Marc Prentki
- Professeur titulaire
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Faculté de médecine - Département de nutrition
- Professeur accrédité
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Faculté de médecine - Département de biochimie et médecine moléculaire
Media
Portrait de chercheur : Dr Marc Prentki
© Université de Montréal
Profile
Research expertise
Signal transduction in the pancreatic β cell and regulation of insulin secretion. Glucose metabolism in the β cell triggers insulin secretion. The metabolic pathways involved in glucose-stimulated insulin secretion are still misunderstood. Our laboratory is working on the identification of the metabolic factors involved in coupling glucose metabolism and insulin secretion. We hypothesized that three metabolic cycles play a role in glucose-, fatty acid- and amino-acid-stimulated insulin secretion: the Krebs cycle, the pyruvate cycle and the glycerolipids/fatty acids cycle. With the help of a biochemical approach and molecular biology techniques such as the RNAi technology, adenovirus and KO mice, we are currently testing this hypothesis by overexpression or downregulation of key enzymes involved in intermediate metabolism regulation. We are also interested in the identification of genetic or nutritional defects (ex. excess of fatty acids) responsible for the aberrant insulin secretion in type 2 diabetes.
Etiology of Type 2 DiabetesType 2 diabetes is caused by a progressive dysfunction of the pancreatic β cell concomitant with insulin resistance of peripheral tissues. To better understand the molecular mechanism underlying this dysfunction and leading to the apoptosis of the b cells, our laboratory makes use of various animal models and primary (isolated islets of Langherans) or immortalized cell lines. The focus of our study are in vitro and in vivo glucolipotoxicity and the detoxification processes of fuel surfeit.Nutrition and cancerEpidemiological studies have underlined a link between the incidence of obesity and intestinal, breast and prostate cancers. Animal studies have also shown that a low calorie and low fat diet can reduce the risk of developping cancer. Nevertheless, the molecular mechanism by which fat induces cancer is still unknown. Our laboratory is testing the hypothesis by which the link between high-fat diet, obesity and cancer would reside in the glycerolipid/fatty acid cycle and the signalling through GPR40.education
- 1986 — Postdoctorat — Biochimie — Université de Pennsylvanie
- 1984 — Postdoctorat — Biochimie — Université de Genève
- 1974 — Baccalauréat — Biochimie — Université de Genève
- 1976 — Maîtrise — Biochimie — Université de Genève
- 1980 — Doctorat — Biochimie — Université de Genève
For more information…
- Centre de recherche du diabète de Montréal
- 2015-02-02 Prix d'excellence en recherche du CRCHUM 2015
- 2015-11-10 Comprendre les causes du diabète de type 2 pour mieux le traiter
- 2016-01-11 Trop de sucre? Il y a une enzyme pour ça!
- Portraits de chercheurs : MARC PRENTKI: LA RECHERCHE DANS LE SANG
- 20-06-2015 Marc Prentki et quatre autres chercheurs subventionnés par les IRSC
- 26-05-2014 Découverte d'une nouvelle cible pour le traitement lié au diabète de type 2
Affiliations and responsabilities
Research affiliations
Research units
Membre
- Centre de recherche du diabète de Montréal
Teaching and supervision
Teaching
Student supervision
Theses and dissertation supervision (Papyrus Institutional Repository)
α/β-hydrolase domain-6 and the development of high-fat diet-induced adipose tissue inflammation
Cycle : Master's
Grade : M. Sc.
Métabolisme du glucose et du glycérol dans la cellule pancréatique β et les hépatocytes et identification des voies de détoxification du glucose.
Cycle : Doctoral
Grade : Ph. D.
Monoacylglycerol, alpha/beta-hydrolase domain-6, and the regulation of insulin secretion and energy metabolism
Cycle : Doctoral
Grade : Ph. D.
Effets directs et aigus de médicaments insulinosensibilisateurs sur la cellule bêta des îlots pancréatiques : de l’outil de recherche à l’identification de la décélération métabolique comme mode d’action
Cycle : Doctoral
Grade : Ph. D.
Étude dans la cellule bêta pancréatique de voies inhibitrices de la sécrétion d'insuline liées au métabolisme des lipides
Cycle : Doctoral
Grade : Ph. D.
Rôle de l'estérification des acides gras dans la régulation de la sécrétion d'insuline et le stress métabolique induits par le glucose
Cycle : Doctoral
Grade : Ph. D.
Monoacylglycerol as a metabolic coupling factor in glucose-stimulated insulin secretion
Cycle : Master's
Grade : M. Sc.
Étude de l'implication des navettes du pyruvate découlant du métabolisme mitochondrial du glucose dans la régulation de la sécrétion d'insuline par les cellules bêta pancréatiques
Cycle : Doctoral
Grade : Ph. D.
Fatty acid metabolism and modulation of human breast cancer cell survival
Cycle : Doctoral
Grade : Ph. D.
Étude des voies de signalisation impliquées lors de la prolifération et l'apoptose des cellules du cancer du sein en réponse aux acides gras
Cycle : Doctoral
Grade : Ph. D.
Le glucagon-like peptide-I : un facteur de croissance et une hormone anti-apoptotique pour la cellule pancréatique[bêta] : étude de la transduction du signal
Cycle : Doctoral
Grade : Ph. D.
Glucolipotoxicity and the control of pancreatic ℓ-cell apoptosis
Cycle : Master's
Grade : M. Sc.
Étude du rôle de la ribonucléotide réductase humaine (RNR) dans la carcinogenèse mammaire
Cycle : Master's
Grade : M. Sc.
Étude du rôle de la malonyl-CoA décarboxylase dans la transduction de signaux de la cellule ℓ-pancréatique
Cycle : Master's
Grade : M. Sc.
Étude du rôle de l'action des acides gras dans la prolifération et l'apoptose des cellules du cancer du sein
Cycle : Master's
Grade : M. Sc.
Étude du rôle de l'interaction malonyl-CoA/carnitine palmitoyltransférase I (CPT I) dans le contrôle de la sécrétion d'insuline
Cycle : Master's
Grade : M. Sc.
Projects
Research projects
Glycerol 3-phosphate phosphatase and the glycerol shunt in senescence and healthy aging
The glycerol shunt and nutrient excess detoxification in the pancreatic ß-cell and liver
Lipid metabolism, insulin secretion and energy homoestasis
LINKING BASIC, CLINICAL & POPULATION HEALTH RESEARCH TO PREVENT & TREAT DIABETES, METABOLIC SYNDROME
Efficacy and mechanism of action of CB1R inverse agonists for enhancing insulin secretion and for preventing metabolic stress and cytokine-induced βcell death in human islets
ABHD6 as a novel drug target for obesity, non-alcoholic fatty liver disease (NASH) and cardiovascular disease (CVD)
Efficacy of CB1R inverse agonists for enhancing insulin secretion in mouse and human islets, ex vivo, and for preventing cytokine-induced -cell death in human islets
DIABETES AND METABOLISM
CMDO - Réseau de recherche en santé cardiométabolique, diabète et obésité
METABOLIC DECELARATION AS A MECHANISM FOR THE ANTI-DIABETIC EFFECTS OF METFORMIN AND BERBERINE
GLUCOSE REGULATION OF INSULIN SECRETION AND METABOLIC ENZYMES'GENE EXPRESSION
MOLECULAR BASIS OF FUEL SURFEIT DETOXIFICATION IN PANCREATIC BETA-CELLS
THE MONTREALCARDIOMETABOLIC BIOMARKER AND DRUG DISCOVERY CONSORTIUM (BIOCMET)
THE MONTREAL CARDIOMETABOLIC BIOMARKER AND DRUG DISCOVERY CONSORTIUM (BIOCMET)
THE MONTREAL CARDIOMETABOLIC BIOMARKER AND DRUG DISCOVERY CONSORTIUM (BIOCMET)
LINKING BASIC, CLINICAL AND POPULATION HEALTH RESEARCH TO PREVENT AND TREAT DIABETES, METABOLIC SYNDROME AND COMPLICATIONS
LINKING BASIC, CLINICAL AND POPULATION HEALTH RESEARCH TO PREVENT AND TREAT DIABETES, METABOLIC SYNDROME AND COMPLICATIONS
LINKING BASIC, CLINICAL AND POPULATION HEALTH RESEARCH TO PREVENT AND TREAT DIABETES, METABOLIC SYNDROME AND COMPLICATIONS
LINKING BASIC, CLINICAL AND POPULATION HEALTH RESEARCH TO PREVENT AND TREAT DIABETES, METABOLIC SYNDROME AND COMPLICATIONS
LINKING BASIC, CLINICAL AND POPULATION HEALTH RESEARCH TO PREVENT AND TREAT DIABETES, METABOLIC SYNDROME AND COMPLICATIONS
LINKING BASIC, CLINICAL AND POPULATION HEALTH RESEARCH TO PREVENT AND TREAT DIABETES, METABOLIC SYNDROME AND COMPLICATIONS
LINKING BASIC, CLINICAL AND POPULATION HEALTH RESEARCH TO PREVENT AND TREAT DIABETES, METABOLIC SYNDROME AND COMPLICATIONS
RECHERCHE FONDAMENTALE ET APPLIQUEE SUR LA PREVENTION DU DIABETE DE TYPE 2
SYMPOSIUM ON CARDIOMETABOLIC DISEASES OF THE MONTREAL DIABETES RESEARCH CENTER
Outreach
Highlights
Hommage
Portrait de chercheur
For more information…
Publications and presentations
Publications
- Sladek,R., Rocheleau, G., Rung, J., Dina, C., Shen, L., Serre, D., Boutin, P., Vincent, D., Belisle, A., Hadjadj, S., Balkau, B., Heude, B., Charpentier, G., Hudson, TJ., Montpetit, A., Prentki, M., Posner, BI., Balding, DJ., Meyre, D., Polychronakos, C., and Froguel. P. A Genome-wide association study identifies novel susceptibility loci for Type 2 Diabetes mellitus. Nature 2007; 445:881-885.
- Peyot ML, Guay C, Latour MG, Lamontagne J, Lussier R, Pineda M, Ruderman NB, Haemmerle G, Zechner R, Joly E, Madiraju SR, Poitout V, Prentki M. Adipose Triglyceride Lipase Is Implicated in Fuel- and Non-fuel-stimulated Insulin Secretion. J Biol Chem 2009; 284:16848-59.
- Peyot ML, Pepin E, Lamontagne J, Latour MG, Zarrouki B, Lussier R, Pineda M, Jetton TL, Madiraju SR, Joly E. Prentki M. Beta-cell failure in diet-induced obese mice stratified according to body weight gain: secretory dysfunction and altered islet lipid metabolism without steatosis or reduced beta-cell mass. Diabetes 2010; 59:2178-87.
- Nolan, CJ, Damn, P. and Prentki M. Type 2 diabetes across generations: from pathophysiology to prevention and management. Lancet 2011; 378:169-81.
- Prentki M, Matschinsky FM, Madiraju SR. Metabolic signaling in fuel-induced insulin secretion. Cell Metab 2013; 18:162-185.
- Lamontagne J, Jalbert-Arsenault E, Pepin E, Peyot ML, Ruderman NB, Nolan CJ, Joly E, Madiraju SR, Poitout V, Prentki M. Pioglitazone acutely reduces energy metabolism and insulin secretion in rats. Diabetes 2013; 62:2122-2129.
- Zhao S, Mugabo Y, Iglesias J, Xie L, Delghingaro-Augusto V, Lussier R, Peyot M-L, Joly E, Davis MA, Brown JM, Abousalham A, Gaisano H, Madiraju SRM and Prentki M. ABHD6 accessible monoacylglycerol is a signal for glucose-stimulated insulin secretion. Cell Metab 2014;19:993-1007.
- Nolan, CJ, Ruderman, NB, Kahn, SE, Pedersen, O, Prentki M. Insulin resistance as a physiological defense against metabolic stress: implication for the management of subsets of type 2 diabetes. Diabetes 2015; 64: 673-86.
- Mugabo Y, Zhao S, Seifried A, Gezzar S, Al-Mass A, Zhang D, Lamontagne J, Attane C, Poursharifi P, Iglesias J, Joly E, Peyot ML, Gohla A, Madiraju SRM, and Prentki M. Identification of a mammalian glycerol-3-phosphate phosphatase: Role in metabolism and signaling in pancreatic β–cells and hepatocytes. Proc Natl Acad Sci USA 2016; 113:E430-E439.
- Zhao S, Mugabo Y, Ballentyne G, Attane C, Iglesias J, Poursharifi P, Zhang D, Nguyen TA, Erb H, Prentki R, Peyot ML, Joly E, Tobin S, Fulton S, Brown JM, Madiraju SRM, and Prentki M. α/β- Hydrolase domain-6 deletion induces adipose browning and prevents obesity and type-2 diabetes. Cell Reports 2016 In Press.
Disciplines
- Nutrition
- Biochemistry
- Medical Biochemistry
- Molecular Biology
- Molecular Medicine
- Cell Biology
Areas of expertise
- Nutrition
- Nutritional Disorders
- Obesity
- Pancreas
- Diabetes
- Metabolic Disorders
- Metabolic Diseases
- Metabolism
- Drug Metabolism
- Energy Metabolism
- Cell
- Enzymes and Proteins
- Glands and Tissues
- Glucotoxicity
- Nutrients
- Drug Administration and Drug Interactions