Mark Richard Lesk
Mécanismes de glaucome et nouvelles therapies
- Professeur titulaire
-
Faculté de médecine - Département d'ophtalmologie
Profile
Research expertise
Etudes qui explore la signification des proprietes biomechaniques de l'oeil dans le development et le progression de glaucome. Development de nouvelles technologies d'imagerie de l'oeil et pour mesurer les proprietes biomechaniques et vasculaires de l'oeil. Etudes sur le development de "Space-Associated Neuro-ocular Syndrome" chez les astronauts de NASA (Laboratoire a Johnson Space Center). Etudes sur les cellules souches dans le regenerescence de la system de drainage de l'oeil en glaucome experimentale. Development de la therapie Genique pour le glaucome avec technologie CRISPR. Etudes cliniques et experimentaux.
Subventions:
- CIHR
- NASA/Canadian Space Agency
- NSERC
- FRQS Vision Health Research Network
- Glaucoma Research Society of Canada
Biography
Médecin ophtalmologue, le docteur Mark Lesk est Directeur de l'Unité de Recherche en Glaucome de la Centre de Recherche de l'Hôpital Maisonneuve-Rosemont. Il est également Professeur Titulaire au Département d'ophtalmologie de l'Université de Montréal, et Ophtalmologiste Chef de la Centre Universitaire d'Ophtalmologie de Universite de Montreal, a l'Hôpital Maisonneuve-Rosemont.
-
Fellowship (glaucome):Wills Eye Hospital, Philadelphie
-
Ophthalmology: Université de Montréal
-
Doctor of Medicine: McGill University
-
MSc: Weizmann Institute of Science, Israel
For more information…
Affiliations and responsabilities
Research affiliations
Research units
Membre
- CRHMR — Centre de recherche de l'Hôpital Maisonneuve-Rosemont
- RRSV — Réseau de recherche en santé de la vision
NASA Foreign Researcher
University service and activities
Administrative responsibilities
Chef d'ophtalmologie, Centre Universitaire d'Ophtalmologie (CUO) , a Hopital Maisonneuve Rosemont
Teaching and supervision
Recruitment in research
MD ou candidat pour PhD pour analyse des bases de donnes d'imagerie et clinques de notre etude (150 patients) portant sur la progression de glaucome. On a developpe des nouvelles techniques d'imagerie, base sur OCT, pour mesurer de proprietes biomechaniques et vasculaires de l'oeil.
Etudiant au MSc pour etude de therapie genetique pour le glaucome avec technologie CRISPR
Student supervision
Theses and dissertation supervision (Papyrus Institutional Repository)
Ocular biomechanics in glaucoma and space-related neuro-ocular syndrome : assessing ocular rigidity and pulsatile optic nerve deformation with video-optical coherence tomography.
Cycle : Doctoral
Grade : Ph. D.
Mechanism of mesenchymal stromal cells secretome-mediated trabecular meshwork regeneration for glaucoma therapy
Cycle : Doctoral
Grade : Ph. D.
Ocular rigidity : a previously unexplored risk factor in the pathophysiology of open-angle glaucoma : assessment using a novel OCT-based measurement method
Cycle : Doctoral
Grade : Ph. D.
Thérapie cellulaire pour le glaucome : régénération tissulaire grâce aux cellules souches mésenchymateuses
Cycle : Doctoral
Grade : Ph. D.
Effect of hormone replacement therapy on retinal and optic nerve head blood flow and topography in postmenopausal women, and retinal tissue perfusion in ovariectomized rats
Cycle : Doctoral
Grade : Ph. D.
Vascular and morphological changes of the optic nerve head following therapeutic intraocular pressure reduction in open angle glaucoma and ocular hypertension
Cycle : Doctoral
Grade : Ph. D.
Projects
Research projects
Spaceflight-Associated Neuro-ocular Syndrome Ocular Rigidity Investigation-2 (SANSORI-2)
Local and global biomechanical properties of the eye as new glaucoma risk factors
Ocular Rigidity as a Novel Risk Factor for Space Flight-Associated Neuro-Ocular Syndrome
Ocular Rigidity as a Novel Risk Factor for Space Flith-Associated Neuro-Ocular Syndrome
Elucidating mechanisms of MSC-induced tissue regeneration: path to mesenchymal stromal cell clinical trial in glaucoma
Biomarqueurs anatomiques dynamiques de la progression de la DMLA
DEVELOPMENT OF NOVEL OCT-BASED CLINICAL MEASUREMENTS OF OCULAR ELASTICITY AND RETINAL DEFORMATION ASRISK FACTORS IN GLAUCOMA
RESEAU DE RECHERCHE EN SANTE DE LA VISION (RRSV) - EFFETS DES ANTI-VEGFS ET DES KININES SUR L'INFLAMMATION DANS UN MODELE DE DMLA NEOVASCULAIRE
LUTTE COLLECTIVE QUEBEC-JAPON CONTRE LE GLAUCOME
PULSATILE DISPLACEMENT OF THE LAMINA CRIBROSA IN THE PATHOGENESIS OF GLAUCOMA : DEVELOPMENT OF A NOVEL DEVICE AND PRELIMINARY CLINICAL TESTING
PULSATILE DISPLACEMENT OF THE LAMINA CRIBROSA IN THE PATHOGENESIS OF GLAUCOMA : DEVELOPMENT OF A NOVEL DEVICE AND PRELIMINARY CLINICAL TESTING
Outreach
Autres activités et contributions
Brevet
- Lesk, MR, Wajszilber, M, et Ozaki, T. Apparatus and Method for Measuring a Biomechanical Property of an in vivo Eye, and Method of Diagnosis. World Wide Patent application, May, 2008.
Publications and presentations
Publications
-
Ocular Biomechanical Responses to Long-Duration Spaceflight. M. M. Solano, R. Dumas, M. R. Lesk and S. Costantino. IEEE Open Journal of Engineering in Medicine and Biology, vol. 6, pp. 127-132, 2025, doi:10.1109/OJEMB.2024.3453049.
-
The Association between the Pulsatile Choroidal Volume Change and Ocular Rigidity. Sayah DN, Descovich D, Costantino S, Lesk MR. Ophthalmol Sci. 2024 Jul 18;4(6):100576. 2024 Nov-Dec.PMID: 39253552.
-
Optic Nerve Head Pulsatile Displacement in Open-Angle Glaucoma after Intraocular Pressure Reduction Measured by Optical Coherence Tomography: A Pilot Study. Masís Solano M, Richer E, Costantino S, Lesk MR. Bioengineering (Basel). 2024 Apr 23;11(5):PMID: 38790278.
-
Ocular rigidity and choroidal thickness changes in response to microgravity: A case study. Masís Solano M, Bélanger Nzakimuena C, Dumas R, Lesk MR, Costantino S. Am J Ophthalmol Case Rep. 2023 Oct 7;32:101940. eCollection 2023 Dec.PMID: 37860670.
-
Variable phenotypic expression of MYOC mutations in a family with inherited pediatric glaucoma. Mullie GA, Javidi S, Soucy JF, Lesk MR, Hamel P. Can J Ophthalmol. 2023 Dec;58(6):e269-e270. Epub 2023 May 27.PMID: 37247815.
-
Ocular Rigidity and Current Therapy. Sayah DN, Lesk MR. Curr Eye Res. 2023 Feb;48(2):105-113. Epub 2022 Jul 6.PMID: 35763027 Review.
-
The Association Between Ocular Rigidity and Neuroretinal Damage in Glaucoma. Sayah DN, Mazzaferri J, Descovich D, Costantino S, Lesk MR. Invest Ophthalmol Vis Sci. 2020 Nov. 2;61(13):11. PMID: 33151280.
-
Non-invasive in vivo measurement of ocular rigidity: Clinical validation, repeatability and method improvement. Sayah DN, Mazzaferri J, Ghesquière P, Duval R, Rezende F, Costantino S, Lesk MR. Exp Eye Res. 2020 Jan;190:107831. Epub 2019 Oct 10.PMID: 31606450.
-
Neuroretinal Rim Area Change in Glaucoma Patients With Visual Field Progression Endpoints and Intraocular Pressure Reduction. The Canadian Glaucoma Study: 4.Malik R, O, Leary N, Mikelberg FS, Balazsi AG, LeBlanc RP, Lesk MR, Nicolela MT, Trope GE, Chauhan BC; Canadian Glaucoma Study Group.Am J Ophthalmol. 2016 Mar;163:140-147. Epub 2015 Dec 17.PMID: 26705093.
- Manuguerra-Gagné R, Boulos PR, Ammar A, Leblond FA, Krosl G, Pichette V, Lesk MR, Roy DC. Transplantation of mesenchymal stem cells promotes tissue regeneration in a glaucoma model through laser-induced paracrine factor secretion and progenitor cell recruitment. Stem Cells. 2013 Jun;31(6):1136-48.
- Freeman EE, Roy-Gagnon MH, Descovich D, Massé H, Lesk MR. The heritability of glaucoma-related traits corneal hysteresis, central corneal thickness, intraocular pressure, an dchoroidal blood flow pulsatility. PLoS One. 2013;8(1)
- Wang J, Freeman EE, Descovich D, Harasymowycz PJ, Kamdeu Fansi A, Li G, Lesk MR. Estimation of ocular rigidity in glaucoma using ocular pulse amplitude and pulsatile choroidal blood flow. Invest Ophthalmol Vis Sci. 2013 Mar 7;54(3):1706-11.
Disciplines
- Ophthalmology
- Physiology
- Cell Biology
- General Pathology
Areas of expertise
- Vision
- Physiology
- Imagery (Characterization Tools)
- Neuronal Transplantation and Stem Cells