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Natural Sciences and Engineering; Health Sciences

Marilène Paquet

Pathologie vétérinaire

Professeure agrégée

Faculté de médecine vétérinaire - Département de pathologie et microbiologie

Tunnel Mapaq - St-hyacinthe, room 1.38

514 343-6111 #49061


Research expertise

  • Oncologie comparée
  • Pathologie comparée et modèles animaux de maladie humaine
  • Physiopathologie du système reproducteur
  • Effets des toxines environnementales sur le système reproducteur

Affiliations and responsabilities

Teaching and supervision


Courses taught (current session only)


Student supervision

Theses and dissertation supervision (Papyrus Institutional Repository)


Ciblage de la voie Hippo avec les statines pour le traitement des tumeurs mammaires canines

Graduate : Vigneau, Anne-Laurence
Cycle : Master's
Grade : M. Sc.

Élucidation du rôle de la voie Hippo dans l’ovaire chez la souris

Graduate : Tsoi, Mayra
Cycle : Doctoral
Grade : Ph. D.

Ciblage thérapeutique de la voie Hippo pour le traitement des cancers mammaires chez la chienne

Graduate : Guillemette, Samantha
Cycle : Master's
Grade : M. Sc.


Research projects

2018 - 2028

Regulation of gonadotropin action by Slit/Robo signaling in the mammalian orary

Lead researcher : Derek Boerboom
Co-researchers : Marilène Paquet , Nicolas Gévry
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet
2018 - 2024

Deciphering the role of the nuclear receptor LRH-1 in the establishment of a specific transcriptional program in triple negative breast cancer.

Lead researcher : Nicolas Gévry
Co-researchers : Marilène Paquet
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs:
2016 - 2018

Negative Pressure Wound Therapy (NPWT) for open, contaminated wounds in horses

Lead researcher : Christine Theoret
Co-researchers : Sheila Laverty , Marie Archambault , Marilène Paquet
Funding sources: American College Veterinary Surgeons Foundation
Grant programs:
2016 - 2017

Hippo pathway dysregulation in canine mammary gland tumorigenesis and it's potential as a novel therapeutic target

Lead researcher : Marilène Paquet
Funding sources: Morris Animal foundation
Grant programs:


Publications and presentations


Manteghi S, Gingras MC, Kharitidi D, Galarneau L, Marques M, Yan M, et al. Haploinsufficiency of the ESCRT Component HD-PTP Predisposes to Cancer. Cell reports. 2016;15(9):1893-900.

Boyer A, Girard M, Thimmahahalli DS, Levasseur A, Celeste C, Paquet M, et al. mTOR Regulates Gap Junction Alpha-1 Protein Trafficking in Sertoli Cells and Is Required for the Maintenance of Spermatogenesis in Mice. Biology of reproduction. 2016.

Labbe DP, Uetani N, Vinette V, Lessard L, Aubry I, Migon E, et al. PTP1B Deficiency Enables the Ability of a High-Fat Diet to Drive the Invasive Character of PTEN-Deficient Prostate Cancers. Cancer research. 2016;76(11):3130-5.

Lee T, Paquet M, Larsson O, Pelletier J. Tumor cell survival dependence on the DHX9 DExH-box helicase. Oncogene. 2016. doi: 10.1038/onc.2016.52. [Epub ahead of print].

Allaire JM, Roy SA, Ouellet C, Lemieux E, Jones C, Paquet M, et al. Bmp signaling in colonic mesenchyme regulates stromal microenvironment and protects from polyposis initiation. International journal of cancer. 2016;138(11):2700-12.

Buensuceso AV, Son AI, Zhou R, Paquet M, Withers BM, Deroo BJ. Ephrin-A5 Is Required for Optimal Fertility and a Complete Ovulatory Response to Gonadotropins in the Female Mouse. Endocrinology. 2016;157(2):942-55.

Abedini A, Zamberlam G, Lapointe E, Tourigny C, Boyer A, Paquet M, et al. WNT5a is required for normal ovarian follicle development and antagonizes gonadotropin responsiveness in granulosa cells by suppressing canonical WNT signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2016;30(4):1534-47.

Nadeau ME, Rico C, Tsoi M, Vivancos M, Filimon S, Paquet M, et al. Pharmacological targeting of valosin containing protein (VCP) induces DNA damage and selectively kills canine lymphoma cells. BMC cancer. 2015;15:479.

Hai L, McGee SR, Rabideau AC, Paquet M, Narayan P. Infertility in Female Mice with a Gain-of-Function Mutation in the Luteinizing Hormone Receptor Is Due to Irregular Estrous Cyclicity, Anovulation, Hormonal Alterations, and Polycystic Ovaries. Biology of reproduction. 2015;93(1):16.

Boerboom D, Kumar V, Boyer A, Wang Y, Lambrot R, Zhou X, et al. beta-catenin stabilization in gonadotropes impairs FSH synthesis in male mice in vivo. Endocrinology. 2015;156(1):323-33.

Stodden GR, Lindberg ME, King ML, Paquet M, MacLean JA, Mann JL, et al. Loss of Cdh1 and Trp53 in the uterus induces chronic inflammation with modification of tumor microenvironment. Oncogene. 2015;34(19):2471-82.

Dauphinee SM, Richer E, Eva MM, McIntosh F, Paquet M, Dangoor D, et al. Contribution of increased ISG15, ISGylation and deregulated type I IFN signaling in Usp18 mutant mice during the course of bacterial infections. Genes and immunity. 2014;15(5):282-92.

Xu E, Forest MP, Schwab M, Avramoglu RK, St-Amand E, Caron AZ, et al. Hepatocyte-specific Ptpn6 deletion promotes hepatic lipid accretion, but reduces NAFLD in diet-induced obesity: potential role of PPARgamma. Hepatology (Baltimore, Md). 2014;59(5):1803-15.

Ramdzan ZM, Vadnais C, Pal R, Vandal G, Cadieux C, Leduy L, et al. RAS transformation requires CUX1-dependent repair of oxidative DNA damage. PLoS biology. 2014;12(3):e1001807.

Shio MT, Paquet M, Martel C, Bosschaerts T, Stienstra S, Olivier M, et al. Drug delivery by tattooing to treat cutaneous leishmaniasis. Scientific reports. 2014;4:4156.

Eva MM, Yuki KE, Dauphinee SM, Schwartzentruber JA, Pyzik M, Paquet M, et al. Altered IFN-gamma-mediated immunity and transcriptional expression patterns in N-Ethyl-N-nitrosourea-induced STAT4 mutants confer susceptibility to acute typhoid-like disease. Journal of immunology (Baltimore, Md : 1950). 2014;192(1):259-70.

Lapointe E, Boyer A, Rico C, Paquet M, Franco HL, Gossen J, et al. FZD1 regulates cumulus expansion genes and is required for normal female fertility in mice. Biology of reproduction. 2012;87(5):104.


  • Veterinary Sciences
  • General Pathology

Areas of expertise

  • Pathologie animale
  • Animal Reproduction
  • Médecine comparée
  • Environnement sain
  • Physiologie de la reproduction
  • Physiologie animale