• Toxicologie et analyse de risque
• Toxicocinétique et pharmacocinétique
• Modélisation à base physiologique de la toxicocinétique des xénobiotiques
• Interactions entre xénobiotiques dans les mélanges
• Extrapolations in vitro-in vivo en toxicocinétique
  • distribution
  • clairance
  • excrétion
  • interactions
• Estimation de l’exposition
• Expositions par inhalation

Formation et diplômes

1990/09 à 1994/05 B. Sc. en Biochimie (Majeure en biochimie et Mineure en études environnementales) Département de biochimie, Université McGill

1994/09 à 1996/08 M. Sc. en Hygiène du travail et de l’environnement, Département de médecine du travail et d'hygiène du milieu, Université de Montréal

• Modélisation pharmacocinétique à base physiologique du pyrène chez le rat

1996/09 à 2000/06 Ph. D. en Santé publique option Toxicologie de l'environnement, Département de médecine du travail et d'hygiène du milieu, Université de Montréal

• Modélisation à base physiologique des interactions toxicocinétiques dans des mélanges complexes de polluants de l'environnement

Formation complémentaire ou post-doctorale

2000/04 à 2001/03 F.Hoffmann-La Roche Ltd, Pharmaceuticals Division, Département de Recherche Préclinique et Sécurité Non-Clinique (PRNS), Section de Toxicologie Moleculaire et Métabolisme.

•     Modélisation pharmacocinétique à base physiologique des interactions métaboliques entre médicaments

Expérience et emplois antérieurs

2001/04 à 2002/08  Chef de laboratoire/Spécialiste en modélisation biomathématique. F.Hoffmann-La Roche Ltd, Pharmaceuticals Division, Département de Recherche Préclinique et Sécurité Non-Clinique (PRNS), Section de Pharmacocinétique.

2002/09 à 2004/07 Associé de recherche. Réseau de Recherche en Santé Environnementale. INRS-Institut-Armand-Frappier, Pointe Claire.
- Modélisation pharmacocinétique des contaminants de l’eau potable
- Mise sur pied d’une unité de toxicogénomique

2004/08 à 2008/05 Professeur adjoint, Département des sciences biologiques, Faculté des sciences, Université du Québec à Montréal.

2008/06 à 2010/08 Professeur agrégé, Département des sciences biologiques, Faculté des sciences, Université du Québec à Montréal.

2010/09 à 2015/05 Professeur agrégé PTU, Département de santé environnementale et santé au travail, Faculté de médecine, Université de Montréal.

2013/01 à ce jour Professeur associé, Département des sciences biologiques, Faculté des sciences, Université du Québec à Montréal.

2015/06 à ce jour Professeur titulaire PTU, Département de santé environnementale et santé au travail, Faculté de médecine, Université de Montréal.

Publications des 10 dernières années dans des revues dotées de Comités de pair

1. Poulin P, Haddad S. 2021. A new guidance for the prediction of hepatic clearance in the early drug discovery and development from the in vitro-to-in vivo extrapolation method and an approach for exploring whether an albumin-mediated hepatic uptake phenomenon could be valid under in vivo conditions. J Pharm Sci. doi: 10.1016/j.xphs.2021.04.002. PMID: 33857483.
2. Brochu P, Ménard J, Marchand A, Haddad S. 2021. Cardiopulmonary values and organ blood flows before and during heat stress: data in nine subjects at rest in the upright position. Canadian Journal of Pharmacology and Physiology. Can J Physiol Pharmacol.  doi: 10.1139/cjpp-2021-0044. PMID: 34062083
3. Plattard N, Dupuis A, Migeot V, Haddad S, Venisse N. 2021. An overview of the literature on emerging waterborne pollutants: chlorinated derivatives of Bisphenol A (ClxBPA). Environment International. 153:106547. doi: 10.1016/j.envint.2021.106547. PMID: 33831741.
4. Bteich M, Poulin P, Haddad S. 2021. Comparative Assessment of Extrapolation Methods Based on the Conventional Free Drug Hypothesis and Plasma Protein-Mediated Hepatic Uptake Theory for the Hepatic Clearance Predictions of Two Drugs Extensively Bound to Both the Albumin And Alpha-1-Acid Glycoprotein. J Pharm Sci. 110(3):1385-1391. doi: 10.1016/j.xphs.2020.11.009. PMID: 33217427  (Featured article).
5. Bteich M, Poulin P, Piette S, Haddad S. 2020. Impact of plasma protein binding on the in situ hepatic uptake and clearance of perampanel and fluoxetine in Sprague Dawley rats. J Pharm Sci. 109(10):3190-3205. doi: 10.1016/j.xphs.2020.07.003. Epub 2020 Jul 8.PMID: 32649937.
6. Tohon H, Nong A, Valcke M, Haddad S. 2020. Estimation of toluene exposure in air from BMA (S-benzylmercapturic acid) urinary measurements using a reverse dosimetry approach based on physiologically based pharmacokinetic modeling. Regul Toxicol Pharmacol. 120:104860. doi: 10.1016/j.yrtph.2020.104860. PMID: 33406392.
7. Bossou YM, Côté J, Mantha M, Haddad S, Achard S, Bouchard M. 2020. Impact of pesticide coexposure: an experimental study with binary mixtures of lambda-cyhalothrin (LCT) and captan and its impact on the toxicokinetics of LCT biomarkers of exposure. Arch Toxicol. 2020 Sep;94(9):3045-3058. doi: 10.1007/s00204-020-02810-6. PMID: 32577784.
8. Bteich M, Poulin P, Haddad S. 2019. The potential protein-mediated hepatic uptake: discussion on the molecular interactions between albumin and the hepatocyte cell surface and their implications for the in vitro-to-in vivo extrapolations of hepatic clearance of drugs. Expert Opin Drug Metab Toxicol. 15(8):633-658. doi: 10.1080/17425255.2019.1640679. PMID: 31274340.
9. Tohon H, Valcke M, Haddad S. 2019. An assessment of the impact of multi-route co-exposures on human variability in toxicokinetics: A case study with binary and quaternary mixtures of volatile drinking water contaminants. J Appl Toxicol. doi: 10.1002/jat.3787. PMID: 30834571. (SOT Risk Assessment Specialty Section award for the 2019 Best Published Paper Advancing the Science of Risk Assessment).
10. Bachelet D, Verner MA, Neri M, Cordina Duverger É, Charlier C, Arveux P, Haddad S, Guénel P. Breast Cancer and Exposure to Organochlorines in the CECILE Study: Associations with Plasma Levels Measured at the Time of Diagnosis and Estimated during Adolescence. Int J Environ Res Public Health. 2019 Jan 18;16(2). pii: E271. doi: 10.3390/ijerph16020271. PubMed PMID: 30669331; PubMed Central PMCID: PMC6351946.
11. Tohon H, Moreau M, Nong A, Valcke M, Haddad S. 2018. Reverse dosimetry modeling of toluene exposure concentrations based on biomonitoring levels from the Canadian Health Measures Survey. J Toxicol Environ Health A. 2018;81(20):1066-1082. doi: 10.1080/15287394.2018.1534174. Epub 2018 Oct 26. PubMed PMID: 30365389.
12. Poulin P, Haddad S. 2018. Extrapolation of the hepatic clearance of drugs in the absence of albumin in vitro to that in the presence of albumin in vivo: comparative assessment of two extrapolation models based on the albumin-mediated hepatic uptake theory and limitations and mechanistic insights. J Pharm Sci 107(7):1791-1797. doi: 10.1016/j.xphs.2018.03.012. PMID: 29567347.
13. Valcke M, Bourgault M-H, Haddad S, Bouchard M, Gauvin D, Levallois P. 2018. Deriving A Drinking Water Guideline for A Non-Carcinogenic Contaminant: The Case of Manganese. Int J Environ Res Pub Health J Expo Sci Environ Epidemiol 20;15(6) pii: E1293. doi: 10.3390/ijerph15061293. PMID: 29925794.
14. Poulin P, Bteich M, Haddad S. 2017 Supplemental Analysis of the Prediction of Hepatic Clearance of Binary Mixtures of Bisphenol A and Naproxen Determined in an Isolated Perfused Rat Liver Model to Promote the Understanding of Potential Albumin-Facilitated Hepatic Uptake Mechanism. J Pharm Sci. 106(11):3207-3214. PMID: 28823401.

15. Marchand A, Haddad S. Simultaneous exposures to heat and chemicals and the impact on toxicokinetics and biomonitoring. Current opinion in toxicology. 2017 April; 4:22-27. doi: 10.1016/j.cotox.2017.03.006.

16. Bounakta S, Bteich M, Mantha M, Poulin P, Haddad S. Predictions of bisphenol A hepatic clearance in the isolated perfused rat liver (IPRL): impact of albumin binding and of co-administration with naproxen. Xenobiotica. 2017 Mar 3;PubMed PMID: 28277163.
17. Pujalté I, Dieme D, Haddad S, Serventi AM, Bouchard M. Toxicokinetics of titanium dioxide (TiO₂) nanoparticles after inhalation in rats. Toxicol Lett. 2017 Jan 4;265:77-85. PubMed PMID: 27884615.
18. Tardif R, Catto C, Haddad S, Simard S, Rodriguez M. Assessment of air and water contamination by disinfection by-products at 41 indoor swimming pools. Environ Res. 2016 Jul;148:411-20. PubMed PMID: 27131795.
19. Poulin P, Burczynski FJ, Haddad S. The Role of Extracellular Binding Proteins in the Cellular Uptake of Drugs: Impact on Quantitative In Vitro-to-In Vivo Extrapolations of Toxicity and Efficacy in Physiologically Based Pharmacokinetic-Pharmacodynamic Research. J Pharm Sci. 2016 Feb;105(2):497-508. PubMed PMID: 26173749.
20. Marchand A, Aranda-Rodriguez R, Tardif R, Nong A, Haddad S. Evaluation and modeling of the impact of coexposures to VOC mixtures on urinary biomarkers. Inhal Toxicol. 2016;28(6):260-73. PubMed PMID: 27053005.
21. Poulin P, Haddad S. Albumin and Uptake of Drugs in Cells: Additional Validation Exercises of a Recently Published Equation that Quantifies the Albumin-Facilitated Uptake Mechanism(s) in Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling Research. J Pharm Sci. 2015 Dec;104(12):4448-58. PubMed PMID: 26457988.
22. Aranda-Rodriguez R, Cabecinha A, Harvie J, Jin Z, Marchand A, et al. A method for quantification of volatile organic compounds in blood by SPME-GC-MS/MS with broader application: From non-occupational exposure population to exposure studies. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Jun 15;992:76-85. PubMed PMID: 25965874.
23. Verner MA, Plusquellec P, Desjardins JL, Cartier C, Haddad S, et al. Prenatal and early-life polychlorinated biphenyl (PCB) levels and behavior in Inuit preschoolers. Environ Int. 2015 May;78:90-4. PubMed PMID: 25796081.
24. Marchand A, Aranda-Rodriguez R, Tardif R, Nong A, Haddad S. Human inhalation exposures to toluene, ethylbenzene, and m-xylene and physiologically based pharmacokinetic modeling of exposure biomarkers in exhaled air, blood, and urine. Toxicol Sci. 2015 Apr;144(2):414-24. PubMed PMID: 25601989.
25. Haddad S, Ayotte P, Verner MA. Derivation of exposure factors for infant lactational exposure to persistent organic pollutants (POPs). Regul Toxicol Pharmacol. 2015 Mar;71(2):135-40. PubMed PMID: 25510832.
26. Rouhou MC, Charest-Tardif G, Haddad S. In vivo effects of naproxen, salicylic acid, and valproic acid on the pharmacokinetics of trichloroethylene and metabolites in rats. J Toxicol Environ Health A. 2015;78(11):671-84. PubMed PMID: 26039745.
27. Valcke M, Haddad S. Assessing human variability in kinetics for exposures to multiple environmental chemicals: a physiologically based pharmacokinetic modeling case study with dichloromethane, benzene, toluene, ethylbenzene, and m-xylene. J Toxicol Environ Health A. 2015;78(7):409-31. PubMed PMID: 25785556.
28. Lehmann GM, Verner MA, Luukinen B, Henning C, Assimon SA, et al. Improving the risk assessment of lipophilic persistent environmental chemicals in breast milk. Crit Rev Toxicol. 2014 Aug;44(7):600-17. PubMed PMID: 25068490; NIHMSID: NIHMS602117; PubMed Central PMCID: PMC4115797.
29. Cheikh Rouhou M, Haddad S. Modulation of trichloroethylene in vitro metabolism by different drugs in human. Toxicol In Vitro. 2014 Aug;28(5):732-41. PubMed PMID: 24632077.
30. Brochu P, Bouchard M, Haddad S. Physiological daily inhalation rates for health risk assessment in overweight/obese children, adults, and elderly. Risk Anal. 2014 Mar;34(3):567-82. PubMed PMID: 24147611.
31. Dumas-Campagna J, Tardif R, Charest-Tardif G, Haddad S. Ethanol toxicokinetics resulting from inhalation exposure in human volunteers and toxicokinetic modeling. Inhal Toxicol. 2014 Feb;26(2):59-69. PubMed PMID: 24495244.
32. Dumas-Campagna J, Charest-Tardif G, Haddad S, Tardif R. Predictions of Blood Ethanol Levels Resulting From Occupational Use of Hydro Alcoholic Solutions and Ethanol-Based Varnishes. Journal of Environmental & Analytical Toxicology. 2014 January 05; 5(2):260.
33. Poulin P, Haddad S. Toward a new paradigm for the efficient in vitro-in vivo extrapolation of metabolic clearance in humans from hepatocyte data. J Pharm Sci. 2013 Sep;102(9):3239-51. PubMed PMID: 23494893.
34. Poulin P, Haddad S. Hepatocyte composition-based model as a mechanistic tool for predicting the cell suspension: aqueous phase partition coefficient of drugs in in vitro metabolic studies. J Pharm Sci. 2013 Aug;102(8):2806-18. PubMed PMID: 23670739.
35. Cheikh Rouhou M, Rheault I, Haddad S. Modulation of trichloroethylene in vitro metabolism by different drugs in rats. Toxicol In Vitro. 2013 Feb;27(1):34-43. PubMed PMID: 23089131.
36. Nadeau S, Bouchard M, Debia M, DeMarcellis-Warin N, Hallé S, et al. ÉquiNanos: innovative team for nanoparticle risk management. Nanomedicine. 2013 Jan;9(1):22-4. PubMed PMID: 22960193.
37. Gascon M, Verner MA, Guxens M, Grimalt JO, Forns J, et al. Evaluating the neurotoxic effects of lactational exposure to persistent organic pollutants (POPs) in Spanish children. Neurotoxicology. 2013 Jan;34:9-15. PubMed PMID: 23085522.
38. Verner MA, Sonneborn D, Lancz K, Muckle G, Ayotte P, et al. Toxicokinetic modeling of persistent organic pollutant levels in blood from birth to 45 months of age in longitudinal birth cohort studies. Environ Health Perspect. 2013 Jan;121(1):131-7. PubMed PMID: 23086694; PubMed Central PMCID: PMC3553439.
39. Poulin P, Hop CE, Ho Q, Halladay JS, Haddad S, et al. Comparative assessment of In Vitro-In Vivo extrapolation methods used for predicting hepatic metabolic clearance of drugs. J Pharm Sci. 2012 Nov;101(11):4308-26. PubMed PMID: 22890957.
40. Belmeskine H, Haddad S, Vandelac L, Sauvé S, Fournier M. Toxic effects of PCDD/Fs mixtures on Eisenia andrei earthworms. Ecotoxicol Environ Saf. 2012 Jun;80:54-9. PubMed PMID: 22401954.
41. Poulin P, Haddad S. Advancing prediction of tissue distribution and volume of distribution of highly lipophilic compounds from a simplified tissue-composition-based model as a mechanistic animal alternative method. J Pharm Sci. 2012 Jun;101(6):2250-61. PubMed PMID: 22388869.
42. Belmeskine H, Haddad S, Vandelac L, Brousseau P, Fournier M. In vitro effects of PCDDs/Fs on NK-like cell activity of Eisenia andrei earthworms. journal of Xenobiotics. 2012 February 22; 2(e1):1-6.
43. Poulin P, Kenny JR, Hop CE, Haddad S. In vitro-in vivo extrapolation of clearance: modeling hepatic metabolic clearance of highly bound drugs and comparative assessment with existing calculation methods. J Pharm Sci. 2012 Feb;101(2):838-51. PubMed PMID: 22009717.
44. Lipscomb JC, Haddad S, Poet T, Krishnan K. Physiologically-based pharmacokinetic (PBPK) models in toxicity testing and risk assessment. Adv Exp Med Biol. 2012;745:76-95. PubMed PMID: 22437814.
45. Verner MA, Bouchard M, Fritsche E, Charbonneau M, Haddad S. In vitro neurotoxicity data in human risk assessment of polybrominated diphenyl ethers (PBDEs): overview and perspectives. Toxicol In Vitro. 2011 Dec;25(8):1509-15. PubMed PMID: 21704695.
46. Belmeskine H, Brousseau P, Haddad S, Vandelac L, Fournier M. Effects of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans on phagocytic response of Eisenia andrei cœlomocytes. journal of xenobiotics. 2011 October 19; 1(1):e6.
47. Poulin P, Haddad S. Microsome composition-based model as a mechanistic tool to predict nonspecific binding of drugs in liver microsomes. J Pharm Sci. 2011 Oct;100(10):4501-17. PubMed PMID: 21574165.
48. Verner MA, Bachelet D, McDougall R, Charbonneau M, Guénel P, et al. A case study addressing the reliability of polychlorinated biphenyl levels measured at the time of breast cancer diagnosis in representing early-life exposure. Cancer Epidemiol Biomarkers Prev. 2011 Feb;20(2):281-6. PubMed PMID: 21177424.