Les travaux de recherche du Dr Séguin portent surtout sur les aspects cognitifs et émotifs du développement de la santé mentale, tout en examinant les facteurs de risque et de protection d'abus de substances et de problèmes de santé cardiovasculaire. Sa formation de clinicien lui permet de travailler tant au niveau des schémas cognitifs qu'avec des modèles de traitement de l'information et des fonctions cérébrales sous-jacentes. Ses travaux de doctorat (Université McGill, 1995) portaient essentiellement sur les aspects neuropsychologiques de l'agression physique. Les travaux subséquents ont élargi la base conceptuelle de ses recherches pour inclure l'hyperactivité, les autres troubles extériorisés, les troubles intériorisés, et le développement cognitif. Une étude longitudinale débutant à la naissance lui a permis d'examiner les premières années du développement des troubles extériorisés et autres troubles de l'autorégulation du point de vue du développement cognitif. De nouvelles études comportent des observations dès la grossesse. Une des hypothèses importantes de ces travaux propose que les troubles d'adaptation ne sont pas tant le résultat de l'apprentissage qu'un échec de l'apprentissage de l'autorégulation. L'autorégulation serait donc acquise en cours de développement. La recherche porte sur les bases physiologiques, génétiques et environnementales de cet apprentissage. L'autorégulation vient-elle de prédispositions génétiques, d'événements périnataux? Réside-t-elle plutôt dans les pratiques parentales,  les environnements scolaires, et les pairs? L'enfant fait-il face à des défis intellectuels, voire neuropsychologiques? Le tempérament de l'enfant joue-t-il un rôle? Ces facteurs sont-ils combinés entre eux? Dans quels contextes les défis et ressources se manifestent-ils? Quelle est la spécificité de la correspondance de l'autorégulation à la santé mentale? Est-ce que des interventions précoces visant à soutenir les parents, les enfants, ou les intervenants peuvent avoir un impact sur le développement de l'auto-régulation?

1. **Gauchat, A., Zadra, A., **El Hourani, M., Parent, S., Renaud, J., Tremblay, R.E., & Séguin, J.R. (2021). Association between recurrent dreams, disturbing dreams and suicidal ideation in adolescents. Dreaming
2. *London-Nadeau, K., Rioux, C., Vitaro, F., Côté, S.M., Boivin, M., Tremblay, R.E., Séguin, J.R., Castellanos-Ryan, N. (2021). Longitudinal associations of cannabis, depression and anxiety in heterosexual and LGB adolescents. Journal of Abnormal Psychology.
3. Cox, S.M.L., Castellanos-Ryan, N., Parent, S., Benkelfat, C., Vitaro, F., Pihl, R.O., Boivin, M., Tremblay, R.E., Leyton, M., Séguin, J.R. (2021). Externalizing risk pathways for adolescent substance use and its developmental onset: A Canadian birth cohort study. Canadian Journal of Psychiatry.
4. *Suffren, S., *La Buissonière-Ariza, V., Tucholka, A., Nassim, M., Séguin, J.R., Boivin, M., Singh, M.K., Foland-Ross, L.R., Lepore, F., Gotlib, I.H., Tremblay, R.E., Maheu, F.S. (2021). Prefrontal cortex and amygdala anatomy in youth with persistent levels of harsh parenting practices and subclinical anxiety symptoms over time during childhood. Development and Psychopathology.
5. *Azar, N., Booij, L., Muckle, G., Arbuckle, T.E., Séguin, J.R., Asztalos, E., Fraser, W.D., Lanphear, B.P., Bouchard, M.F. (2021). Prenatal Exposure to Polybrominated Diphenyl Ethers (PBDEs) and Cognitive Ability in Early Childhood. Environment International, 146 https://doi.org/10.1016/j.envint.2020.106296
6. **Gauchat, A., Zadra, A., **El Hourani, M., Parent, S., Tremblay, R.E., and Séguin, J.R. (2020). The relation between disturbing dreams and psychosocial maladjustment in children: A prospective study of the moderating role of early negative emotionality. Frontiers in Neurology, 11:762, 1-11. https://www.frontiersin.org/articles/10.3389/fneur.2020.00762/
7. Cox, S.M.L., Tippler, M., *Jaworska, N., Smart, K., Castellanos-Ryan, N., Durand, F., Allard, D., Benkelfat, C., Parent, S., Dagher, A., Vitaro, F., Boivin, M., Pihl, R.O., Côté, S.M., Tremblay, R.E., Séguin, J.R., Leyton, M. (2020). mGlu5 receptor availability in youth at risk for addictions: Effects of vulnerability traits and cannabis use. Neuropsychopharmacology. https://www.nature.com/articles/s41386-020-0708-x.pdf
8. *Orri, M., Séguin, J. R., Castellanos-Ryan, N., Tremblay, R. E., Côté, S. M., Turecki, G., Geoffroy, M.-C. (2020). A genetically informed study on the association of cannabis, alcohol, and tobacco smoking with suicide attempt. Molecular Psychiatry. https://doi.org/10.1038/s41380-020-0785-6
9. *Orri, M., *Scardera, S., *Perret, L.C., **Bolanis, D., Temcheff, C., Séguin, J.R., Boivin, M., Turecki, G., Tremblay, R.E., Côté, S.M., Geoffroy, M.C. (2020). Mental health problems and risk of suicidal ideation and attempts in adolescents. Pediatrics, 146(1), e20193823. https://doi.org/10.1542/peds.2019-3823
10. *Jaworska, N., Cox, S.M.L., Tippler, M., Castellanos-Ryan, N., Benkelfat, C., Parent, S., Dagher, A., Vitaro, F., Boivin, M., Pihl, R.O., Côté, S.M., Tremblay, R.E., Séguin, J.R., Leyton, M. (2020). Extra-striatal D2/3 receptor availability in youth at risk for addiction. Neuropsychopharmacology, 45(9), 1498-1505. https://www.nature.com/articles/s41386-020-0662-7
11. **Bolanis, D., Orri, M., Castellanos-Ryan, N., Renaud, J., Montreuil, T., Boivin, M., Vitaro, F., Tremblay, R.E., Turecki, G., Côté, S.M., Séguin, J.R., Geoffroy, M.C. (2020). Cannabis use, depression and suicidal ideation in Canadian adolescents: Comorbidity and direction of associations. Journal of Affective Disorders, 274, 1076-1083. https://doi.org/10.1016/j.jad.2020.05.136.
12. *Afzali, M. H., Stewart, S. H., Séguin, J. R., & Conrod, P. J. (2020). The network constellation of personality and substance use: Evolution from early to late adolescence. European Journal of Personality. https://doi.org/10.1002/per.2245
13. Oulhote, Y., Lanphear, B., Braun, J.M., Webster, G.M., Arbuckle, T.E., Etzel, T., Forget-Dubois, N., Séguin, J.R., Bouchard, M.F., MacFarlane, A., Ouellet, E., Fraser, W.D., Muckle, G. (2020). Gestational exposures to phthalates and folic acid, and autistic traits in Canadian children. Environmental Health Perspectives, 128, 2, https://ehp.niehs.nih.gov/doi/10.1289/EHP5621.
14. *Paquin, C., Côté, S.M., Tremblay, R.E., Séguin, J.R., Boivin, M., Herba, C.M. (2020). Maternal depressive symptoms and children’s cognitive development: Does early childcare and child’s sex matter? PLoS One, 15, e0227179. https://doi.org/10.1371/journal.pone.0227179.
15. Krzeczkowski, J. E., Boylan, K., Arbuckle, T. E., Muckle, G., Poliakova, N., Séguin, J. R., Favotto, L.A., Savoy, C., Amani, B., Mortaji, N.; Van Lieshout, R.J. (2020). Maternal pregnancy diet quality is directly associated with autonomic nervous system function in 6-month-old offspring. The Journal of Nutrition, 150, 267-275 https://doi.org/10.1093/jn/nxz228
16. *Paquin, C., Castellanos-Ryan, N., Vitaro, F., Côté, S.M., Tremblay, R.E., Séguin, J.R., Boivin, M., Herba, C.M. (2020). Maternal depression symptoms, child behavior problems and their transactional relations: Probing the role of formal childcare. Development and Psychopathology, 32(3), 831-844. https://doi.org/10.1017/S0954579419000956
17. *Charrois, J., Côté, S.M., Paquin, S., Séguin, J.R., Japel, C., Vitaro, F., Kim-Cohen, J., Tremblay, R.E., Herba, C.M. (2019). Maternal depression in early childhood and child emotional and behavioral outcomes at school-age: Examining the roles of preschool childcare quality and current maternal depression symptomatology. European Child and Adolescent Psychiatry, 29(5), 637-648. https://link.springer.com/article/10.1007%2Fs00787-019-01385-7
18. Rioux,C., *Murray,J., Castellanos-Ryan,N., Séguin,J.R., Tremblay,R.E., Parent,S. (2020). Moderation of parenting by inhibitory control in the prediction of the common and unique variance of hyperactivity-impulsivity and inattention. Development and Psychopathology, 32(3), 909-921. https://doi.org/10.1017/S0954579419000774
19. Arbuckle, T.E., MacPherson, S., Barrett, E., Muckle, G., Séguin, J.R., Foster, W.G., Sathyanarayana, S., Dodds, L., Fisher, M., Agarwal, A., Monnier, P., Walker, M., Fraser, W.D. (2019). Do stressful life events during pregnancy modify associations between phthalates and anogenital distance in newborns? Environmental Research, 177, 108593. http://www.sciencedirect.com/science/article/pii/S0013935119303901, https://doi.org/10.1016/j.envres.2019.108593
20. *La Buissonnière-Ariza V., Séguin, J.R., Nassim, M., Boivin, M., Pine, D.S., Lepore, F., Tremblay, R.E., Maheu, F.S. (2019). Chronic Harsh Parenting and Anxiety Associations with Fear Circuitry Function in Healthy Adolescents: A Preliminary Study. Biological Psychology, 145, 198-210. http://www.sciencedirect.com/science/article/pii/S0301051118301248 https://doi.org/10.1016/j.biopsycho.2019.03.019
21. *Gorin, H. M., Kosson, D. S., Miller, S. A., Fontaine, N. M. G., Vitaro, F., Séguin, J. R., Boivin, M., Côté, S. & Tremblay, R. E. (2019). Psychopathic Traits in Middle Childhood: Evidence of a Hierarchical Three-Factor Structure. Journal of Psychopathology and Behavioral Assessment, 41, 341-352. https://doi.org/10.1007/s10862-019-09733-2
22. *Farooqi, N. A. I., *Scotti, M., Yu, A., Lew, J., Monnier, P., Botteron, K. N., Campbell, B.C., Booij, L., Herba, C.M., Séguin, J.R., Castellanos-Ryan, N., McCracken, J.T., Nguyen, T.V. (2019). Sex-specific contribution of DHEA-cortisol ratio to prefrontal-hippocampal structural development, cognitive abilities and personality traits. Journal of Neuroendocrinology, 31, e12682. https://doi.org/10.1111/jne.12682
23. *Smart, K., Cox, S. M. L., Kostikov, A., Shalai, A., Scala, S. G., Tippler, M., *Jaworska, N., Boivin, M., Séguin, J. R., Benkelfat, C., Leyton, M. (2019). Effect of (z)-isomer content on [¹¹C]ABP688 binding potential in humans. European Journal of Nuclear Medicine and Molecular Imaging, 46 (5), 1175-1178. https://link.springer.com/article/10.1007/s00259-018-4237-3
24. *Smart, K., Cox, S. M. L., Scala, S. G., Tippler, M., *Jaworska, N., Boivin, M., Séguin, J. R., Benkelfat, C., Leyton, M. (2019). Sex differences in [¹¹C]ABP688 Binding A positron emission tomography study of mGlu5 receptors. European Journal of Nuclear Medicine and Molecular Imaging, 46 (5), 1179-1183. https://link.springer.com/article/10.1007/s00259-018-4252-4
25. *Afzali, M. H., Sunderland, M., Stewart, S. H., Mâsse, B., Séguin, J. R., Newton, N., Teeson, M., Conrod, P. J. (2019). Machine-learning prediction of adolescent alcohol use: A cross-study, cross-cultural validation. Addiction, 114(4), 662-671. https://onlinelibrary.wiley.com/doi/epdf/10.1111/add.14504
26. **Rioux, C., Castellanos-Ryan, N. Vitaro, F., Séguin, J.R. (2019). The interactive effects of parental knowledge with impulsivity and sensation seeking in adolescent substance use. Child Psychiatry and Human Development, 50, 95-107. https://link.springer.com/article/10.1007/s10578-018-0825-5
27. **Rioux, C., & Séguin, J. R. (2019). Commentary on Otten et al. (2019): Moderators and person-environment interactions in developmental cascade models. Addiction, 114(2), 335-336.
28. *Sharkey, R.J., *Bourque, J, Larcher, K., Misic, B., Zhang, Y., Altinkaya, A., Sadikot, A., Conrod, P.J., Evans, A.C., Garavan, H., Leyton, M., Séguin, J.R., Pihl, R.O., Dagher, A. (2019). Early adolescent striatal and midbrain resting state connectivity correlate with impulsivity, sensation-seeking, and body weight. Appetite, 132, 25-36. https://www.sciencedirect.com/science/article/pii/S0195666318306184?via%3Dihub
29. Li, N., Arbuckle, T.E., Muckle, G., Lanphear, B.P., Boivin, M., Chen, A., Dodds, L., Fraser, W.D., Ouellet, E., Séguin, J.R., Vélez, M.P., Yolton, K., Braun, J.M. (2019). Associations of cord blood leptin and adiponectin with children’s cognitive abilities. Psychoneuroendocrinology, 99, 257-264. https://www.sciencedirect.com/science/article/pii/S0306453018308187?via%3Dihub https://doi.org/10.1016/j.psyneuen.2018.10.021
30. Parent, S., Lupien, S., Herba, C., Dupéré, V., Gunnar, M., and Séguin, J.R. (2019). Children’s cortisol response to the transition from preschool to formal schooling: A review. Psychoneuroendocrinology, 99, 196-205. https://doi.org/10.1016/j.psyneuen.2018.09.013.
31. *Morin, J.-F. G., *Afzali, M. H., *Bourque, J., Stewart, S. H., Séguin, J. R., *O'Leary-Barrett, M. & Conrod, P. J. (2019) A population-based analysis of the relationship between substance use and adolescent cognitive development. American Journal of Psychiatry, 176, 98-106. https://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2018.18020202#
32. **Rioux, C., Séguin, J.R., Paris, J. (2018). Perspective: Differential susceptibility to the environment and Borderline Personality Disorder. Harvard Psychiatry Review, 26(6), 374-383. https://doi.org/10.1097/HRP.0000000000000182.
33. Etzel, T., Muckle, G., Arbuckle, T. E., Fraser, W. D., Ouellet, E., Séguin, J. R., Lanphear, B., Braun, J.M. (2018). Prenatal urinary triclosan concentrations and child neurobehavior. Environment International, 114, 152-159. https://www.sciencedirect.com/science/article/pii/S0160412017319979