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Catherine Larochelle
Interactions lymphocytes-neuroglie en neuroinflammation et neurodégénérescence
- Professeure agrégée de clinique
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Faculté de médecine - Département de neurosciences
Media
Profile
Research expertise
- Mécanismes sous-tendant les interactions entre les lymphocytes T et les oligodendrocytes en sclérose en plaques et dans son modèle animal (EAE);
- Impact du vieillissement du système immunitaire sur la progression et la réponse thérapeutique en sclérose en plaques;
- Modulation de l’évolution clinique et pathologique en neuroinflammation par des interventions ciblant le métabolisme des lymphocytes T;
- Rôle du système immunitaire et des lymphocytes T pro-inflammatoires en épilepsie réfractaire.
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Affiliations and responsabilities
Research affiliations
Affiliated institutions
- Centre hospitalier de l’Université de Montréal (CHUM)
Teaching and supervision
Student supervision
Theses and dissertation supervision (Papyrus Institutional Repository)
Impacts de la diète réduite en méthionine sur l'encéphalomyélite autoimmune expérimentale
Cycle : Master's
Grade : M. Sc.
Th17 cells – oligodendrocytes interactions in multiple sclerosis : damage, death and adhesion mechanisms
Cycle : Doctoral
Grade : Ph. D.
Rôle des lymphocytes Th17 et de l’inflammation dans l’épilepsie réfractaire
Cycle : Doctoral
Grade : Ph. D.
Impact de la restriction diététique en méthionine sur l’activation des lymphocytes T et leur capacité à envahir le SNC en neuroinflammation
Cycle : Master's
Grade : M. Sc.
Projects
Research projects
Neuroinflammation as a biomarker for epilepsy and neuropsychiatric comorbidities among people with tuberous sclerosis complex: a prospective, multicentre study
Manipulating methionine metabolism to shape immune responses and modify disease progression in both sexes in MS
Identifier et cibler des mécanismes immunitaires de dommage neuroglial comme stratégie neuroprotectrice en neuroinflammation
Is cannabis a useful adjunct in the treatment of symptoms of persons with multiple sclerosis? A formal trial of CBD and THC for the control of spasticity and other symptoms: assessing the clinical effects and the basic mechanisms.
Molecular mechanisms underlying T cell/oligodendrocyte interactions as target for neuroprotective strategies in MS
COVID-19 Variant Supplement - Early immune predictors of sustained SARS-CoV-2 antibody responses after COVID-19 disease
Early immune predictors of sustained SARS-CoV-2 antibody responses after COVID-19 disease
Targeting T cell metabolism to reduce neuroinflammation ins MS
Identifier et cibler les mécanismes immunitaires contribuant aux dysfonctions de la neuroglie dans les maladies neuroinflammatoires
Subvention d'établissement de jeune chercheur
Molecular mechanisms underlying T cell/oligodendrocyte interaction as target for neuroprotective strategies in MS
Interaction des processus neuroinflammatoires et neurodégénératifs en maladie chronique du système nerveux central
Interplay between peripheral immune factors and anti-epileptic drugs: tools to predict treatment response in epilepsy
The role of Th17 lymphocytes in drug-refractory epilepsy
Molecular mechanisms underlyin T lymphocytes interactions with oligodendrocytes in neuroinflammation
Fonds de démarrage - CRCHUM
Publications and presentations
Publications
Publications choisies
- Ouedraogo O, Rébillard RM, Jamann H, Mamane VH, Clénet ML, Daigneault A, Lahav B, Uphaus T, Steffen F, Bittner S, Zipp F, Bérubé A, Lapalme-Remis S, Cossette P, Nguyen DK, Arbour N, Keezer MR, Larochelle C. Increased frequency of pro-inflammatory CD4 T cells and pathological levels of serum neurofilament light chain in adult drug-resistant epilepsy. (2020) Epilepsia October 7th 2020;
- Roy, D. G.; Chen, J.; Mamane, V.; Ma, E. H.; Muhire, B. M.; Sheldon, R. D.; Shorstova, T.; Koning, R.; Johnson, R. M.; Esaulova, E.; Williams, K. S.; Hayes, S.; Steadman, M.; Samborska, B.; Swain, A.; Daigneault, A.; Chubukov, V.; Roddy, T. P.; Foulkes, W.; Pospisilik, J. A.; Bourgeois-Daigneault, M. C.; Artyomov, M. N.; Witcher, M.; Krawczyk, C. M.; Larochelle, C.; Jones, R. G. (2020). Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming. Cell Metabolism. 31(2), 250–266.e9;
- Larochelle C, Uphaus T, Broux B, Gowing E, Paterka M, Michel L, Lemaître F, Stankovic D.N, Bicker F, Prat A, Mirko H. Schmidt, Zipp F. (2018). EGFL7 reduces CNS inflammation in mouse. Nat Commun. 9: article number 819 ;
- Larochelle C, Metz I, Lécuyer MA, Terouz S, Roger M, Arbour N, Brück W, Prat A. (2017). Immunological and pathological characterization of fatal rebound MS activity following natalizumab withdrawal. Mult Scler . 23(1): 72-81 ;
- Larochelle C, Uphaus T, Prat A, Zipp F. (2016). Secondary Progression in Multiple Sclerosis: Neuronal Exhaustion or Distinct Pathology? Trends Neurosci. May;39(5):325-339.
Disciplines
- Neurosciences
- General Pathology
- Immunology
Areas of expertise
- Multiple Sclerosis
- Lymphoma
- Neurological Diseases
- Cellular Degeneration
- Neurodegenerative Diseases (Aging)
- Animal
- Immune System
- Gene Therapy (Neurosciences)
- Metabolism
- Pathology
- Convulsive Disorders/ Epilepsy