4143-57. 

Schoderboeck L, Riad S, Boker A, Wicky H, Strauss M, Bostina M, Oswald M, Empson R, Hughes S, Chimeric rabies SADB19-VSVg pseudotyped lentiviral vectors mediate long-range retrograde transduction from the mouse spinal cord. Gene Ther (2015),22(5):357-64. 

Panjwani A, Strauss M, Gold S, Wenham H, Jackson T, Chou JJ, Rowlands DJ, Stonehouse NJ, Hogle JM, Tuthill TJ, Capsid protein VP4 of human rhinovirus induces membrane permeability by the formation of a size-selective multimeric pore, PLoS Pathog (2014) 10(8): e1004294. 

Schotte L, Strauss M, Thys B, Halewyck H, Filman DJ, Bostina M, Hogle JM, Rombaut B, Mechanism of action and capsid-stabilizing properties of VHHs with an in vitro antipolioviral activity, J Virology (2014) 88(8):4403-13 

Ma H-C, Liu Y, Wang C, Strauss, M, Rehage, N, Hogle, JM, Wimmer, E, Mueller, S, Paul, AV, Jiang P. An Interaction between glutathione and the capsid is required for the morphogenesis of c-cluster enteroviruses. PLoS Pathog (2014) 10(4): e1004052. 

Strauss M, Levy H, Bostina M, Filman DJ, Hogle JM, RNA transfer from poliovirus 135S particles across membranes is mediated by long umbilical connectors, J Virology (2013) 87(7):3903-14. 

Even-Faitelson L, Fussner E, Li R, Strauss M, Bazett-Jones D, Electron spectroscopic tomography of specific chromatin domains, Meth Mol Bio (2013) vol 1042:181-95. 

Mills DJ, Vitt S, Strauss M, Shima S, Vonck J, De novo modelling of the F420-reducing [NiFe]-hydrogenase from a methanogenic archaeon by cryo-electron microscopy, eLife (2013) vol 2: p. e00218. 

Fussner E*, Strauss M*, Djuric U, Li R, Ahmed K, Hart M, Ellis J, Bazett-Jones DP, Open and closed domains in the mouse genome are configured as 10 nm chromatin fibres, EMBO Rep (2012) Sept 18, vol 13(11):992-6. 

Davies K*, Strauss M*, Daum B*, Kief J, Rycovska A, Osiewacz H, Zickermann V, Kühlbrandt W, Macromolecular organisation of ATP synthase and complex I in whole mitochondria, PNAS (2011) Aug 23;108(34):14121-6. 

Wilk L, Strauss M, Rudolf M, Nicolaisen K, Flores E, Kühlbrandt W. and Schleiff E, Outer membrane continuity and septosome formation between vegetative cells in the filaments of Anabaena sp. PCC7120. Cell Microbiol (2011) Nov 13(11): 1744-54. 

Fussner E, Djuric U, Strauss M, Hotta A, Perez-Iratxeta C, Lanner F, Dilworth FJ, Ellis J, Bazett-Jones DP, Constitutive heterochromatin reorganization during somatic cell reprogramming, EMBO J (2011), 30, 1778-1789. 

Porrati F, Sachser, R, Strauss, M, et al, Artificial granularity in two-dimensional arrays of nanodots fabricated by focused electron beam induced deposition, Nanotechnology (2010), vol 21, 375302. 

Strauss M*, Hofhaus G.*, Schröder RR, Kühlbrandt W, Dimer ribbons of ATP synthase shape the inner mitochondrial membrane, EMBO J (2008), v27 (7) pp. 1154-60. 

Torrie B, Brinbek O, Strauss M, Swainson I, Phase transitions in solid methanol, J Solid State Chemistry (2002) 166(2): 415-20.