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Health Sciences; Medical Sciences

Sarah Gagliano Taliun

Génomique computationnelle sur des traits génétiques complexes

Professeure sous octroi adjointe

Faculté de médecine - Département de médecine

sarah.gagliano@umontreal.ca

Profile

Research expertise

Our group uses state-of-the-art computational and bioinformatics approaches, including machine-learning techniques, to understand the genetic factors contributing to complex traits and common diseases in humans, specifically cardiovascular or neurological diseases. 

education

  • 2020 — Stage de formation postdoctoral — Épidémiologie et biostatistiqueUniversité de Michigan
  • 2016 — Ph.D — Sciences biomédicalesUniversité de Toronto

Affiliations and responsabilities

Research affiliations

Teaching and supervision Currently recruiting

Recruitment in research Currently recruiting

The development of predictive models for personalized medicine in cardiovascular and neurological health – M.Sc./Ph.D/PostDoc 

Montreal Heart Institute 

Principal Investigator :  Sarah A Gagliano Taliun, Ph.D
Assistant Professor, Faculty of Medicine - Université de Montréal

Starting date : Immediate

Project description 

The newly formed group of Dr. Gagliano Taliun uses state-of-the-art computational and bioinformatics approaches, including machine-learning techniques, to understand the genetic factors contributing to complex traits and common diseases in humans, specifically cardiovascular or neurological diseases. The official language of the Université de Montréal is French, but the lab operates in English. 

Requested profile 

  • Ambitious and highly motivated 
  • University degree in genetics, biology, biochemistry, bioinformatics or computer science 
  • Strong background and interest in genetics 
  • Excellent oral and written communication skills 

How to apply 

Interested candidates are invited to submit their application before December 31, 2020 by e‐mail to sarah <dot> gagliano <at> icm-mhi.orgincluding:

  • CV
  • Cover letter
  • Transcripts
  • Names and contact information for 2 references 

Lab & Publications Information sgagliano.github.io/

About the Research Center 

Affiliated with Université de Montréal, the MHI is the flagship of cardiovascular medicine in Quebec, a recognized research leader in Canada and around the world, and a true spearhead in cutting-edge cardiovascular medicine. In concrete terms, the Research Centre represents over 350 scientific articles published each year, over 80 basic researchers and clinician researchers, for an equivalent of over 48 full-time researchers. In addition to, cutting-edge technological research infrastructure, the Montreal Health Innovations Coordinating Center, which works with 2,500 clinical sites in 20 countries on 4 continents, a Biobank, which contains samples from a cohort of over 20,000 patients (target of 30,000 patients) who have been fully phenotyped, an annual budget of over $50 million, unrivalled leadership and a key centre for the coordination of national and international research. 

Projects

Research projects

2020 - 2024

Le développement des modèles prédictifs qui sont spécifiques au sexe pour la médecine personnalisée en santé cardiovasculaire

Lead researcher : Sarah Gagliano Taliun
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Bourse de chercheur-boursier : Junior 1

Outreach

Publications and presentations

Publications

Publications choisies
* Equal contribution    Co-senior author

S.A. Gagliano Taliun*, P. VandeHaar*, A.P. Boughton, R.P. Welch, D. Taliun, E.M. Schmidt, W. Zhou, J.B. Nielsen, C.J. Willer, S. Lee, L.G. Fritsche, M. Boehnke, G.R. Abecasis (2020) Exploring and visualizing large-scale genetic associations using PheWeb. Nature Genetics. 52:550–552. PMID: 32504056

W. Zhou*, Z. Zhao*, J.B. Nielsen, L.G. Fritsche, J. LeFaive, S.A. Gagliano Taliun, W. Bi, M.J. Daly, B.M. Neale, K. Hveem, G.R. Abecasis, C.J. Willer, S. Lee. (2020) Scalable generalized linear mixed model for region-based association tests in large biobanks and cohorts. Nature Genetics. 52:634–639. PMID: 32424355

R.H. Reynolds, J. Hardy, M. RytenS.A. Gagliano Taliun (2019) Informing disease modelling with brain-relevant functional genomic annotations. Brain. 0:1-19. PMID: 31603214

D. Dutta, S.A. Gagliano Taliun, J. Weinstock, M. Zawistowski, C. Sidore, F. Cucca, D. Schlessinger, G. Abecasis, C. Brummett, S. Lee. (2019) Meta-MultiSKAT: Multiple phenotype meta-analysis for region-based association test. Genetic Epidemiology. 43(7):800-814. PMID: 31433078

R.H. Reynolds, J.A. Botía, M.A. Nalls, International Parkinson’s Disease Genomics Consortium (IPDGC), J. Hardy, S.A. Gagliano Taliun, M. Ryten (2019) Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson’s disease heritability. 5:6. NPJ Parkinsons Disease. PMID: 31016231

S.A. Gagliano, S. Sengupta, C. Sidore, A. Maschio, F. Cucca, D. Schlessinger, G.R Abecasis (2018) Relative impact of indels versus SNPs on complex disease. Genetic Epidemiology. 43(1):112-117. PMID: 30565766

W. Zhou, J.B. Nielsen, L.G. Fritsche, R. Dey, M.B. Elvestad, B.N. Wolford, J. LeFaive, P. VandeHaar, S.A. Gagliano, A. Gifford, L.A. Bastarache, W-Q. Wei, J.C. Denny, M. Lin, K. Hveem, H.M. Kang, G.R. Abecasis, C.J. Willer, S. Lee (2018) Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies. Nature Genetics. 50(9):1335-1341. PMID: 30104761

S.A. Gagliano, J. G. Pouget, J. Hardy, J. Knight, M.R. Barnes, M. Ryten, M.E. Weale (2016) Genomics implicates adaptive and innate immunity in Alzheimer’s and Parkinson’s. Annals of Clinical and Translational Neurology. 3(12):924-933. PMID: 28097204

S.A. Gagliano, C. Ptak, D.Y.F. Mak, M. Shamsi, G. Oh, J. Knight, P.C. Boutros, A. Petronis (2016) Allele-skewed DNA modification in the brain: relevance to schizophrenia GWAS. American Journal of Human Genetics. 98(5):956-962. PMID: 27087318

Communications

S.A. Gagliano Taliun(2019) Teaching at the university-level is not a hassle. Nature. 574(7777): 285. PMID: 31591538

Disciplines

  • Genetics
  • Bioinformatics
  • Epidemiology and Biostatistics

Areas of expertise

  • Complex Trait Genetics
  • Genomics
  • Genetics of Neurological and Psychiatric Diseases
  • Cardiovascular Diseases
  • Neurological Diseases