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Health Sciences; Medical Sciences

Laboratoire de thrombose et hémostase

Centre de recherche hospitalier Faculté de médecine
Secondary number: 514 376-3330 #3035 (Laboratoire)
Secondary email: (Personne contact)



Research units

  • Centre de recherche de l'Institut de cardiologie de Montréal

Other Institutions and Research Units

  • Institut de cardiologie de Montréal (ICM)


500, rue Bélanger, room S-4600
Montréal (Québec), H1T 1C8, Canada



At Université de Montreal


Projects and funding

Publications and presentations


Pour une liste complète des publications

Bou Khzam L, Bouchereau O, Boulahya R, Hachem A, Zaid Y, Abou-Saleh H, Merhi Y. Early outgrowth cells versus endothelial colony forming cells functions in platelet aggregation. J Transl Med. 2015 Nov 9;13:353. doi: 10.1186/s12967-015-0723-6.

Noel S, Hachem A, Merhi Y, De Crescenzo G. Development of a Polyester Coating Combining Antithrombogenic and Cell Adhesive Properties: Influence of Sequence and Surface Density of Adhesion Peptides. Biomacromolecules. 2015 Jun 8;16(6):1682-94. doi: 10.1021/acs.biomac.5b00219. Epub 2015 May 4.

Endothelial progenitor cells inhibit platelet function in a P-selectin-dependent manner. Abou-Saleh H, Hachem A, Yacoub D, Gillis MA, Merhi Y. J Transl Med. 2015 May 7;13:142. doi: 10.1186/s12967-015-0508-y.

Tidjane N, Hachem A, Zaid Y, Merhi Y, Gaboury L, Girolami JP, Couture R. A primary role for kinin B1 receptor in inflammation, organ damage, and lethal thrombosis in a rat model of septic shock in diabetes. Eur J Inflamm. 2015 Apr 1;13(1):40-52.

Alturaihi H, Hassan GS, Al-Zoobi L, Salti S, Darif Y, Yacoub D, El Akoum S, Oudghiri M, Merhi Y, Mourad W. Interaction of CD154 with different receptors and its role in bidirectional signals. Eur J Immunol. 2015 Feb;45(2):592-602. doi: 10.1002/eji.201444941. Epub 2014 Dec 16.

Chondroitin sulfate coatings display low platelet but high endothelial cell adhesive properties favorable for vascular implants. Thalla PK, Fadlallah H, Liberelle B, Lequoy P, De Crescenzo G, Merhi Y, Lerouge S. Biomacromolecules. 2014 Jul 14;15(7):2512-20. doi: 10.1021/bm5003762. Epub 2014 Jun 25.

Chan-Chan LH, Vargas-Coronado RF, Cervantes-Uc JM, Cauich-Rodríguez JV, Rath R, Phelps EA, García AJ, San Román Del Barrio J, Parra J, Merhi Y, Tabrizian M. Platelet adhesion and human umbilical vein endothelial cell cytocompatibility of biodegradable segmented polyurethanes prepared with 4,4'-methylene bis(cyclohexyl isocyanate), poly(caprolactone) diol and butanediol or dithioerythritol as chain extenders. J Biomater Appl. 2013 Aug;28(2):270-7. doi: 10.1177/0885328212448259. Epub 2012 Jun 7.

Bou Khzam L, Hachem A, Zaid Y, Boulahya R, Mourad W, Merhi Y. Soluble CD40 ligand impairs the anti-platelet function of peripheral blood angiogenic outgrowth cells via increased production of reactive oxygen species. Thromb Haemost. 2013 May;109(5):940-7. doi: 10.1160/TH12-09-0679. Epub 2013 Feb 21.

Hassan GS, Yacoub D, Alaaeddine N, Nadiri A, Merhi Y, Mourad W. CD154: the atherosclerotic risk factor in rheumatoid arthritis? Arthritis Res Ther. 2013 Feb 22;15(1):206. doi: 10.1186/ar4153. Review.

Thalla PK, Contreras-García A, Fadlallah H, Barrette J, De Crescenzo G, Merhi Y, Lerouge S. A versatile star PEG grafting method for the generation of nonfouling and nonthrombogenic surfaces. Biomed Res Int. 2013;2013:962376. doi: 10.1155/2013/962376. Epub 2012 Dec 20.

Bou Khzam L, Boulahya R, Abou-Saleh H, Hachem A, Zaid Y, Merhi Y. Soluble CD40 ligand stimulates the pro-angiogenic function of peripheral blood angiogenic outgrowth cells via increased release of matrix metalloproteinase-9.PLoS One. 2013 Dec 16;8(12):e84289. doi: 10.1371/journal.pone.0084289. eCollection 2013.

Hachem A, Yacoub D, Zaid Y, Mourad W, Merhi Y. Involvement of nuclear factor κB in platelet CD40 signaling. Biochem Biophys Res Commun. 2012 Aug 17;425(1):58-63. doi: 10.1016/j.bbrc.2012.07.049. Epub 2012 Jul 20.

El Fakhry Y, Alturaihi H, Yacoub D, Liu L, Guo W, Leveillé C, Jung D, Khzam LB, Merhi Y, Wilkins JA, Li H, Mourad W. Functional interaction of CD154 protein with α5β1 integrin is totally independent from its binding to αIIbβ3 integrin and CD40 molecules. J Biol Chem. 2012 May 25;287(22):18055-66. doi: 10.1074/jbc.M111.333989. Epub 2012 Mar 29.

Hassan GS, Merhi Y, Mourad W. CD40 ligand: a neo-inflammatory molecule in vascular diseases. Immunobiology. 2012 May;217(5):521-32. doi: 10.1016/j.imbio.2011.03.010. Epub 2011 Apr 7. Review.


  • Cardiology
  • Pharmacology
  • Molecular Biology
  • Molecular Medicine

Areas of expertise

  • Thrombosis and Embolism
  • Blood Flow and Transfusions
  • Cardiovascular Diseases
  • Cardiovascular System