Les enfants sont exposés à plusieurs contaminants de l’environnement (p. ex. les BPC, les insecticides, le bisphénol A) qui se retrouvent dans la poussière, dans la nourriture, dans l’eau et même dans le lait maternel. Certains de ces contaminants sont susceptibles de perturber le développement normal de l’enfant, incluant le développement du cerveau et du système immunitaire de l’enfant, ce qui peut entraîner des effets néfastes à long terme. Il est donc primordial d’estimer l’exposition des enfants aux différents contaminants, d’identifier leurs effets et de déterminer les façons dont les enfants sont exposés afin d’établir des stratégies pour réduire les expositions en bas âge. Le programme de recherche de Marc André Verner, qui  recoupe les domaines de la toxicologie et de l’épidémiologie environnementale, vise à élaborer des modèles mathématiques pour estimer l’exposition des enfants à plusieurs contaminants et de les mettre à contribution pour évaluer le risque lié aux expositions en bas âge.

• Responsable de l'option Toxicologie et analyse du risque du doctorat en santé publique

Lévêque L, Tahiri N, Goldsmith MR, Verner MA. Quantitative Structure-Activity Relationship (QSAR) Modeling to Predict the Transfer of Environmental Chemicals Across the Placenta. Computational Toxicology (sous presse).

Caron-Beaudoin E, Whyte KP, Bouchard MF, Chevrier J, Haddad S, Copes R, Frohlich KL, Dokkie D, Treaty 8 Tribal Association, Juul S, Bouchard M, Verner MA. Volatile organic compounds (VOCs) in indoor air and tap water samples in residences of pregnant women living in an area of unconventional natural gas operations: Findings from the EXPERIVA study. Science of the Total Environment 2021; 805:150242

Ho V, Pelland-St-Pierre L, Gravel S, Bouchard MF, Verner MA, Labrèche F. Endocrine disruptors: Challenges and future directions in epidemiologic research. Environmental Research 2021; 204:111969.

Pelland St-Pierre L, Sernoksie S, Verner MA, Ho V. Genotoxic effect of meat consumption. Genetic toxicology and Environmental Mutagenesis 2021; 863-864:503311.

Prichystalova R, Caron-Beaudoin E, Richardson L, Dirkx E, Amadou A, Brzicova T, Cihak R, Cogliano V, Hynes J, Pelland-St-Pierre L, Verner MA, van Tongeren M, Ho V. An approach to classifying occupational exposures to endocrine disrupting chemicals by sex hormone function using an expert judgement process. Journal of Exposure Science and Environmental Epidemiology 2021; 31(4):753-768.

Caron-Beaudoin E, Whitworth KW, Bosson-Rieutort D, Wendling G, Liu S, Verner MA. Density and proximity to hydraulic fracturing wells and birth outcomes in Northeastern British Columbia, Canada. Journal of Exposure Science and Environmental Epidemiology 2021; 31(1):53-61.

Verner MA, Salame H, Housand C, Birnbaum LS, Bouchard MF, Chevier J, Aylward L, Naiman DQ, LaKind J. How many urine samples are needed to accurately assess exposure to non-persistent chemicals? The Biomarker Reliability Assessment Tool (BRAT) for scientists, research sponsors, and risk managers. International Journal of Environmental Research and Public Health 2020; 17(23) : 9102.

Nguyen L, Gravel S, Labrèche F, Bakhiyi B, Verner MA, Zayed J, Jantunen L, Arrandale VH, Diamond M. Can silicone passive samplers be used for measuring exposure of e-waste workers to flame retardants? Environmental Science & Technology 2020; 54(23) : 15277-15286.

Plouffe L, Bosson-Rieutort D, Madaniyazi L, Iwai-Shimada M, Nakai K, Tatuta N, Nakayama SF, Verner MA. Estimated postnatal p,p’-DDT and p,p’-DDE levels and body mass index at 42 months of age in a longitudinal study of Japanese children. Environmental Health 2020; 19:49.

Forns J, Verner MA, Iszatt N, Nowack N, Bach CC, Vrijheid M, Costa O, Andiarena A, Sovcikova E, Høyer BB, Wittsiepe J, Lopez-Espinosa MJ, Ibarluzea J, Hertz-Picciotto I, Toft G, Stigum H, Guxens M, Liew Z, Eggesbø M. Early life exposure to Perfluoroalkyl substances (PFAS) and ADHD: a meta-analysis of nine European population-based studies. Environmental Health Perspectives 2020; 128(5):57002.

Gravel S, Lavoué J, Bakhiyi B, Lavoie J, Roberge B, Patry L, Bouchard MF, Verner MA, Zayed J, Labrèche F. Multi-exposures to suspected endocrine disruptors in electronic waste recycling workers : Associations with thyroid and reproductive hormones. International Journal of Hygiene and Environmental Health 2020; 225: 113445.

Caron-Beaudoin E, Bouchard M, Wendling G, Barroso A, Bouchard MF, Ayotte P, Frohlich KL, Verner MA. Urinary and hair concentrations of trace metals in pregnant women from Northeastern British Columbia, Canada: A pilot study. Journal of Exposure Science and Environmental Epidemiology 2019 : 29:613-623.

Montiel-León JM, Duy SV, Munoz G, Verner MA, Hendawi MY, Moya-Rojas HE, Amyot M, Sauvé S. Occurrence of pesticides in fruits and vegetables from organic and conventional agriculture by QuEChERS extraction liquid chromatography tandem mass spectrometry. Food Control 2019; 104 : 74-82.

Gravel S, Lavoué J, Bakhiyi B, Diamond ML, Jantunen L, Lavoie J, Roberge B, Verner MA, Zayed J, Labrèche F. Halogenated flame retardants and organophosphate esters in the air of electronic waste recycling facilities: Evidence of high concentrations and multiple exposures. Environment International 2019 ; 128 : 244-253.

LaKind JS, Idri F, Naiman DQ, Verner MA. Biomonitoring and nonpersistent chemicals – understanding and addressing variability and exposure misclassification. Current Environmental Health Reports 2019; 6(1):16-21.

Bachelet D, Verner MA, Neri M, Duverger EM, Charlier C, Arveux P, Haddad S, Guénel P. Breast Cancer and Exposure to Organochlorines in the CECILE Study: Associations with Plasma Levels Measured at the Time of Diagnosis and Estimated during Adolescence. Int. J. Environ. Res. Public Health 2019; 16(2): 271.

Verner MA, Chevrier J, Ngueta G, Rauch S, Bornman R, Eskenazi B. Early-life exposure to p,p′-DDT and p,p′-DDE in South African children participating in the VHEMBE study: An assessment using repeated serum measurements and pharmacokinetic modeling. Environment International 2018; 119:478-484.

Kieskamp KK, Worley RR, McLanahan ED, Verner MA. Incorporation of fetal and child PFOA dosimetry in the derivation of health-based toxicity values. Environment International 2018; 111 :260-267.

Caron-Beaudoin É, Valter N, Chevrier J, Ayotte P, Frohlich K, Verner MA. Gestational exposure to volatile organic compounds (VOCs) in Northeastern British Columbia, Canada: A pilot study. Environment International 2018; 110:131-138.

Ngueta G, Verner MA, Fiocco AJ, Lupien S, Plusquellec P. Blood lead levels and hypothalamic-pituitary-adrenal function in middle-aged individuals. Environmental Research 2018; 160:554-561.

Ngueta G, Longnecker MP, Yoon M, Ruark CD, Clewell HJ, Andersen ME, Verner MA. Quantitative bias analysis of a reported association between perfluoroalkyl substances (PFAS) and endometriosis: The influence of oral contraceptive use. Environment International 2017; 104:118-121.

Verner MA, Plouffe L, Kieskamp KK, Rodríguez-Leal I, Marchitti SM. Evaluating the influence of half-life, milk:plasma partition coefficient, and volume of distribution on lactational exposure to chemicals in children. Environment International 2017; 102:223-229.

Ruark CD, Song G, Yoon M, Verner MA, Andersen ME, Clewell HJ, Longnecker MP. Quantitative Bias Analysis for Epidemiological Associations of Perfluoroalkyl Substance Serum Concentrations and Early Onset of Menopause. Environment International 2017; 99:245-254.

Jusko TA, Oktapodas M, Palkovičová L, Babjakova J, Verner MA, DeWitt J, Babinska K, Thevenet-Morrison K, Conka K, Drobná B, Jana C, Thurston S, Lawrence B, Dozier A, Järvinen K, Patayova H, Trnovec T, Legler J, Hertz-Picciotto I, Lamoree M. Demographic, reproductive, and dietary determinants of perfluorooctane sulfonic (PFOS) and perfluorooctanoic acid (PFOA) concentrations in human colostrum. Environmental Science and Technology 2016; 50(13):7152-62.

Song G, Peeples CR Wu H, Verner MA, Andersen ME Clewell HJ, Longnecker MP. Pharmacokinetic Bias Analysis of the Epidemiological Associations between Serum Polybrominated Diphenyl Ether (BDE-47) and Timing of Menarche. Environmental Research 2016; 150:541–548.

Verner MA, Ngueta G, Jensen ET, Fromme H, Völkel W, Nygaard UC, Granum B, Longnecker MP. A Simple Pharmacokinetic Model of Prenatal and Postnatal Exposure to Perfluoroalkyl Substances (PFASs). Environmental Science and Technology 2016; 50(2):978-86.

Jusko TA, De Roos AJ, Lee SY, Thevenet-Morrison K, Schwartz SM, Verner MA, Murínová L, Drobná B, Kočan A, Fabišiková A, Čonka K, Trnovec T, Hertz-Picciotto I, Lawrence P. A Birth Cohort Study of Maternal and Infant Serum PCB-153 and DDE Concentrations and Responses to Infant Tuberculosis Vaccination. Environmental Health Perspectives 2016; 124:813–821.

Verner MA, Loccisano AE, Morken NH, Yoon M, Wu H, McDougall R, Maisonet M, Marcus M, Kishi R, Miyashita C, Chen MH, Hsieh WS, Andersen ME, Clewell HJ, Longnecker MP. Associations of Perfluoroalkyl Substances (PFASs) with Lower Birth Weight: An Evaluation of Potential Confounding by Glomerular Filtration Rate Using a Physiologically Based Pharmacokinetic Model (PBPK). Environmental Health Perspectives 2015; 123(12):1317-24.

Verner MA, Hart JE, Sagiv SK, Bellinger DC, Altshul LM, Korrick SA. Measured Prenatal and Estimated Postnatal Levels of Polychlorinated Biphenyls (PCBs) and ADHD-Related Behaviors in 8-Year-Old Children. Environmental Health Perspectives 2015; 123(9):888-894.

Iszatt N, Stigum H, Verner MA, Govarts E, Palkovicova L, Schoeters G, Trnovec T, Legler J, Pelé F, Botton J, Chevrier C, Wittsiepe J, Ranft U, Vandentorren S, Kasper-Sonnenberg M, Klümper C, Weisglas-Kuperus N, White RA, Polder A, Eggesbø M, OBELIX. Prenatal and postnatal exposure to persistent organic pollutants and infant growth: a pooled analysis of 7 European birth cohorts. Environmental Health Perspectives 2015; 123(7):730-736.

Verner MA, Gaspar FW, Chevrier J, Gunier RB, Sjödin A, Bradman A, Eskenazi B. Increasing Sample Size in Prospective Birth Cohorts: Back-Extrapolating Prenatal Levels of Persistent Organic Pollutants in Newly Enrolled Children. Environmental Science and Technology 2015; 49(6):3940-3948

Verner MA, Plusquellec P, Desjardins J, Cartier C, Haddad S, Ayotte P, Dewailly É, Muckle G. Prenatal and Early-Life Polychlorinated Biphenyl (PCB) Levels and Behavior in Inuit Preschoolers. Environment International 2015; 78:90-94.

Haddad S, Ayotte P, Verner MA. Derivation of Exposure Factors for Infant Lactational Exposure to Persistent Organic Pollutants (POPs). Regulatory Toxicology and Pharmacology 2015; 71(2):135-40.

Lehmann GM, Verner MA, Luukinen B, Henning C, Assimon SA, LaKind JS, McLanahan ED, Phillips LJ, Davis MH, Powers CM, Hines EP, Haddad S, Longnecker MP, Poulsen MT, Farrer DG, Marchitti SA, Tan YM, Swartout JC, Sagiv SK, Welsh C, Campbell Jr. JL, Foster WG, Yang RSH, Fenton SE, Tornero-Velez R, Francis BM, Barnett JB, El-Masri HA, Simmons JE. Improving the Risk Assessment of Lipophilic Persistent Environmental Chemicals in Breast Milk. Critical Reviews in Toxicology 2014; 44(7):600-617.

Verner MA, McDougall R, Glynn A, Andersen ME, Clewell HJ, Longnecker MP. Is the Relationship between Prenatal Exposure to PCB-153 and Decreased Birth Weight Attributable to Pharmacokinetics? Environmental Health Perspectives 2013; 121:1219-1224.

Verner MA, Sonneborn D, Lancz K, Muckle G, Ayotte P, Dewailly É, Trnovec T, Haddad S, Hertz-Picciotto I, Eggesbø M. Toxicokinetic Modeling of Children’s Blood Persistent Organic Pollutant Levels from Birth to 45 Months in Longitudinal Birth Cohort Studies. Environmental Health Perspectives 2013; 121:131-137.

Verner MA, McDougall R, Johanson G. Using Population Physiologically Based Pharmacokinetic Modeling to Determine Optimal Sampling Times and to Interpret Biological Exposure Markers: The Example of Occupational Exposure to Styrene. Toxicology Letters 2012; 213(2): 299-304.

Verner MA, Bouchard M, Fritsche E, Charbonneau M, Haddad S. In Vitro Neurotoxicity Data in Human Risk Assessment of Polybrominated Diphenyl Ethers (PBDEs): Overview and Perspectives. Toxicology In Vitro 2011; 25(8):1509-1515.

Verner MA, Bachelet D, McDougall R, Charbonneau M, Guénel P, Haddad S. Polychlorinated Biphenyls (PCBs) and Breast Cancer: A Case Study Addressing the Reliability of Levels Measured at Diagnosis in Representing Early Life Exposure. Cancer Epidemiology, Biomarkers and Prevention 2010; 20(2):281-286.

Verner MA, Plusquellec P, Muckle G, Ayotte P, Dewailly E, Jacobson SW, Jacobson JL, Charbonneau M, Haddad S. Alteration of Infant Attention and Activity by Polychlorinated Biphenyls: Unravelling Critical Windows of Susceptibility Using Physiologically Based Pharmacokinetic Modeling. Neurotoxicology 2010; 34(5):424-431.

Verner MA, Magher T, Haddad S. High Concentrations of Commonly Used Drugs can Inhibit the In Vitro Glucuronidation of Bisphenol A and Nonylphenol in Rats. Xenobiotica 2009; 40(2):83-92.

Verner MA, Ayotte P, Muckle G, Charbonneau M, Haddad S. A Physiologically-Based Pharmacokinetic Model for the Assessment of Infant Exposure to Persistent Organic Pollutants in Epidemiologic Studies. Environmental Health Perspectives 2009; 117(3):481-487.

Verner MA, Charbonneau M, Lopez-Carillo L, Haddad S. Physiologically-Based Pharmacokinetic Modeling of Persistent Organic Pollutants for Lifetime Exposure Assessment: A New Tool for Breast Cancer Epidemiologic Studies, Environmental Health Perspectives 2008; 116(7):886-892.