Philippe P. Roux
Signalisation cellulaire et protéomique
- Professeur titulaire
-
Faculté de médecine - Département de pathologie et biologie cellulaire
Pavillon Marcelle-Coutu, local 1306-17
Portrait
Expertise de recherche
Philippe Roux et son équipe visent à caractériser les mécanismes de signalisation de plusieurs oncogènes et suppresseurs de tumeurs dans la régulation de la croissance et la prolifération cellulaire, en utilisant des techniques biochimiques et en biologie cellulaire, en génétique de la souris, en plus de méthodologies de pointes en protéomique, ils envisagent de découvrir de meilleures cibles thérapeutiques contre le cancer.
Thèmes
- Signalisation cellulaire
- Supresseur de tumeur
- Cancer
- Ras/MAPK
- mTOR
- Protéine kinase
- Oncogène
- Phosphorylation
- Protéomique
Prix et distinctions
- Chercheur-boursier sénior, Fonds de recherche du Québec - Santé (FRQS) 2016-2020
- Prix Nouveau scientifique GE Healthcare, 2013
- Chaire de recherche du Canada en signalisation cellulaire et protéomique, 2006-2016
- Bourse Développement de la carrière, Human Frontier Science Program, 2007-
- Boursier postdoctoral, Human Frontier Science Program, 2003-2006
- Boursier postdoctoral, Instituts de Recherche en Santé du Canada, 2002-2003
- Liste d’honneur du doyen, Faculté de Médecine, Université McGill, 2002
- Boursier doctoral, Instituts de Recherche en Santé du Canada, 1999-2002
- Boursier doctoral, Fondation Neuroscience Canada, 1998-1999
- Boursier doctoral, Fondation Jean Timmons Costello, 1997-1998
- Boursier à la maîtrise, Conseil des Services Sociaux du Québec, 1995-1997
Formation
- 2006 — Stage postdoctoral en biologie du cancer — Biologie cellulaire, Oncologie — Harvard Medical School
- 2002 — Ph.D. Neurosciences moléculaires — Neurosciences — Université McGill - Institut Neurologique de Montréal
- 1997 — M.Sc. Microbiologie et immunologie — Immunologie, Microbiologie — Université de Montréal - Centre de Recherche de l’Hôpital Sainte-Justine
- 1995 — B.Sc. Sciences biologiques — Immunologie, Microbiologie — Université de Montréal, Montréal
Pour en savoir plus…
Affiliations et responsabilités
Affiliations de recherche
Unités de recherche
Directeur scientifique
Enseignement et encadrement
Encadrement
Thèses et mémoires dirigés (dépôt institutionnel Papyrus)
Identification of copper metabolism as a KRAS-specific vulnerability in colorectal cancer
Cycle : Doctorat
Diplôme obtenu : Ph. D.
Analyse protéomique de la sénescence induite par la chimiothérapie dans le cancer de l'ovaire
Cycle : Maîtrise
Diplôme obtenu : M. Sc.
Rôle du complexe NF45-NF90 dans la régulation post-transcriptionnelle du cycle cellulaire
Cycle : Doctorat
Diplôme obtenu : Ph. D.
Étude des kinases RSK : de l’interactome aux fonctions biologiques
Cycle : Doctorat
Diplôme obtenu : Ph. D.
Rôles non-canoniques des arrestines dans la signalisation et l’endocytose des récepteurs couplés aux protéines G
Cycle : Doctorat
Diplôme obtenu : Ph. D.
Characterization of p120-catenin, a novel RSK substrate in the Ras/MAPK signalling pathway.
Cycle : Maîtrise
Diplôme obtenu : M. Sc.
Phosphorylation et régulation de l’E3 ubiquitine ligase MDM2 par la protéine kinase RSK dans les mélanomes
Cycle : Maîtrise
Diplôme obtenu : M. Sc.
Understanding the role of CAP proteins in the polarization process of C. elegans
Cycle : Maîtrise
Diplôme obtenu : M. Sc.
Régulation du métabolisme des ARNm par les voies de signalisation MAPK et mTOR
Cycle : Doctorat
Diplôme obtenu : Ph. D.
Feedback regulation of Gab2-dependent signaling by the Ras/MAPK pathway
Cycle : Doctorat
Diplôme obtenu : Ph. D.
Projets
Projets de recherche
Targeting ENPP1-dependent immune evasion in ErbB2-positive breast cancer
Identification of MYC-dependent vulnerabilities in breast cancer
Live cell imaging platform for the mechanistic analysis of cell differentiation, migration and division
CECR_IRICoR_Therapeutic antibody development in acute myeloid leukemia
Engineered hematopoietic stem cells (eHSCs) as vehicles for next generation therapies
StemCell Nerwork - Réseau des cellules souches - Engineered hematopoietic stem cells (eHSCs) as vehicles for next generation therapies
Cellular reprogramming during cell cycle progression
Targeting CDK12 to overcome melanoma chemoresistance
Interrogating and implementing Omics for precision medicine in Acute Myeloid Leukemia.
A functional surfaceome map of human hematopoietic stem and progenitor cells
Identification of MYC-dependent vulnerabilities in breast cancer
Copper bioavailability as a new vulnerability in colorectal cancer
Interrogating and implementing Omics for precision medicine in Acute Myeloid Leukemia
The role of LARP1 in the translation of growth promoting mRNAs
Bioluminescence resonance energy transfer detection system for the monitoring of proteinprotein interactions, posttranslational modifications and cell signalling.
Interrogating and implementing Omics for precision medicine in Acute Myeloid Leukemia
Supplément COVID-19 CRSNG_Cellular reprogramming during cell cycle progression
Identification de nouveaux régulateurs de la voie Ras/MAPK à l'aide d'une nouvelle approche protéomique
Dual molecular functions of LMO2 as a master oncogene in T-cell acute lymphoblastic leukemia
Régulation oncogénique de la croissance cellulaire par la voie de signalisation mTOR
Targeting pre-leukemic stem cells in T acute lymphoblastic leukemia
UNE APPROCHE CHIMIO- ET PROTEO-GENOMIQUE EN MEDECINE PERSONNALISEE POUR LA LEUCEMIE MYELOIDE AIGUE
Control of hematopoietic cell fate by LMO2
Development of Companion Therapies for Poor Outcome HMGA2+ Acute Myeloid Leukemia
MAPK-DEPENDENT REGULATION OF GAB2 FUNCTION
IDENTIFICATION AND CHARACTERIZATION OF NOVEL RSK SUBSTRATES
ROLE OF CK1 IN TUMOUR GROWTH AND RESISTANCE
INTERPLAY BETWEEN MECHANICAL AND BIOLOGICAL MECHANISMS DURING CELL CORTEX ASSEMBLY - RENEWAL APPLICATION
EVALUATION OF RSK4 AS SENESCENCE-RELATED TUMOUR SUPRESSOR IN COLORECTAL CANCER
CHAIRE DE RECHERCHE DU CANADA : CELL SIGNALLING AND PROTEOMICS
MITOGENIC AND ONCOGENIC REGULATION OF RSK SIGNALING
REGULATION AND FUNCTION OF THE RSK FAMILY IN BREAST CANCER
Rayonnement
Publications et communications
Publications
2020
NF45 and NF90 regulate mitotic gene expression by competing with Staufen-mediated mRNA decay
Nourreddine S, Lavoie G, Paradis J, Ben El Kadhi K, Meant A, Aubert L, Grondin B, Gendron P, Chabot B, Bouvier M, Carreno S, Roux PP
Cell Reports 31,107660 (2020)
Controversies around the function of LARP1
Berman AJ*, Thoreen CC*, Dedeic Z, Chettle J, Roux PP*, Blagden SP*
RNA Biol. 1, 1-11 (2020)
F-Actin interactome reveals Vimentin as a key regulator of Actin organization and cell mechanics in mitosis
Serres MP, Samwer M, Truong Quang BA, Petronczki M, Roux PP*, Paluch EK*
Dev. Cell 52, 210-222 (2020)
Loss of DP1 aggravates vascular remodeling in pulmonary arterial hypertension via mTORC1 signaling
He Y, Zuo C, Jia D, Bai P, Kong D, Chen D, Liu G, Li J, Wang Y, Chen G, Yan S, Xiao B, Zhang J, Piao L, Li Y, Deng Y, Li B, Roux PP, Andreasson KI, Breyer RM, Su Y, Wang J, Lyu A, Shen Y, Yu Y
Am. J. Respir. Crit. Care Med. 1, 1-15 (2020)
Proteomic analysis reveals a role for RSK in p120-catenin phosphorylation and melanoma cell-cell adhesion
Meant A, Gao B, Lavoie G, Nourreddine S, Jung F, Aubert L, Tcherkezian J, Gingras AC, Roux PP
Mol. Cell. Proteomics 19, 50-64 (2020)
2019
Regulation of protein kinase C delta Nuclear Import and Apoptosis by mTORC1
Layoun A, Goldberg AA, Baig A, Eng M, Attias O, Nelson K, Carella A, Amberber N, Fielhaber JA, Joung KB, Martin Schmeing T, Han Y, Downey J, Divangahi M, Roux PP, Kristof AS
Sci. Reports 9, 17620-33 (2019)
Human models of NUP98-KDM5A megakaryocytic leukemia in mice contribute to uncovering new biomarkers and therapeutic vulnerabilities
Cardin S, Bilodeau M, Roussy M, Aubert L, Milan T, Jouan L, Rouette A, Laramee L, Gendron P, Duchaine J, Decaluwe H, Spinella JF, Mourad S, Couture F, Sinnett D, Haddad E, Landry JR, Ma J, Humphries RK, Roux PP, Hebert J, Gruber TA, Wilhelm BT, Cellot S
Blood Advances 3, 3307-3321 (2019)
Misshapen coordinates protrusion restriction and actomyosin contractility during collective cell migration
Plutoni C, Keil S, Zeledon C, Delsin LEA, Decelle B, Roux PP, Carreno S, Emery G
Nature Comm. 10, 3940 (2019)
Mubritinib targets the electron transport chain complex I and reveals the landscape of OXPHOS dependency in acute myeloid leukemia
Baccelli I, Gareau Y, Lehnertz B, Gingras S, Spinella JF, Corneau S, Mayotte N, Girard S, Frechette M, Blouin-Chagnon V, Leveille K, Boivin I, MacRae T, Krosl J, Thiollier C, Lavallee VP, Kanshin E, Bertomeu T, Coulombe-Huntington J, St-Denis C, Bordeleau ME, Boucher G, Roux PP, Lemieux S, Tyers M, Thibault P, Hebert J, Marinier A, Sauvageau G
Cancer Cell 36, 84-99 (2019)
Predisposing germline mutations in high hyperdiploid acute lymphoblastic leukemia in children
de Smith AJ, Lavoie G, Walsh KM, Aujla S, Evans E, Hansen HM, Smirnov I, Kang AY, Zenker M, Ceremsak JJ, Stieglitz E, Muskens IS, Roberts W, McKean-Cowdin R, Metayer C, Roux PP, Wiemels JL
Genes Chromosomes Cancer 58, 723-730 (2019)
ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation
Shin S, Buel GR, Nagiec MJ, Han MJ, Roux PP, Blenis J, Yoon SO
Proc. Natl Acad. Sci. USA. 116, 2967-2976 (2019)
2018
The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression
Goyette MA, Duhamel S, Aubert L, Pelletier A, Savage P, Thibault MP, Johnson RM, Carmeliet P, Basik M, Gaboury L, Muller WJ, Park M, Roux PP, Gratton JP, Côté JF
Cell Reports 23, 1476-1490 (2018)
Signaling pathways involved in the regulation of mRNA translation
Roux PP, Topisirovic I
Mol. Cell. Biol. 38, e00070-18 (2018)
RSK Regulates PFK-2 Activity to Promote Metabolic Rewiring in Melanoma
Houles T, Gravel SP, Lavoie G, Shin S, Savall M, Meant A, Grondin B, Gaboury L, Yoon SO, St-Pierre J, Roux PP
Cancer Res. 78, 2191-2204 (2018)
CdGAP/ARHGAP31 is regulated by RSK phosphorylation and binding to 14-3-3 adaptor protein
Ben Djoudi Ouadda A, He Y, Calabrese V, Ishii H, Chidiac R, Gratton JP, Roux PP, Lamarche-Vane N
Oncotarget 9, 11646-11664 (2018)
Defining the role of the RSK isoforms in cancer
Houles T, Roux PP
Semin. Cancer Biol. 48, 53-61 (2018)
2017
Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition
Yoon SO, Shin S, Karreth FA, Buel GR, Jedrychowski MP, Plas DR, Dedhar S, Gygi SP, Roux PP, Dephoure N, Blenis J
Mol. Cell 67, 1-16 (2017)
Actin cortex architecture regulates cell surface tension
Chugh P, Clark A, Smith M, Cassani D, Dierkes K, Ragab A, Roux PP, Charras G, Salbreux G, Paluch E
Nature Cell. Biol. 19, 689-697 (2017)
EPCR expression marks UM171-expanded CD34+ cord blood stem cells
Fares I, Chagraoui J, Lehnertz B, MacRae T, Mayotte N, Tomellini E, Aubert L, Roux PP, Sauvageau G
Blood. 129, 3344-3351 (2017)
A new inhibitor of the B-arrestin/AP-2 endocytic complex reveals interplay between GPCR internalization and signalling
Beautrait A, Paradis JS, Zimmerman B, Armando S, Khoury E, Audet M, Roux PP, Laporte SA, Bouvier M
Nature Commun. 8, 15054 (2017)
ERK1/2 phosphorylate Gab2 to promote a negative feedback loop that attenuates PI3K/Akt signaling
Zhang X, Lavoie G, Meant A, Aubert L, Cargnello M, Haman A, Hoang T, Roux PP
Mol. Cell. Biol. 37, e00357-16 (2017)
Proteomics screen identifies class I Rab11 family interacting proteins as key regulators of cytokinesis
Laflamme C, Galan JA, Ben El Kadhi K, Meant A, Zeledon C, Carreno S, Roux PP*, Emery*
Mol. Cell. Biol. 37, e00278-16 (2017)
2016
High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells
Gerby B, Veiga DF, Krosl J, Nourreddine S, Ouellette J, Haman A, Lavoie G, Fares I, Tremblay M, Litalien V, Ottoni E, Kosic M, Geoffrion D, Ryan J, Maddox PS, Chagraoui J, Marinier A, Hebert J, Sauvageau G, Kwok BH, Roux PP, Hoang T.
J. Clin. Invest. 126, 4569-4584 (2016)
2015
Receptor sequestration in response to Beta-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression
Paradis JS, Ly S, Blondel-Tepaza E, Galan JA, Beautrait A, Scott MGH, Enslen H, Marullo S, Roux PP*, Bouvier M*
Proc. Natl Acad. Sci. USA. 112, E5160-8 (2015)
Regulation of global and specific mRNA translation by the mTOR signaling pathway
Nandagopal N, Roux PP
Translation 3, e983402 (2015)
The expanding role of mTOR in cancer cell growth and proliferation
Cargnello M, Tcherkezian J, Roux PP
Mutagenesis 30, 169-176 (2015)
Effect of the transient pharmacological inhibition of mapk3/1 pathway on ovulation in mice
Siddappa D, Beaulieu E, Gevry N, Roux PP, Bordignon V, Duggavathi R
PLoS One 10, e0119387 (2015)
Translational control by oncogenic signaling pathways
Gao B, Roux PP
Biochim. Biophys. Acta. 1849, 753-765 (2015)
2014
Phosphoproteomic Analysis Identifies the Tumor Suppressor PDCD4 as a RSK Substrate Negatively Regulated by 14-3-3
Galan JA, Geraghty KM, Lavoie G, Kanshin E, Tcherkezian J, Calabrese V, Jeschkee GR, Turk BE, Ballif BA, Blenis J, Thibault P, Roux PP
Proc. Natl Acad. Sci. USA. 111, E2918-27 (2014)
A Biosensor to monitor Dynamic Regulation and Function of Tumour Suppressor PTEN in Living Cells
Lima-Fernandes E, Misticone S, Boularan C, Paradis JS, Enslen H, Roux PP, Bouvier M, Baillie GS, Marullo S, Scott MGH
Nat. Commun. 5, 4431 (2014)
Cellular control of cortical actin nucleation
Bovellan M, Romeo Y, Biro M, Boden A, Chugh P, Yonis A, Vaghela M, Fritzsche M, Moulding D, Thorogate R, Jegou A, Thrasher AJ,Romet-Lemonne G, Roux PP*, Paluch EK*, Charras G*
Curr. Biol. 24, 1628-1635 (2014)
Mechanistic target of rapamycin (mTOR) signaling during ovulation in mice
Siddappa D, Kalaiselvanraja A, Bordignon V, Dupuis L, Gasperin BG, Roux PP, Duggavathi R.
Mol Reprod Dev. 81, 655-665 (2014)
Mutations in DOCK7 in Individuals with Epileptic Encephalopathy and Cortical Blindness
Perrault I, Hamdan FF, Rio M, Capo-Chichi JM, Boddaert N, Decarie JC, Maranda B, Nabbout R, Sylvain M, Lortie A, Roux PP, Rossignol E, Gerard X, Barcia G, Berquin P, Munnich A, Rouleau GA, Kaplan J, Rozetemail JM, Michaud JL
Am J Hum Genet. 94, 1-7 (2014)
Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translation
Tcherkezian J, Cargnello M, Romeo Y, Huttlin EL, Lavoie G, Gygi SP, Roux PP
Genes & Dev. 28, 357-371 (2014)
Casein kinase 1e promotes cell proliferation by regulating mRNA translation
Shin S, Wolgamott L, Roux PP, Yoon SO
Cancer Res. 74, 201-211 (2014)
Glycogen synthase kinase-3β positively regulates protein synthesis and cell proliferation through the regulation of translation initiation factor 4E-binding protein 1
Shin S, Wolgamott L, Tcherkezian J, Vallabhapurapu S, Yu Y, Roux PP, Yoon SO.
Oncogene. 33, 1690-1699 (2014)
2013
The coming of age of phosphoproteomics; From large data sets to inference of protein functions
Roux PP, Thibault P
Mol. Cell. Proteomics. 12, 3453-3464 (2013)
Rapamycin resistance: mTORC1 substrates hold some of the answers
Yoon SO, Roux PP
Curr. Biol. 23, R880-R883 (2013)
Gab2 Phosphorylation by RSK Inhibits Shp2 Recruitment and Cell Motility
Zhang X, Lavoie G, Fort L, Huttlin EL, Tcherkezian J, Galan JA, Gu H, Gygi SP, Carreno S, Roux PP.
Mol. Cell. Biol. 33, 1657-1670 (2013)
Cell cortex composition and homeostasis resolved by integrating proteomics and quantitative imaging
Biro M, Romeo Y, Kroschwald S, Bovellan M, Boden A, Tcherkezian J, Roux PP*, Charras G*, Paluch E*
Cytoskeleton. 70, 741-754 (2013)
RSK promotes G2 DNA damage checkpoint silencing and participates in melanoma chemoresistance
Ray-David H, Romeo Y, Lavoie G, Deleris P, Tcherkezian J, Galan JA, Roux PP.
Oncogene. 32, 4480-4489 (2013)
Insulin activates RSK to trigger a new negative feedback loop that regulates insulin signaling for glucose metabolism
Smadja-Lamere N, Shum M, Deleris P, Roux PP, Abe JI, Marette A.
J. Biol. Chem. 288, 31165-31176 (2013)
Cell cycle regulation of Greatwall kinase localization facilitates mitotic progression
Wang P, Galan, JA, Bonneil E., Hickson GR, Roux PP, Thibault P, Archambault V.
J. Cell. Biol. 202, 277-293 (2013)
Role of TBC1D7, a subunit of the TSC1/TSC2 complex, in intellectual disability and megalencephaly
Capo-Chichi JM, Tcherkezian J, Decarie JC, Dobrzeniecka S, Patry L, Nadon MA, Mucha-Le Ny B, Shevell M, Cheikh BB, Joober R, Samuels ME, Rouleau GA, Hamdan FF, Roux PP, Michaud JL.
J. Med. Genet. 50, 740-744 (2013)
RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth
Romeo Y, Moreau J, Zindy PJ, Saba-El-Leil M, Lavoie G, Dandachi F, Baptissart M, Borden KLB, Meloche S, Roux PP.
Oncogene. 32, 2917-26 (2013)
Disciplines
- Biochimie
- Biologie cellulaire
- Génétique
Champ d’expertise
- Signalisation cellulaire (neurosciences)
- Signalisation cellulaire et cancer
- Interaction hôte-tumeur
- Thérapie cellulaire du cancer
- Oncogènes
- Protéomique
- Génétique du cancer
Aide en ligne pour votre profil | Nous joindre
Le Répertoire des professeurs est propulsé par les données du SADVR et est un projet du CENR.