Casimiro Gerarduzzi
Profile
Research expertise
Ses intérêts se recherche portent sur les mécanismes de signalisation menant à la fibrose rénale, en contexte pré-clinique et clinique, afin d'identifier les marqueurs moléculaires utiles au diagnostic et à la thérapeutique.
Biography
Casimiro Gerarduzzi, Ph.D., est chercheur principal au sein de l’unité de recherche sur la fibrose rénale. Il est également professeur adjoint sous octroi au Département de médecine de l’Université de Montréal.
Awards and recognitions
- 2018 - Bourse nouveau chercheur (KRESCENT)
- 2018 - Soutien à l’infrastructure (KRESCENT/IRSC)
- 2017 - Subvention (Fondation de l’Hôpital Maisonneuve-Rosemont)
- 2016 - Innovation Discovery (Partners HealthCare/Brigham & Women’s Hospital)
- 2011 - Bourse doctorale (Université McGill)
For more information…
Affiliations and responsabilities
Research affiliations
Research units
Membre
- Membre de l'Oncopole
Affiliated institutions
- CIUSSS de l'Est-de-l'Île-de-Montréal – Hôpital Maisonneuve-Rosemont (HMR)
Teaching and supervision
Student supervision
Theses and dissertation supervision (Papyrus Institutional Repository)
Understanding the role of the matricellular protein SMOC-2 in renal cell carcinoma
Cycle : Master's
Grade : M. Sc.
Projects
Research projects
Characterizing the Novel Role of Matrix Gla-Protein in Fibroblasts and Kidney Fibrosis
Investigating the Dynamic Interplay between the Extracellular Matrix and Cellular Behaviour
Targeting SMOC2-induced epithelial-to-mesenchymal transition inhibits senescence in mouse models of kidney fibrosis
Investigating the Dynamic Interplay between the Extracellular Matrix and Cellular Behaviour
Le rôle des protéines matricellulaires dans le microenvironnement des tissus affectés par la maladie
Le rôle des protéines matricellulaires dans le microenvironnement des tissus affectés par la maladie
A novel pathway of VEGF-C/FLT4 signalling for Renal Cell Carcinoma development
A novel pathway of VEGF-C/FLT4 signalling for Renal Cell Carcinoma development
Investigating the Provisional-Immune Matrix in Kidney Injury via SMOC2
Réseau CMDO // THE REPARATIVE EFFECT OF SMOC2 ON EPITHELIAL CELLS IN DIABETIC NEPHROPATHY
The Role of Matricellular Proteins in Kidney Repair and Development
The Role of Matricellular Proteins in Kidney Repair and Development
The Role of SMOC2 in Renal Cell Carcinoma
The role of matricellular proteins in kidney repair and development
Transitation Grant
The role of matricellular proteins in kidney repair and development
The role of matricellular proteins in kidney repair and development
Outreach
Publications and presentations
Publications
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Gerarduzzi, C., Kumar, R., Trivedi, T., Ajay, A., Iyer, A., Boswell, S., Hutchinson, J., Waikar, S., and Vaidya, V.S. Silencing SMOC2 ameliorates kidney fibrosis by inhibiting fibroblast to myofibroblast transformation. 2017. JCI Insight. [Epub ahead of print].
Plus d'informations -
Gerarduzzi, C., and Di Battista, J.A. Myofibroblast repair mechanisms post-inflammatory response: A fibrotic perspective. 2017. Inflamm Res. 66:451-465. *Auteur Correspondant
Plus d'informations -
Gerarduzzi, C., We, Q., Zhai, B., Antoniou, J., and Di Battista, J.A. Prostaglandin E2-Dependent Phosphorylation of RAS Inhibition 1 (RIN1) at Ser 291 and 292 Inhibits Transforming Growth Factor-β-Induced RAS Activation Pathway in Human Synovial Fibroblasts: Role in Cell Migration. 2017. J Cell Physiol. 232(1):202-15. *Auteur Correspondant
Plus d'informations -
de Polo, A., Luo, Z., Gerarduzzi, C., Cheng, X., Little, J., and Yuan, Z.M. AXL receptor signalling suppresses p53 in melanoma through stabilization of the MDMX-MDM2 complex. 2017. J Mol Cell Biol. 9(2):154-165.
Plus d'informations -
Trivedi, P., Kumar, R., Iyer, A., Boswell, S., Gerarduzzi, C., Herbert, Z., Joshi, N., Luyendyk, J., and Vaidya, V.S. Targeting Phospholipase D4 Attenuates Kidney Fibrosis. 2017. J Am Soc Nephrol. [Epub ahead of print].
Plus d'informations -
Gerarduzzi, C., de Polo, A., Liu, X.S., El Kharbili, M., Little, J., and Yuan, Z.M. Human epidermal growth factor receptor 4 (Her4) Suppresses p53 Protein via Targeting the MDMX-MDM2 Protein Complex: IMPLICATION OF A NOVEL MDMX SER-314 PHOSPHOSITE. 2016. J Biol Chem. 291(50):25937-25949.
Plus d'informations -
Liu, X.S., Liu, Z., Gerarduzzi, C., Choi, D.E., Ganapathy, S., Pandolfi, P.P., and Yuan, Z.M. Somatic human ZBTB7A zinc finger mutations promote cancer progression. 2016. Oncogene 35(23):3071-8.
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Gerarduzzi, C., We, Q., Antoniou, J., and Di Battista, J.A. Prostaglandin E2-Dependent Blockade of Actomyosin and Stress Fiber Formation Is Mediated Through S1379 Phosphorylation of ROCK2. 2014. J Cell Biochem. 115(9):1516-27. *Auteur Correspondant
Plus d'informations -
Demoulins, T., Abdallah, A., Kettaf, N., Baron, M.L., Gerarduzzi, C., Gauchat, D., Gratton, S., and Sekaly, RP. Reversible blockade of thymic output: an inherent part of TLR ligand-mediated immune response. 2008. J Immunol. 181:6757-6769.
Plus d'informations
Disciplines
- Nephrology
- Clinical Sciences
Areas of expertise
- Renal Diseases
- Renal System
- Fibrosis
- Molecular Transportation