Health Sciences
Serguei Chteinberg
ARN : bio-informatique, génomique et protéomique
- Professeur titulaire
-
Faculté de médecine - Département de biochimie et médecine moléculaire
Roger-Gaudry, room C338
Secondary number:
514 343-2210
(Télécopieur)
Profile
Research expertise
Theoretical and experimental analysis of the three-dimensional structure of RNA; relations between the sequence, conformation and function of RNA; in silico generation of new RNA molecules, followed by experimental study; structure, function and evolution of transfer RNA and the ribosome; experimental study of mechanisms of protein biosynthesis; in vivo expression of combinatorial libraries of transfer RNA and ribosomal genes.
Affiliations and responsabilities
Teaching and supervision
Student supervision
Theses and dissertation supervision (Papyrus Institutional Repository)
2014
Étude in vivo de la relation entre la structure et la fonction de la boucle variable de l'ARN de transfert de la sélénocystéine d'E. coli
Graduate : Nemours, Stéphane
Cycle : Master's
Grade : M. Sc.
Cycle : Master's
Grade : M. Sc.
2014
The study of RNA tertiary interactions in tRNA structure and function
Graduate : Ishii, Tetsu
Cycle : Doctoral
Grade : Ph. D.
Cycle : Doctoral
Grade : Ph. D.
2013
Structural aspects of the ribosome evolution and function
Graduate : Bokov, Konstantin
Cycle : Doctoral
Grade : Ph. D.
Cycle : Doctoral
Grade : Ph. D.
2013
Structural rules for the formation of backbone-backbone interactions between closely packed RNA double helices
Graduate : Tao, Fatou
Cycle : Master's
Grade : M. Sc.
Cycle : Master's
Grade : M. Sc.
2011
RNA recurrent motifs : identification and characterization
Graduate : Butorin, Yury
Cycle : Doctoral
Grade : Ph. D.
Cycle : Doctoral
Grade : Ph. D.
2009
Le motif d’empaquetage le long du sillon: une nouvelle entité structurale récurrente dans les ARN ribosomiques
Graduate : Gagnon, Matthieu
Cycle : Doctoral
Grade : Ph. D.
Cycle : Doctoral
Grade : Ph. D.
2008
Étude des interactions entre les boucles D et T chez les ARNs de transfert (ARNts)
Graduate : Doyon, Félix
Cycle : Master's
Grade : M. Sc.
Cycle : Master's
Grade : M. Sc.
2005
Analyse structurale de la sélectivié de la liaison à l'ADN par les récepteurs des oestrogènes et des glucocorticoïdes
Graduate : Pesant, Geneviève
Cycle : Master's
Grade : M. Sc.
Cycle : Master's
Grade : M. Sc.
2004
Shape-keeping elements in tRNA
Graduate : Zagriadskaia, Ekaterina
Cycle : Doctoral
Grade : Ph. D.
Cycle : Doctoral
Grade : Ph. D.
Projects
Research projects
2000
- 2016
LINKING THEORETICAL AND EXPERIMENTAL APPROACHES IN THE STUDY OF THE TRNA STRUCTURE-FUNCTION RELATIONSHIPS
Lead researcher :
Serguei Chteinberg
Funding sources:
CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs:
PVX20965-(RGP) Programme de subvention à la découverte individuelle ou de groupe
2008
- 2015
EXPLORING THE MECHANISMS OF ALTERNATIVE READING OF GENETIC CODE
Lead researcher :
Serguei Chteinberg
Funding sources:
IRSC/Instituts de recherche en santé du Canada
Grant programs:
PVXX5647-(MOP) Subvention de fonctionnement incluant les subventions de fonctionnement programmatiques (général)
2010
- 2014
LINKING THEORETICAL AND EXPERIMENTAL APPROACHES IN THE STUDY OF THE TRNA STRUCTURE-FUNCTION RELATIONSHIPS
Lead researcher :
Serguei Chteinberg
2008
- 2013
EXPLORING THE MECHANISMS OF ALTERNATIVE READING OF GENETIC CODE
Lead researcher :
Serguei Chteinberg
Outreach
Publications and presentations
Publications
- Kotlova N, Ishii TM, Zagryadskaya EI, Steinberg SV. (2007) : Active suppressor tRNAs with a double helix between the D- and T-loops. J Mol Biol. 373:462-75.
- Steinberg SV, Boutorine YI. (2007) : G-ribo motif favors the formation of pseudoknots in ribosomal RNA. RNA. 13:1036-42.
- Steinberg SV, Boutorine YI. (2007) : G-ribo: a new structural motif in ribosomal RNA. RNA. 13:549-54.
- Gagnon MG, Mukhopadhyay A, Steinberg SV. (2006) :Close packing of helices 3 and 12 of 16 S rRNA is required for the normal ribosome function. J Biol Chem. 281:39349-57.
Disciplines
- Biochemistry
- Molecular Biology
Areas of expertise
- Nucleic Acids
- Cell
- Combinatorial Chemistry
- Chromosome (Living Organisms)
- Inorganic and Organometallic Compounds
- Enzymes and Proteins
- Gene (Living Organisms)
- Macromolecules
- Biological and Biochemical Mechanisms
- Metals and Nonmetals
- Bioactive Molecules
- Organic Molecules and Biomolecules
- Quantum Phenomena
- Chemical Synthesis and Catalysis