Mark Richard Lesk
Mécanismes pathophysiologiques de l'oeil
- Professeur titulaire
-
Faculté de médecine - Département d'ophtalmologie
Profile
Research expertise
Nous poursuivrons les études sur la réponse vasculaire à la réduction thérapeutique de la tension intra-oculaire. Nous continuerons des études sur les facteurs de risques en ce qui a trait à la progression causée par le glaucome. Nous continuerons les études sur la guérison post-chirurgicale en glaucome. Réalisations: Études sur l'effet des médicaments anti-angiogéniques sur la guérison de la chirurgie expérimentale de glaucome.
Biography
Médecin ophtalmologue, le docteur Mark Lesk est chercheur au sein de l'unité de recherche sur les mécanismes pathophysiologiques de l’œil de l'Hôpital Maisonneuve-Rosemont. Il est également professeur titulaire au Département d'ophtalmologie de l'Université de Montréal.
For more information…
Affiliations and responsabilities
Research affiliations
Teaching and supervision
Student supervision
Theses and dissertation supervision (Papyrus Institutional Repository)
Mechanism of mesenchymal stromal cells secretome-mediated trabecular meshwork regeneration for glaucoma therapy
Cycle : Doctoral
Grade : Ph. D.
Ocular rigidity : a previously unexplored risk factor in the pathophysiology of open-angle glaucoma : assessment using a novel OCT-based measurement method
Cycle : Doctoral
Grade : Ph. D.
Thérapie cellulaire pour le glaucome : régénération tissulaire grâce aux cellules souches mésenchymateuses
Cycle : Doctoral
Grade : Ph. D.
Effect of hormone replacement therapy on retinal and optic nerve head blood flow and topography in postmenopausal women, and retinal tissue perfusion in ovariectomized rats
Cycle : Doctoral
Grade : Ph. D.
Vascular and morphological changes of the optic nerve head following therapeutic intraocular pressure reduction in open angle glaucoma and ocular hypertension
Cycle : Doctoral
Grade : Ph. D.
Projects
Research projects
Local and global biomechanical properties of the eye as new glaucoma risk factors
Ocular Rigidity as a Novel Risk Factor for Space Flight-Associated Neuro-Ocular Syndrome
Elucidating mechanisms of MSC-induced tissue regeneration: path to mesenchymal stromal cell clinical trial in glaucoma
Biomarqueurs anatomiques dynamiques de la progression de la DMLA
DEVELOPMENT OF NOVEL OCT-BASED CLINICAL MEASUREMENTS OF OCULAR ELASTICITY AND RETINAL DEFORMATION ASRISK FACTORS IN GLAUCOMA
RESEAU DE RECHERCHE EN SANTE DE LA VISION (RRSV) - EFFETS DES ANTI-VEGFS ET DES KININES SUR L'INFLAMMATION DANS UN MODELE DE DMLA NEOVASCULAIRE
LUTTE COLLECTIVE QUEBEC-JAPON CONTRE LE GLAUCOME
PULSATILE DISPLACEMENT OF THE LAMINA CRIBROSA IN THE PATHOGENESIS OF GLAUCOMA : DEVELOPMENT OF A NOVEL DEVICE AND PRELIMINARY CLINICAL TESTING
PULSATILE DISPLACEMENT OF THE LAMINA CRIBROSA IN THE PATHOGENESIS OF GLAUCOMA : DEVELOPMENT OF A NOVEL DEVICE AND PRELIMINARY CLINICAL TESTING
Outreach
Autres activités et contributions
Brevet
- Lesk, MR, Wajszilber, M, et Ozaki, T. Apparatus and Method for Measuring a Biomechanical Property of an in vivo Eye, and Method of Diagnosis. World Wide Patent application, May, 2008.
Publications and presentations
Publications
- Manuguerra-Gagné R, Boulos PR, Ammar A, Leblond FA, Krosl G, Pichette V, Lesk MR, Roy DC. Transplantation of mesenchymal stem cells promotes tissue regeneration in a glaucoma model through laser-induced paracrine factor secretion and progenitor cell recruitment. Stem Cells. 2013 Jun;31(6):1136-48.
- Freeman EE, Roy-Gagnon MH, Descovich D, Massé H, Lesk MR. The heritability of glaucoma-related traits corneal hysteresis, central corneal thickness, intraocular pressure, an dchoroidal blood flow pulsatility. PLoS One. 2013;8(1)
- Wang J, Freeman EE, Descovich D, Harasymowycz PJ, Kamdeu Fansi A, Li G, Lesk MR. Estimation of ocular rigidity in glaucoma using ocular pulse amplitude and pulsatile choroidal blood flow. Invest Ophthalmol Vis Sci. 2013 Mar 7;54(3):1706-11.
Disciplines
- Ophthalmology
- Physiology
- Cell Biology
- General Pathology
Areas of expertise
- Vision
- Physiology
- Imagery (Characterization Tools)
- Neuronal Transplantation and Stem Cells