Pharmacien expert en maladies infectieuses, antibiogouverance, et pharmacométrie. A completé la formation de B.Pharm. et M.Sc. à la Faculté de pharmacie de l'Université de Montréal, puis un PharmD de 3e cycle à Wayne State University à Detroit, suivi d'une formation spécialisée en maladies infectieuses à UCSF. Pratique active au Centre universitaire de santé McGill en pharmacocinétique et en antibiogouvernance. Enseignement en maladies infectieuses, microbiologie médicale, soins pharmaceutiques - pharmacocinétique - pharmacothérapie en maladies infectieues, antibiogouvernance dans les programmes de 1er à 3e cycle de la Faculté de pharmacie. Recherche orientée sur l'impact des interventions sur la résistance aux antibiotiques et l'usage optimale des anti-infectieux. Récipiendaire de prix d'excellence dans l'ensemble des sphères de travail.

Pharmacien expert en maladies infectieuses au Centre universitaire de santé McGill, service de pharmacocinétique pour patients hospitalisés, service d'antibiogouvernance (antimicrobial stewardship)

Membre des organisations suivantes:

Permis de pratique actif de l'Ordre des pharmaciens du Québec

Association des pharmaciens en établissement de santé

Regroupement des pharmaciens experts en infectiologie

Canadian Society of Hospital Pharmacists

Association des facultés de pharmacie du Canada

Association of Medical Microbiology and Infectious Disease Canada

Articles révisés par les pairs

Chadi A, Thirion DJG, David PM. Vaccine promotion strategies in community pharmacy addressing vulnerable populations: a scoping review. BMC Public Health (accepted)

Rudnick W, Conly J, Thirion DJG, et al. and the Canadian Nosocomial Infection Surveillance Program. Antimicrobial use among paediatric inpatients at hospital sites within the Canadian Nosocomial Infection Surveillance Program 2017/2018. Antimicrob Resist Infect Control 2023 Apr 18;12(1):35. doi: 10.1186/s13756-023-01219-x.

El Hassani M, Thirion DJG, Koloskoff K, Matouk E, Simard C, Cloutier I, Pilote S, Marsot A. Development and Evaluation of a Height-Based Tobramycin Initial Dosing Nomogram for the Treatment of Adult Cystic Fibrosis Pulmonary Exacerbations.  Ther Drug Monit. 2023;45(2):259-264. doi: 10.1097/FTD.0000000000001053. PMID: 36730982

Koloskoff K, Thirion DJG, Matouk E, Marsot A. New Recommendations of a Height-Based Dosing Regimen of Tobramycin for Cystic Fibrosis in Adults: A Population Pharmacokinetic Analysis. Ther Drug Monit. 2023;45(2):251-258. doi: 10.1097/FTD.0000000000001021.

Bougchiche M, Besnier P, Poulin F, Thirion DJG. Étude exploratoire rétrospective sur l’utilisation des bêta-lactamines chez les personnes de 75 ans et plus. Pharmactuel 2023;56(1) :23-30.

Thirion DJG, Caissy JA, Poulin F, et al. Ciprofloxacin Alone vs. Ciprofloxacin plus an Aminoglycoside for the Prevention of Infectious Complications following a Transrectal Ultrasound-Guided Prostate Biopsy: A Retrospective Cohort Study. Antibiotics 2022;12(1):56.

Liang JJ, Rudnick W, Mitchell R, et al. Antimicrobial use in Canadian acute-care hospitals: Findings from three national point-prevalence surveys between 2002 and 2017. Infect Control Hosp Epidemiol 2022;1-7. doi: 10.1017/ice.2021.519

Duong, Thirion DJG, Williamson D, et al. Aminoglycosides’ dosing and monitoring practices in critically ill patients in Quebec hospitals. J Chemother 2022;1-4.

Aljutayli A, Thirion DJG, Bonnefois G, Nekka F. Pharmacokinetic Equations Versus Bayesian Guided Vancomycin Monitoring: Pharmacokinetic Model and Model-Informed Precision Dosing Trial Simulations. Clin Transl Sci 2022;15(4):942-953.

German G, Frenette C, Caissy JA, et al. The 2018 Global Point Prevalence Survey of Antimicrobial Consumption and Resistance in 47 Canadian Hospitals: a cross-sectional survey. CMAJ OPEN 2021;9(4):E1242-E1251. doi: 10.9778/cmajo.20200274 .

Grant J, Le Saux N, and Members of the Antimicrobials Stewardship and Resistance Committee (ASRC) of AMMI Canada. Practice point: duration of antibiotic therapy for common infections. JAMMI 2021 doi:10.3138/jammi-2021-04-29

Pauwels I, Versporten A, Drapier N, Vlieghe E, Goossens H, on behalf of the Global-PPS network. Hospital antibiotic prescribing patterns in adult patients according to the WHO Access, Watch, and Reserve classification (AWaRe): results from a worldwide point prevalence survey in 69 countries. J Antimicrob Chemother 2021;76(6):1614-1624 doi:10.1093/jac/dkab050

Fortin E, Thirion DJG, Ouakki M, et al. Role of high-risk antibiotic use on the decrease of health-care associated C. difficile infection incidence in Quebec, Canada: a population-level ecological study. Lancet Microbe 2021;2:e182-90. https://doi.org/10.1016/ S2666-5247(21)00005-7

Steward JJ, Jorgensen S, Dresser L, et al. A Canadian Perspective on the Revised 2020 ASHP/IDSA/PIDS/SIDP Guidelines for Vancomycin AUC-Based Therapeutic Drug Monitoring for Serious MRSA Infections. JAMMI 2021;6(1) :3-9

Butler-Laporte G, Cheng MP, Thirion DJG, et al. Clinical Trials Increase Off-Study Drug Use: A Segmented Time Series Analysis. Open Forum Infect Dis 2020;11(7):1-5

Frenette C, Sperlea D, German GJ, et al. The 2017 Global Point Prevalence Survey of Antimicrobial Consumption and Resistance in Canadian Hospitals. Antimicrob Resist Infect Control 2020;9:104. https://rdcu.be/b5zjD

Dalton BR (Pro), Dresser LD (Pro), Thirion DJG (Con), Lau T (Con). Antiviral Therapy during the Coronavirus Disease (COVID-19) Pandemic: Is It Appropriate to Treat Patients in the Absence of Significant Evidence?” Point-Couterpoint. Can J Hosp Pharm 2020;73(2):167-70.

Thirion DJG, Pasche V, Matouk E, Marsot A. Amikacin nomogram for treatment of adult cystic fibrosis exacerbations based on an external evaluation of a population pharmacokinetic model. Pediatr Pulomonol 2020;55(5):1154-1160.

Rudnick W, Science M, Thirion DJG, et al. and the Canadian Nosocomial Infection Surveillance Program. Antimicrobial use among adult inpatients at hospital sites within the Canadadian Nosocomial Infection Surveillance Program: 2009 to 2016. Antimicrob Resist Infect Control 2020;9(1):31.

Lombardi J,Nguy P, Robichaud Ducharme A, et al. Assessment of Surgical Antibiotic Prophylaxis Compliance in Pediatrics (ASAP-P): A Pre-Post Quasi-Experimental Study. Pediatr Infect Dis J. 2020;39(1):48-53

Thirion DJG, Pasche V, Marsot A. What is the recommended amikacin dosing for cystic fibrosis patients with acute pulmonary exacerbations? Ped Pulmonol. 2019;54(11):1652-1653.

Lee SB, Thirion DJG, Irfan N, et al. Antimicrobial utilization data : Does point prevalence data correlate with defined daily doses? Infect Control Hosp Epidemiol 2019;11:1-2.

Morris AM, Rennert-May E, Dalton B, Daneman N, et al. Rationale and development of a business case for antimicrobial stewardship programs in acute care hospital settings. Antimicrob Resist Infect Control 2018;7:104.

Dolcé L, Quach C, Thirion DJG, et al. Surveillance of Antimicrobial Use in Quebec Acute Care Hospitals : A Survey. JAMMI 2018;3.1:37-46.

Le Saux N, Dalton B, Abbass K, et al. Funding for Antimicrobial Stewardship Programs: A Customizable Business Case Template. Can J Hosp Pharm 2018;71: 50-51.

Association des pharmaciens des établissements de santé du Québec (A.P.E.S.). Rôle du pharmacien d’établissement en infectiologie : Données probantes. Document élaboré par le Regroupement de pharmaciens experts en infectiologie. Montréal, Québec : A.P.E.S.;2018. 52 p.

Mavrakanas TA, Fournier MA, Clairoux S, Amiel JA, Tremblay ME, Vinh DC, et al. Neutropenia in kidney and liver transplant recipients: Risk factors and outcomes. Clinical Transplantation 2017;31(10):e13058.

Frenette C, Sperlea D, Leharova Y, Thirion DJG. Impact of an Infection Control and Antimicrtobial Stewardship Program on Solid Organ Transplantation and Hepatobiliary Surgical Site Infections. Infect Control Hosp Epidemiol 2016;37(12):1468-1474.

Frenette C, Sperlea D, Tesolin J, Patterson C, Thirion DJG. Impact of a 5-year serial infection control and antibiotic stewardship intervention on cardiac surgical site infections. Am J Infect Control 2016;44:977-82

Carle S, Thirion DJG. La procalcitonine est-elle vraiment utile comme aide à la decision de prescrire ou non des antibiotiques chez les patients de soins critiques. Pharmactuel 2016;49(2)

Livres et chapitres de livres (5 dernières années)

Thirion DJG. Chap 63 :Antimicrobial Prophylaxis for Surgical Procedures. In: Koda-Kimble MA, Young LY, Alldredge BK, Corelli RL, Guglielmo BJ, Kradjan WA, et al. eds. Applied Therapeutics; The Clinical Use of Drugs. 11^th  ed. Philadelphia, Lippincott Williams & Wilkins: 2016 (In press).

Thirion DJG. Acute Cough. Dans: Repchinksy C, ed. Therapeutic Choices for Minor Ailments. 2nd ed. Canadian Pharmacists’ Association, Ottawa ON. 2016 pages 212-220.

Thirion DJG. Assessment of Patients with Upper Respiratory Tract Infections. Dans: Repchinksy C, ed. Therapeutic Choices for Minor Ailments. 2nd ed. Canadian Pharmacists’ Association, Ottawa ON. 2016 pages 245-249.

Thirion DJG. Viral Rhinitis, Influenza, Sinusitis and Pharyngitis. Dans: Repchinksy C, ed. Therapeutic Choices for Minor Ailments. 2nd ed. Canadian Pharmacists’ Association, Ottawa ON. 2016 pages 250-268.

Afshar K, Bedford J, Chan T, Flintoft V, Fryters S, Glenn N, et al. Prevent Surgical Site Infections. Getting Started Kit. Safer Healthcare Now!  Canadian Patient Safety Institute. August 2014

Thirion DJG. Antimicrobial Prophylaxis for Ambulatory Surgery. Dans Dong BJ, Elliott DP, eds. Infection Primary Care 1, Ambulatory Care Self-Assessment Program (ACSAP). American College of Clinical Pharmacy. 2013, pages 7-17.

Thirion’s Snippets for Snappy Antimicrobial Therapy, 3^rd ed. Thirion DJG, éd. Publications PRISM., Montréal 2013, 352 pages.

Thirion DJG. Basics in Antimicrobial Therapy Dans: Thirion’s Snippets for Snappy Antimicrobial Therapy, 3^rd ed. Thirion DJG, éd. Publications PRISM, Montréal. 2013, pages 2-5.

Thirion DJG. Bacterial Resistance and Antimicrobial Therapy. Thirion’s Snippets for Snappy Antimicrobial Therapy, 3^rd ed. Thirion DJG, éd. Publications PRISM, Montréal. 2013, pages 6-11.

Thirion DJG. Acute Rhinosinusitis. Dans: Thirion’s Snippets for Snappy Antimicrobial Therapy, 3^rd ed. Thirion DJG, éd. Publications PRISM, Montréal. 2013, pages 60-63.

Thirion DJG. The Common Cold and the Flu. Dans: Thirion’s Snippets for Snappy Antimicrobial Therapy. Thirion DJG, éd. Publications PRISM, Montréal. 2013, pages 64-67.

Thirion DJG. Pharyngitis. Dans: Thirion’s Snippets for Snappy Antimicrobial Therapy, 3^rd ed. Thirion DJG, éd. Publications PRISM, Montréal. 2013, pages 68-70.

Thirion DJG. Hospital Acquired Pneumonia-Ventilator Associated Pneumonia. Dans: Thirion’s Snippets for Snappy Antimicrobial Therapy, 3^rd ed. Thirion DJG, éd. Publications PRISM, Montréal. 2013, pages 111-119.

Zoé Thiboutot, Thirion DJG, Williamson DR. Peritonitis. Dans: Thirion’s Snippets for Snappy Antimicrobial Therapy, 3^rd ed. Thirion DJG, éd. Publications PRISM, Montréal. 2013, pages 137-141.

Thirion DJG. Urinary Tract Infections and Prostatitis. Dans: Thirion’s Snippets for Snappy Antimicrobial Therapy, 3^rd ed. Thirion DJG, éd. Publications PRISM, Montréal. 2013, pages 163-168.

Thirion DJG. Invasive Fungal Infections. Dans: Thirion’s Snippets for Snappy Antimicrobial Therapy, 3^rd ed. Thirion DJG, éd. Publications PRISM, Montréal. 2013, pages 228-233.

Thirion DJG. Superficial Fungal Infections. Dans: Thirion’s Snippets for Snappy Antimicrobial Therapy, 3^rd ed. Thirion DJG, éd. Publications PRISM, Montréal. 2013, pages 234-243.

Thirion DJG. Antimicrobial Drug Interactions. Dans: Thirion’s Snippets for Snappy Antimicrobial Therapy, 3^rd ed. Thirion DJG, éd. Publications PRISM, Montréal. 2013, pages 270-282.

Thirion DJG. Antibiotic Combination Therapy. Dans: Thirion’s Snippets for Snappy Antimicrobial Therapy, 3^rd ed. Thirion DJG, éd. Publications PRISM, Montréal. 2013, pages 287-288.

Thirion DJG. Antibiotic Prophylaxis for Surgery. Dans: Thirion’s Snippets for Snappy Antimicrobial Therapy, 3^rd ed. Thirion DJG, éd. Publications PRISM, Montréal. 2013, pages 306-309.

Thirion DJG. Antifungal Agents for Invasive Fungal Infections. Dans: Thirion’s Snippets for Snappy Antimicrobial Therapy, 3^rd ed. Thirion DJG, éd. Publications PRISM, Montréal. 2013, pages 340-343.

Thirion DJG. Acute Cough. Dans: Repchinksy C, ed. Therapeutic Choices for Minor Ailments. 1st ed. Canadian Pharmacists’ Association, Ottawa ON. 2013 pages 207-214.

Thirion DJG. Assessment of Patients with Upper Respiratory Tract Infections. Dans: Repchinksy C, ed. Therapeutic Choices for Minor Ailments. 1st ed. Canadian Pharmacists’ Association, Ottawa ON. 2013 pages 175-178.

Thirion DJG. Viral Rhinitis, Influenza, Sinusitis and Pharyngitis. Dans: Repchinksy C, ed. Therapeutic Choices for Minor Ailments. 1st ed. Canadian Pharmacists’ Association, Ottawa ON. 2013 pages 194-206.

Thirion DJG, Carle S. Recommendations pour la mise en œuvre d’un programme de parrainage des antimicrobiens en établissement de santé. Guide de pratique pour l’Association des Pharmaciens en Établissements de Santé. www.apesquebec.org  04/2012

Mise en œuvre d’un programme de surveillance de l’usage des antibiotiques en établissement de santé, Normes et pratiques de gestion, Tome II. MSSS, Gouvernement du Québec. Circulaire 2011-021

Thirion DJG. Chap 61 :Antimicrobial Prophylaxis for Surgical Procedures. Dans: Koda-Kimble MA, Young LY, Alldredge BK, Corelli RL, Guglielmo BJ, Kradjan WA, et al. éd. Applied Therapeutics; The Clinical Use of Drugs. 10e éd. Philadelphie, Lippincott Williams & Wilkins: 2012;1461-1467.

Couture S, Frenette C, Alfaro R, et al. The Changing Epidemiology of Clostridioides difficile Infection and the NAP1/027 Strain in Two Quebec Hospitals. ID Week 2021. Virtuel, Septembre 2021. Open Forum Infectious Diseases 8(Supplement_1):S471-S471

Thirion DJG, Koloskoff K, Caissy JA, Matouk E, Marsot A. Assessment of tobramycin dosing in Cystic Fibrosis patients with acute pulmonary exacerbation. North American Cystic Fibrosis Conference 2020. San Antonia, Tx, USA, octobre 2020.

Couture S, Frenette C, Alfaro R, et al. The changing epidemiology of Clostridioides difficile infection and the NAP1/027 strain in two Quebec hospitals. ECCMID Paris, France, avril 2020 (Accepted but conference cancelled due to COVID-19)

Thirion DJG, Pasche V, Matouk E, Marsot A. Amikacin nomogram for treatment of adult cystic fibrosis exacerbations based on an external evaluation of a population pharmacokinetics model. ECCMID Paris, France, avril 2020. (Accepted but conference cancelled due to COVID-19).

Rudnick W, Pelude L, Science ME, et al. for the CNISP PHAC. Variability in antimicrobial use among hospitals participating in the Canadian Nosocomial Infection Surveillance Program. Infect Control Hosp Epidemiol 41(S1):S509. (Accepted for the Sixth decennial internationl conference on healthcare associated infections but cancelled due to COVID-19).

Sheehan N, Perreault M, Villeneuve E, et al. Évaluation de la participation en recherche des pharmaciens en établissement de santé au Canada. Association des pharmaciens en établissement de santé. Avril 2020. Remis à 2021.

Sheehan N, Perreault M, Villeneuve E, et al. Expérience, attitudes, compétences perçues et besoins en formation des pharmaciens pour mener des activités de recherche dans un centre hospitalier universitaire. Association des pharmaciens en établissement de santé. Avril 2020. Remis à 2021.

Sheehan N, Perreault M, Villeneuve E, et al. Pharmacists’ experience, motivation, attitudes, self-perceived competence and training needs to conduct pharmacist-drive research in a tertiary care teaching hospital. 51^st Professional Practice Conference, Canadian Society of Hospital Pharmacy, Toronto, Canada February 2020

Sheehan N, Perreault M, Villeneuve E, et al. Environmental scan of hospital pharmacist participation in research in Canada. 51^st Professional Practice Conference, Canadian Society of Hospital Pharmacy, Toronto, Canada February 2020

Rudnick W, Science M, Thirion DJG, et al. Antimicrobial use surveillance among adult inpatients at hospitals participating in a Canadian sentinel surveillance program, 2009-2017. CSHP Professional Practice Conference, Toronto, Canada, February 2020

Thirion DJG, Lanfranchi C, Deda A, et al. Ciprofloxacin versus ciprofloxacin and aminoglycoside for prevention of systemic inflammatory response syndrome, bacteraemia, sepsis and septic shock in transrectal ultrasound-guided prostate biopsy. Abstract 1389. 29th European Congress of Clinical Micorbiology and Infectious Diseases (ECCMID), Amsterdam, Pays Bas 13-16/04/2019

Fortin E, Thirion DJG, Ouakki M, et al. Could variations in antimicrobial use explain a major decline in rates of healthcare-associated Clostridium difficile infections in Québec, Canada? Abstract 6118. 29th European Congress of Clinical Micorbiology and Infectious Diseases (ECCMID), Amsterdam, Pays Bas 13-16/04/2019

Rudnick W, L Pelude, K Abdesselam, et al. Antimicrobial Use among Adult Inpatients at Canadian Nosocomial Infection Surveillance Program (CNISP) Hospital Sites across Canada, 2009 to 2016. Abstract C05. AMMI Canada/CACMID Annual Conference 2019, Ottawa, Canada, 4-6/04/2019.

Abdesselam K, Pelude L, Laverty M, Amaratunga K, Comeau J, Dalton B, Embree J, Evans GA, Forrester L, Frenette C, Fryters S, German G, Grant J, Gravel D, Katz K, Kibsey P, Lee BE, Lefebvre M-A, Leis JA, McGeer A, McKenna S, Mulvey MR, Neville H, Nixon K, Simor AE, Slater K, Suh H, Weiss K, Thirion D, Science M, Conly JM, CNISP participating hospitals. Quantitative Antimicrobial Usage Surveillance from 2009–2015 among Hospitals Participating in the Canadian Nosocomial Infection Surveillance Program (CNISP). AMMI Canada/CACMID Annual Conference 2018, Vancouver, Canada, May 2-5, 2018. JAMMI 2018;3(S1):51-2.

Lee SB, Thirion D, Irfan N, Sung M, Brooks A, Frenette C, Mertz D. Antimicrobial Utilization Data: Does Point Prevalence Data Correlate with Defined Daily Doses (DDD)? AMMI Canada/CACMID Annual Conference 2018, Vancouver, Canada, May 2-5, 2018. JAMMI 2018;3(S1):122.

Glass-Kaastra S, Conly JM, German G, Morris AM, Patrick DM, Thirion D, Weiss K, Gravel D. Use of oral and parenteral antimicrobials of last resort in Canada according to the WHO essential medicines list. AMMI Canada/CACMID Annual Conference 2018, Vancouver, Canada, May 2-5, 2018. JAMMI 2018;3(S1):50-1.

Glass-Kaastra S, Taylor JC, Conly JM, Arthur J, German G, Morris AM, Patrick DM, Thirion D, Weiss K, Gravel D. Antimicrobial prescribing by dentists, nurses, and pharmacists in the ambulatory setting in Canada. AMMI Canada/CACMID Annual Conference 2018, Vancouver, Canada, May 2-5, 2018. JAMMI 2018;3(S1):52.

Glass-Kaastra S, Conly JM, German G, Morris AM, Patrick DM, Thirion D, Weiss K, Gravel D. Measurement of parenteral and oral antimicrobial usage in Canadian hospitals via assessment of purchasing data. AMMI Canada/CACMID Annual Conference 2018, Vancouver, Canada, May 2-5, 2018. JAMMI 2018;3(S1):20-1.

Abdeesselam K, Conly J, Evans G, German G, Katz K, Kibsey P, McGeer A, Pelude L, Simor A, Suh K, Thirion D, Weiss K, Amartaunga K, Gravel D, and the Canadian Nosocomial Infection Surveillance Program (CNISP). Quantitative Antimicrobial Usage Surveillance Amongst CNISP Hospital Sites across Canada : Pilot Study REsults 2009 to 2013. AMMI Canada/CACMID Annual Conference 2017. Toronto, Canada  May 4, 2017

Rachel S, Thirion DJG, Frenette C. Reducing surgical site infections in neurosurgery : a multidisciplinary approach. APIC 44th Annual Conference. Portland, OR June 15th 2017. EPOP-157. Am J Infect Control 2017;45(6)Suppl.:S110

Mavrakanas T, Coursol C, Vinh DC, Thirion DJG, Cantarovich M. Neutropenia in kidney and liver transplant recipients : Risk factors and consequences. Abstract 1729. 2017 American Transplant Congress (ATC). Chicago, IL, April 2017.

Richard ME, Tisnado-Garland C, Frenette C, Thirion DJG. Attributable inpatient costs of nosocomial Clostridium difficile infection in a Canadian tertiary care center. Abstract 2339. 27th European Congress of Clinical Microbiology and Infectious Diseaes 2017, Vienna, Austria, April 2017.

Longpré AA, Maurrasse RK, Monast PO, Vujanovic S, Carle S, Guévremont C, Frenette C, Thirion DJG. Impact of an Antimicrobial Stewardship Program on Surgical Antibiotic Prophylaxis Conformity According to 2013 ASHP/IDSA Guidelines, Abstract 49957 IDWeek 2015, SanDiego, CA, US, Octobre 2015. Open Forum Infect Dis 2015;2(suppl1) : doi: 10.1093/ofid/ofv133.979

Fortin E, Thirion DJG, Bergeron L, Gonzales M, Papenburg J, Dionne M, Quach C. Surveillance of Antimicrobial Use in Québec Acute Care Hospitals : A Dream or Almost Reality? Presented at : Canadian Association of Clinical Microbiologists and Infections Diseases Annual Conference, Charlottetown, Canada, 04/2015.

Ducepppe MA, Thirion DJG. Antimicrobial spectra of activity chart based on North American susceptibility data. Presented at : International Union of Microbiological Societies 2014 Congresses, Montreal, Canada, 06/2014.

Clairoux S, Amiel JA, Tremblay ME, Fournier MA, Coursol C, Vinh D, Cantarovich M, Thirion DJG. Risk Factors, Rejection and Infections Associated with Neutropenia in Solid Organ Transplantation : A Retrospective Study. Présenté à American Transplant Congress 2013.