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Health Sciences

Serguei Chteinberg

ARN : bio-informatique, génomique et protéomique

Professeur titulaire

Faculté de médecine - Département de biochimie et médecine moléculaire

Roger-Gaudry, room C338

514 343-6320

serguei.chteinberg@umontreal.ca

Secondary number: 514 343-2210 (Télécopieur)

Profile

Research expertise

Theoretical and experimental analysis of the three-dimensional structure of RNA; relations between the sequence, conformation and function of RNA; in silico generation of new RNA molecules, followed by experimental study; structure, function and evolution of transfer RNA and the ribosome; experimental study of mechanisms of protein biosynthesis; in vivo expression of combinatorial libraries of transfer RNA and ribosomal genes.

Teaching and supervision

Student supervision

Theses and dissertation supervision (Papyrus Institutional Repository)

2014

The study of RNA tertiary interactions in tRNA structure and function

Graduate : Ishii, Tetsu
Cycle : Doctoral
Grade : Ph. D.
2013

Structural aspects of the ribosome evolution and function

Graduate : Bokov, Konstantin
Cycle : Doctoral
Grade : Ph. D.
2011

RNA recurrent motifs : identification and characterization

Graduate : Butorin, Yury
Cycle : Doctoral
Grade : Ph. D.
2008

Étude des interactions entre les boucles D et T chez les ARNs de transfert (ARNts)

Graduate : Doyon, Félix
Cycle : Master's
Grade : M. Sc.
2004

Shape-keeping elements in tRNA

Graduate : Zagriadskaia, Ekaterina
Cycle : Doctoral
Grade : Ph. D.

Projects

Research projects

2000 - 2016

LINKING THEORETICAL AND EXPERIMENTAL APPROACHES IN THE STUDY OF THE TRNA STRUCTURE-FUNCTION RELATIONSHIPS

Lead researcher : Serguei Chteinberg
Funding sources: CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs: PVX20965-(RGP) Programme de subvention à la découverte individuelle ou de groupe
2008 - 2015

EXPLORING THE MECHANISMS OF ALTERNATIVE READING OF GENETIC CODE

Lead researcher : Serguei Chteinberg
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXX5647-(MOP) Subvention de fonctionnement incluant les subventions de fonctionnement programmatiques (général)
2010 - 2014

LINKING THEORETICAL AND EXPERIMENTAL APPROACHES IN THE STUDY OF THE TRNA STRUCTURE-FUNCTION RELATIONSHIPS

Lead researcher : Serguei Chteinberg
2008 - 2013

EXPLORING THE MECHANISMS OF ALTERNATIVE READING OF GENETIC CODE

Lead researcher : Serguei Chteinberg

Publications and presentations

Publications

  • Kotlova N, Ishii TM, Zagryadskaya EI, Steinberg SV. (2007) : Active suppressor tRNAs with a double helix between the D- and T-loops. J Mol Biol. 373:462-75.
  • Steinberg SV, Boutorine YI. (2007) : G-ribo motif favors the formation of pseudoknots in ribosomal RNA. RNA. 13:1036-42.
  • Steinberg SV, Boutorine YI. (2007) : G-ribo: a new structural motif in ribosomal RNA. RNA. 13:549-54.
  • Gagnon MG, Mukhopadhyay A, Steinberg SV. (2006) :Close packing of helices 3 and 12 of 16 S rRNA is required for the normal ribosome function. J Biol Chem. 281:39349-57.

Disciplines

  • Biochemistry
  • Molecular Biology

Areas of expertise

  • Nucleic Acids
  • Cell
  • Combinatorial Chemistry
  • Chromosome (Living Organisms)
  • Inorganic and Organometallic Compounds
  • Enzymes and Proteins
  • Gene (Living Organisms)
  • Macromolecules
  • Biological and Biochemical Mechanisms
  • Metals and Nonmetals
  • Bioactive Molecules
  • Organic Molecules and Biomolecules
  • Quantum Phenomena
  • Chemical Synthesis and Catalysis