Lipids constitute over 50% of the dry weight of the mammalian brain, serving as structural cornerstones of synaptic membranes and dynamic regulators of cell signaling, axonal integrity, and synaptic plasticity [5]. Over the past ten years, our research group has focused on utilizing advanced Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging (MALDI-MSI) to map the spatial organization of the brain lipidome in both pathological and physiological states [3, 6].

This research portfolio compiles translational lipidomic and pathomechanical results obtained across several clinical models. These include defining the irreversible molecular impacts of diet-induced obesity on the brain, mapping synaptic phospholipid rescue in the Alzheimer’s disease hippocampus under pharmacological Stearoyl-CoA Desaturase (SCD) inhibition, characterizing lipid remodeling in response to diverse nutritional interventions, establishing striatal and substantia nigra lipid alterations in a unilateral 6-OHDA Parkinson’s disease model, and characterizing lipid remodeling and inflammation-resolution biology within infarcted myocardial tissues. This body of work underscores the power of MALDI-MSI as a label-free molecular histology tool to localize and identify critical lipid pathomechanisms directly in tissue sections.

Responsabilités administratives et autres activités

2015-2023 Responsable administrative et p.dagogique du master international: Analytical Chemistry for

Drugs and Natural Products

2015-2022 Responsable administrative et p.dagogique du master professionnel en alternance AC2QMAPS (

contr.le qualit. des m.dicaments et autres produits de sant.)

2019-2020 Membre du conseil scientifique de l’Agence Nationale des plantes m.dicinales et Aromatiques du

Maroc

2018-2019 Membre du conseil scientifique . International conference on advanced Materials, Microscopy and

Energy .

2016-2022 Membre nomm. au bureau euro-m.diterran.en . la direction des relations internationales, Vicepr.sidence

relations ext.rieures- Universit. de Bordeaux

2015–2020 Conseill.re projet professionnel, UFR de pharmacie, Universit. de Bordeaux

2016 Membre du jury de recrutement de maitre de conf.rences section 85, UFR de pharmacie,

Universit. de Bordeaux

2015-2022 Membre du comit. web de laboratoire CBMN, Universit. de Bordeaux

Conseil en controle qualité.

American society of mass spectrometry

Metabolomic Society

Ourcon

Bénévolat au collège Jean de Brébeuf

Bénévolat à l'association jeunes au soleil_Montréal

Bénévolat au PSNM

Présidente fondation amis de l'école Lajoie Outremont_Montréal