Thèmes

• Neuropathologie
• Pathologie ultrastructurale
• Pathologie oculaire

Intérêts de recherche

• Biobanking
• Neuro-oncologie pédiatrique
• Maladies neuro-musculaires
• Rétinoblastome

• Création et direction de la biobanque du CHU Sainte-Justine sur les maladies du système nerveux et neuro-musculaires

• Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma. Nikbakht H, Panditharatna E, Mikael LG, […], Ellezam B, […], Jabado N, Majewski J, Nazarian J. Nat Commun. 2016 Apr 6;7:11185
• Specific detection of methionine 27 mutation in histone 3 variants (H3K27M) in fixed tissue from high-grade astrocytomas (2014) Bechet D, Gielen GG, Korshunov A, Pfister SM, Rousso C, Faury D, Fiset PO, Benlimane N, Lewis PW, Lu C, David Allis C, Kieran MW, Ligon KL, Pietsch T, Ellezam B, Albrecht S, Jabado N. Acta Neuropathol 128(5):733-41.
• Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation (2014) Mayo L, Trauger SA, Blain M, Nadeau M, Patel B, Alvarez JI, Mascanfroni ID, Yeste A, Kivisäkk P, Kallas K, Ellezam B, Bakshi R, Prat A, Antel JP, Weiner HL, Quintana FJ. Nat Med 20(10):1147-56.
• Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma (2014) Fontebasso AM, Papillon-Cavanagh S, Schwartzentruber J, […] Ellezam B, […], Pfister SM, Ligon KL, Majewski J, Jabado N, Kieran MW. Nat Genet. 46(5):462-6
• SYK is a target of lymphocyte-derived microparticles in the induction of apoptosis of human retinoblastoma cells (2015) Qiu Q, Yang C, Xiong W, Tahiri H, Payeur M, Superstein R, Carret AS, Hamel P, Ellezam B, Martin B, Vezina M, Sapieha P, Liu G, Hardy P. Apoptosis 20(12):1613‑22
• Low rate of R132H IDH1 mutation in infratentorial and spinal cord grade II and III diffuse gliomas. (2012) Ellezam B, Theeler BJ, Walbert T, Mammoser AG, Horbinski C, Kleinschmidt-Demasters BK, Perry A, Puduvalli V, Fuller GN, Bruner JM, Aldape KD. Acta Neuropathol. 124:449