Passer au contenu

/ Research

Je donne

Rechercher

Health Sciences; Medical Sciences

André Denault

Professeur titulaire

Faculté de médecine - Département d'anesthésiologie et de médecine de la douleur

andre.denault@umontreal.ca

Professeur accrédité

Faculté de médecine - Département de pharmacologie et physiologie

Secondary number: 514 376-3330 #3732 (Travail 1)
Secondary email: andre.denault@gmail.com (Travail)

Profile

Research expertise

  • Échocardiographie transoesophagienne opératoire et périopératoire
  • Complications post-op de chirurgie cardiaque et prédicteurs
  • Mécanisme du sevrage difficile de la circulation extra-corporelle et de l’instabilité hémodynamique
  • Défaillance ventriculaire droite et hypertension portale
  • Thérapie par inhalation d’hypertension pulmonaire et de la dysfonction ventriculaire droite
  • Oximétrie cérébrale et somatique
  • Delirium post-opératoire

Affiliations and responsabilities

Research affiliations

Teaching and supervision

Student supervision

Theses and dissertation supervision (Papyrus Institutional Repository)

2023

Effects of inhaled therapies on pulmonary hypertension and right ventricular function in cardiac surgery

Graduate : Elmi-Sarabi, Mahsa
Cycle : Doctoral
Grade : Ph. D.
2021

L’insuffisance rénale aiguë congestive en chirurgie cardiaque

Graduate : Beaubien-Souligny, William
Cycle : Doctoral
Grade : Ph. D.
2021

L’obstruction de la chambre de chasse du ventricule droit en chirurgie cardiaque adulte

Graduate : Zeng, Yu Hao
Cycle : Master's
Grade : M. Sc.

Projects

Research projects

2022 - 2025

Proactive prescription-based fluid management vs usual care in critically ill patients on Kidney Replacement Therapy

Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet
2019 - 2023

TECHNO-5: Validation of cerebral non-invasive monitoring and prediction of post-operative delirium and outcomes: A prospective observational study

Lead researcher : André Denault
Co-researchers : Tanya Mailhot
Funding sources: Fondation de l'Institut de cardiologie de Montréal
Grant programs:
2017 - 2022

Design of a bracelet embedding high-frequency ultrasound transducers to acquire venous blood echogenicity spectral data for patient monitoring

Lead researcher : Guy Cloutier
Co-researchers : Jean-François Cailhier , André Denault , Frédéric Lesage
Funding sources: IRSC/Instituts de recherche en santé du Canada , CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs: PVXXXXXX-(PRCS) Recherche concertée sur la santé (en partenariat avec le CRSNG) , PVXXXXXX-(PRCS/CHRP) Recherche en équipe concertée sur la santé avec l'appareillage (avec IRSC)
2009 - 2020

UNIVERSITY OF MONTREAL CARDIAC SURGERY CLINICAL INVESTIGATION GROUP

Lead researcher : Louis Paul Perrault
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs:
2018 - 2019

The clinical significance of portal hypertension after cardiac surgery: an international multicenter prospective observational study

Lead researcher : André Denault
Funding sources: Société canadienne anesthésiologistes
Grant programs:
2013 - 2019

SUBVENTION FICM 2013-2018

Lead researcher : André Denault
Funding sources: Fondation de l'Institut de cardiologie de Montréal
Grant programs:
2012 - 2019

PLANE-WAVE QUANTITATIVEULTRASOUND IMAGING OF BLOOD MECHANICAL PROPERTIES

Lead researcher : Guy Cloutier
Co-researchers : Louis Paul Perrault , André Denault , Damien Garcia , Mark Blostein
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXX5647-(MOP) Subvention de fonctionnement incluant les subventions de fonctionnement programmatiques (général)
2013 - 2016

EEG-FNIRS MONITORING FOR CRITICALLY ILL PATIENTS

Lead researcher : Frédéric Lesage
Co-researchers : André Denault , Alain Deschamps , Dang Khoa Nguyen , Céline Odier
Funding sources: CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs: PVXXXXXX-(PRCS/CHRP) Recherche en équipe concertée sur la santé avec l'appareillage (avec IRSC)
2013 - 2016

EEG-FNIRS MONITORING FOR CRITICALLY ILL PATIENTS

Lead researcher : Frédéric Lesage
Co-researchers : André Denault , Alain Deschamps , Dang Khoa Nguyen , Céline Odier
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PRCS) Recherche concertée sur la santé (en partenariat avec le CRSNG)
2013 - 2015

A PORTABLE WIRELESS NEAR INFRARED SPECTROSCOPY SYSTEM COMBINED WITH ELECTROENCEPHALOGRAPHY FOR BEDSIDE MONITORING OF STROKE AND CARDIAC PATIENTS

Lead researcher : Mohamad A. Sawan
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs:
2013 - 2014

PRACTICE PATTERN VARIATION IN DISCONTINUING MECHANICAL VENTILATION IN CRITICAL III ADULTS : AN INTERNATIONAL PROSPECTIVE OBSERVATIONAL STUDY

Lead researcher : André Denault
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs:
2009 - 2013

DEFAILLANCE VENTRICULAIRE DROITE EN CHIRURGIE CARDIAQUE: IMPORTANCE, DIAGNOSTIC, PREVENTION ET TRAITEMENT

Lead researcher : André Denault
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Bourse de chercheur-boursier: junior I et II et senior (offre seulement)
2009 - 2012

DEFAILLANCE VENTRICULAIRE DROITE EN CHIRURGIE CARDIAQUE: IMPORTANCE, DIAGNOSTIC, PREVENTION ET TRAITEMENT

Lead researcher : André Denault

Outreach

Publications and presentations

Publications

Publications (depuis 2019)

  1. Sia YT, Gebhard CE, Denault AY. Reversal of Acute Right Ventricular Failure Early Post Left Ventricular Assist Device Placement by Intratracheal Milrinone Administration: Case Report. Chest. 2021 Jan;159(1):e57-e60. doi: 10.1016/j.chest.2020.01.059. PMID: 33422243.
  2. Bianco JC, Stang MV, Denault AY, Marenchino RG, Belziti CA, Musso CG. Acute Kidney Injury After Heart Transplant: The Importance of Pulmonary Hypertension. J Cardiothorac Vasc Anesth. 2020 Dec 13:S1053-0770(20)31355-0. doi: 10.1053/j.jvca.2020.12.010. Epub ahead of print. PMID: 33414071.
  3. Aldred MP, Elhaj B, Zeng YH, Couture EJ, Rivard L, Lamarche Y, Denault AY. Right Ventricular Epicardial Pacing Postcardiac Surgery Can Cause Dynamic Right Ventricular Outflow Tract Obstruction: A Case Report. A A Pract. 2020 Dec;14(14):e01346. doi: 10.1213/XAA.0000000000001346. PMID: 33295744.
  4. Bernardo RJ, Haddad F, Couture EJ, Hansmann G, de Jesus Perez VA, Denault AY, de Man FS, Amsallem M. Mechanics of right ventricular dysfunction in pulmonary arterial hypertension and heart failure with preserved ejection fraction. Cardiovasc Diagn Ther. 2020 Oct;10(5):1580-1603. doi: 10.21037/cdt-20-479. PMID: 33224775; PMCID: PMC7666917.
  5. Azzam MA, Couture EJ, Beaubien-Souligny W, Brassard P, Gebhard CE, Denault AY. A proposed algorithm for combining transcranial Doppler ultrasound monitoring with cerebral and somatic oximetry: a case report. Can J Anaesth. 2021 Jan;68(1):130-136. English. doi: 10.1007/s12630-020-01832-z. Epub 2020 Oct 15. PMID: 33063295.
  6. Denault AY, Aldred MP, Hammoud A, Zeng YH, Beaubien-Souligny W, Couture EJ, Jarry S, Gebhard CE, Langevin S, Lamarche Y, Robillard P. Doppler Interrogation of the Femoral Vein in the Critically Ill Patient: The Fastest Potential Acoustic Window to Diagnose Right Ventricular Dysfunction? Crit Care Explor. 2020 Sep 28;2(10):e0209. doi: 10.1097/CCE.0000000000000209. PMID: 33063023; PMCID: PMC7523763.
  7. Carrier FM, Denault AY, Nozza A, Rioux-Massé B, Roy A, Massicotte L. Association between intraoperative rotational thromboelastometry or conventional coagulation tests and bleeding in liver transplantation: an observational exploratory study. Anaesth Crit Care Pain Med. 2020 Dec;39(6):765-770. doi: 10.1016/j.accpm.2020.07.018. Epub 2020 Oct 1. PMID: 33011332.
  8. Bouabdallaoui N, Beaubien-Souligny W, Oussaïd E, Henri C, Racine N, Denault AY, Rouleau JL. Assessing Splanchnic Compartment Using Portal Venous Doppler and Impact of Adding It to the EVEREST Score for Risk Assessment in Heart Failure. CJC Open. 2020 Mar 30;2(5):311-320. doi: 10.1016/j.cjco.2020.03.012. PMID: 32995715; PMCID: PMC7499287.
  9. Ricarte Bratti JP, Chronopoulos A, Sia YT, Carrier FM, Denault AY. Biventricular thrombosis and survival after two different mechanical supports before heart transplantation. Clin Case Rep. 2020 Apr 17;8(7):1199-1201. doi: 10.1002/ccr3.2865. PMID: 32695356; PMCID: PMC7364061.
  10. Bouabdallaoui N, Sirois MG, Beaubien-Souligny W, Denault AY, Rouleau JL. Lymphocytopenia During Hospitalization for Acute Heart Failure and Its Relationship With Portal Congestion and Right Ventricular Function. J Card Fail. 2020 Dec;26(12):1043-1049. doi: 10.1016/j.cardfail.2020.07.001. Epub 2020 Jul 10. PMID: 32659436.
  11. Denault AY, Delisle S, Canty D, Royse A, Royse C, Serra XC, Gebhard CE, Couture ÉJ, Girard M, Cavayas YA, Peschanski N, Langevin S, Ouellet P. A proposed lung ultrasound and phenotypic algorithm for the care of COVID-19 patients with acute respiratory failure. Can J Anaesth. 2020 Oct;67(10):1393-1404. doi: 10.1007/s12630-020-01704-6. Epub 2020 May 21. PMID: 32440906; PMCID: PMC7241588.
  12. Bouabdallaoui N, Beaubien-Souligny W, Denault AY, Rouleau JL. Impacts of right ventricular function and venous congestion on renal response during depletion in acute heart failure. ESC Heart Fail. 2020 Aug;7(4):1723-1734. doi: 10.1002/ehf2.12732. Epub 2020 May 13. PMID: 32400036; PMCID: PMC7373894.
  13. Beaubien-Souligny W, Rola P, Haycock K, Bouchard J, Lamarche Y, Spiegel R, Denault AY. Quantifying systemic congestion with Point-Of-Care ultrasound: development of the venous excess ultrasound grading system. Ultrasound J. 2020 Apr 9;12(1):16. doi: 10.1186/s13089-020-00163-w. PMID: 32270297; PMCID: PMC7142196.
  14. Beaubien-Souligny W, Neagoe PE, Gagnon D, Denault AY, Sirois MG. Increased Circulating Levels of Neutrophil Extracellular Traps During Cardiopulmonary Bypass. CJC Open. 2019 Dec 16;2(2):39-48. doi: 10.1016/j.cjco.2019.12.001. PMID: 32190824; PMCID: PMC7067687.
  15. Grønlykke L, Couture EJ, Haddad F, Amsallem M, Ravn HB, Raymond M, Beaubien- Souligny W, Demers P, Rochon A, Sarabi ME, Lamarche Y, Desjardins G, Denault AY. Preliminary Experience Using Diastolic Right Ventricular Pressure Gradient Monitoring in Cardiac Surgery. J Cardiothorac Vasc Anesth. 2020 Aug;34(8):2116-2125. doi: 10.1053/j.jvca.2019.12.042. Epub 2020 Jan 8. PMID: 32037274.
  16. Nguyen AQ, Denault AY, Théoret Y, Perrault LP, Varin F. Inhaled milrinone in cardiac surgical patients: a pilot randomized controlled trial of jet vs. mesh nebulization. Sci Rep. 2020 Feb 7;10(1):2069. doi: 10.1038/s41598-020-58902-x. PMID: 32034202; PMCID: PMC7005849.
  17. Palermo J, Bojanowski M, Langevin S, Denault AY. Point-of-care handheld ophthalmic ultrasound in the diagnosis and evaluation of raised intracranial pressure and Terson syndrome: a description of two cases. Can J Anaesth. 2020 Mar;67(3):353-359. English. doi: 10.1007/s12630-019-01531-4. Epub 2019 Nov 22. PMID: 31758491.
  18. Beaubien-Souligny W, Kontar L, Blum D, Bouchard J, Denault AY, Wald R. Meta- Analysis of Randomized Controlled Trials Using Tool-Assisted Target Weight Adjustments in Chronic Dialysis Patients. Kidney Int Rep. 2019 Jul 12;4(10):1426-1434. doi: 10.1016/j.ekir.2019.07.003. PMID: 31701052; PMCID: PMC6829199.
  19. Roter E, Denault AY. Radial artery reliability using arterial Doppler assessment prior to arterial cannulation. Can J Anaesth. 2019 Oct;66(10):1272-1273. doi: 10.1007/s12630-019-01443-3. Epub 2019 Jul 9. PMID: 31290123.
  20. Beaubien-Souligny W, Brand FZA, Lenoir M, Amsallem M, Haddad F, Denault AY. Assessment of Left Ventricular Diastolic Function by Transesophageal Echocardiography Before Cardiopulmonary Bypass: Clinical Implications of a Restrictive Profile. J Cardiothorac Vasc Anesth. 2019 Sep;33(9):2394-2401. doi: 10.1053/j.jvca.2019.05.014. Epub 2019 May 16. PMID: 31235379.
  21. Massicotte L, Carrier FM, Karakiewicz P, Hevesi Z, Thibeault L, Nozza A, Bilodeau M, Roy A, Denault AY. Impact of MELD Score-Based Organ Allocation on Mortality, Bleeding, and Transfusion in Liver Transplantation: A Before-and- After Observational Cohort Study. J Cardiothorac Vasc Anesth. 2019 Oct;33(10):2719-2725. doi: 10.1053/j.jvca.2019.03.008. Epub 2019 Mar 8. PMID: 31072701.
  22. Gebhard CE, Rochon A, Cogan J, Ased H, Desjardins G, Deschamps A, Gavra P, Lebon JS, Couture P, Ayoub C, Levesque S, Elmi-Sarabi M, Couture EJ, Denault AY. Acute Right Ventricular Failure in Cardiac Surgery During Cardiopulmonary Bypass Separation: A Retrospective Case Series of 12 Years’ Experience With Intratracheal Milrinone Administration. J Cardiothorac Vasc Anesth. 2019 Mar;33(3):651-660. doi: 10.1053/j.jvca.2018.09.016. Epub 2018 Sep 13. PMID: 30683595.
  23. Couture EJ, Grønlykke L, Denault AY. Commentary to « Right Ventricular Systolic Performance Determined by 2D Speckle-Tracking Echocardiography and Acute Kidney Injury After Cardiac Surgery ». J Cardiothorac Vasc Anesth. 2019 Apr;33(4):1168-1169. doi: 10.1053/j.jvca.2018.12.013. Epub 2018 Dec 11. PMID: 30655199.
  24. Denault AY, Brassard P, Jacquet-Lagrèze M, Halwagi AE. Targeting optimal blood pressure monitoring: what’s next? J Thorac Dis. 2018 Sep;10(Suppl 26):S3281-S3285. doi: 10.21037/jtd.2018.08.115. PMID: 30370138; PMCID: PMC6186585.
  25. Beaubien-Souligny W, Pépin MN, Legault L, Cailhier JF, Éthier J, Bouchard L, Willems B, Denault AY. Acute Kidney Injury Due to Inferior Vena Cava Stenosis After Liver Transplantation: A Case Report About the Importance of Hepatic Vein Doppler Ultrasound and Clinical Assessment. Can J Kidney Health Dis. 2018 Oct 3;5:2054358118801012. doi: 10.1177/2054358118801012. PMID: 30302268; PMCID: PMC6172939.
  26. Raymond M, Grønlykke L, Couture EJ, Desjardins G, Cogan J, Cloutier J, Lamarche Y, L’Allier PL, Ravn HB, Couture P, Deschamps A, Chamberland ME, Ayoub C, Lebon JS, Julien M, Taillefer J, Rochon A, Denault AY. Perioperative Right Ventricular Pressure Monitoring in Cardiac Surgery. J Cardiothorac Vasc Anesth. 2019 Apr;33(4):1090-1104. doi: 10.1053/j.jvca.2018.08.198. Epub 2018 Aug 25. PMID: 30269893.
  27. Couture EJ, Tremblay JA, Elmi-Sarabi M, Lamarche Y, Denault AY. Noninvasive Administration of Inhaled Epoprostenol and Inhaled Milrinone in Extubated, Spontaneously Breathing Patients With Right Ventricular Failure and Portal Hypertension: A Report of 2 Cases. A A Pract. 2019 Mar 15;12(6):208-211. doi: 10.1213/XAA.0000000000000886. PMID: 30216198.
  28. Tremblay JA, Couture ÉJ, Albert M, Beaubien-Souligny W, Elmi-Sarabi M, Lamarche Y, Denault AY. Noninvasive Administration of Inhaled Nitric Oxide and its Hemodynamic Effects in Patients With Acute Right Ventricular Dysfunction. J Cardiothorac Vasc Anesth. 2019 Mar;33(3):642-647. doi: 10.1053/j.jvca.2018.08.004. Epub 2018 Aug 8. PMID: 30206010.
  29. Couture EJ, Provencher S, Denault AY. Management of Severe Pulmonary Hypertensive Disease for Surgical and Nonsurgical Procedures. Int Anesthesiol Clin. 2018 Fall;56(4):e28-e55. doi: 10.1097/AIA.0000000000000202. PMID: 30204604.
  30. Beaubien-Souligny W, Denault AY. Real-Time Assessment of Renal Venous Flow by Transesophageal Echography During Cardiac Surgery. A A Pract. 2019 Jan 1;12(1):30-32. doi: 10.1213/XAA.0000000000000841. PMID: 30020109.

Livres

  1. Denault AY, Couture P, Buithieu J, Tardif JC. Transesophageal Echocardiography Manual. Éditions Taylor & Francis, 2005.
  2. Denault AY, Couture P, Vegas, A, Buithieu J, Tardif JC. Transesophageal Echocardiography Manual. Second Edition. Éditions Informa HealthCare, 2011.
  3. Steinmetz P. Denault AY, McAuley D, Rola P. Bedside Ultrasound Level 1. First Edition 2013. A line Press. 20134 (Consultant Editor)
  4. Denault AY, Couture P, Lamarche Y, Tardif JC, Vegas. Basic Transesophageal and Critical Care Ultrasound. First Edition. Éditions RC Press, 2018. (ISBN 978-1-4822-3712-2)

Chapitres de livre

  1. Ducharme A, Pitre C, Denault AY. Online Clinical Ultrasound and Echocardiography Courses. Dilated cardiomyopathies.
    University of Melbourne, Australia 2013
  2. Coté G, Denault A, Desjardins G. Chapter 1 : Patient safety and imaging artefact in Basic Transesophageal and Critical Care Ultrasound. CRC press (Sous presse 2015)
  3. Denault A, Paquin S. Chapter 4 : Extracardiac transesophageal ultrasound examination in Basic Transesophageal and Critical Care Ultrasound. CRC press (Sous presse 2015)
  4. Denault A, Cogan J, Vegas A. Chapter 9 : Basic perioperative hemodynamic assessment in Basic Transesophageal and Critical Care Ultrasound. CRC press (Sous presse 2015)
  5. Roscoe A, Fayad A, Carrier FM, Denault A. Chapter 12 : Special consideration in non-cardiacprocedures in Basic Transesophageal and Critical Care Ultrasound. CRC press (Sous presse 2015)
  6. Denault A, Giard A, Chagnon DO. Chapter 16 : Critical care examination of the abdomen in Basic Transesophageal and Critical Care Ultrasound. CRC press (Sous presse 2015)
  7. Roy L, Huot-Marchand JE, Elmi-Sarabi M, Denault AY, Beaulieu P. Chapitre 12 Pharmacologie vasculaire. Dans Précis de pharmacologie. Beaulieu P. Éditions de l’Université de Montréal, (Sous presse 2015).

Disciplines

  • Anesthesiology
  • Cardiac Surgery

Areas of expertise

  • Cardiovascular System
  • Heart Failure
  • Cardiovascular Diseases