Les activités de recherche du laboratoire de pharmacologie analytique du Pr Francis Beaudry concernent les axes suivants  :

1. Neurochimie de la douleur et de la nociception à l'aide d'organismes modèles (ex. C. elegans) etde la spectrométrie de masse.
2. Découverte de nouvelles cibles thérapeutiques.
3. Développement de nouvelles stratégies thérapeutiques pour le traitement de la douleur et de la maladie de Parkinson.
4. Étude de la pharmacocinétique et le métabolisme de médicaments utilisés pour le traitement de la douleur et de la maladie de Parkinson.

Le Pr Francis Beaudry est professeur à la Faculté de médecine vétérinaire de l’Université de Montréal (UdeM) et titulaire de la Chaire de recherche du Canada de niveau 1 en métrologie des molécules bioactives et découverte de cibles. Ses travaux portent sur la pharmacologie de la douleur, la neurochimie de la transmission de la douleur, la protéomique et la spectrométrie de masse. Son équipe excelle dans l’utilisation de stratégies analytiques de pointe en protéomique et métabolomique ainsi que dans les expérimentations pharmacologiques animales, afin de relier les phénotypes aux protéotypes et identifier les signatures pathologiques et développer des stratégies thérapeutiques. Auteur de 166 articles évalués par les pairs et de 153 résumés, son h-index est de 39 (Google Scholar, 29 avril 2025). Il a supervisé ou co-supervisé 49 étudiants aux cycles supérieurs. Son programme de recherche contribue significativement à la formation d’une relève hautement qualifiée dans des domaines de pointe, essentiels pour le milieu académique et biomédical canadien.

• Membre de l'Ordre des chimistes du Québec

Publications (2022-2025)

J.D. Castano and F. Beaudry (2025). Optimization of protein identifications through the use of different chromatographic approaches and multiple search engines. Rapid Communications in Mass Spectrometry. 2025;39:e9937. https://doi.org/10.1002/rcm.993

J. Castaño and F. Beaudry (2025). Comparative Analysis of Data-Driven Rescoring Platforms for Improved Peptide Identification in HeLa Digest Samples. PROTEOMICS. 0:e202400225. https://doi.org/10.1002/pmic.202400225

J. Shaqfah, W. Kang, F. Gaudette, M. Khalil, C. Kwan, S. Belliveau, É. Bourgeois-Cayer, A. Hamadjida, D. Bédard, F. Beaudry and P. Huot (2025). The anti-dyskinetic effect of the clinic-ready mGluR2 positive allosteric modulator AZD8529 in the 6-OHDA-lesioned rat. Naunyn-Schmiedeberg's Archives of Pharmacology. https://doi.org/10.1007/s00210-024-03627-1

KC Lister, C Wong, S Uttam, M Parisien, P Stecum, N Brown, W Cai, M Hooshmandi, N Gu, M Amiri, F Beaudry, S M Jafarnejad, D Tavares-Ferreira, N N Inturi, K Mazhar, H T Zhao, B Fitzsimmons, Ch G Gkogkas, N Sonenberg, T J Price, L Diatchenko, Y Atlasi, J S Mogil, A Khoutorsky (2024),Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain. eLife 13:RP100451. https://doi.org/10.7554/eLife.100451.1

J. Pelletier, C. Bouchard, C. Aenishaenslin, F. Beaudry, N. H. Ogden, P. A. Leighton and J.-P. Rocheleau (2024). Pharmacological studies and pharmacokinetic modelling to support the development of interventions targeting ecological reservoirs of Lyme disease. Scientific Reports. 14, Article number: 13537. https://doi.org/10.1038/s41598-024-63799-x. 

F. Boujenoui, J. Ben Salem, B. Nkambeu, J.D. Castano Uruena and F. Beaudry (2024). Cannabidiol and Tetrahydrocannabinol Antinociceptive Activity is Mediated by Distinct Receptors in Caenorhabditis elegans. Neurochemical Research. 49(4):935-948.

E. Alpizar-Sosa, F. Zimbres, B. Suárez Mantilla, E. Dickie, W. Wei, G. Burle-Caldas, L. Filipe, K. van Bocxlaer, H. Price, A. Meneses, F. Beaudry, C. Fernandez-Prada, P. Whiltfield, M. Barrett, P. Denny (2024). Evaluation of the Leishmania inositol phosphorylceramide synthase as a drug target using a chemical and genetic approach. ACS Infectious Diseases. 10(8):2913-2928. https://doi.org/10.1021/acsinfecdis.4c00284

 M. Abdollahi, J. Ben Salem, J.D. Castano Uruena and F. Beaudry (2024). Anandamide Modulates Thermal Avoidance in Caenorhabditis elegans through Vanilloid and Cannabinoid Receptor Interplay. Neurochemical Research, 49; 2423–2439. https://doi.org/10.1007/s11064-024-04186-w

C. Otis, KA Cristofanilli, M. Frezier, A. Delsart, J. Martel-Pelletier, JP. Pelletier, F. Beaudry, B. Lussier, A. Boyer and E. Troncy (2024). Predictive and concurrent validity of pain sensitivity phenotype, neuropeptidomics and neuroepigenetics in the MI-RAT osteoarthritic surgical model in rats. Frontiers in Cell and Developmental Biology. 12:1400650. 

L. Bernardo, A. Victoria Ibarra-Meneses, N. Douannec, A. Corbeil, J. Carlos Solana, F. Beaudry, E. Carrilloa, J. Morenoa and C. Fernandez-Prada (2024). Potential selection of antimony and methotrexate cross-resistance in Leishmania infantum circulating strains. PLOS Neglected Tropical Diseases. 18 (2), e0012015

M. Lahaise, F. Boujenoui and F. Beaudry (2024). Cannflavins Isolated from Cannabis sativa Impede Caenorhabditis elegansResponse to Noxious Heat. Naunyn-Schmiedeberg's Archives of Pharmacology. 397(1); 535-548 https://doi.org/10.1007/s00210-023-02621-3

G. Millette, E. Lacasse, R. Binette, V. Belley, L-P. Chaumont, C. Ster, F. Beaudry, K. Boyapelly, P-L. Boudreault, F. Malouin (2023). Rationally Designed Pyrimidine Compounds: Promising Novel Antibiotics for the Treatment of Staphylococcus aureus-Associated Bovine Mastitis. Antibiotics. 12(8), 1344. https://doi.org/10.3390/ antibiotics12081344

C. Otis, E. Bouet, S. Keita-Alassane, M. Frezier, A. Delsart, M. Guillot, A. Bédard, J-P. Pelletier, J. Martel-Pelletier, B. Lussier, F. Beaudry and E. Troncy. Face and Predictive Validity of MI-RAT (Montreal Induction of Rat Arthritis Testing), a Surgical Model of Osteoarthritis Pain in Rodents Combined with Calibrated Exercise. International Journal of Molecular Sciences. 2023; 24(22):16341. https://doi.org/10.3390/ijms242216341

J. Pujol, C. Vergneau-Grosset, F. Beaudry, F. Gaudette, A. Vigneault and I-C. Cruz Benedetti (2023). Pharmacokinetics and innocuity of a single dose of intravenous, intramuscular and subcutaneous methadone in domestic rabbit, Journal of Exotic Pet Medicine. 47, 41-46

M. I. Atmane, A-L. Vigneau, F. Beaudry, C. Rico, D. Boerboom, M. Paquet (2023). Therapeutic trial of fluvastatin in a cell line xenograft model of canine mammary gland cancer. Veterinary and Comparative Oncology. 21:634–645. https://doi.org/10.1111/vco.12926

W. Kang, S.G. Nuara, D. Bédard, I. Frouni, C. Kwan, A. Hamadjida, J.C. Gourdon, F. Gaudette, F. Beaudry and P. Huot (2023). The mGluR_2/3 orthosteric agonist LY-404,039 reduces dyskinesia, psychosis-like behaviours and parkinsonism in the MPTP-lesioned marmoset. Naunyn Schmiedebergs Arch Pharmacol. doi: 10.1007/s00210-023-02587-2

A. Zareifard, F. Beaudry, K. Ndiaye (2023). Janus Kinase 3 phosphorylation and the JAK/STAT pathway are positively modulated by follicle- stimulating hormone (FSH) in bovine granulosa cells. BMC Molecular and Cell Biology 24 (1), 1-19

I. Frouni, D.Bédard, É. Bourgeois-Cayer, A. Hamadjida, F. Gaudette, F. Beaudry and P. Huot (2023). Pharmacokinetic profile of bitopertin, a selective GlyT1 inhibitor, in the rat. Naunyn-Schmiedeberg's Archives of Pharmacology. 396:1053–1060

 W. Bo Sam Zhou, X. Qun Shi, Y. Liu, S. D. Tran, F. Beaudry and J. Zhang (2023). Unbiased proteomic analysis detects painful systemic inflammatory profile in the serum of nerve injured mice. Pain. 1;164(2):e77-e90.

M. Abdollahi, PA Segura and F. Beaudry (2023). Is non-targeted data acquisition for target analysis (nDATA) in mass spectrometry a forward-thinking analytical approach? Biomedical Chromatography. 37(7):e5531. doi: 10.1002/bmc.5531

B. Nkambeu, J. Ben Salem and F. Beaudry (2023). Antinociceptive Activity of Vanilloids in Caenorhabditis elegans is Mediated by the Desensitization of the TRPV Channel OCR-2 and Specific Signal Transduction Pathways. Neurochemical Research. 48(6): 1900-1911. https://doi.org/10.1007/s11064-023-03876-1

S. Mainguy-Seers, F. Beaudry, C. Fernandez Prada, J. G. Martin and J-P. Lavoie (2022). Neutrophilic extracellular vesicles and airway smooth muscle proliferation in the natural model of severe asthma in horses. Cells. 11(21):3347

P. Segura, C. Guillaumin, E. Eysseric, J. Boudrias, M. Moreau, C. Guérette, R. Clementin and F. Beaudry (2022). Ultra-fast analysis of peptides by laser diode thermal desorption-triple quadrupole mass spectrometry. Rapid Communications in Mass spectrometry. e9373. https://doi.org/10.1002/rcm.9373

A. Victoria Ibarra-Meneses, V. Wagner, A. Corbeil, F. Beaudry, R. L. do Monte-Neto and C. Fernandez-Prada (2022). Exploring direct and indirect targets of current antileishmanial drugs using a novel thermal proteomics profiling approach. Frontiers in Cellular and Infection Microbiology. 12:954144. doi: 10.3389/fcimb.2022.954144. 

J. Ben Salem, J. S. Iacovoni, D. Calise, D. N. Arvanitis, F. Beaudry (2022). Proteomics reveals long-term alterations in signaling and metabolic pathways following both myocardial infarction and chemically induced denervation. Neurochemical Research. 47(8):2416-2430  https://doi.org/10.1007/s11064-022-03636-7

S. Keita-Alassane, C. Otis, E. Bouet, M. Guillot, M. Frezier, A. Delsart, M. Moreau, A. Bédard, I. Gaumond, J-P Pelletier, J. Martel-Pelletier, F. Beaudry, B. Lussier, R. Lecomte, S. Marchand, E. Troncy (2022). Estrogenic impregnation alters pain expression: Analysis through functional neuropeptidomics in a surgical rat model of osteoarthritis. Naunyn-Schmiedeberg’s Archives of Pharmacology. 395(6):703-715 https://doi.org/10.1007/s00210-022-02231-5

W. Kang, F. Gaudette, D. Bédard, F. Beaudry and P. Huot (2022). Quantitative determination of LY-404,039, a metabotropic glutamate 2/3 receptor agonist, in rat plasma by high performance liquid chromatography tandem mass spectrometry. Biomedical Chromatography. 9:e5423. Doi: 10.1002/bmc.5423

A.F. Salmin, M.J. Pesant, Y. Burgher, C. Provost, J. Labrie, M. Jacques, C. A. Gagnon and F. Beaudry (2022). Untargeted and targeted metabolomics reveal that adenosine nucleotides released in Actinobacillus pleuropneumoniae supernatant inhibit porcine reproductive and respiratory syndrome virus replication. Talanta. 242 :123315https://doi.org/10.1016/j.talanta.2022.123315

S. Mainguy-Seers, R. Boivin, S. Pourali Dogaheh, F. Beaudry, P. Hélie, A. G. Bonilla, J. G. Martin, J- Lavoie (2022). Effects of azithromycin on bronchial remodeling in the natural model of severe neutrophilic asthma in horses. Scientific Reports, 12, Article number: 446 

J. Ben Salem, B. Nkambeu, D. Arvanitis and F. Beaudry (2022). Resiniferatoxin hampers the nocifensive response of Caenorhabditis elegans to noxious heat, and pathway analysis revealed that the Wnt signaling pathway is involved. Neurochemical Research. 47:622–633. https://doi.org/10.1007/s11064-021-03471-2

K. O’Dowd, L. Sánchez, J. Ben Salem, F. Beaudry and N. Barjesteh (2021). Characterization of the Role of Extracellular Vesicles Released from Chicken Tracheal Cells in the Antiviral Responses against Avian Influenza Virus. Membranes. 12, 53 https://doi.org/10.3390/ membranes12010053