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Ryszard Grygorczyk

Purinergic signaling, ATP release, ATP imaging, cystic fibrosis, mucus properties, FLIM microscopy

Professeur associé

Faculté de médecine - Département de médecine

Secondary numbers: 514 890-8000 #15089 (Travail 1) 514 412-7204 (Télécopieur)
Secondary email: ryszard.grygorczyk@umontreal.ca (Travail)

Profile

Research expertise

Our research is focused on different aspects of lung epithelial cell physiology, including mechano-sensitive ATP release and purinergic signaling in the lungs, mucus rheological properties in cystic fibrosis, and cell volume regulation. In our studies, we use advanced light microscopy imaging techniques, such as real-time luminescence imaging of ATP release, total internal reflection fluorescence microscopy (TIRF) and fluorescence life time imaging (FLIM). Our current research collaborations include scientist at McGill University (Canada), University of North Texas (USA), University of Nagoya (Japan) and Fudan University in Shanghai (China). 

Affiliations and responsabilities

Research affiliations

Research units

Membre

Affiliated institutions

  • Centre hospitalier de l’Université de Montréal (CHUM)

Teaching and supervision

Projects

Research projects

2018 - 2025

Cell volume regulation the search for a volume sensor

Lead researcher : Ryszard Grygorczyk
Funding sources: CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs: PVX20965-(RGP) Programme de subvention à la découverte individuelle ou de groupe
2019 - 2024

Role of ATP-P2X7 axis in pathogenesis of ventilator induced lung injury

Lead researcher : Ryszard Grygorczyk
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet
2020 - 2021

Supplément COVID-19 CRSNG_Cell volume regulation the search for a volume sensor

Funding sources: CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs: PVXXXXXX-Supplément à l’appui des étudiants, des stagiaires postdoctoraux et du personnel de soutien à la recherche COVID-19
2016 - 2019

Regulation of mucin release and rhelogy in cystic fibrosis

Lead researcher : Ryszard Grygorczyk
Funding sources: Fibrose kystique canada
Grant programs: PVX11578-Subvention de recherche
2013 - 2019

CELL VOLUME REGULATION - THE SEARCH FOR A VOLUME SENSOR

Lead researcher : Ryszard Grygorczyk
Funding sources: CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs: PVX20965-(RGP) Programme de subvention à la découverte individuelle ou de groupe
2009 - 2017

RENOUVELLEMENT : MECHANOSENSITIIVE ATP RELEASE IN THE LUNGS

Lead researcher : Ryszard Grygorczyk
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXX5647-(MOP) Subvention de fonctionnement incluant les subventions de fonctionnement programmatiques (général)
2014 - 2016

Novel approach to image mucin release and swelling

Co-researchers : Ryszard Grygorczyk
Funding sources: NIH/National Institutes of Health (NIH)
Grant programs: PVXXXXXX-Subvention de recherche
2011 - 2014

AIRWAY SURFACE LIQUID LAYER - SENSORY AND REGULATORY MECHANISMS

Lead researcher : Ryszard Grygorczyk
Funding sources: Fibrose kystique canada
Grant programs:
2009 - 2014

MECHANOSENSITIIVE ATP RELEASE IN THE LUNGS

Lead researcher : Ryszard Grygorczyk
2008 - 2012

CELL VOLUME REGULATION - THE SEARCH FOR A VOLUME SENSORE

Lead researcher : Ryszard Grygorczyk

Outreach

Publications and presentations

Disciplines

  • Physiology

Areas of expertise

  • Cell
  • Physiology
  • Cystic Fibrosis (Circulatory and Respiratory Health)
  • Cell Signaling (Circulatory and Respiratory Health)