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Dindial Ramotar
Protéines et réparation des dommages à l’ADN
- Professeur titulaire
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Faculté de médecine - Département de médecine
Profile
Research expertise
Caractérisation structurale et fonctionnelle des protéines d'eucaryotes qui réparent spécifiquement les dommages a l'ADN causés par les especes réactives oxygénées. Domaine: Biochimie - Biologie moléculaire - Génétique. Méthodologie: Fondamentale. Pathologie: Cancers des voies respiratoires.
Affiliations and responsabilities
Research affiliations
Teaching and supervision
Student supervision
Theses and dissertation supervision (Papyrus Institutional Repository)
The yeast Rts1, a subunit of PP2A phosphatase, is involved in stress response
Cycle : Master's
Grade : M. Sc.
L’exploitation d’un modèle de levure présentant une déficience de l’absorption des anthracyclines révèle qu’une protéine de Caenorhabditis elegans, OCT-1, est un transporteur fonctionnel d’anthracyclines
Cycle : Master's
Grade : M. Sc.
The human organic cation transporter OCT1 mediates high affinity uptake of the anticancer drug daunorubicin
Cycle : Master's
Grade : M. Sc.
The regulatory roles of APE1 and Prdx1 interaction
Cycle : Doctoral
Grade : Ph. D.
Investigating the role of the isomerase Rrd1/PTPA : from yeast to human
Cycle : Doctoral
Grade : Ph. D.
The overexpression of the efflux pump Tpo1 leads to the bleomycin resistance in Saccharomyces cerevisiae.
Cycle : Master's
Grade : M. Sc.
The in vivo characterization of the DNA repair gene apn-1 in the model organism Caenorhabditis elegans
Cycle : Master's
Grade : M. Sc.
The role of the peptidyl prolyl isomerase Rrd1 in the transcriptional stress response
Cycle : Doctoral
Grade : Ph. D.
The role of GAPDH in maintaining the functional state of the DNA repair enzyme APE1
Cycle : Master's
Grade : M. Sc.
The Na+/H+ exchanger Nhx1 of Saccharomyces cerevisiae is essential to limit drug toxicity
Cycle : Master's
Grade : M. Sc.
Deletion of the RNR4 gene causes hyperresistance to the carcinogen 4-NQO in the yeast model
Cycle : Master's
Grade : M. Sc.
Characterization of the AP endonuclease enzyme APN-1 from C. elegans
Cycle : Master's
Grade : M. Sc.
Étude du rôle biologique de l'activateur de phosphatase Rrd 1 chez la levure Saccharomyces cerevisiae
Cycle : Doctoral
Grade : Ph. D.
The biological importance of apurinic/apyrimidinic endonucleases in the maintenance of genetic stability
Cycle : Doctoral
Grade : Ph. D.
The function of the Saccharomyces Cerevisiae ribonucleotide reductase second [beta] subunit in DNA repair
Cycle : Master's
Grade : M. Sc.
Taf14 : un cofacteur de transcription impliqué dans l'activation de la transcription de Imp2 : un gène nécessaire pour la résistance à la bléomycine chez la levure Saccharomyces cerevisiae
Cycle : Master's
Grade : M. Sc.
Genetically engineering the mouse genome to study the role of the Phosphotyrosyl Phosphatase Activator (PTPA) gene in the response to oxidative stress
Cycle : Master's
Grade : M. Sc.
Mécanismes de résistance cellulaires de Saccharomyces cerevisiae face à la bléomycine, un agent antitumoral : implication du gène IMP2
Cycle : Master's
Grade : M. Sc.
Iip1, une protéine possédant un motif F-box, est impliquée dans le maintien de la stabilité des mitochondries
Cycle : Master's
Grade : M. Sc.
Identification of a protein required to target the DNA repair enzyme Apn1 into yeast mitochondria
Cycle : Master's
Grade : M. Sc.
YPtpa1p, une protéine impliquée dans la résistance aux dommages oxydatifs interagit avec un membre de la famille des chaperones DnaJ
Cycle : Master's
Grade : M. Sc.
Projects
Research projects
Role of C. elegans AP endonuclease, APN1,in removing DNA lesions generated through transportermediated uptake of naturally occurring toxic compounds.
Linking defects in the uptake transporter OCT1 with cancer patients resistance towards anthracyclines
A microcalorimetry system to define the biochemical parameters of molecular interactions
BIOLOGICAL FUNCTION OF THE DNA REPAIR ENZYME APN-1 IN C.ELEGANS
THE ROLE OF HUMAN GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE IN MAINTAINING THE REDOX STATE OF THE DNA REPAIR ENZYME APE1
THE ROLE OF HUMAN GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE IN REACTIVATING OXIDIZED FORMS OF THE DNA REPAI ENZYME APE1
Disciplines
- Molecular Biology
- Oncology
Areas of expertise
- Apoptosis and Cancer
- Cancer of the Musculoskeletal System
- Cancer of the Reproductive System
- Skin Cancer
- Prostate Cancer
- Head and Neck Cancer
- Cancer of the Digestive System
- Cancer of the Urinary System
- Lung Cancer
- Leukemia
- Breast Cancer
- Hereditary Cancer
- Hormone Dependent Cancers
- Carcinogenesis
- Cell
- Combinatorial Chemistry
- Chemotherapy
- Chromosome (Living Organisms)
- Inorganic and Organometallic Compounds
- Cancer Diagnosis and Detection
- Cellular Differentiation
- Cellular Division
- Environment and Cancer
- Growth Factors (Cancer)
- Gene (Living Organisms)
- Suppressor Gene
- Cancer Genetics
- Host-Tumour Interaction
- Lymphoma
- Macromolecules
- Metals and Nonmetals
- Organic Molecules and Biomolecules
- Nutrition and Cancer
- Oncogenes
- Quantum Phenomena
- Radiotherapy
- Cell Signaling and Cancer
- Stress and Cancer
- Chemical Synthesis and Catalysis
- Smoking and Cancer
- Cell Therapy of Cancer
- Gene Therapy of Cancer
- Cerebral Tumors
- Retinal and Ocular Neoplasms
- Vaccine and Cancer
- Life and Economic Production