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Health Sciences; Medical Sciences

Casimiro Gerarduzzi

Professeur sous octroi adjoint

Faculté de médecine - Département de médecine

casimiro.gerarduzzi@umontreal.ca

Secondary number: 514 252-3400 #2813 (Travail 1)
Secondary email: csmrgrrdzz@gmail.com (Personnel)

Profile

Research expertise

Ses intérêts se recherche portent sur les mécanismes de signalisation menant à la fibrose rénale, en contexte pré-clinique et clinique, afin d'identifier les marqueurs moléculaires utiles au diagnostic et à la thérapeutique.

Biography

Casimiro Gerarduzzi, Ph.D., est chercheur principal au sein de l’unité de recherche sur la fibrose rénale. Il est également professeur adjoint sous octroi au Département de médecine de l’Université de Montréal. 

Awards and recognitions

  • 2018 - Bourse nouveau chercheur  (KRESCENT)
  • 2018 - Soutien à l’infrastructure  (KRESCENT/IRSC)
  • 2017 - Subvention  (Fondation de l’Hôpital Maisonneuve-Rosemont)
  • 2016 - Innovation Discovery  (Partners HealthCare/Brigham & Women’s Hospital)
  • 2011 - Bourse doctorale  (Université McGill)

Affiliations and responsabilities

Research affiliations

Research units

Membre

Affiliated institutions

  • CIUSSS de l'Est-de-l'Île-de-Montréal – Hôpital Maisonneuve-Rosemont (HMR)

Teaching and supervision

Projects

Research projects

2020 - 2026

Targeting SMOC2-induced epithelial-to-mesenchymal transition inhibits senescence in mouse models of kidney fibrosis

Lead researcher : Casimiro Gerarduzzi
Co-researchers : Frédérick Antoine Mallette
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet
2019 - 2025

Investigating the Dynamic Interplay between the Extracellular Matrix and Cellular Behaviour

Lead researcher : Casimiro Gerarduzzi
Funding sources: CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs: PVXXXXXX-(DGECR) Tremplin vers la découverte
2019 - 2025

Investigating the Dynamic Interplay between the Extracellular Matrix and Cellular Behaviour

Lead researcher : Casimiro Gerarduzzi
Funding sources: CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs: PVX20965-(RGP) Programme de subvention à la découverte individuelle ou de groupe
2019 - 2021

The Role of Matricellular Proteins in Kidney Repair and Development

Lead researcher : Casimiro Gerarduzzi
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXX5664-Bourse salariale pour nouveau chercheur
2019 - 2021

The Role of Matricellular Proteins in Kidney Repair and Development

Lead researcher : Casimiro Gerarduzzi
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXX5664-Bourse salariale pour nouveau chercheur
2018 - 2021

Transitation Grant

Lead researcher : Casimiro Gerarduzzi
Funding sources: COLE Foundation/Fondation Cole
Grant programs:
2018 - 2021

The role of matricellular proteins in kidney repair and development

Lead researcher : Casimiro Gerarduzzi
Funding sources: Fondation de HMR
Grant programs:
2018 - 2021

The role of matricellular proteins in kidney repair and development

Lead researcher : Casimiro Gerarduzzi
Funding sources: KRESCENT Program The Kidney Foundation of Canada
Grant programs:
2018 - 2019

The role of matricellular proteins in kidney repair and development

Lead researcher : Casimiro Gerarduzzi
Funding sources: Fondation canadienne du rein
Grant programs:

Outreach

Publications and presentations

Publications

  • Gerarduzzi, C., Kumar, R., Trivedi, T., Ajay, A., Iyer, A., Boswell, S., Hutchinson, J., Waikar, S., and Vaidya, V.S. Silencing SMOC2 ameliorates kidney fibrosis by inhibiting fibroblast to myofibroblast transformation. 2017. JCI Insight. [Epub ahead of print].
    Plus d'informations

  • Gerarduzzi, C., and Di Battista, J.A. Myofibroblast repair mechanisms post-inflammatory response: A fibrotic perspective. 2017. Inflamm Res. 66:451-465. *Auteur Correspondant
    Plus d'informations

  • Gerarduzzi, C., We, Q., Zhai, B., Antoniou, J., and Di Battista, J.A. Prostaglandin E2-Dependent Phosphorylation of RAS Inhibition 1 (RIN1) at Ser 291 and 292 Inhibits Transforming Growth Factor-β-Induced RAS Activation Pathway in Human Synovial Fibroblasts: Role in Cell Migration. 2017. J Cell Physiol. 232(1):202-15. *Auteur Correspondant
    Plus d'informations

  • de Polo, A., Luo, Z., Gerarduzzi, C., Cheng, X., Little, J., and Yuan, Z.M. AXL receptor signalling suppresses p53 in melanoma through stabilization of the MDMX-MDM2 complex. 2017. J Mol Cell Biol. 9(2):154-165.
    Plus d'informations

  • Trivedi, P., Kumar, R., Iyer, A., Boswell, S., Gerarduzzi, C., Herbert, Z., Joshi, N., Luyendyk, J., and Vaidya, V.S. Targeting Phospholipase D4 Attenuates Kidney Fibrosis. 2017. J Am Soc Nephrol. [Epub ahead of print].
    Plus d'informations

  • Gerarduzzi, C., de Polo, A., Liu, X.S., El Kharbili, M., Little, J., and Yuan, Z.M. Human epidermal growth factor receptor 4 (Her4) Suppresses p53 Protein via Targeting the MDMX-MDM2 Protein Complex: IMPLICATION OF A NOVEL MDMX SER-314 PHOSPHOSITE. 2016. J Biol Chem. 291(50):25937-25949.
    Plus d'informations

  • Liu, X.S., Liu, Z., Gerarduzzi, C., Choi, D.E., Ganapathy, S., Pandolfi, P.P., and Yuan, Z.M. Somatic human ZBTB7A zinc finger mutations promote cancer progression. 2016. Oncogene 35(23):3071-8.

  • Gerarduzzi, C., We, Q., Antoniou, J., and Di Battista, J.A. Prostaglandin E2-Dependent Blockade of Actomyosin and Stress Fiber Formation Is Mediated Through S1379 Phosphorylation of ROCK2. 2014. J Cell Biochem. 115(9):1516-27. *Auteur Correspondant
    Plus d'informations

  • Demoulins, T., Abdallah, A., Kettaf, N., Baron, M.L., Gerarduzzi, C., Gauchat, D., Gratton, S., and Sekaly, RP. Reversible blockade of thymic output: an inherent part of TLR ligand-mediated immune response. 2008. J Immunol. 181:6757-6769.
    Plus d'informations

Disciplines

  • Nephrology
  • Clinical Sciences

Areas of expertise

  • Renal Diseases
  • Renal System
  • Fibrosis
  • Molecular Transportation