Gilles Hickson
Profile
Research expertise
Thèmes
- Cytokinèse
- Anilline
- Septines
- Cytosquelette
- Actine
- Signalisation de la GTPase Rho
- Division cellulaire
- Myosine
- Midbody (corps centrale)
- Drosophile
Intérêts de recherche
- Les mécanismes moléculaires de la cytokinèse
- La transition de l’anneau contractile à l’anneau du midbody («corps centrale »)
- Le contrôle du cytosquelette d’actine de myosine et de septines par la protéine d’échaffaudage, l’Anilline
- Les variations développementales de la cytokinèse en utilisant la drosophile comme modèle
- L’implication potentielle de la machinerie de la cytokinèse dans la migration cellulaire et la cancérogenèse
Awards and recognitions
- Bourse Postdoctorale de la Fondation Komen for the Cure (2004-2007)
- Special Fellow de la Société Leukemia & Lymphoma Society (2007-2010)
- Genetics Society of America, DeLill Nasser Travel Award (2008)
- FRQS Chercheur Boursier, Junior 1 (2009-2013)
- FRQS Chercheur Boursier, Junior 2 (2014-2017)
- FRQS Chercheur Boursier, Sénior (2017-2021)
- Finaliste, Prix de Nouveau Investigateur Maud Menten 2014, Institut de Génétique, IRSC/CIHR
- Transition Award de la Fondation Cole (2013)
- Subvention de fonctionnement des IRSC/CIHR (2009-2019, 2022-2027)
- Subvention de fonctionnement du CRSNG/NSERC (2014-2026)
- Subvention d’infrastructure de la Fondation Canadienne pour l’Innovation
Affiliations and responsabilities
Research affiliations
Research units
Membre
Affiliated institutions
- Centre hospitalier universitaire Sainte-Justine (CHU Sainte-Justine)
University service and activities
Activities within organizations or entities of the institution
Directeur-Adjoint, Affaires Académiques, Centre de recherche du CHU Sainte-Justine
Co-directeur scientifique, Plateforme d'Imagerie Microscopique (PIM), Centre de Recherche du CHU Sainte-Justine
Responsable de l'unité d'attache CHU-Sainte-Justine, Programmes en Biologie Moléculaire, Faculté de Médecine, Université de Montréal
Membre du Comité de Révision Interne, Centre de recherche du CHU Sainte-Justine
Responsable du Cours MMD1042, Médecine Moléculaire et Microscopique, Année préparatoire en médecine, Faculté de Médecine, Université de Montréal
Teaching and supervision
Recruitment in research
I am always looking for motivated graduate students curious to understand complex intracellular molecular mechanisms relevant to our work. A strong work ethic, as demonstrated by a strong academic record, and intellectual audacity are required. If interested in becoming a member of our lab, please send me a brief letter of motivation detailing why you think you would be a good fit, together with your academic transcripts. Thanks for your interest!
Teaching
Courses taught (current session only)
Programs
Student supervision
Theses and dissertation supervision (Papyrus Institutional Repository)
Coordination des réseaux cytosquelettiques dans la cytokinèse
Cycle : Master's
Grade : M. Sc.
Détermination du rôle du domaine de liaison à la myosine de l’anilline durant la cytokinèse
Cycle : Master's
Grade : M. Sc.
Déchiffrage des mécanismes d’assemblage des filaments de septines
Cycle : Master's
Grade : M. Sc.
Caractérisation des rôles de l"Anilline durant la cytokinèse
Cycle : Doctoral
Grade : Ph. D.
Caractérisation du rôle de Citron Kinase durant la cytokinèse
Cycle : Doctoral
Grade : Ph. D.
L'implication de la Cycline B dans le processus de cytocinèse
Cycle : Master's
Grade : M. Sc.
Caractérisation des structures de septines hautement organisées chez la drosophile et leur interaction avec le cytosquelette d’actine
Cycle : Master's
Grade : M. Sc.
La formine Diaphanous est essentielle pour l’organisation et la maturation de l’anneau contractile pendant la cytokinèse
Cycle : Master's
Grade : M. Sc.
Projects
Research projects
Coordination of actomyosin and anillo-septin sub-networks of the contractile ring during cytokinesis
Mechanisms of assembly and function of the septin cytoskeleton in Drosophila
Multimode determination of gene transcription and metabolic labeling
HIGHER-ORDERED ASSEMBLY OF SEPTINS IN A CELL-BASED SYSTEM
Mécanismes moléculaires de la division cellulaire.
THE CONTRACTILE RING TO MIDBODY RING TRANSITION DURING CYTOKINESIS
DOSSIER 29008 MECANISMES MOLECULAIRES DE LA DIVISION CELLULAIRE
Les microparticules d'origine cellulaire répriment fortement la néovascularisation choroïdienne pathologique par modulation du microenvironnement angiostatique
Maud Menten New Principal Investigator Prize 2014 Finalist - Biomedical Theme. MOP FNR - 97788
MECHANISMS OF MIDBODY RING BIOGENESIS DURING CYTOKINESIS
MOLECULAR MECHANISMS OF CELL DIVISION.
MECHANISMS OF MIDBODY RING BIOGENESIS DURING CYTOKINESIS
MECANISMES MOLECULAIRES DE LA CYTOCINESE
MECANISMES MOLECULAIRES DE LA CYTOCINESE
Outreach
Expertise professionnelle (hors de l’institution)
Editorial Board Member, Scientific Reports (2014-présent)
Publications and presentations
Publications
- Carim, S.C. & Hickson, G. R. (2023). The Rho1 GTPase controls anillo-septin assembly to facilitate contractile ring closure during cytokinesis. iScience. 26(6): 106903. https://doi.org/10.1016/j.isci.2023.106903
- Hickson, G. R. (2022). A back-up source of microtubules for the midbody during cytokinesis. J. Cell Biol. 221: e202201028. doi: 10.1083/jcb.202201028. https://rupress.org/jcb/article/221/3/e202201028/213023
- Carim, S.*, Kechad, A.* & Hickson, GRX. (2020) Hypothesis and Theory: The Rho-dependent actomyosin-anilloseptin contractile ring as a membrane microdomain gathering, compressing and sorting machine.Front Cell Dev Biol 8:575226. doi: 10.3389/fcell.2020.575226. https://www.frontiersin.org/articles/10.3389/fcell.2020.575226/full
- El-Amine, N.*, Carim, S.*, Wernike, D*. & Hickson, GRX. (2019) Rho-dependent control of the Citron kinase, Sticky, drives midbody ring maturation.Mol. Biol. Cell 30(17): 2185-2204. doi: 10.1091/mbc.E19-04-0194 https://www.molbiolcell.org/doi/10.1091/mbc.E19-04-0194
- Carim, S.C., El Kadhi, K.B., Yan., G., Sweeney, S.T., Hickson, G.R., Carréno, S. and Lowe, M. (2019) IPIP27 coordinates PtdIns (4,5) P2 homeostasis for successful cytokinesis. Curr. Biol. 29(5) 775-789. https://doi.org/10.1016/j.cub.2019.01.043
- Jananji, S., Risi, C., Lindamulage, I.K., Picard, L-P, Van Sciver, R., Laflamme, G., Albaghjati, A., Hickson, G.R*, Kwok., B. H.*, and Galkin, V.E.* Multimodal and polymorphic interactions between anillin and actin: their implications for cytokinesis. J. Mol. Biol. 2017. pii: S0022-2836(17)30061-X. doi: 10.1016/j.jmb.2017.01.020 *auteurs co-correspondants. http://www.sciencedirect.com/science/article/pii/S002228361730061X
- Kechad, A & Hickson, G. R. (2017). Imaging cytokinesis of Drosophila S2 cells. Methods Cell Biol. 2017;137:47-72. doi: 10.1016/bs.mcb.2016.03.034 http://www.sciencedirect.com/science/article/pii/S0091679X1630026
- Rodrigues, N.T., Lekomtsev, S., Jananji, S., Kriston-Vizi, J., Hickson, G.R., Baum, B. (2015) Kinetochore-localized PP1/Sds22 induces anaphase polar relaxation to couple chromosome segregation to cytokinesis. Nature, 524(7566):489-92 http://www.nature.com/nature/journal/v524/n7566/full/nature14496.html
- Kachaner, D.*, Pinson, X.*, Ben El Khadi, K., Normandin, K., Talje, L., Carréno, S., Kwok, B., Hickson, G.R. and Archambault, V. (2014) Inter-domain allosteric regulation of Polo kinase by Aurora B and Map205 is required for cytokinesis.*Contributions égales. J. Cell Biol. 207(2):201-11
- El Amine, N, Kechad, A$, Jananji, S. and Hickson, G.R. (2013). Opposing actions of septins and Sticky on Anillin promote the transition from contractile to midbody ring. J. Cell Biol. 203(3):487-504 http://jcb.rupress.org/content/203/3/487.long
- Wang, P., Galan, J., Normandin, K., Bonneil, E., Hickson, G.R., Roux, P.P., Thibault, P., & Archambault, V. (2013) Cell cycle regulation of Greatwall kinase nuclear localization facilitates mitotic progression. J. Cell Biol. 202: 277-93
- Kechad, A$, Jananji, S., Ruella, Y. and Hickson, G.R. (2012). Anillin acts as a bifunctional linker coordinating midbody ring biogenesis during cytokinesis. Curr. Biol. 22: 197-203 http://www.sciencedirect.com/science/article/pii/S0960982211013959
- Smurnyy, Y., Toms, A. V., Hickson, G. R., Eck, M. J. and Eggert, U. S. (2010). Binucleine 2, an isoform-specific inhibitor of Drosophila Aurora B kinase, provides insights into the mechanism of cytokinesis. ACS Chem Biol, 5(11):1015-20. doi: 10.1021/cb1001685
- Hickson, G. R.* and O’Farrell, P. H. (2008). Rho-dependent control of Anillin behavior during cytokinesis. J. Cell Biol. 180: 285-294(*auteur correspondant)
- Hickson, G. R., Echard, A. and O’Farrell, P. H. (2006). Rho-kinase controls cell shape changes during cytokinesis. Curr. Biol. 16: 359-370
- Fielding, A. B., Schonteich, E., Matheson, J., Wilson, G., Yu, X., Hickson, G. R., Srivastava, S., Baldwin, S. A., Prekeris, R. and Gould, G. W. (2005). Rab11-FIP3 and Rab11-FIP4 interact with Arf6 and the Exocyst to control membrane traffic during cytokinesis. Embo J. 24: 3389-99
- Echard, A*, Hickson, G. R.*, Foley, E. and O’Farrell, P. H. (2004). Terminal cytokinesis events uncovered after an RNAi screen. Curr. Biol. 14: 1685-1693(*contributions égales)
- Riggs, B., Rothwell, W., Mische, S., Hickson, G. R., Matheson, J., Gould, G. W., Hays, T. S., and Sullivan, W. (2003) Actin cytoskeleton remodeling during metaphase and cellular furrow formation requires recycling endosome components Nuclear-fallout and Rab11. J. Cell Biol., 163: 143-54 (voir news and views in brief, Nature 425, 914)
- Hickson, G. R., Matheson, J., Riggs, B., Maier, V. H., Fielding, A. B., Prekeris, R., Sullivan, W., Barr, F. A., and Gould, G. W. (2003). Arfophilins are dual Arf/Rab11 binding proteins that regulate recycling endosome distribution and are related to Drosophila nuclear fallout. Mol. Biol. Cell, 14: 2908-2920
- Parry, D. H., Hickson, G. R., and O’Farrell, P. H. (2003). Cyclin B destruction triggers changes in kinetochore behavior essential for successful anaphase. Curr. Biol. 13: 647-653
- Hickson, G. R., Chamberlain, L. H., Maier, V. H., and Gould, G. W. (2000). Quantification of SNARE protein levels in 3T3-L1 adipocytes: implications for insulin-stimulated glucose transport. Biochem. Biophys. Res. Commun. 270:841-845
Disciplines
- General Pathology
- Cell Biology
Areas of expertise
- Cellular Division
- Biological and Biochemical Mechanisms
- Cell Signaling and Cancer
- Cancer Genetics
- Cell Therapy of Cancer