Health Sciences; Natural Sciences and Engineering
Léa Harrington
Homéostasie de la longueur des télomères et instabilité génomique
- Professeure titulaire
-
Faculté de médecine - Département de médecine
Profile
Research expertise
Lea Harrington and her colleagues pursue the mechanisms by which chromosome ends, telomeres, are maintained and protected from degradation and recombination. The activity of an enzyme responsible for new telomere addition in most eukaryotes, telomerase, is increased in many cancers and conversely is decreased in many somatic tissues. Since critically short telomeres that elicit a DNA damage response are incompatible with cell viability, the regulation of telomerase activity and dosage is thus a critical determinant of normal and cancer cell proliferation.
Affiliations and responsabilities
Research affiliations
Teaching and supervision
Student supervision
Theses and dissertation supervision (Papyrus Institutional Repository)
2024
Study of the biphasic effect of resveratrol and ATR-inhibitors on cellular fitness
Graduate : Zeinaty, Alya
Cycle : Master's
Grade : M. Sc.
Cycle : Master's
Grade : M. Sc.
2023
Extrinsic and intrinsic factors that regulate cell fitness in telomerase-inhibited human cells
Graduate : Borges, Gustavo
Cycle : Doctoral
Grade : Ph. D.
Cycle : Doctoral
Grade : Ph. D.
2023
Genetic and epigenetic regulation of differentiation stability in stem cells with eroded telomeres
Graduate : Gallinari, Angélique
Cycle : Master's
Grade : M. Sc.
Cycle : Master's
Grade : M. Sc.
2022
Différenciation des cellules souches et intégrité des télomères
Graduate : Criqui, Mélanie
Cycle : Doctoral
Grade : Ph. D.
Cycle : Doctoral
Grade : Ph. D.
2021
The role of the human INO80 complex in telomere maintenance
Graduate : Henry, Danielle
Cycle : Master's
Grade : M. Sc.
Cycle : Master's
Grade : M. Sc.
2021
Genome-wide CRISPR screens for the interrogation of genome integrity maintenance networks
Graduate : Benslimane, Yahya
Cycle : Doctoral
Grade : Ph. D.
Cycle : Doctoral
Grade : Ph. D.
Projects
Research projects
2021
- 2028
Exploiting the synthetic-lethal vulnerabilities of stem cells and cancer cells with eroded telomeres
Lead researcher :
Léa Harrington
Funding sources:
IRSC/Instituts de recherche en santé du Canada
Grant programs:
PVXXXXXX-(PJT) Subvention Projet
2019
- 2024
Genetic and chemical ablation of senescent cells that result from age-dépendent telomere erosion
Lead researcher :
Léa Harrington
Co-researchers :
Michael David Tyers
Funding sources:
IRSC/Instituts de recherche en santé du Canada
Grant programs:
PVXX5647-(MOP) Subvention de fonctionnement incluant les subventions de fonctionnement programmatiques (général)
2016
- 2024
Telomere instability transforms differentiated stem cells into teratomas: implications for aging and disease
Lead researcher :
Léa Harrington
Funding sources:
IRSC/Instituts de recherche en santé du Canada
Grant programs:
PVXXXXXX-(PJT) Subvention Projet
2014
- 2021
TELOMERE INTEGRITY AND STABILITY OF THE DIFFERENTIATED STATE
Lead researcher :
Léa Harrington
Co-researchers :
Dean Betts
Funding sources:
IRSC/Instituts de recherche en santé du Canada
Grant programs:
PVXX5647-(MOP) Subvention de fonctionnement incluant les subventions de fonctionnement programmatiques (général)
2015
- 2020
UNE APPROCHE CHIMIO- ET PROTEO-GENOMIQUE EN MEDECINE PERSONNALISEE POUR LA LEUCEMIE MYELOIDE AIGUE
Lead researcher :
Guy Sauvageau
Co-researchers :
Claude Perreault
,
Stephen Hanessian
,
Michel Bouvier
,
Trang Hoang
,
François Major
,
Denis-Claude Roy
,
Louis Gaboury
,
Sylvie Mader
,
Sylvain Meloche
,
Marc Therrien
,
Pierre Thibault
,
Katherine Borden
,
Jean-Claude Labbé
,
Alain Verreault
,
Julie Lessard
,
Jean Roy
,
Martine Raymond
,
Vincent Archambault
,
Sébastien Lemieux
,
Anne Marinier
,
Jean-Sébastien Delisle
,
Brian Wilhelm
,
Damien D'Amours
,
Philippe P. Roux
,
Josée Hébert
,
Julie Bergeron
,
Léa Harrington
,
Michael David Tyers
,
Grégoire Leclair
Funding sources:
FCI/Fondation canadienne pour l'innovation
Grant programs:
PVXXXXXX-Fonds d'innovation
2011
- 2014
INVESTIGATION OF NOVEL METHODS OF TELOMERE MAINTENANCE IN CELLULAR SENESCENCE, AGING AND CANCER
Lead researcher :
Léa Harrington
Funding sources:
FCI/Fondation canadienne pour l'innovation
Grant programs:
Disciplines
- Biochemistry