During embryonic development, esophagus and trachea develop from the anterior foregut (AF) tube. Disruption in the separation into two distinct tubes results in foregut malformations such as esophageal atresia and trachea-esophageal fistula (EA/TEF) affecting 1 in 3,500 births. The only treatment available for children born with these malformations involves surgically connecting the deformed esophagus with the stomach with life-long complications.

 
The mechanisms underlying the embryonic and fetal development of EA/TEF are poorly understood. Much work has focused on understanding the differentiation of the respiratory and digestive system from the AF tube but many questions about the process of compartmentalization remain unanswered. Most of our knowledge on foregut bifurcation, and subsequent esophagus development is based on genetic mouse models which revealed key genes, molecular pathways and signaling molecules that regulate foregut separation andcontinue to play key roles in esophagus development and homeostasis.

Human pluripotent stem cells (hPSCs) provide an efficient system to model and understand human organ development based on mimicking embryonic developmental stages to generate cell and tissue types originating from all 3 germ layers. Our Lab focuses on generation of mature esophageal and respiratory epithelium using induced pluripotent stem cells to better understand the developmental pathways involved in the normal development of the esophagus and trachea. 

Our ultimate goal is to use iPSC-derived esophageal, endothelial and mesenchymal progenitors to generate a 3D patient-derived neo-esophagus, to be used as an esophageal replacement in children with long-gap EA without the need of immunosuppression.

Nous recrutons Étudiants de maitrise et PhD (motivés!)  dans notre laboratoire au CHU Sainte Justine dès que possible

Merci de m'envoyer vos CV à. Je suis disponible à tout moment pour discuter.

Il a publié au cours des 5 dernières années, 27 articles dans des revues avec comité de pairs (sur un total de 95 depuis le début de sa carrière), ainsi que 20 chapitres de livre. Il est éditeur principal du livre Pediatric Neurogastroenterology. Nous vous détaillons ci-dessous cinq de ses publications les plus récentes :

1. Halb C, Pomerleau M, Faure C. Multichannel Intraesophageal Impedance Pattern of Children with Aerophagia. Neurogastroenterol Motil 2014
2. Vandenplas Y, Cruchet S, Faure C, Lee HC, Di Lorenzo C, Staiano A, Xu Chundi, Aw MM, Gutiérrez-Castrellón P, Asery A, Spolidoro J, Heine RG, Miqdady M , Arancibia ME, Alarcón P. A Review of Potential Clinical Applications of Partially Hydrolyzed Formulas in Young Children. Acta Paediatr 2014
3. Chapuy L, Pomerleau M, Perreault P, Faure C. Mucosal bridge as a cause of dysphagia after surgery for esophageal atresia. Can J Gastroenterol 2014
4. Lemoine C,Aspirot A, Morris M, Faure C. Esophageal dysmotility is present before surgery in isolated tracheoesophageal fistula: evidence for a primary motility disorder. J Pediatr Gastroenterol Nutr 2015
5. Berthet S, Tenisch E, Miron Mc, Alami N, Aspirot A, Faure C. Vascular Anomalies Associated With Esophageal Atresia and Tracheoesophageal Fistula. J Pediatr 2015