Health Sciences
Dindial Ramotar
Protéines et réparation des dommages à l’ADN
- Professeur titulaire
-
Faculté de médecine - Département de médecine
Secondary numbers:
514 252-3400 #4684
(Travail 1)
514 252-3430
(Télécopieur)
Profile
Research expertise
Caractérisation structurale et fonctionnelle des protéines d'eucaryotes qui réparent spécifiquement les dommages a l'ADN causés par les especes réactives oxygénées. Domaine: Biochimie - Biologie moléculaire - Génétique. Méthodologie: Fondamentale. Pathologie: Cancers des voies respiratoires.
Affiliations and responsabilities
Research affiliations
Teaching and supervision
Student supervision
Theses and dissertation supervision (Papyrus Institutional Repository)
2018
The yeast Rts1, a subunit of PP2A phosphatase, is involved in stress response
Graduate : Eshrif, Abdelmolez
Cycle : Master's
Grade : M. Sc.
Cycle : Master's
Grade : M. Sc.
2016
L’exploitation d’un modèle de levure présentant une déficience de l’absorption des anthracyclines révèle qu’une protéine de Caenorhabditis elegans, OCT-1, est un transporteur fonctionnel d’anthracyclines
Graduate : Brosseau, Nicolas
Cycle : Master's
Grade : M. Sc.
Cycle : Master's
Grade : M. Sc.
2016
The human organic cation transporter OCT1 mediates high affinity uptake of the anticancer drug daunorubicin
Graduate : Andreev, Emil
Cycle : Master's
Grade : M. Sc.
Cycle : Master's
Grade : M. Sc.
2015
The regulatory roles of APE1 and Prdx1 interaction
Graduate : Wang, Zhiqiang
Cycle : Doctoral
Grade : Ph. D.
Cycle : Doctoral
Grade : Ph. D.
2012
Investigating the role of the isomerase Rrd1/PTPA : from yeast to human
Graduate : Jouvet, Nathalie
Cycle : Doctoral
Grade : Ph. D.
Cycle : Doctoral
Grade : Ph. D.
2012
The overexpression of the efflux pump Tpo1 leads to the bleomycin resistance in Saccharomyces cerevisiae.
Graduate : Berra, Siham
Cycle : Master's
Grade : M. Sc.
Cycle : Master's
Grade : M. Sc.
2010
The in vivo characterization of the DNA repair gene apn-1 in the model organism Caenorhabditis elegans
Graduate : Zakaria, Chadi
Cycle : Master's
Grade : M. Sc.
Cycle : Master's
Grade : M. Sc.
2010
The role of the peptidyl prolyl isomerase Rrd1 in the transcriptional stress response
Graduate : Poschmann, Jeremie
Cycle : Doctoral
Grade : Ph. D.
Cycle : Doctoral
Grade : Ph. D.
2010
The role of GAPDH in maintaining the functional state of the DNA repair enzyme APE1
Graduate : Ayoub, Emily
Cycle : Master's
Grade : M. Sc.
Cycle : Master's
Grade : M. Sc.
2010
The Na+/H+ exchanger Nhx1 of Saccharomyces cerevisiae is essential to limit drug toxicity
Graduate : Khodami-Pour, Ali
Cycle : Master's
Grade : M. Sc.
Cycle : Master's
Grade : M. Sc.
2009
Deletion of the RNR4 gene causes hyperresistance to the carcinogen 4-NQO in the yeast model
Graduate : Bulet, Lisa
Cycle : Master's
Grade : M. Sc.
Cycle : Master's
Grade : M. Sc.
2008
Characterization of the AP endonuclease enzyme APN-1 from C. elegans
Graduate : Patel, Devang
Cycle : Master's
Grade : M. Sc.
Cycle : Master's
Grade : M. Sc.
2007
Étude du rôle biologique de l'activateur de phosphatase Rrd 1 chez la levure Saccharomyces cerevisiae
Graduate : Douville, Julie
Cycle : Doctoral
Grade : Ph. D.
Cycle : Doctoral
Grade : Ph. D.
2007
The biological importance of apurinic/apyrimidinic endonucleases in the maintenance of genetic stability
Graduate : Vongsamphanh, Ratsavarinh
Cycle : Doctoral
Grade : Ph. D.
Cycle : Doctoral
Grade : Ph. D.
2006
The function of the Saccharomyces Cerevisiae ribonucleotide reductase second [beta] subunit in DNA repair
Graduate : Zhao, Chunyu
Cycle : Master's
Grade : M. Sc.
Cycle : Master's
Grade : M. Sc.
2006
Taf14 : un cofacteur de transcription impliqué dans l'activation de la transcription de Imp2 : un gène nécessaire pour la résistance à la bléomycine chez la levure Saccharomyces cerevisiae
Graduate : Aoulad Aissa, Mohamed
Cycle : Master's
Grade : M. Sc.
Cycle : Master's
Grade : M. Sc.
2005
Genetically engineering the mouse genome to study the role of the Phosphotyrosyl Phosphatase Activator (PTPA) gene in the response to oxidative stress
Graduate : Sabbah, Cyril
Cycle : Master's
Grade : M. Sc.
Cycle : Master's
Grade : M. Sc.
2002
Mécanismes de résistance cellulaires de Saccharomyces cerevisiae face à la bléomycine, un agent antitumoral : implication du gène IMP2
Graduate : Leduc, Anick
Cycle : Master's
Grade : M. Sc.
Cycle : Master's
Grade : M. Sc.
2002
Iip1, une protéine possédant un motif F-box, est impliquée dans le maintien de la stabilité des mitochondries
Graduate : Fortier, Pierre-Karl
Cycle : Master's
Grade : M. Sc.
Cycle : Master's
Grade : M. Sc.
2001
Identification of a protein required to target the DNA repair enzyme Apn1 into yeast mitochondria
Graduate : Vongsamphanh, Ratsavarinh
Cycle : Master's
Grade : M. Sc.
Cycle : Master's
Grade : M. Sc.
2000
YPtpa1p, une protéine impliquée dans la résistance aux dommages oxydatifs interagit avec un membre de la famille des chaperones DnaJ
Graduate : Brodeur, Isabelle
Cycle : Master's
Grade : M. Sc.
Cycle : Master's
Grade : M. Sc.
Projects
Research projects
2017
- 2023
Role of C. elegans AP endonuclease, APN1,in removing DNA lesions generated through transportermediated uptake of naturally occurring toxic compounds.
Lead researcher :
Dindial Ramotar
Funding sources:
CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs:
PVX20965-(RGP) Programme de subvention à la découverte individuelle ou de groupe
2017
- 2022
Linking defects in the uptake transporter OCT1 with cancer patients resistance towards anthracyclines
Lead researcher :
Dindial Ramotar
Funding sources:
IRSC/Instituts de recherche en santé du Canada
Grant programs:
PVXXXXXX-(PJT) Subvention Projet
2016
- 2018
A microcalorimetry system to define the biochemical parameters of molecular interactions
Lead researcher :
El Bachir Affar
Co-researchers :
Janos G. Filep
,
Puttaswamy Manjunath
,
Dindial Ramotar
,
Éric Milot
,
Przemyslaw (Mike) Sapieha
,
Sylvie Lesage
,
Jean-Sébastien Delisle
,
Frédérick Antoine Mallette
,
Hugo Wurtele
Funding sources:
CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs:
PVXXXXXX-(OIR) Outils et d'instruments de recherche (de 7 001 $ à 150 000 $)
2012
- 2018
BIOLOGICAL FUNCTION OF THE DNA REPAIR ENZYME APN-1 IN C.ELEGANS
Lead researcher :
Dindial Ramotar
Funding sources:
CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs:
PVX20965-(RGP) Programme de subvention à la découverte individuelle ou de groupe
2012
- 2017
THE ROLE OF HUMAN GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE IN MAINTAINING THE REDOX STATE OF THE DNA REPAIR ENZYME APE1
Lead researcher :
Dindial Ramotar
Funding sources:
IRSC/Instituts de recherche en santé du Canada
Grant programs:
PVXX5647-(MOP) Subvention de fonctionnement incluant les subventions de fonctionnement programmatiques (général)
2008
- 2011
THE ROLE OF HUMAN GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE IN REACTIVATING OXIDIZED FORMS OF THE DNA REPAI ENZYME APE1
Lead researcher :
Dindial Ramotar
Outreach
Publications and presentations
Disciplines
- Molecular Biology
- Oncology
Areas of expertise
- Apoptosis and Cancer
- Cancer of the Musculoskeletal System
- Cancer of the Reproductive System
- Skin Cancer
- Prostate Cancer
- Head and Neck Cancer
- Cancer of the Digestive System
- Cancer of the Urinary System
- Lung Cancer
- Leukemia
- Breast Cancer
- Hereditary Cancer
- Hormone Dependent Cancers
- Carcinogenesis
- Cell
- Combinatorial Chemistry
- Chemotherapy
- Chromosome (Living Organisms)
- Inorganic and Organometallic Compounds
- Cancer Diagnosis and Detection
- Cellular Differentiation
- Cellular Division
- Environment and Cancer
- Growth Factors (Cancer)
- Gene (Living Organisms)
- Suppressor Gene
- Cancer Genetics
- Host-Tumour Interaction
- Lymphoma
- Macromolecules
- Metals and Nonmetals
- Organic Molecules and Biomolecules
- Nutrition and Cancer
- Oncogenes
- Quantum Phenomena
- Radiotherapy
- Cell Signaling and Cancer
- Stress and Cancer
- Chemical Synthesis and Catalysis
- Smoking and Cancer
- Cell Therapy of Cancer
- Gene Therapy of Cancer
- Cerebral Tumors
- Retinal and Ocular Neoplasms
- Vaccine and Cancer
- Life and Economic Production