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Sciences de la santé; Sciences de la vie

David Williamson

Professeur titulaire de clinique

Faculté de pharmacie

Pavillon Jean Coutu, local 2181

514 343-6111 #1924

david.williamson@umontreal.ca

Autres numéros : 514 338-2222 #2666 (Travail 1) 514 343-6120 (Télécopieur)

Portrait

Formation

  • 2014 — Ph.D — Sciences cliniquesUniversité de Sherbrooke
  • 1997 — M.Sc. (pharmacothérapie avancée) — PharmacieUniversité de Montréal
  • 1996 — B.Pharm — PharmacieUniversité de Montréal

Affiliations et responsabilités

Affiliations de recherche

Projets

Projets de recherche

2023 - 2028

Impact of Vitamin C on the Reduction of Opioid Consumption After an Emergency Department Visit for Acute Musculoskeletal Pain: A Double-Blind Randomized Control Trial

Chercheur principal : Raoul Daoust
Co-chercheurs : Dominique Rouleau , David Williamson , Caroline Arbour , Alexis Cournoyer , Perry Jeffery , Marcel Émond
Sources de financement : IRSC/Instituts de recherche en santé du Canada
Programmes de subvention : PVXXXXXX-(PJT) Subvention Projet
2024 - 2027

Effects of dexmedetomidine on agitation in critically ill TBI patients – DEX-TBI

Chercheur principal : David Williamson
Sources de financement : IRSC/Instituts de recherche en santé du Canada
Programmes de subvention : PVXXXXXX-(PJT) Subvention Projet
2022 - 2026

Large reductions in arterial CARbon dioxide and development of acute Brain Injury in invasively mechanically ventilated patients with acute respiratory failure (CARBI)

Chercheur principal : Yiorgos Alexandros Cavayas
Sources de financement : IRSC/Instituts de recherche en santé du Canada
Programmes de subvention : PVXXXXXX-(PJT) Subvention Projet
2020 - 2026

A prospective translational model of the therapeutic potential of cannabidiol in reducing acute pain symptoms and opioid usage following traumatic injury.

Chercheur principal : Louis De Beaumont
Sources de financement : IRSC/Instituts de recherche en santé du Canada
Programmes de subvention : PVXXXXXX-Subvention d'équipe
2021 - 2025

Adverse Drug Events and Medication Errors in adult Intensive Care Units

Chercheur principal : Nadezhda Roumeliotis
Sources de financement : IRSC/Instituts de recherche en santé du Canada
Programmes de subvention : PVXXXXXX-(PJT) Subvention Projet
2021 - 2024

Prise en charge pharmacothérapeutique des conséquences physiques, comportementales et cognitives des lésions cérébrales traumatiques aiguës

Chercheur principal : David Williamson
Sources de financement : FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Programmes de subvention : PVXXXXXX-Bourse de chercheur-boursier clinicien : Junior 2
2018 - 2024

Quantity of Opioids for Acute Pain and Limit Unused Medication (OPUM study)

Chercheur principal : Raoul Daoust
Sources de financement : IRSC/Instituts de recherche en santé du Canada
Programmes de subvention : PVXXXXXX-(PJT) Subvention Projet
2018 - 2021

Identifier les patients à risque de douleur chronique après un traumatisme craniocérébral modéré/sévère dès les premiers jours d'hospitalisation aux soins intensifs

Chercheur principal : Caroline Arbour
Co-chercheurs : Francis Bernard , David Williamson , Louis De Beaumont
Sources de financement : FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Programmes de subvention : PVXXXXXX-Volet 1 - Consortium pour le développement de la recherche en traumatologie
2018 - 2021

Implantation des meilleures pratiques de gestion de la douleur à l'unité des soins intensifs de traumatologie: un travail d'équipe.

Chercheur principal : Céline Gélinas
Co-chercheurs : Manon Choinière , Francis Bernard , Marc Perreault , David Williamson
Sources de financement : FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Programmes de subvention : PVXXXXXX-Volet 3 - Consortium pour le développement de la recherche en traumatologie
2018 - 2020

Sedatives newly prescribed following intensive care unit admission among sedative-naïve elderly patients: Understanding the risk of falls and determining targets for deprescribing (SNOW-FALL)

Chercheur principal : Lisa Denise Burry
Co-chercheurs : David Williamson
Sources de financement : IRSC/Instituts de recherche en santé du Canada
Programmes de subvention : PVXXXXXX-(PJT) Subvention Projet
2016 - 2020

Agitation et délirium en traumatologie et aux soins intensifs

Chercheur principal : David Williamson
Sources de financement : FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Programmes de subvention : PVXXXXXX-Bourse de chercheur-boursier clinicien : Junior 1
2016 - 2020

PROSPECT: Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial

Chercheur principal : Jennie Johnstone
Co-chercheurs : Emmanuel Charbonney , David Williamson
Sources de financement : IRSC/Instituts de recherche en santé du Canada
Programmes de subvention :
2017 - 2019

Revue systématique et méta-analyse sur les agents sédatifs en traumatisme crânien

Chercheur principal : David Williamson
Sources de financement : Fondation NeuroTrauma Marie-Robert
Programmes de subvention :
2016 - 2019

Agitation et délirium en traumatologie et aux soins intensifs

Chercheur principal : David Williamson
Sources de financement : FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Programmes de subvention : PVXXXXXX-Établissement de jeunes chercheurs Juniors 1
2016 - 2018

Traitement des hémorragies intracrâniennes chez les patients anticoagulés ayant subi un traumatisme crânien léger : Revue systématique et méta-analyse

Chercheur principal : Jean Marc Chauny
Co-chercheurs : Martin Albert , David Williamson , Natalie Le Sage
Sources de financement : FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Programmes de subvention : PVXXXXXX-Volet 4 - Consortium pour le développement de la recherche en traumatologie
2016 - 2017

Managing Pain In Collaboration in the Intensive Care Unit (MPIC-ICU): A Stepped Wedge Cluster Randomized Trial.

Chercheur principal : Céline Gélinas
Co-chercheurs : Manon Choinière , Francis Bernard , Emmanuel Charbonney , David Williamson
Sources de financement : IRSC/Instituts de recherche en santé du Canada
Programmes de subvention : PVXXXXXX-(PJT) Subvention Projet
2015 - 2017

Interventions pharmacologiques pour le contrôle du délirium et de l'agitation suite à un traumatisme cranio-cérébral: une revue systématique de données cliniques et précliniques

Chercheur principal : David Williamson
Sources de financement : FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Programmes de subvention : PVXXXXXX-Volet 4 - Consortium pour le développement de la recherche en traumatologie

Rayonnement

Publications et communications

Publications

50 dernières publications:

  1. Lapierre, A., Bérubé, M., Giroux, M., Tardif, P.-A., Turcotte, V., Mercier, É., Richard-Denis, A., Williamson, D., & Moore, L. (2024). Interprofessional interventions that impact collaboration and quality of care across inpatient trauma care continuum: A scoping review. Injury, 55(11), 111873.

  2. Mohktari KW, Wong A, Nguyen M, Giard A, Ly B, Wazzan D, Williamson D, Dagenais-Beaulé V. Post-discharge opioid prescription and consumption in surgical inpatients: the POPCORN observational Study. Can J Hosp Pharmacy 2024;77:e3574.

  3. Dahel H, Burry L, Tabbara N, Williamson D, Hornstein G, Wang HT. Optimizing Subsequent CARdiovascular Medication Re-introduction in the Intensive Care Unit (OSCAR-ICU). Can J Kidney Disease 2024;11:Sept 5th.

  4. Daoust R, Paquet J, Emond M, Iseppon M, Williamson D, Yan J, Perry JJ, Huard V, Lavigne G, Lee J, Lessard J, Lang E, Cournoyer A. Opioids for acute pain: how much to prescribe to minimize unused medication? (OPUM Study). CMAJ 2024;196:E866-E874.

  5. Wang Y, Parpia S, Ge L, Heels-Ansdell D, Lai H, Esfahani MA, Pan E, Alhazzani W, Schandelmaier S, Lauzier F, Arabi Y, Barletta J, Deane A, Finfer S, Williamson D, Kanji S, Moller MH, Perner A, Krag M, Young PJ, Dionne JC, Hammond N, Ye Z, Ibrahim Q, Cook, D. Proton Pump Inhibitors for Prophylaxis Against Gastrointestinal Bleeding in Critically Ill Patients: A Systematic Review with Meta-Analysis. NEJM Evidence 2024. ePub June 14th

  6. Cook D, Dean A, Lauzier F, Zytaruk N, Guyatt G, Saunders L, Hardie M, Heels-Ansdell D, Alhazzani W, Marshall J, Muscedere J, Myburgh J, English S, Arabi Y, Ostermann M, Knowles S, Hammond N, Byrne KM, Chapman M, Venkatesh B, Young P, Rajbhandari D, Poole A, Al Fares A, Reis G, Johnson D, Iqbal M, Hall R, Meade M, Hand L, Duan E, Clarke F, Dionne JC, Tsang JLY, Rochwerg B, Karachi T, Lamontagne F, D’Aragon F, St-Arnauld C, Reeve B, Geagea A, Niven F, Vasquez-Grande G, Zarychanski R, Ovakim D, Wood G, Burns K, Goffi A, Wilcox E, Henderson W, Forrest D, Fowler R, Adhikari N, Ball I, Mele T, Binnie A, Trop S, Mehta S, Morgan I, Loubani O, Vanstone M, Fiest K, Charbonney E, Cavayas A, Archambault P, Rewa O, Lau V, Kristoff AS, Khwaja K, Williamson D, Kanji S, Sy E, Dennis B, Reynolds S, Marquis F, Lellouche F, Rahman A, Hosek P, Barletta J, Cirone R, Tutschka M, Xie F, Billot L, Thabane L, Finfer S, for the REVISE Trial Investigators. Stress Ulcer Prophylaxis for Invasively Ventilated Patients: A Randomized Trial. N Engl J Med 2024. ePub June 14th
  7. Burry LD, Bell C, Hill A, Pinto R, Scales D, Bronskill S, Rose L, Williamson D, Fowler R, Wunsch H. Trends in Sedative Prescription Among Older Adults after Critical Illness: A Population-Based Cohort Study. Am J Resp Crit Care 2024;ePub June 11th
  8. Lapierre A, Proulx A, Gélinas C, Dollé S, Alexander S, Williamson D, Bernard F, Arbour C. Association between pupil light reflex measurements during mechanical ventilation and post-extubation delirium in adults with traumatic brain injury: Preliminary findings. J Neuroscience Nursing 2024:ePub June 3rd.
  9. Saavedra-Mitjans, M., Van der Maren, S., Gosselin, N., Duclos, C., Frenette, A. J., Arbour, C., … Williamson, D. R. (2024). Use of actigraphy for monitoring agitation and rest-activity cycles in patients with acute traumatic brain injury in the ICU. Brain Injury, 1–7. https://doi.org/10.1080/02699052.2024.2341323
  10. Cataford G, Monton LA, Karzon S, et al. Cognitive and motor function effects of antipsychotics in traumatic brain injury: a systematic review of pre-clinical studies. Neurotrauma Reports 2024:5(1):181–193.
  11. El-Hattaf I, Marsot A, Hachemi D, Pesout T, Williams V, Smith MA, Albert M, Williamson D. Exposure Levels and Target Attainment of Piperacillin/Tazobactam in Intensive Care Unit Adult Patients: a Prospective Observational Study. Can J Anesth 2024;ePub Jan 19th.
  12. Saavedra-Mitjans M, Frenette AJ, McCredie V, Arbour C, Charbonney E, Albert M, Mehta S, Wang HT, Burry L, Bernard F, Williamson D. ICU physicians’ beliefs and perceived importance of agitation in TBI patients: A survey of Canadian intensivists. Can J Anesth 2024;71:264-73.
  13. White G, Adessky N, Chen FW, Regazzoni A, Tourian L, Chagnon M, Gursahaney A, Roux M, Alharbi M, Williamson D, Perreault. Impact Of Valproic Acid For Agitation In The Intensive Care Unit: a Retrospective Analysis Of Psychiatric Consults. Int J Clin Pharm 2024;1:177-85.
  14. Leclerc C, Gervais C, Hjeij D, Briand MM, Williamson D, Bernard F, Duclos C, Arbour C. Sleep in hospitalized adults sustaining a traumatic brain injury: A scoping review. J Head Trauma Rehab 2023;ePub 28 sept
  15. D’Amours M, Ettis F, Ginefri L, Lim J, Lin Poo Yuan A-S, Fontaine J, Wazzan D, Williamson D, Dagenais-Beaulé V. A pilot study to improve geriatric care through a pharmacist-led psychotropic stewardship program. Drugs and Aging 2023; 40:1037-1045.
  16. El-Hattaf I, Laverdière J, Albert M, Marsot A, Williamson D. Potential Benefits of Therapeutic Drug Monitoring for Beta-lactam Antibiotics in Augmented Renal Clearance Patients: A Case Report. Canadian Journal of Physiology and Pharmacology 2023;102:69-74.
  17. Daoust R, Paquet J, Marquis M, Williamson D, Fontaine G, Chauny JM, Frégeau A, Orkin A, Cournoyer A. Efficacy and Safety of Prescribed Opioids for Acute Pain after Being Discharged from the Emergency Department: A Systematic Review. 30:1253-1263.
  18. Duceppe MA, Kanji S, Ruo N, Do A, Cavayas YA, Robert-Halabi M, Albert M, Zavalkoff S, Samoukovic G, Williamson DR. Alterations in the pharmacokinetics and pharmacodynamics of commonly used antimicrobials in pediatric critical care patients during extracorporeal membrane oxygenation: A systematic review. Pediatric Drugs 2023;25:515-535
  19. Daoust R, Paquet J, Chauny JM, Williamson D, Huard V, Arbour C, Emond M, Rouleau D, Cournoyer A. Impact of Vitamin C on the Reduction of Opioid Consumption After an Emergency Department Visit for Acute Musculoskeletal Pain: A Double-Blind Randomized Control Trial Protocol. BMJ Open 2023;13:e699230.
  20. Kanji S, Williamson D, Hartwick M. Pharmacological confounders in the setting of brain death declaration. Can J Anesth 2023;70:713-23.
  21. Beaucage-Charron J, Rinfret J, Coveney R, Williamson D. Melatonin and Ramelteon in the Treatment of Delirium: A Systematic Review and Meta-analysis. J Psychomatic Res 2023;170:111345.
  22. Ouerd S, Frenette AJ, Williamson D, Serri K, D’Aragon F, Meade M, Bichet D, Charbonnney E. Vasopressin use in organ donors: a narrative review of the literature and evidences. Crit Care Explorations 2023;5:e0907
  23. Flynn F, Dobrescu MA, Richard G, Hassan C, Pigeon M, Chagnon M, Charbonney E, Serri K, D’Aragon F, Weiss MJ, Williamson DR, Frenette AJ. Self-perceived role and knowledge of community pharmacists in organ donation. Int J Clin Pharm 2023;45:748-57.
  24. Duquet-Armand M, Bouziane A, Arruda A, Denault JS, Routhier A, Cusson T, Halwagi A, Williamson D, Perreault M, Lordkipanidzé, Létourneau-Guillon L, Thiboutot Z. Spontaneous intracranial hemorrhage and oral anticoagulation: a retrospective study. Can Journ Gen Int Med 2023;18:54-65.
  25. Duong A, Simard C, Williamson D, Marsot A. Tobramycin a priori dosing regimens based on PopPK model’s simulations in critically ill patients: are they transferable? Ther Drug Monit 2023;45:616-622
  26. Dionne JC, Johnstone J, Heels-Ansdell D, Duan E, Lauzier F, Arabi YM, Adhikari NKJ, Sligl W, Dodek P, Rochwerg B, Marshall JC, Niven DJ, Williamson DR, Reynolds S, Zytaruk N, Cook D.Clostridioides Difficile Infection in Mechanically Ventilated Critically Ill Patients: A Nested Cohort Study. J Crit Care 2023; 75:154254.
  27. Burry LD, Bell C, Hill A, Pinto R, Scales DC, Bronskill SE, Williamson D, Rose L, Fu L, Fowler R, Martin CM, Dolovich L, Wunsch H. New and persistent sedative prescription after critical illness among older adults: A population-based cohort study. Chest 2023;163:1425-36.
  28. Hardy A, Beetz G, Chamali K, Courgeon M, Sandman E, Williamson D, Goetti P, Leduc S, de Beaumont L, Rouleau DM. Traumatic Brain Injuries in Proximal Humeral or Clavicle Fractures Studies: The Missing Link – A Systematic Review. International Orthopedics 2023;47:17-50.
  29. Daoust R, Paquet J, Williamson D, Perry J, Iseppon M, Castonguay V, Morris J, Cournoyer A. Accuracy of a Self-Report Prescription Opioid Use Diary for Patients Discharge from the Emergency Department with Acute Pain. BMJ Open 2022;12:e062984.
  30. Duong A, Simard C, Williamson D, Marsot A. Model re-estimation: an alternative for poor predictive performance during external evaluations? Example of gentamicin in critically ill patients. Pharmaceutics 2022 ;14:1426.
  31. Marsolais P, Larouche G, Lagacé AM, Williams V, Bernard F, Rico P, Frenette AJ, Williamson D, Albert M, Charbonney E. The feasibility of potential organ donors using real case-scenarios; do we need to create a “donor board” process for donors perceived as unlikely feasible? Transplant Intl 2022;35:10107.
  32. Duong A, Simard C, Williamson D, Thirion D, Marsot A. Aminoglycosides’ dosing and monitoring practices in intensive care unit settings in Quebec. J Chemother 2022; 34:341-44.
  33. Chan C, Burry L, Tse C, de Castro C, Wunsch H, Williamson D. Impact of ketamine analgosedation on outcomes in critically ill patients: Systematic review and meta-analysis. Ann Pharmacother 2022; 56:1139-1158
  34. Daoust R, Paquet J, Marquis M, Chauny JM, Williamson D, Huard V, Arbour C, Émond M, Cournoyer A. Evaluation of Interventions to Reduce Opioid Prescribing for Patients Discharged From the Emergency Department: A Systematic Review and Meta-analysis. JAMA Netw Open. 2022;5(1):e2143425.
  35. Martineau-Lessard, C., Arbour, C., Germélus, N-É., Williamson, D., De Beaumont, L., Bernard, F. Pupil light reflex for the assessment of analgesia in critically ill sedated patients with traumatic brain injury: A preliminary study. Journal of Neuroscience Nursing 2022;54:6-12.
  36. Daoust R, Paquet J, Huart V, Chauny JM, Lavigne G, Williamson D, Choiniere M, Lang E, Yan JW, Perry JJ, Emond M, Gosselin S, Cournoyer A. Association Between Fentanyl Treatment for Acute Pain in the Emergency Department and Opioid Use Two Weeks After Discharge. Am J Emerg Med 2022;52:137-142.
  37. Johnstone J, Meade M, Lauzier F, Marshall J, Duan E, Dionne J, Arabi Y, Heels-Ansdell D; Thabane L, Lamarche D; Surette M; Zytaruk N, Mehta S, Dodek, P, Mcintyre L, English S; Rochwerg B,Karachi T, Henderson W, Wood G, Ovakim D, Herridge M, Granton J, Wilcox E, Gioffi A, Stelfox H; Niven D, Muscedere, J, Lamontagne F, D'Aragon, F, St-Arnaud C, Ball I, Nagpal D, Girard M, Aslanian P, Charbonney E, Williamson D, Sligl W, Friedrich J, Adhikari N; Marquis F, Archambault P, Khwaja K, Kristof A, Kutsiogiannis J, Zarychanski R, Paunovic, B, Reeve B, Lellouche F, Hosek P, Tsang J, Binnie A, Trop S, Loubani O, Hall R, Cirone R, Reynolds S, Lysecki P, Golan E, Carten Ceba R, Taylor R, Cook D. Lactobacillus Rhamnosus GG in Critical Illness: A Randomized Trial. JAMA 2021;326:1024-33.
  38. Burry L, Chen W, Williamson D, Guenette M, Hutton B, Mehta S, Egerod I, Kanji S, Adhikari NK, Moher D, Martin C, Rose L. Intensive Care Med 2021;47:943-60.
  39. Saavedra Mitjans M, David PM, Frenette AJ, Arbour C, Perreault MM, Williams V, Bernard F, Williamson DR. EXperienceS and aTtitudes towards Agitated behaviors in Tbi ICu patients (EXSTATIC): a protocol for an interprofessional mixed-method study. BMJ Open 2021; 11:e045816
  40. Duceppe MA, Kanji S, Ruo N, Do A, Cavayas YA, Robert-Halabi M, Albert M, Zavalkoff S, Samoukovic G, Williamson DR. Alterations in the pharmacokinetics and pharmacodynamics of commonly used antimicrobials in critical care patients during extracorporeal membrane oxygenation: A systematic review. Drugs. 2021;81:1307-1329.
  41. Morris JL, Bernard F, Bérubé M, Dubé JN, Houle J, Laporta D, Morin SN, Perreault M, Williamson D, Gélinas C. Determinants of Pain Assessment Documentation in Intensive Care Units. Can J Anaesth. 2021;68:1176-1184
  42. Duong A, Simard C, Wang YL, Williamson D, Marsot A. Aminoglycosides in the intensive care unit: what’s new in population PL modeling. Antibiotics (Basel) 2021;10:507.
  43. Williamson DR, Kanji S, Burry LD. Advanced Pharmacist Practitioner Series – Clinician scientist. Can J Hosp Pharm 2021;74:130-4.
  44. Bilodeau V, Saavedra Mitjans M, Frenette AJ, Burry L, Albert M, Bernard F, Williamson DR. . J Clin Pharm Ther 2021;46:1020-26.
  45. Bendayan M, Mardigyan V, Williamson D, Chen-Tournoux A, Eintracht S, Rudski L, MacNamara E, Blostein M, Afilalo M, Afilalo J. Association of Muscle Mass With Direct Oral Anticoagulant Activity in Older Adults. J Am Geriatr Soc 2021;69:1012-1018.
  46. Williamson DR, Cherifa S, Saavedra Mitjans M, Arbour C, Frenette AJ, Charbonney E, Blais L, Burry LD, Mehta S, Bernard F. A pilot feasibility cohort study of agitated behaviors in critically traumatic brain injury patients. Pilot and feasibility Studies 2020;6:193.
  47. Gagnon A, Laroche M, Williamson DR, Giguère JF, Giroux M, Bernard F. Incidence and characteristics of cerebral hypoxia after craniectomy in brain injured patients: a cohort study. J Neurosurgery 2020;135 :554-61.
  48. Flynn F, Richard G, Dobrescu MA, Bouchard J, Williamson DR, Brindamour D, Charbonney E, Dupuis S. Refractory dabigatran-induced hemorrhage despite multiple idarucizumab administration and renal replacement therapy. J Pharm Pract 2022;35:302-07.
  49. Frenette AJ, Williamson DR, Rochwerg B, Weiss MJ, Ball I, D’Aragon F, Serri K, Brindamour D, Meade M, Charbonney E.Worldwide management of donors after neurological death: a systematic review and narrative synthesis of guidelines. Can J Anesth 2020;67:1839-1857
  50. Cavayas YA, Noël A, Brunette V, Williamson DR, Bellemare P, Lagrenade-Verdant C, LeGuillan S, Levesque E, Frenette AJ, Lamarche Y, Giasson M, Rico P, Beaulieu Y, Marsolais P, Serri K, Bernard F, Albert M. Early experience with critically ill patients with COVID-19 in Montreal. Can J Anaesth. 2021;68:204-213.

Champ d’expertise

  • Axe : Médicament et santé des populations
  • Pharmacothérapie (soins critiques)
  • Recherche clinique
  • Recherche épidémiologique

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