L'objectif de ma recherche est de mieux comprendre le fonctionnement du follicule ovarien, afin de mieux contrôler la fertilité chez la vache. Plus précisément, j'étudie les facteurs qui affectent l'expression des gènes clés (i.e. les facteurs de croissance) dans les cellules de granulosa et de la thèque.

• BSc de l'University of Nottingham, Angleterre, PhD de l'Edinburgh University, Ecosse.
• Stage post-doctoral fait en Nouvelle-Zélande.

Buratini J, Dellaqua TT, Lima PF, Renzini MM, Canto MD, Price CA. Oocyte secreted factors control genes regulating FSH signaling and the maturation cascade in cumulus cells: the oocyte is not in a hurry. JARG doi.org/10.1007/s10815-023-02822-y

Reyes-Perea AD,  Guerrero-Netro HM, Meza-Serrano E, Estienne A, Price CA (2023) The mycotoxin de-epoxy-deoxynivalenol (DOM-1) increases endoplasmic reticulum stress in ovarian theca cells. Toxins 15: 228. doi.org/10.3390/toxins15030228

Daudon M, Ramé C, Price CA*, Dupont J* (2023) Irisin modulates glucose metabolism and inhibits steroidogenesis in bovine granulosa cells. Reproduction 165:533-542. https://doi.org/10.1530/REP-22-0404

Wang S, Yao Q, Zhao F, Cui W, Price CA, Wang Y, Lv J, Tang H, Jiang Z (2023). 1α,25(OH)2D3 promotes the autophagy of porcine ovarian granulosa cells as a protective mechanism against ROS through BNIP3/PINK1 pathway. Int J Mol Sci 24: 4364. doi.org/10.3390/ijms24054364

Biolková M, Moore T, Schindler K, Swann K, Vail A, Flook L, Dick H, Fitzharris G, Price C*, Spears N* (2023). Investigation of potential gender bias in the peer review system at Reproduction. Learned Publishing 36: 25-30. https://doi.org/10.1002/leap.1537.

Relav L, dos Santos, EC, Zamberlam G, Price CA. Abundance of dual specificity phosphatase (DUSP) 1 and DUSP6 mRNA is regulated by Hippo signaling in bovine pre-ovulatory granulosa cells.  Reproductive Sciences. https://doi.org/10.1007/s43032-022-01142-3.

Goetten ALF, Koch J, Rocha CC, Mezzalira A, Price CA, Portela VM, Barreta MH. (2023) Expression profile of key genes involved in DNA repair mechanisms in bovine cumulus cells cultured with bovine serum albumin or fetal calf serum. Reproductive Biology 23: 100709.

Daudon M, Rame C, Estienne A, Price CA*, Dupont J*. (2022) Impact of Fibronectin type III Domain-Containing Family in the changes in metabolic and hormonal profiles during peripartum period in dairy cows.  Frontiers in Vet Sci 9:960778. DOI 10.3389/fvets.2022.960778.

Daudon M, Bigot Y, Dupont J*, Price CA* (2022) Irisin and the fibronectin type III domain-containing family: Structure, signalling and role in female reproduction. Reproduction 164: R1-R9.

Estienne AE, Relav L, Benkoura M, Monniaux D, Morin F, Fabre S, Price CA (2022) Endothelial cell-derived fibroblast growth factor-18 regulates ovarian function in sheep. J Cell Physiol. 237:2528-2538. http://doi.org/10.1002/jcp.30718

Liu N, Wang S, Yao Q, Li Y, Hu H, Xiaorong T, Ran H, Price C, Jiang ZL (2022) Activin A attenuates apoptosis of granulosa cells in atretic follicles through ERβ-induced autophagy. Reprod Dom Anim. 57:625-634.

Dos Santos EC, Lalonde-Larue A, Antoniazzi AQ, Barreta MH, Price CA, Gonçalves PBD, Portela VM, Zamberlam GO (2022) YAP signaling in preovulatory granulosa cells is critical for the functioning of the EGF network during ovulation. Mol Cell Endo 541:111524

Relav L, Price CA (2021) Regulation of Dual Specificity Phosphatases by Fibroblast Growth Factor signaling pathways in bovine granulosa cells. Reproduction 162: 367-374. (http://dx.doi.org/10.1530/REP-21-0270)

Juengel JL, Cushman RA, Dupont J, Fabre S, Lea RG, Martin GB, Mossa F, Pitman JL, Price CA, Smith P (2021) The ovarian follicle of ruminants: the path from conceptus to adult. Reprod Fertil Devel. 33: 621-642. https://doi.org/10.1071/RD21086

Relav L, Estienne A, Price CA (2021) Dual-specificity phosphatase 6 (DUSP6) mRNA and protein abundance is regulated by fibroblast growth factor 2 in sheep granulosa cells and inhibits c-Jun N-terminal kinase (MAPK8) phosphorylation. Mol Cell Endo 531: 111297. https://doi.org/10.1016/j.mce.2021.111297

Guerro-Netro H, Barreta M, Costa E, Goetten A, Dupras R, Mills L, Koch J, Portela VM, Price CA, Chorfi Y (2021) Effects of the mycotoxin metabolite de-epoxy-deoxynivalenol (DOM-1) on embryo development and sperm motility in cattle. J Appl Toxicol 41:1180-1187.  DOI: 10.1002/jat.4102

Han P, Relav L, Price CA (2020) Regulation of the early growth response-1 binding protein NAB2 in bovine granulosa cells and effect on connective tissue growth factor expression. Mol Cell Endo 518: 111041.   doi.org/10.1016/j.mce.2020.111041

Jaton C, Schenkel FS, Chud TCS, Malchiodi F, Sargolzaei M, Price CA, Cánovas A,, Baes C, Miglior F. (2020) Genetic and genomic analyses of embryo production in dairy cattle. Reproduction, Fertility and Development 32, 50–55. doi.org/10.1071/RD19275

Sahmi F, Sahmi M, Gévry N, Sahadevan P, Allen BG, Price CA. (2019) A putative protein:RNA complex regulates post-transcriptional processing of cytochrome P450 aromatase (CYP19A1) in bovine granulosa cells. Mol Reprod Develop 86:1901-1908. https://doi.org/10.1002/mrd.23289

Zhang N, Wang L, Juo G, Tang X, Ma L, Zheng Y, Liu S, Price CA, Jiang Z (2019) Arachidonic acid regulation of intracellular signaling pathways and target gene expression in bovine ovarian granulosa cells. Animals 9: 374.

Estienne A, Portela VM, Choi Y, Zamberlam G, Boerboom D, Roussel V, Meinsohn MC, Brännström M, Curry TE, Jo M, Price CA. (2019) The endogenous hydrogen sulfide generating system regulates ovulation. Free Rad Biol Med 138:43-52. doi.org/10.1016/j.freeradbiomed.2019.03.028