Martin Gerbert Frasch
Prématurité et neurodéveloppement
Profile
Research expertise
- Antenatal brain development under normal and stress conditions. Focus on autonomic nervous system responses to inflammation (fetal neuroimmunology).
- Fetal cholinergic anti-inflammatory pathway;
- Monitoring fetal and neonatal well-being using computer-aided EEG and ECG (HRV) analyses;
- Postnatal consequences of prenatal stress (fetal programming of adult diseases).
- I am also interested in how methods derived from the theory of nonlinear dynamics can be used to estimate neuronal complexity and to improve prediction of the physiological and pathophysiological behavior mentioned above.
Biography
Postdoctoral Fellow
Department of Obstetrics and Gynaecology, Children Health Research Institute, Lawson Health Research Institute, University of Western Ontario, Canada, 2009.
Research Topics and Interests
Effects of chronic hypoxia without progressive acidemia as might be seen in the human fetus antenatally on brain development and inflammatory response; Effects of acute hypoxia with progressive acidemia as might be seen during labor on fetal electrical brain activity (ECoG, EEG) and systemic and brain inflammatory responses; Developmental changes in fetal electrocortical activity (sleep states) due to chronic hypoxia in the last pregnancy trimester.
Residency and Research
Department of Neurology, School of Medicine, Friedrich Schiller University, Jena, Germany. Research on fetal asphyxia and programming of adult diseases (Principal Investigator: Matthias Schwab, Prof. Dr. med. habil.), 2006.
Research Topics and Interests
Acute and chronic effects of hypoxia with and without acute or long-term effects of betamethasone administration on fetal heart rate variability as well as fetal electrical spontaneous (ECoG) and evoked (SEP, AEP) brain activity and cerebral blood flow;
Acute and subacute alterations in autonomic nervous system activity in adult patients with ischemic stroke.
Doctorate in Neurosciences (summa cum laude)
Institute for Pathophysiology (School of Medicine), Friedrich Schiller University, Jena, Germany. Advisor: Prof. Ulrich Zwiener, Dr. med. habil., PhD. Thesis: Investigating complex coordination of neurovegetative and brain electrical activities in sleep and anesthesia using nonlinear signal analysis. Awarded October 4, 2004.
Research Topics and Interests
By studying the coupling between heart rate variability and respiratory movements, I was able to retrospectively discriminate human neonates at low and normal risk for adverse outcomes during the first year of life. I also characterized information flow in reticulo-thalamo-cortical communication in an animal model of propofol sedation using analysis of linear and complexity properties of cortical and thalamic electrical activity.
Doctor of Medicine
Friedrich Schiller University, Jena, Germany, 2001.
education
- 2004 — Doctorat — Neurosciences — Université Friedrich-Schiller
For more information…
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PudMed
Publications de FRASCH, Martin sur le site de PubMed.
Affiliations and responsabilities
Research affiliations
Research units
Membre
Affiliated institutions
- Centre hospitalier universitaire Sainte-Justine (CHU Sainte-Justine)
Teaching and supervision
Projects
Research projects
MECHANISMS AND THE MANIPULATION OF TH FETAL NEUROIMMUNE RESPONSE TO INFLAMMATION
REGROUPEMENT STRATEGIQUE - RESEAU QUEBECOIS EN REPRODUCTION (RQR)
Mechanisms and manipulation of fetal neuroimmune responses to inflammation
Description
The immune system can cause inflammation that damages organs. The normal brain and the normal immune system “talk” to each other and influence each other. By emitting “cholinergic” signals, the brain limits the ability of the immune system to cause damaging inflammation. When a fetus suffers from infection, the immune system’s inflammatory response can damage his or her brain and make it more likely to develop chronic inflammatory diseases after birth. Lifelong disabilities can result. When doctors suspect such condition, they deliver the baby urgently, usually by Cesarian section. However, doctors cannot accurately predict which fetuses need urgent delivery and which pregnancies can be safely allowed to continue. My research team develops monitors that better detect which fetuses are truly distressed by measuring certain mathematical properties of the fetal heart beat directly controlled by “cholinergic” brain signals. Now, we are learning how to improve cholinergic anti-inflammatory brain signaling using electric nerve stimulation as the first step to develop drug treatments. By harnessing the brain’s innate power to reduce dangerous inflammation, we think we can protect the fetal brain, reduce unnecessary Cesarean sections, and decrease the number of babies born with increased risk to develop newborn or adult neurological diseases due to inflammatory brain damage.
MECANISMES ET LA MANIPULATION DES REPONSES NEUROIMMUNITAIRES FTALES A L'INFECTION
MÉCANISMES ET LA MANIPULATION DES RÉPONSES NEUROIMMUNITAIRES FOETALES À L'INFECTION
MECANISMES ET LA MANIPULATION DES REPONSES NEUROIMMUNITAIRES FTALES A L'INFECTION
DOES MANIPULATION OF FOETAL CHOLINERGIC ANTI-INFLAMMATORY PATHWAY IMPROVE PERINATAL HEALTH OUTCOME FOLLOWING SEPSIS?
Outreach
Publications and presentations
Disciplines
- Obstetrics and Gynecology
- Neurosciences
- Physiology
Areas of expertise
- Canada (Québec)
- Prenatal and Neonatal Screening
- Nervous System Development
- Diseases of the Immune System
- Stress
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