Passer au contenu

/ La recherche

Je donne

Rechercher

Sciences de la santé; Sciences de la vie

David Williamson

Professeur titulaire de clinique

Faculté de pharmacie

Pavillon Jean Coutu, local 2181

514 343-6111 #1924

david.williamson@umontreal.ca

Autres numéros : 514 338-2222 #2666 (Travail 1) 514 343-6120 (Télécopieur)

Portrait

Formation

  • 2014 — Ph.D — Sciences cliniquesUniversité de Sherbrooke
  • 1997 — M.Sc. (pharmacothérapie avancée) — PharmacieUniversité de Montréal
  • 1996 — B.Pharm — PharmacieUniversité de Montréal

Affiliations et responsabilités

Affiliations de recherche

Enseignement et encadrement

Encadrement

Thèses et mémoires dirigés (dépôt institutionnel Papyrus)

2020

Pharmacological interventions for the hemodynamic management of deceased organ donors

Diplômé(e) : Frenette, Anne Julie
Cycle : Doctorat
Diplôme obtenu : Ph. D.

Projets

Projets de recherche

2020 - 2026

A prospective translational model of the therapeutic potential of cannabidiol in reducing acute pain symptoms and opioid usage following traumatic injury.

Chercheur principal : Louis De Beaumont
Sources de financement : IRSC/Instituts de recherche en santé du Canada
Programmes de subvention : PVXXXXXX-Subvention d'équipe
2018 - 2022

Quantity of Opioids for Acute Pain and Limit Unused Medication (OPUM study)

Chercheur principal : Raoul Daoust
Sources de financement : IRSC/Instituts de recherche en santé du Canada
Programmes de subvention : PVXXXXXX-(PJT) Subvention Projet
2018 - 2021

Implantation des meilleures pratiques de gestion de la douleur à l'unité des soins intensifs de traumatology: un travail d'équipe.

Chercheur principal : Céline Gélinas
Co-chercheurs : Marc Perreault , Manon Choinière , David Williamson , Francis Bernard
Sources de financement : FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Programmes de subvention : PVXXXXXX-Volet 3 - Consortium pour le développement de la recherche en traumatologie
2018 - 2021

Identifier les patients à risque de douleur chronique après un traumatisme craniocérébral modéré/sévère dès les premiers jours d'hospitalisation aux soins intensifs

Chercheur principal : Caroline Arbour
Co-chercheurs : Louis De Beaumont , David Williamson , Francis Bernard
Sources de financement : FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Programmes de subvention : PVXXXXXX-Volet 1 - Consortium pour le développement de la recherche en traumatologie
2017 - 2021

REVISE: Re-Evaluating the Inhibition of Stress Erosions in the ICU

Chercheur principal : David Williamson
Sources de financement : IRSC/Instituts de recherche en santé du Canada
Programmes de subvention : PVXXXXXX-(PJT) Subvention Projet
2018 - 2020

Sedatives newly prescribed following intensive care unit admission among sedative-naïve elderly patients: Understanding the risk of falls and determining targets for deprescribing (SNOW-FALL)

Chercheur principal : Lisa Denise Burry
Co-chercheurs : David Williamson
Sources de financement : IRSC/Instituts de recherche en santé du Canada
Programmes de subvention : PVXXXXXX-(PJT) Subvention Projet
2016 - 2020

Agitation et délirium en traumatologie et aux soins intensifs

Chercheur principal : David Williamson
Sources de financement : FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Programmes de subvention : PVXXXXXX-Bourse de chercheur-boursier clinicien : Junior 1
2016 - 2020

PROSPECT: Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial

Chercheur principal : Jennie Johnstone
Co-chercheurs : David Williamson , Emmanuel Charbonney
Sources de financement : IRSC/Instituts de recherche en santé du Canada
Programmes de subvention :
2017 - 2019

Revue systématique et méta-analyse sur les agents sédatifs en traumatisme crânien

Chercheur principal : David Williamson
Sources de financement : Fondation NeuroTrauma Marie-Robert
Programmes de subvention :
2016 - 2019

Agitation et délirium en traumatologie et aux soins intensifs

Chercheur principal : David Williamson
Sources de financement : FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Programmes de subvention : PVXXXXXX-Établissement de jeunes chercheurs Juniors 1
2016 - 2018

Traitement des hémorragies intracrâniennes chez les patients anticoagulés ayant subi un traumatisme crânien léger : Revue systématique et méta-analyse

Chercheur principal : Jean Marc Chauny
Co-chercheurs : Martin Albert , David Williamson , Natalie Le Sage
Sources de financement : FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Programmes de subvention : PVXXXXXX-Volet 4 - Consortium pour le développement de la recherche en traumatologie
2016 - 2017

Managing Pain In Collaboration in the Intensive Care Unit (MPIC-ICU): A Stepped Wedge Cluster Randomized Trial.

Chercheur principal : Céline Gélinas
Co-chercheurs : Manon Choinière , David Williamson , Emmanuel Charbonney , Francis Bernard
Sources de financement : IRSC/Instituts de recherche en santé du Canada
Programmes de subvention : PVXXXXXX-(PJT) Subvention Projet
2015 - 2017

Interventions pharmacologiques pour le contrôle du délirium et de l'agitation suite à un traumatisme cranio-cérébral: une revue systématique de données cliniques et précliniques

Chercheur principal : David Williamson
Sources de financement : FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Programmes de subvention : PVXXXXXX-Volet 4 - Consortium pour le développement de la recherche en traumatologie

Rayonnement

Publications et communications

Publications

  1. Cavayas YA, Noël A, Brunette V, Williamson DR, Bellemare P, Lagrenade-Verdant C, LeGuillan S, Levesque E, Frenette AJ, Lamarche Y, Giasson M, Rico P, Beaulieu Y, Marsolais P, Serri K, Bernard F, Albert M. Early experience with critically ill patients with COVID-19 in Montreal. Can J Anesth 2020. Published online: September 15th, 2020
  2. Burry LD, Barletta J, Williamson D, , Kanji S, Maves RC, Dichter J, Christian MD, Geiling J, Erstad B. It Takes a Village… Contending with Drug Shortages During Disasters. Chest 2020. In Press Journal Pre-Proof. Published online: August 13, 2020
  3. Jutras M, Williamson DR, Chassé M, Leclair G. Development and validation of a liquid chromatography coupled to tandem mass spectrometry method for the simultaneous quantification of five analgesics and sedatives, and six of their active metabolites in human plasma: Application to a clinical study on the determination of neurological death in the intensive care unit. J Pharm Biomed Anal 2020. In Press, Journal Pre-proof, Available online 15 August 2020
  4. Sneyers B, Duceppe MA, Frenette AJ, Burry LD, Rico P, Lavoie A, Gélinas C, Mehta S, Dagenais M, Williamson DR, Perreault MM. Strategies for the Prevention and Treatment of Iatrogenic Withdrawal from Opioids and Benzodiazepines in Critically Ill Neonates, Children and Adults: A Systematic Review of Clinical Studies. Drugs 2020 Jun 26:1-23.
  5. Kanji S, Burry L, Williamson D, Pittman M, Dubinsky S, Patel D, Natarajan S, MacLean R, Huh JH, Scales D, Neillipovitz D. Therapeutic Alternatives and Strategies for Drug Conservation in the ICU During Times of Drug Shortage. Can J Anesth. (ePub 27 may 2020)
  6. Burry L, Hutton B, Williamson DR, Mehta S, Adhikari NKJ, Cheng W, Ely EW, Egerod I, Fergusson DA, Rose L. Pharmacological interventions for the treatment of delirium in critically ill adults. Cochrane Database of Systematic Reviews 2019, Issue 8. Art. No.: CD011749. DOI: 10.1002/14651858.CD011749.pub2.
  7. Capilnean A, Martone A, Sandu PR, Rosu VA, Murgoi P, Frenette AJ, Williamson DR, Lecavalier A, Javaraman D, Rico P, Bellemare P, Gelinas C, Perreault MM. Withdrawal assessment in the adult ICU population. Am J Crit Care 2019; 28:361-369.
  8. Frenette AJ, Veillette C, Poulin F, Albert M, Marsolais P, Bernard F, D’Aragon F, Williamson D, Charbonney E, Serri K. Evaluation of left and right heart function by echocardiography in potential heart donors: a cohort study. J Crit Care 2019; 15;54:37-41
  9. Williamson DR, Frenette AJ, Perreault MM, Burry LD, Charbonney E, Lamontagne F, Potvin MJ, Giguère JF, Mehta S, Bernard F. Pharmacological interventions for agitated behaviors in traumatic brain injury: a systematic review. BMJ Open 2019; 9:e029604.
  10. Fortier M, Ferreira V, Pinsonneault M, Pistre P, Meideros Charbonneau J, Buisson A, Proulx C, Guenette S, Bally M, Williamson DR, Ang A. Impact of a pharmacist antimicrobial checklist on hospital antimicrobial use: A patient-level interrupted time series study. J Hosp infection 2019; 103:251-258.
  11. Sokoloff C, Williamson D, Serri K, Albert M, Odier C, Charbonney E and Bernard F. Trans-cranial Doppler as an Inference Tool of Cerebral Hypoxic Episodes Early after Moderate and Severe TBI. Neurocritical Care  (ePub 19 juin)
  12. Frenette AJ, Williamson DR, Williams V, Lagacé AM, Charbonney E Serri K. Efficacy and safety of levothyroxine on cardiac function in brain dead organ donors: a pilot study. Prog Transplant 29:261-268.
  13. Daoust R, Paquet J, Cournoyer A, Piette E, Morris J, Lessard J, Castonguay V, Williamson D, Chauny JM. Opioid Induced Side Effects, Including Constipation, For The Acute Pain of Emergency Department Discharged Patients. Am J Emerg Med (ePub 5 juin)
  14. Frenette AJ, Charbonney E, D’Aragon F, Serri K, Marsolais P, Chassé M, Meade M, Williamson DR. A Canadian Survey of Deceased organ donor’s management centered on hemodynamic and hormonal aspects. Can J Anesth 2019; 66:1162-1172.
  15. Dupuis S, Brind’amour D, Karzon S, Bellemare P, Charbonney E, Frenette AJ, Burry L, Perreault MM, Williamson DR. Pharmacological interventions used to facilitate mechanical ventilation weaning in difficult to wean patients: a systematic review and meta-analysis. Can J Anesth 2019;66(3) :318-327
  16. Duceppe MA, Perreault MM, Frenette AJ, Burry LD, Rico P, Lavoie A, Gélinas C, Mehta S, Dagenais M, Williamson DR. Frequency, risk factors and symptomatology of iatrogenic withdrawal from opioids and benzodiazepines in critically Ill neonates, children and adults: A systematic review of clinical studies. J Clin Pharm Ther 2019; 44:148-156.
  17. Dellazizzio L, Demers SP, Charbonney E, Williams V, Serri K, Albert M, Williamson DR, Bernard F. Minimal PaO2 threshold after Traumatic Brain Injury and clinical utility of a novel Brain Oxygenation Ratio (BOx Ratio). J Neurosurg (Published online November 2, 2018; DOI: 10.3171/2018.5.JNS18651)
  18. Wang HT, Williamson DR, Francispillai M, Richard-Denis A, Albert M. Pneumonia as a modifiable risk factor of mechanical ventilation and prolonged mechanical ventilation in cervical spinal chord injuries. Can Journal of Respiratory, Critical Care, and Sleep Medicine 2018;2:213-217
  19. Chartrand M, Martineau J, Brouillette D, Williamson DR, Côté S, Landry J, Huot R, White-Guay B, Hudon E, Perreault S, Kano G, Martin E, Gagnon MM, Lalonde L. Quality indicators for community pharmacist management of anticoagulation. J Manag Care Pharm 2018; 24:357-365
  20. Wang PP, Huang E, Feng X, Bray CA, Perreault MM, Rico P, Bellemare P, Murgoi P, Gélinas C, Lecavalier A, Jayaraman D, Frenette AJ, Williamson DR. Iatrogenic Withdrawal Syndrome due to Opioids in Critically Ill Patients: a Multicenter Prospective Cohort Study. Ann Intensive Care 2017;7:88.
  21. Ada Chiu, Lisa Burry, Jennifer Korman, Marc Perreault, David Williamson, Sangeeta Mehta. Opioid Withdrawal in Critically Ill Patients: Frequency, Risk Factors, and A Review of Current Assessment Tools. Ann Pharmacother 2017; 51:1099-1111.
  22. Burry L, Williamson D, Perreault MM, Smith O, Mantas I, Fergusson DA, Mehta S, Rose L. Delirium and exposure to psychoactive medications in critically ill adults: A multi-centre observational study. J Crit Care. 2017;42:268-274
  23. Arnold DM, Lauzier F, Albert M, Williamson D, Li N, Zarychanski R, Doig C, McIntyre L, Freitag A, Crowther M, Saunders L, Clarke F, Cooper J, Qushmaq I, Lopes RD, Heels-Ansdell D, Webert K, Cook D. The Association Between Platelet Transfusions and Bleeding in Critically Ill Patients with Thrombocytopenia. Res Pract Thromb Haemost. 2017;103–111.
  24. Doré M, San Juan A, Frenette AJ, Williamson DR. Clinical importance of monitoring the unbound valproic acid concentration in patients with hypoalbuminemia. Pharmacotherapy 2017; 37(8):900-907.
  25. Burry LD, Scales D,Williamson DR, Mehta S, Wilcox E, Bernard F, Azad A, Fan E, Rose L. for Prevention of in Critically Ill Patients (MELLOW-1) – Study protocol. BMJ Open 2017 Mar 30;7(3):e015420.
  26. Duceppe MA*,Williamson D*, Elliott A, Para M, Poirier MC, Delisle MS, Frenette AJ, Deckelbaum D, Razek T, Desjardins M, Bertrand JC,Bernard F, Rico P, Burry L, Perreault MM. Modifiable risk factors for delirium in critically ill trauma patients: a multicenter prospective study. J Intensive Care Med E-Pub (24 mars 2017)
  27. Chapdelaine A, Doré M, Troyanov Y, Williamson DR, Mansour AM. Metabolite monitoring to guide thiopurine therapy in systemic autoimmune diseases. Clin Rheumatol 2017;36 :1341-8.
  28. Albert M, Corsilli D, Williamson DR, Brosseau M, Bellemare P, Delisle S, Nguyen AQN, Varin F. Comparison of inhaled milrinone, nitric oxide and prostacyclin in acute respiratory distress syndrome. World J Crit Care Med 2017; 2017 Feb 4;6:74-78.
  29. Williamson DR, Frenette AJ, Perreault MM, Burry LD, Charbonney E, Lamontagne F, Potvin MJ, Giguère JF, Mehta S, Bernard F. Pharmacological interventions for agitation and delirium in traumatic brain injury: a systematic review and meta-analysis. Protocol. Syst Rev 2016 Nov 17;5:193.
  30. Hutton B, Burry LD, Kanji S, Mehta S, Guenette M; Martin CM, Fergusson DA, Adhikari NK, Egerod I, Williamson D, Straus D, Moher D, Ely EW, Rose L. Comparison of sedation strategies for critically ill patients: A protocol for a systematic review incorporating network meta-analyses. Syst Reviews 2016;20:157.
  31. Burry L, Hutton B, Guenette M, Williamson D, Mehta D; Egerod I; Kanji S, Adhikari NK, Moher D, Martin C, Rose L. Comparison of pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: A protocol for a systematic review incorporating network meta-analyses. Syst Reviews  2016;5:153.
  32. Chauny JM, Marquis M, Laroche M, Bernard F, Williamson D, Albert M, Daoust R. Risk of Delayed Traumatic Intracranial Hemorrhage in Anticoagulated Patients with Minor Blunt Head Trauma: Systematic Review and Meta-analysis. Ann Emerg Med 2016;51:519-528.
  33. Dupuis S, Vinet J, Arfa T, Williamson DR, Perreault MM. Survey on decisional factors influencing pharmacy students’ decisions to pursue hospital residency training. Can J Hosp Pharm 2016 ;69:209-15.
  34. Thiboutot Z, Perreault MM, Williamson DR, Mehta S, Rose L, Burry LD. Delirium screening and use of antipsychotics in mechanically ventilated patients in Canadian intensive care units. Can J Hosp Pharm 2016 ; 69:107-13
  35. Serri K, El Rayes M, Giraldeau G, Williamson DR, Bernard F. Traumatic brain injury is not associated with significant myocardial dysfunction. Scand J Trauma Resus Emerg Med 2016;24:31.
  36. Frenette AJ, Bebawi, E, Deslauriers L, Tessier AA, Perreault MM, Delisle MS, Bertrand JC, Rico P, Bernard F, Desjardins M, Kwaja K, Burry L, Williamson DR. Validating and comparing the CAM-ICU and the ICDSC in mild and moderate traumatic brain injury patients: A multicenter prospective study. Intensive Care Med 2016;42(1):122-3.
  37. Bernier-Jean A, Albert M, Shiloh AL, Eisen LA, Williamson D, Beaulieu Y.The Diagnostic and therapeutic impact of Point-of-Care ultrasonography in the intensive care unit. J Intensive Care Med 2017;32:197-203.
  38. Bouchard J, Ghannoum M, Bernier-Jean A, Williamson D, Kershaw G, Weatherburn C, Eris JM, Tran H, Patel J, Roberts DM. Extracorporeal therapies for the enhanced elimination of dabigatran: a case series. Clin Toxicol 2015;53(3):156-63.
  39. Doré M, Frenette AJ, Chagnon I, Routhier N, Williamson DR. Assessment of the 4Ts and HEP score clinical scoring systems as predictors of heparin-induced thrombocytopenia. Am J Health-System Pharm 2014;71:2045-52.
  40. Frenette AJ, Bouchard J, Bernier P, Charbonneau A, Nguyen LT, Rioux JP, , Heylbroeck C, Troyanov S, Williamson DR. Albumin for fluid resuscitation is an independent risk factor of acute kidney injury in cardiac surgery. Crit Care 2014;18:602.
  41. Albert M, Williamson DR, Muscedere J, Kanj S, Lauzier F, Rostein C, Jiang, X, Heyland DK. Candida in the Respiratory Tract Secretions of Critically Ill Patients and TheImpact of Empiric Antifungal Treatment: a randomized placebo controlled trial (CANTREAT Study). Intensive Care Med 2014;40:1313-22.
  42. Dupuis S, Amiel JA, Desgroseilliers M, Williamson DR, Thiboutot Z, Perreault MM. Serri K, Marsolais P, Frenette AJ. Corticosteroids in Brain Dead Potential Organ Donor Management: A Systematic Review of Randomized Controlled Trials. Br J Anesth 2014;113:346-359.
  43. Burry LD, Williamson DR, Perreault MM, Rose L, Cook DJ, Ferguson ND, Lapinsky SC, Mehta S. Sedative, analgesic, antipsychotic, and neuromuscular blocker use in Canadian ICUs: a multicenter, observational study. Can J Anesth 2014; 61:619-630.
  44. Crowther M, Cook D, Guyatt G, Zytaruk N, McDonald H, Williamson D, Albert M, Dodek P, Finfer S, Vallance S, Heels-Ansdell D, McIntyre L, Mehta G, Lamontagne F, Muscedere J, Jacka M, Lesur O, Kutsiogiannis J, Friedrich J, Klinger J, Qushmaq I, Burry L, Kwaja K, Sherppard JA, Warkentin T. Heparin Induced Thrombocytopenia in the Critically Ill: Interpreting the 4Ts Test in a Randomized Trial. J Crit Care 2014;29:470e.
  45. Williamson DR, Lesur O, Tétrault JP, Pilon D. Drug-induced thrombocytopenia in the critically ill: a case-control study. Annals of Pharmacotherapy 2014;48:697-704.
  46. Luk E, Sneyers B, Rose L, Perreault MM, Williamson DR, Wong S, Lapinsky S, Cook D, Mehta S, Burry L. Physical restraint use among mechanically ventilated patients in Canadian intensive care units. Crit Care;2014:18:R46
  47. Williamson DR, Albert M, Heels-Ansdell D, Arnold DM, Lauzier F, Zarychanski R, Crowther M, Warkentin TE, Dodek P, Cade J, Lesur O, Lim W, Fowler R, Lamontagne F, Langevin S, Freitag A, Muscedere J, Friedrich JO, Geerts W, Burry L, Alhashemi J, Cook D. Thrombocytopenia in the critically ill: frequency, risk factors, and outcomes. Chest  2013;144:1207-15.
  48. Couture J, Létourneau A, Dubuc A, Williamson DR. Evaluation of an Electrolyte Replacement Protocol in a Surgical Intensive Care Unit. Can J Hosp Pharm 2013;66:96-103.
  49. Williamson DR, Lesur O, Tétrault JP, Nault V, Pilon D. Thrombocytopenia in the medical and surgical ICU: risk factors and clinical outcomes. Can J Anaesth 2013;60:1167-73.
  50. Bérubé M, Bernard F, Marion H, Thibault M, Parent, J, Williamson DR, Albert, M. Impact of a preventive program on the occurrence of incidents during the transport of critically ill patients. Intensive Crit Care Nurs. 2013;29:9-19.
  51. Perreault MM, Thiboutot Z, Burry L, Leblanc J, Carr R, Rose L, Kanji S, Williamson DR. Survey of Canadian Critical Care Pharmacist’s views and involvement in research. Ann Pharmacother 2012;49:1167-73.
  52. Kanji S, Williamson DR, Yaghchi BM, Albert M, McIntyre L. Epidemiology and Management of Atrial Fibrillation in Critically Ill Adults. J Crit Care 2012;Epub 4 jan.
  53. Frenette AJ, Kanji S, Rees L, Williamson DR, Perreault MM, Bernard F, Turgeon A, Fergusson D. Efficacy and Safety of dopamine agonists in traumatic brain injury: A systematic review of randomized controlled trials. J Neurotrauma 2012;29:1-18.
  54. Frenette AJ, MacLean R, Williamson D, Marsolais P, Donnelly R. Stability of levothyroxin infusions for organ donor support. Am J Health Sys Pharm 2011;68:1723-28.

Champ d’expertise

  • Axe : Médicament et santé des populations
  • Pharmacothérapie (maladies thromboemboliques)
  • Pharmacothérapie (complications hématologiques)
  • Pharmacothérapie (soins critiques)
  • Recherche clinique
  • Recherche épidémiologique