Jacques Michaud
La différenciation neuronale
- Professeur titulaire
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Faculté de médecine - Département de pédiatrie
- Professeur titulaire
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Faculté de médecine - Département de neurosciences
Profile
Research expertise
The group’s research focuses on the biochemical and cell-based characterization of medically relevant enzymes to uncover the molecular basis of their mechanisms of action, specificities and regulation. We also aim to identify compounds that modulate enzyme activities. This knowledge can provide insight into the precise physiological role of these enzymes, and contribute to the design of potential therapeutic agents. Application of enzyme kinetic techniques to study the molecular basis of the mechanism and specificity of enzymes; structure-function relationships; study of enzyme-inhibitor interactions with the aim of designing new or improved inhibitors of therapeutic importance; modification of enzymes to alter their structural and/or functional properties (stability, specificity, catalytic mechanism); design of experimental protocols in enzyme kinetics; assay development for high-throughput-screening of compound libraries and for functional studies.
Deubiquitinating EnzymesThe modification of cellular proteins by ubiquitin and ubiquitin-like proteins is an essential regulatory mechanism in many biological processes. The isopeptide bond between ubiquitin and a protein, or between ubiquitin molecules in a polyubiquitin chain, can be cleared by deubiquitinating enzymes. The human genome encodes approximately 95 deubiquitinating enzymes, most of them being cysteine proteases, which are relatively poorly characterized. Our group uses detailed biochemical characterization and cell-based studies to provide insights into the molecular mechanisms and physiological roles of these enzymes, in order to elaborate novel molecular therapeutic strategies based on interference with deubiquitinating events.Enzymes from Clostridium difficileStudies are being carried out to characterize at the molecular level cysteine proteases from the bacteria Clostridium difficile, an important human pathogen. In the search for alternative antibiotics for treating bacterial infections, we are also evaluating how these enzymes influence the virulence of Clostridium difficile infections.Other cysteine proteasesIt was demonstrated that a viral papain-like cysteine protease (PLpro) from the Severe Acute Respiratory Syndrome (SARS) coronavirus, previously known to be involved in processing a viral polyprotein precursor and to contribute to the virus replicative cycle, also possesses deubiquitinating activity. This discovery raised provocative hypotheses regarding the ability of the SARS virus to evade cellular defense mechanisms. Our group has also made many important contributions to the study of cathepsin mechanisms, catalysis, specificity and regulation. In addition to general intracellular protein degradation and turnover within the endosomal/lysosomal system, cathepsins (mammalian cysteine proteases) can fulfill specific functions and also play an important role in a variety of pathological processes such as degenerative diseases and malignant tumour development.Affiliations and responsabilities
Research affiliations
Research units
Directeur scientifique
Titulaire
Teaching and supervision
Student supervision
Theses and dissertation supervision (Papyrus Institutional Repository)
Validation fonctionnelle des variants du récepteur de l’acide rétinoïque bêta identifiés chez le syndrome PDAC en utilisant le modèle du poisson zèbre
Cycle : Master's
Grade : M. Sc.
Tbc1d7 joue un rôle dans la mémoire à long terme et la croissance cervicale chez la souris
Cycle : Master's
Grade : M. Sc.
Rôles des facteurs de transcriptions SIM1, OTP et POU3F2 dans le développement de l'hypothalamus antérieur
Cycle : Master's
Grade : M. Sc.
Étude longitudinale d’un modèle murin de dystonie progressive causée par un gain de fonction du récepteur bêta de l’acide rétinoïque
Cycle : Master's
Grade : M. Sc.
L’haploinsuffisance de Syngap1 dans les neurones GABAergiques induit une hyperactivation de mTOR et des déficits cognitifs.
Cycle : Master's
Grade : M. Sc.
Implication de Syngap1 dans la transmission GABAergique et la plasticité synaptique
Cycle : Master's
Grade : M. Sc.
Bases moléculaires et cellulaires d’un trouble neurodéveloppemental causé par l’haploinsuffisance de SYNGAP1.
Cycle : Doctoral
Grade : Ph. D.
Exploration génomique de la déficience intellectuelle
Cycle : Doctoral
Grade : Ph. D.
Genetic Landscape of Joubert syndrome in French Canadians
Cycle : Doctoral
Grade : Ph. D.
Évaluation du caryotype moléculaire en tant qu’outil diagnostique chez les enfants avec déficience intellectuelle et/ou malformations congénitales
Cycle : Master's
Grade : M. Sc.
Régulation transcriptionelle du développement de l'hypothalamus chez l'amphibien
Cycle : Master's
Grade : M. Sc.
Dissection du programme développemental du noyau paraventriculaire de l'hypothalamus.
Cycle : Doctoral
Grade : Ph. D.
Impact de l'haploinsuffisance du gène Sim1 sur le développement et la fonction du noyau paraventriculaire de l'hypothalamus
Cycle : Doctoral
Grade : Ph. D.
SMN interagit-il avec PFNII pour accomplir une fonction neuronale? : développement d'un système d'intégration dirigé, stable, dans les cellules P19
Cycle : Master's
Grade : M. Sc.
Sim1 function in the developing and adult brain
Cycle : Doctoral
Grade : Ph. D.
Rôle de Sim1 et Sim2 dans la guidance des axones du corps mammillaire
Cycle : Master's
Grade : M. Sc.
Projects
Research projects
Cell analytics infrastructure investment at the Centre Hospitalier Universitaire (CHU) Ste. Justine Research Centre
Centre québécois de données génomiques (CQDG)
Estimating the effect size of rare genomic variants on cognitive and behavioral traits underlying neurodevelopmental disorders
Defining a Canadian data solution that will deliver precision health for rare genetic disease
Multilevel analyses of retinoic acid signaling to understand and treat a rare form of progressive motor impairment. (RAinRARE project).
Bridging the Gap in Paediatric Traumatic Brain Injury: Environmental, biological and clinical markers associated with preschool concussion and TBI
Séquençage rapide du génome pour l'investigation des nouveau-nés et nourrissons admis aux soins intensifs.
RAinRARE : Integrated analyses of retinoic acid signaling to understand and treat rare form of progressive motor impairment
Synaptic dysfunction in intellectual disabiity caused by SYNGAP1. Translational research to develop human models and advanced pharmacological treatments, TREAT SYNGAP.
Développement de la capacité en études cliniques précoces
DE NOVO MUTATIONS IN BIRTH DEFECTS
Canadian "Rare Diseases: Models & Mechanisms" Network (RDMM) Réseau Canadien "Maladies Rares: Modèles et Mécanismes" (MRMM)
Fondation des étoiles : Neurodéveloppement, santé mentale et maladies rares.
PERSONALIZED MEDICINE IN TREATMENT OF EPILEPSY
DE NOVO MUTATIONS IN INTELLECTUAL DISABILITY
DE NOVO MUTATIONS IN INTELLECTUAL DISABILITY
(RESEAUTETE) - THE INTEGRATED RESEARCH NETWORK ON PERINATOLOGY
LETTER OF INTENT (LOI) - The POPEYE project: Prevention of ongoing psychological comorbidities through early intervention in youth living with epilepsy. A new transformative model for the management of chronic diseases.
PERSONALIZED MEDICINE IN TREATMENT OF EPILEPSY
SUBVENTION DE FORMATION DES IRSC-FRSQ EN MEDECINE GENETIQUE APPLIQUEE
LA FORMATION EN RECHERCHE AU SEIN DU RESEAU DE MEDECINE GENETIQUE APPLIQUEE DU FRSQ
GENETICS OF DEVELOPMENTAL DISORDERS
GENETICS OF DEVELOPMENTAL DISORDERS
GENETICS OF DEVELOPMENTAL DISORDERS
IDENTIFICATION OF AUTOSOMAL RECESSIVE MUTATIONS ASSOCIATED WITH DEVELOPMENTAL ABNORMALITIES THROUGH NEXT-GENERATION RESEQUENCING
GENETIQUE DES MALADIES NEURO-DEVELOPPEMENTALES
EMERGING TEAM IN DEVELOPMENT OF STRATEGIES FOR UPTAKE AND ANALYSIS OF NANOSEQUENCING-DERIVED DATA SETS AND LINKING TO DISEASE
DOSSIER #20289 GENETIQUE DES MALADIES NEURO-DEVELOPPEMENTALES
IDENTIFICATION OF AUTOSOMAL RECESSIVE MUTATIONS ASSOCIATED WITH DEVELOPMENTAL ABNORMALITIES THROUGH NEXT-GENERATION RESEQUENCING
IDENTIFICATION OF AUTOSOMAL RECESSIVE MUTATIONS ASSOCIATED WITH INTELLECTUAL DISABILITY THROUGH NEXT-GENERATION RESEQUENCING
GENETIQUE DES MALADIES NEURO-DEVELOPPEMENTALES
EMERGING TEAM IN DEVELOPMENT OF STRATEGIES FOR UPTAKE AND ANALYSIS OF NANOSEQUENCING-DERIVED DATA SETS AND LINKING TO DISEASE
Outreach
Publications and presentations
Disciplines
- Genetics
Areas of expertise
- Genetic Mapping
- Chromosomes: Structure / Organization
- Genetic Screening of Diseases
- Genomic Damage and Repair
- Gene Regulation and Expression
- Genes
- Susceptibility Genes
- Applied Genetics
- Complex Trait Genetics
- Developmental Genetics
- Genetics and Ethics
- Genetics and Heredity
- Evolutionary Genetics
- Molecular Genetics
- Population Genetics
- Genome
- Genomics
- Gene-Environment Interactions
- Genetic Diseases
- Genetic Markers
- DNA and RNA Chips
- Transgenic Model
- Mutation (Process)
- Phenotype
- Polymorphism
- Proteins
- Proteomics
- Telomeres
- Gene Therapy
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