Intérêt clinique et de recherche en lien avec  les domaines de la pharmacotherapie aux soins intensifs: evaluation et traitement de la douleur, de l'agitation, et du délire. Plus récemment, un intérêt sur le syndrome de sevrage iatrogénique associé à un séjour aux soins intensifs et une exposition prolongée à des opioïdes et des sedatifs  et ses modalités d'évaluations, de facteurs de risque, de prévention et de traitement.

Baccalaureat en Pharmacie à UdeM

Maitrise en Pharmacie d'hôpital à Hôpital Saint-Luc, Montreal

PharmD de 2ième Cycle de SUNY at Buffalo

Fellowship de recherche à l'Hotel-Dieu de Montreal

Pharmacien spécialiste en soins critiques à l'Hôpital Général d'Ottawa (1994-2001)

Pharmacien clinicien en soins critiques au sein du reseau CUSM (2001- )

Pharmacien spécialiste oeuvrant en soins critiques - réseau CUSM

Participation à la clinique PICS au sein du reseau CUSM  (Post-Intensive care Unit Syndrome)

Conférencier - Université Catholique de Louvain, Bruxelles, Belgique

Directeur du programme de MSc en Pharmacothérapie avancée (2007-2016)

Participation au comité d'agrément facultaire

Participation au comité EDI facultaire

Stages d'internat de 6 mois de candidats francais inscrits au programme en pharmacie d'hôpital

Stages en soins critiques dans le cadre d'un DEPA de 3ième cycle

Membre du comité exécutif du Conseil Canadien de la Résidence en pharmacie (2016-2020)

Participation au Conseil Canadien de la Residence en Pharmacie (CCRP) à titre d'enquêteur (2020- )

Éditeur associé du Journal Canadien de la Pharmacie hospitalière (2012-2022)

Publications depuis 2014:

Dupuis S, Amiel JA, Desgroseillers M, Williamson DR, Thiboutot Z, Serri K, Perreault MM, Marsolais P, Frenette AJ. Corticosteroids in brain dead potential organ donor management – a systematic review of randomized controlled trials. Br J Anesth 2014; 113(3): 346-359.

Burry L, Williamson D, Perreault MM et al. Sedative, analgesic, anti-psychotic, and neuromuscular blocker use in Canadian ICUs: a multicenter observational study. Can J Anesthesia 2014: 61(7) 619-630.

Sneyers B, Laterre PF, Bricq E, Perreault MM, Wouters D, Spinewine A. What stops us from following sedation recommendations in intensive care units ? A multicentric qualitative study. J Critical Care 2014; 29(2): 291-7.

R Vlavonou, MM Perreault, R Larouche, D Anctil, F Trabelsi, M Tanguay. Pharmacokinetic characterization of baclofen in renal impairment. J Clin Pharmacol 2014 ; 54(5) : 584-92.

Elena Luk, Barbara Sneyers, Louise Rose, Marc M. Perreault, David R. Williamson, Sangeeta Mehta, Deborah Cook, Stephanie Lapinski, Lisa Burry. Predictors of physical restraints use in Canadian intensive care units. Critical care 2014; 18: R24 (DOI: 10.1186//cc13789).

B Sneyers, PF Laterre, MM Perreault, D Wouters, A Spinewine. Barriers impairing physicians and nurses’ adherence to analgo-sedation recommendations in the intensive care unit – a national survey. Crit Care 2014; 18:655. Publié online Dec 5, 2014.

Zoe Thiboutot, Marc M Perreault, David R Williamson, Sangeeta Mehta, Louise Rose, Stephanie C Lapinsky, Deborah Cook, Lisa Burry. Delirium screening and use of antipsychotics in mechanically ventilated patients in Canadian intensive care units. CJHP 2016; 69(2): 107-13.

B Sneyers, S Henrard, PF Laterre, MM Perreault, C Beguin, N Speybroeck, A Spinewine. Predictors of clinicians’underuse of daily sedation interruption and sedations scales. J Crit Care 2016; publié en ligne 11 aout 2016.

Frenette AJ, Bebawi E, Deslauriers LC, Tessier AAL, Perreault MM, Delisle MS, Bertrand JC, Desjardins M, Bernard F, Rico P, Khwaja K, Bury L, Williamson DR, Validation and comparison of CAM-ICU and ICDSC in mild and moderate traumatic brain injury. Intensive care Medicine 2016; 42:122-3.

Perreault MM. La surabondance des termes lies à la sécurité des patients: un obstacle au progrès. JCPH 2015; 68(5): 367-68.

Dupuis S, Martel A, Arfa T, Valma J, Williamson D, Perreault MM. Decisional factors influencing fourth year pharmacy students’ decisions to pursue hospital residency. JCPH 2016; 69 (3): 209-15.

Wheeler KE, Cook DJ, Mehta S, Calce A, Guenette M, Perreault MM, Thiboutot Z, Duffett M, Burry L. Use of probiotics to prevent ventilator-associated pneumonia: A  Survey of Pharmacists’ attitudes. J Crit Care October 2015. doi: 10.1016/j.jcrc.2015.10.016

Williamson DR, Frenette AJ, Burry L, Perreault MM, Charbonney E, Lamontagne F, Potvin MJ, Giguère JF, Mehta S, Bernard F. Pharmacological interventions for agitation in patients with traumatic brain injury – a protocol for a systematic review and meta-analysis. Systematic Reviews 2016 ; 5 : 19

Duceppe MA, Williamson D, Elliott A, Para M, Poirier MC, Delisle MS, Deckelbaum D, Razek T, Desjardins M, Bertrand JC, Bernard F, Rico P, Burry L, Frenette AJ, Perreault MM. Modifiable risk factors for delirium in critically ill trauma patients : a multicenter prospective study. J Intensive Care Med ; 2017; March 24 (ePub).

Burry L, Williamson D, Mehta S, Perreault MM, Mantas I, Mallick R, Fergusson D, Smith O, Fan E, Dupuis S, Herridge M, Rose L. Delirium and exposure to psychoactive medications in critically ill adults : a multi-centre observational study. J Crit Care 2017 ; 42 : 268-274.

Chiu AW, Contreras S, Mehta S, Korman J, Perreault MM, Williamson DR, Burry LD. Iatrogenic Opioid Withdrawal in Critically Ill Patients: A Review of Assessment Tools, and Management. Ann Pharmacother 2017 ; 51(12) : 1099-1111.

Perreault MM. Today’s research is tomorrow’s practice : promoting a culture of research. JCPH 2017 ; 70(3) : 167-8.

Wang PP, Huang E, Feng X, Bray CA, Perreault MM, Rico P, Bellemare P, Murgoi P, Gélinas C, Lecavalier A, Jayaraman D, Frenette AJ, Williamson DR.WAAICUP - I: Determining the Incidence and Evaluating the Risk Factors of Iatrogenic Withdrawal Syndrome due to Opioids in Critically Ill Patients: a Multicenter Prospective Cohort Study. Ann Intens Care 2017; 7 : 88 : 1-7.

Dupuis S, Brindamour D, Karzon S, Frenette AJ, Charbonney E, Perreault MM, Bellemarre P, Burry L, Williamson DR. Interventions to facilitate extubation in difficult to wean patients because of delirium, agitation or anxiety : A systematic review and meta-analysis. Can J Anesth, Jan 23, 2019, publié en ligne (DOI : 10.1007/s12630-018-01289-1).

Duceppe MA, Perreault MM, Frenette AJ, Burry LD, Rico P, Lavoie A, Gélinas C, Mehta S, Dagenais M, Williamson DR. Frequency, Risk Factors and Symptomatology of Iatrogenic Withdrawal from Opioids and Benzodiazepines in Critically Ill Neonates, Children and Adults: A Systematic Review of Clinical Trials. J Clin Pharm Ther 2018; 1-9. DOI : 10.1111/jcpt.12787

Burry L, Mehta S, Perreault MM, Luxenberg JS, Siddiqi N, Hutton B, Fergusson DA, Bell C, Rose L. Antipsychotics for treatment of delirium in hospitalized non-ICU patients. Cochrane Database of Systematic Reviews 2018, Issue 6. Art. No : CD005594. DOI: 10.1002/14651858.CD005594.pub3.

Capilnean A, Martone A, Rosu V, Sandu P, Murgoi P, Frenette AJ, Williamson D, Lecavalier A, Jayaraman D, Rico P, Bellemare P, Gelinas C, Perreault MM. Withdrawal assessment in adult ICU patients : Validation of the WAT-1 scale. Am J Crit Care 2019 28:361-369; doi:10.4037/ajcc2019559

Williamson DR, Frenette AJ, Burry L, Perreault MM, Charbonney E, Lamontagne F, Potvin MJ, Giguère JF, Mehta S, Bernard F. Pharmacological interventions for agitation in patients with traumatic brain injury – a systematic review. BMJ Open 2019; 9:e029604.

Perreault MM. The dose makes the poison. JCPH 2019; 72(2) : 107-108.

Perreault MM. La dose fait le poison. JCPH 2019; 72(2) : 109-110.

Sheehan NL. Williamson D, Letarte N, Perreault MM. Programmes de résidences de pratique avancée en pharmacie au Quebec. Pharmactuel 2019; 52(1) : 6-8.

Sneyers B,  M.Sc, Ph.D.¹*; Duceppe MA,  Pharm.D, M.Sc.²*;  Frenette AJ Pharm.D, M.Sc.^3,4;  Burry LD Pharm.D ^5,6;  Rico P MD ^7,8; Lavoie A B.Pharm, M.Sc.⁹; Gélinas C RN, Ph.D ^10,11; Mehta S, MD, FRCPC ¹²; Dagenais M, RN, M.Sc.¹³;  Williamson DR, B.Pharm, M.Sc, Ph.D ^3,4; Perreault MM, M.Sc, Pharm.D ^2,3 Strategies for the Prevention and Treatment of Iatrogenic Withdrawal from Opioids and Benzodiazepines in Critically Ill Neonates, Children and Adults: A Systematic Review of Clinical Studies. Drugs. 2020; 80 : 1211-1233. https://doi.org/10.1007/s40265-020-01338-4

Perreault MM, Williamson DR, Capilnean A. Response to a letter to the editor: The neuropsychiatric iceberg under withdrawal syndrome. Am J Crit Care 2020; vol 29 (3): 168-9.

Morris JL, Bernard F, Bérubé M, Dubé JN, Houle J, Laporta D, Morin SN, Perreault M, Williamson D, Gélinas C. Determinants of Pain Assessment Documentation in Intensive Care Units. Canadian J of Anesthesia 2021; 68: 1176-1184. https://doi.org/10.1007/s12630-021-02022-1

Saavedra-Mitjans M, David PM, Frenette AJ, Arbour C, Perreault MM, Williams V, Bernard F, Williamson D. Experiences and attitudes  towards agitated behaviours  in TBI ICU patients (EXSTATIC): a protocol for an interprofessional  mixed-method  study. BMJ Open 2021; 11: e045816. https://doi.org/10.1136/bmjopen-2020-045816

Perreault MM. Are We Closing the Loop on Meeting the Therapeutic Needs of Critically-Ill Patients? JCPH 2021; 74(3): 199-200. https://doi.org/10.4212/cjhp.v74i3.3136

Mahmoud SH, Hefny FR, Panos NG, Delucilla L, Ngan Z, Perreault MM, Hamilton LA, Rowe AS, Buschur PL, Owusu-Guha J, Almohaish S, Sandler M, Armahizer MJ, Barra ME, Cook AM, Barthol CA, Hintze TD, Cantin A, Traeger J, Blunck JR, Shewmaker J, Burgess SV, Kaupp K, Brown CS, Clark SL, Wieruszewski ED, Tesoro EP,  Ammar AA, Ammar MA, Binning MJ, Naydin S, Fox N, Peters DM,  Mahmoud LN, Keegan SP, Brophy GM. Comparison of Nimodipine Formulations and Administration Techniques via Enteral Feeding Tubes in Patients with Aneurysmal Subarachnoid Hemorrhage: A Multicenter Retrospective Cohort Study. Pharmacotherapy. 2023;43:279–290. DOI: 10.1002/phar.2791

Bing E, Archambault K, Sananikone A, Nguyen KD, Jabamikos C, Fang YT, Gras C, Marsot A,  Duceppe MA, Perreault MM. Risk factors associated with augmented renal clearance in a mixed icu population: a retrospective study. Int J Clin Pharmacy, Publié en ligne le 14 juillet 2022. https://doi.org/10.1007/s11096-022-01458-9

Jabamikos C, Fang YT, Nguyen KD, Sananikone A, Archambault K, Bing E, Chagnon M, Husainalamoodi  O, Marsot A, Duceppe MA, Perreault MM. Validation of the augmented renal clearance in trauma intensive care (arctic) scoring system for augmented renal clearance prediction in a trauma subgroup of a mixed icu population. Journal of Clinical Pharmacy and Therapeutics, Publié en ligne le 28 Mai 2022.  https://doi.org/10.1111/jcpt.13695

Duquet-Armand M, Bouziane A, Arruda A, Denault JS, Routhier A, Cusson T, Halwagi A, Williamson D, Perreault MM, Lordkipanidze M, Létourneau-Guillon L, Thiboutot Z. Spontaneous intracranial hemorrhage and oral anticoagulation: a retrospective study. Canadian Journal of General Internal Medicine. 2023; 18(no 1). DOI: https://doi.org/10.22374/cjgim.v18i1.666

Bolesta S, Burry L, Perreault MM, Gélinas C, Smith KE, Eadie R, Carini F, Saltarelli K, Mitchell J, Harpel J, Stewart R, Riker RR, Fraser GL, Erstad BL on behalf of the ALERT-ICU study investigators International Analgesia and Sedation Weaning and Withdrawal Practices in Critically Ill Adults: The AduLt iatrogEnic withdRawal sTudy in the ICU (ALERT-ICU) Crit Care Med 2023; Publié en ligne le 8 juin 2023. DOI:10.1097/CCM.000000000000595

Depuis 2015

Duceppe MA, Elliott A, Para M, Poirier MC, Delisle MS, Frenette AJ, Deckelbaum D, Razek T, Desjardins M, Bertrand JC, Bernard F, Rico P, Burry L, Williamson D, Perreault MM. Evaluating modifiable risk factors for delirium in critically ill trauma patients: A multicenter prospective study. Crit Care 2015; 19 (Suppl 1): p 478.

Dupuis S, Martel A, Arfa T, Valma J, Williamson D, Perreault MM. Facteurs influencant la decision des étudiants de 4ième année de pharmacie de poursuivre leurs études à la residence en pharmacie hospitalière. Pharmactuel 2015; 48(3): 180.

Dupuis S, Brindamour D, Frenette AJ, Perreault MM, Burry L, Karzon S, Bellemarre P, Charbonney E, Williamson D. Interventions to facilitate weaning from mechanical ventilation in difficult to wean patients due to delirium, agitation or anxiety: a systematic review and meta-analysis. Presenté au Critical Care Canada Forum 2016, Novembre, Toronto

Wang PP, Huang E, Xue F, Bray CA, Perreault MM, Rico P, Bellemarre P, Murgoi P, Gelinas C, Lecavalier A, Jayaraman D, Frenette AJ, Williamson D. Iatrogenic Withdrawal Syndrome due to Opioids in Critically Ill Patients: a Multicenter Prospective Obeservationnal Study. Presenté au Critical Care Canada Forum 2016, Novembre Toronto.

Perreault MM, Martone A, Sandu PR, Rosu VA, Capilnean A, Murgoi P, Frenette AJ, Lecavalier A, Jayaraman D, Rico P, Bellemare P, Gelinas C, Williamson D. Withdrawal assessment in adult ICU patients: validation of the WAT-1 scale. Crit Care 2017; 21(Suppl1): p277.

Perreault MM, Talic J, Frenette AJ, Burry L, Bernard F, Williamson DR. Agitation after mild to moderate traumatic brain injury in the intensive care unit. Crit Care 2017; 21(Suppl1): p219.

Letarte N, Vinet J, Perreault M. Accreditation of experiential learning sites at the Faculté de Pharmacie de l’Université de Montréal. Présenté au congrès annuel de l’AFPC Canadian Pharmacy Education and Research Conference. June 5-6 2017, Quebec (PE27).

Capelle H, Villeneuve E, Delisle MS, Daigneault AM, Monast PO, Perreault MM. Rôle du pharmacien dans la prise en change des traumatisés crâniens graves dans un centre de traumatologie canadien de niveau 1. Presentation orale aux 12ième Rencontres Convergences Santé Hôpital, Dijon, France, 20 au 22 septembre 2017.

Duceppe MA, Perreault MM, Frenette AJ, Burry L, Rico P, Lavoie A, Gelinas C, Mehta S, Dagenais M, Williamson D. Frequency, risk factors, and symptomatology of iatrogenic withdrawal from opioids and benzodiazepines in critically ill neonates, children, and adults: a systematic review of clinical trials. Crit Care 2018; 22(suppl 1): P489.

Williamson D, Frenette AJ, Perreault M, Burry L, Charbonney E, Lamontagne F, Potvin MJ, Giguere JF, Mehta S, Bernard F. Pharmacological interventions for agitation in traumatic brain injury: a systematic review. Crit Care 2018; 22(suppl 1): P376.

Genest M, King V, El-Ghaddaf Y, Perreault MM, Schnitzer M, Longpré AA, Fontela P, Di Genova T, Dagenais M, Ruo NN. Impact of dexmedetomidine on the duration of invasive mechanical ventilation in pediatric intensive care patients - DEXPED trial. Crit Care 2018; 22(suppl 1): P503.

Arruda A, Denault JS, Routhier A, Bouziane A, Lordkipanidze M, Perreault MM, Williamson D, Thiboutot Z. Spontaneous Intracranial Hemorrhage Under Direct Oral Anticoagulants Versus Warfarin  (The PREMIUM DOAC-WARFARIN study). Crit Care Med 2019;47(1 suppl):354.

Gélinas, C., Richard-Lalonde, M., Bernard, F., Bérubé, M., Charbonney, E., Dubé, J. N., Houle, J., Morin, S., Perreault, M., Thiffault, N., Tousignant-Laflamme, Y., Tsoller, D. M., Williams, V., Williamson, D., & Choinière, M. Pain assessment documentation in adult intensive care units: A lot of room for improvement!  Poster presentation, 40th Annual Meeting, Canadian Pain Society, Toronto, Canada, April 4 2019. Canadian Journal of Pain, 2019; 3: A104.

Zerrouki K, Li Q, Delucilla L, Cabot JF, Khadadah S, Duceppe MA, Delisle MS, Burry L, Jayaraman D, Gelinas C, Tourian L, Perreault MM. Symptomatology of opioid-associated withdrawal syndrome in critically ill adults: a descriptive study. Crit Care 2019; 23(Suppl2): 72 : P403.

LeBlanc V, Méthot J, Perreault M, Mallet L. Évaluation du cours de communication scientifique du programme de la Maîtrise en pharmacotherapie avancée. Présenté au congrès annuel de l’APES – Mars 2019.

LeBlanc V,Méthot J, Perreault M, Mallet L. Evaluation of the Course “Writing a Scientific Paper” in the Master’s Program in Advanced Pharmacotherapy. Présenté à l’AFPC, Juin 2019, Edmonton.

Burry L, Williamson DR, Rose L, Mailman J, Lee S, MacLean R, Capelle H, Carter A, D’Aragon F,  Turgeon AF, Blouin ME, McCredie V, Mehta S, Lee C, Perreault MM. TBI seizure prophylaxis practices in Canadian ICUs: a multicenter, observational cohort study. Neuro Crit Care 2019; 31: S175.

Williamson DR, Perreault MM, Rose L, Mailman J, Bouthillier M, Carter A, MacLean R,  D’Aragon F, Turgeon AF, Blouin ME, McCredie V, Lee C, Burry L. Antipsychotics use in critically ill TBI patients: a Canadian multicenter, observational cohort study. Distinguished Poster. Neuro Crit Care 2019; 31 : S29.

Williamson DR, Perreault MM, Rose L, Mailman J, Lee S, Sadiq R, MacLean R, Carter A,  D’Aragon F, Turgeon AF, Blouin ME, McCredie V, Mehta S, Lee C, Burry L. Sedative and analgesic use in TBI patients admitted to Canadian ICUs: a multicenter, observational study. Présenté au Crit Care Forum, Toronto Nov 10-13 2019.

Sheehan N, Perreault M, Villeneuve E, Thirion D, Charbonneau-Allard A, Ruo N, Dupont C, Guevremont C, Mallet L, Matte G, Normandin K, Bonnici A. Environmental scan of hospital pharmacist participation in research in Canada. CJHP 2020; 73(1) : 75.

Sheehan N, Perreault M, Villeneuve E, Ruo N, Dupopnt C, Guevremont C, Mallet L, Matte G, Thirion D, Charbonneau-Allard A, Normandin K, Bonnici A. Pharmacist’s experience, motivation, attitudes, self-perceived competence, and training needs to conduct pharmacist-driven research in a tertiary care teaching hospital. CJHP 2020; 73(1) : 75.

Shahiri S, Bernard F, Berubé M, Choinière M, Dubé JN, Houle J, Laporta D, Morin SN, Perreault M, Richard-Lalonde M, Tousignant Laflamme Y, Tsoller D, Williams V, Williamsomn D,  Gelinas C. Predictive factors of pain intensity in critically ill adults at  their discharge from the intensive care unit. Soumis au IASP 2021 Virtual World Congress on Pain, June 2021.

Sheehan N, Perreault M, Villeneuve E, Ruo N, Dupont C, Guevremont C, Mallet L, Matte G, Thirion D, Charbonneau-Allard A, Normandin K, Bonnici A. Évaluation de la participation en recherche des pharmaciens en établissement de santé au Canada. Pharmactuel 2021; 54(2) : 127.

Sheehan N, Perreault M, Villeneuve E, Ruo N, Dupont C, Guevremont C, Mallet L, Matte G, Thirion D, Charbonneau-Allard A, Normandin K, Bonnici A. Expérience, attitudes, compétences perçues et besoins en formation des pharmaciens pour mener des activités de recherche dans un centre hospitalier universitaire. Pharmactuel 2021; 54(2) : 127.

Perreault M, Archambault K, Bing E, Fang YT, Gras C, Jabamikos C, Nguyen KD, Sananikone A, Duceppe MA, Marsot A. Risk factors associated with augmented renal clearance in a mixed icu population: a retrospective study. Critical Care 2022; 26(Suppl 1): P132.

Perreault M, Archambault K, Bing E, Fang YT, Jabamikos C, Nguyen KD, Sananikone A, Duceppe MA, Marsot A, Chagnon M. Validation of the augmented renal clearance in trauma intensive care (arctic) scoring system for augmented renal clearance prediction in a trauma subgroup of a mixed icu population. Critical Care 2022; 26 (suppl 1): P134.

Bolesta S, Burry L, Perreault MM, Gélinas C, Smith KE, Carini F, Eadie R, Saltarelli K, Mitchell J, Harpel J, Stewart R, Riker RR; Fraser GL, Erstad BL, on behalf of the ALERT-ICU study investigators. International Analgesia and Sedation Weaning and Withdrawal Practices in Critically Ill Adults: The AduLt iatrogEnic withdRawal sTudy in the ICU (ALERT-ICU). Int Care Med Experimental 2022; 10(2): 000239.

Bolesta S, Smith KE, Gélinas C, Perreault MM,  Burry L, Eadie R, Carini F, Harpel J, Stewart R, Riker R,  Erstad BL, on behalf of the ALERT-ICU study investigators. Opioid and Sedative Use in Adult ICUs: AduLt iatrogEnic withdRawal sTudy in the ICU (ALERT-ICU). Crit Care Med 2023; 51(1 Suppl): 398. Silver Snapshot Award.

Perreault M, Adessky N, Regazzoni A, White G, Chen FW, Tourian L, Chagnon M, Gursahaney A, Alharbi M, Williamson D. Valproic acid for agitation: retrospective analysis of psychiatric consults. Critical Care 2023, 27(S1): P106