Health Sciences
Ryszard Grygorczyk
Purinergic signaling, ATP release, ATP imaging, cystic fibrosis, mucus properties, FLIM microscopy
Secondary numbers:
514 890-8000 #15089
(Travail 1)
514 412-7204
(Télécopieur)
Secondary email:
ryszard.grygorczyk@umontreal.ca
(Travail)
Profile
Research expertise
Our research is focused on different aspects of lung epithelial cell physiology, including mechano-sensitive ATP release and purinergic signaling in the lungs, mucus rheological properties in cystic fibrosis, and cell volume regulation. In our studies, we use advanced light microscopy imaging techniques, such as real-time luminescence imaging of ATP release, total internal reflection fluorescence microscopy (TIRF) and fluorescence life time imaging (FLIM). Our current research collaborations include scientist at McGill University (Canada), University of North Texas (USA), University of Nagoya (Japan) and Fudan University in Shanghai (China).
Affiliations and responsabilities
Research affiliations
Research units
Membre
Affiliated institutions
- Centre hospitalier de l’Université de Montréal (CHUM)
Teaching and supervision
Student supervision
Theses and dissertation supervision (Papyrus Institutional Repository)
2021
Mechanosensitive ATP release in the lungs
Graduate : Tan, Ju Jing
Cycle : Doctoral
Grade : Ph. D.
Cycle : Doctoral
Grade : Ph. D.
2010
Autocrine loop in the purinergic control of airway surface liquid volume : monitoring with a novel side-view imaging technique
Graduate : Dubois, David
Cycle : Master's
Grade : M. Sc.
Cycle : Master's
Grade : M. Sc.
2008
Role of nucleotides on lung epithelial cells : mechanism of release and development of a side-view microscopic chamber to study nucleotide-dependent airway surface liquid height
Graduate : Tatur, Sabina
Cycle : Doctoral
Grade : Ph. D.
Cycle : Doctoral
Grade : Ph. D.
2006
Amélioration des techniques de volumétrie, tant au niveau technique et numérique, et étude des variations du volume cellulaire lors de chocs hypotoniques
Graduate : Groulx, Nicolas
Cycle : Master's
Grade : M. Sc.
Cycle : Master's
Grade : M. Sc.
2005
Contribution à l'étude du mécanisme de sécrétion d'ATP par des cellules épithéliales pulmonaires et des fibroblastes soumis à un choc hypotonique
Graduate : Boudreault, Francis
Cycle : Doctoral
Grade : Ph. D.
Cycle : Doctoral
Grade : Ph. D.
2003
Conséquence du choc hypotonique sur le transport sodique des cellules épithéliales alvéolaires de type II
Graduate : Tessier, Marie-Claude
Cycle : Master's
Grade : M. Sc.
Cycle : Master's
Grade : M. Sc.
Projects
Research projects
2018
- 2025
Cell volume regulation the search for a volume sensor
Lead researcher :
Ryszard Grygorczyk
Funding sources:
CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs:
PVX20965-(RGP) Programme de subvention à la découverte individuelle ou de groupe
2019
- 2024
Role of ATP-P2X7 axis in pathogenesis of ventilator induced lung injury
Lead researcher :
Ryszard Grygorczyk
Funding sources:
IRSC/Instituts de recherche en santé du Canada
Grant programs:
PVXXXXXX-(PJT) Subvention Projet
2020
- 2021
Supplément COVID-19 CRSNG_Cell volume regulation the search for a volume sensor
Funding sources:
CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs:
PVXXXXXX-Supplément à l’appui des étudiants, des stagiaires postdoctoraux et du personnel de soutien à la recherche COVID-19
2016
- 2019
Regulation of mucin release and rhelogy in cystic fibrosis
Lead researcher :
Ryszard Grygorczyk
Funding sources:
Fibrose kystique canada
Grant programs:
PVX11578-Subvention de recherche
2013
- 2019
CELL VOLUME REGULATION - THE SEARCH FOR A VOLUME SENSOR
Lead researcher :
Ryszard Grygorczyk
Funding sources:
CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs:
PVX20965-(RGP) Programme de subvention à la découverte individuelle ou de groupe
2009
- 2017
RENOUVELLEMENT : MECHANOSENSITIIVE ATP RELEASE IN THE LUNGS
Lead researcher :
Ryszard Grygorczyk
Funding sources:
IRSC/Instituts de recherche en santé du Canada
Grant programs:
PVXX5647-(MOP) Subvention de fonctionnement incluant les subventions de fonctionnement programmatiques (général)
2014
- 2016
Novel approach to image mucin release and swelling
Co-researchers :
Ryszard Grygorczyk
Funding sources:
NIH/National Institutes of Health (NIH)
Grant programs:
PVXXXXXX-Subvention de recherche
2011
- 2014
AIRWAY SURFACE LIQUID LAYER - SENSORY AND REGULATORY MECHANISMS
Lead researcher :
Ryszard Grygorczyk
Funding sources:
Fibrose kystique canada
Grant programs:
2009
- 2014
MECHANOSENSITIIVE ATP RELEASE IN THE LUNGS
Lead researcher :
Ryszard Grygorczyk
2008
- 2012
CELL VOLUME REGULATION - THE SEARCH FOR A VOLUME SENSORE
Lead researcher :
Ryszard Grygorczyk
Outreach
Publications and presentations
Disciplines
- Physiology
Areas of expertise
- Cell
- Physiology
- Cystic Fibrosis (Circulatory and Respiratory Health)
- Cell Signaling (Circulatory and Respiratory Health)