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Health Sciences; Life Sciences

David Williamson

Professeur titulaire de clinique

Faculté de pharmacie

Pavillon Jean Coutu, room 2181

514 343-6111 #1924

david.williamson@umontreal.ca

Secondary numbers: 514 338-2222 #2666 (Travail 1) 514 343-6120 (Télécopieur)

Profile

education

  • 2014 — Ph.D — Sciences cliniquesUniversité de Sherbrooke
  • 1997 — M.Sc. (pharmacothérapie avancée) — PharmacieUniversité de Montréal
  • 1996 — B.Pharm — PharmacieUniversité de Montréal

Affiliations and responsabilities

Teaching and supervision

Student supervision

Theses and dissertation supervision (Papyrus Institutional Repository)

Projects

Research projects

2023 - 2028

Impact of Vitamin C on the Reduction of Opioid Consumption After an Emergency Department Visit for Acute Musculoskeletal Pain: A Double-Blind Randomized Control Trial

Lead researcher : Raoul Daoust
Co-researchers : Dominique Rouleau , David Williamson , Caroline Arbour , Alexis Cournoyer , Perry Jeffery , Marcel Émond
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet
2024 - 2027

Effects of dexmedetomidine on agitation in critically ill TBI patients – DEX-TBI

Lead researcher : David Williamson
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet
2022 - 2026

Large reductions in arterial CARbon dioxide and development of acute Brain Injury in invasively mechanically ventilated patients with acute respiratory failure (CARBI)

Lead researcher : Yiorgos Alexandros Cavayas
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet
2020 - 2026

A prospective translational model of the therapeutic potential of cannabidiol in reducing acute pain symptoms and opioid usage following traumatic injury.

Lead researcher : Louis De Beaumont
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-Subvention d'équipe
2021 - 2025

Adverse Drug Events and Medication Errors in adult Intensive Care Units

Lead researcher : Nadezhda Roumeliotis
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet
2023 - 2024

REVIVe : fragilité, réadaptation et dénouements chez survivants adultes et pédiatriques de la COVID-19.

Lead researcher : David Williamson
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs:
2021 - 2024

Prise en charge pharmacothérapeutique des conséquences physiques, comportementales et cognitives des lésions cérébrales traumatiques aiguës

Lead researcher : David Williamson
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Bourse de chercheur-boursier clinicien : Junior 2
2018 - 2024

Quantity of Opioids for Acute Pain and Limit Unused Medication (OPUM study)

Lead researcher : Raoul Daoust
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet
2018 - 2021

Identifier les patients à risque de douleur chronique après un traumatisme craniocérébral modéré/sévère dès les premiers jours d'hospitalisation aux soins intensifs

Lead researcher : Caroline Arbour
Co-researchers : Francis Bernard , David Williamson , Louis De Beaumont
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Volet 1 - Consortium pour le développement de la recherche en traumatologie
2018 - 2021

Implantation des meilleures pratiques de gestion de la douleur à l'unité des soins intensifs de traumatologie: un travail d'équipe.

Lead researcher : Céline Gélinas
Co-researchers : Manon Choinière , Francis Bernard , Marc Perreault , David Williamson
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Volet 3 - Consortium pour le développement de la recherche en traumatologie
2018 - 2020

Sedatives newly prescribed following intensive care unit admission among sedative-naïve elderly patients: Understanding the risk of falls and determining targets for deprescribing (SNOW-FALL)

Lead researcher : Lisa Denise Burry
Co-researchers : David Williamson
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet
2016 - 2020

Agitation et délirium en traumatologie et aux soins intensifs

Lead researcher : David Williamson
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Bourse de chercheur-boursier clinicien : Junior 1
2016 - 2020

PROSPECT: Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial

Lead researcher : Jennie Johnstone
Co-researchers : Emmanuel Charbonney , David Williamson
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs:
2017 - 2019

Revue systématique et méta-analyse sur les agents sédatifs en traumatisme crânien

Lead researcher : David Williamson
Funding sources: Fondation NeuroTrauma Marie-Robert
Grant programs:
2016 - 2019

Agitation et délirium en traumatologie et aux soins intensifs

Lead researcher : David Williamson
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Établissement de jeunes chercheurs Juniors 1
2016 - 2018

Traitement des hémorragies intracrâniennes chez les patients anticoagulés ayant subi un traumatisme crânien léger : Revue systématique et méta-analyse

Lead researcher : Jean Marc Chauny
Co-researchers : Martin Albert , David Williamson , Natalie Le Sage
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Volet 4 - Consortium pour le développement de la recherche en traumatologie
2016 - 2017

Managing Pain In Collaboration in the Intensive Care Unit (MPIC-ICU): A Stepped Wedge Cluster Randomized Trial.

Lead researcher : Céline Gélinas
Co-researchers : Manon Choinière , Francis Bernard , Emmanuel Charbonney , David Williamson
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet
2015 - 2017

Interventions pharmacologiques pour le contrôle du délirium et de l'agitation suite à un traumatisme cranio-cérébral: une revue systématique de données cliniques et précliniques

Lead researcher : David Williamson
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Volet 4 - Consortium pour le développement de la recherche en traumatologie

Outreach

Publications and presentations

Publications

  1. Xie F, Yao Y, Ma Y, Humphries B, Lau VI, Fowler R, Rochwerg B, Heels-Ansdell D, Zytaruk, Barletta J, Kanji S, Arabi Y, Johnson DW, Williamson D, Deane A, Myburgh J, Geagea A, Poole A, Archambault P, Khwaja K, Ostermann M, Burry L, Guyatt G, Cook D. Cost-effectiveness of Pantoprazole vs No Pantoprazole for the Prevention of Upper Gastrointestinal Bleeding in Critically Ill Patients. JAMA Network Open 2025;8:e2552771.
  2. El-Haffaf I, Marsot A, Paillault A, Giang V, Williams V, Smith MA, Albert M, Chassé M, Williamson D. Exposure levels and target attainment of meropenem in adult patients admitted to the intensive care unit: a prospective observational study. Canadian Journal of Physiology and Pharmacology 2025;103;418-28.
  3. Klimenko T, Briand MM, Dumais C, Cavayas YA, Bernard F, Burry L, Arbour C, Perreault M, Potvin MJ, Williamson D. Pharmacological interventions for agitated behaviors in traumatic brain injury: an updated systematic review. J Neurotrauma 2025;ePub Oct 6th.
  4. De Koninck B, Maschke C, Briand MM, Apinis-Deshaies A, Brazeau D, Girard Pepin R, Martens G, Williams V, Arbour C, Williamson D, Duclos C, Bernard F, Blain-Moraes S, De Beaumont L. Longitudinal characterization of EEG features in consciousness recovery following severe traumatic brain injury: a case series study. Neuroscience of Consciousness 2025;ePub Sept 11th
  5. Lapierre A, Bérubé M, Turcotte V, Giroux M, Severino F, Boisvert L, Williamson D, Mercier E, Richard-Denis A, Moore L. Perceived use, effectiveness and barriers of interprofessional interventions in an integrated Canadian trauma system: A practice survey. J Interprofessional Education and Practice 2025;Epub Aug 28th.
  6. Daoust R, Paquet J, Perry JJ, Yan J, Williamson D, Castonguay V, Lavigne G, Rouleau D, Lessard J, Cournoyer A. How does self-reported chronic pain compare to other definitions? Pain Research and Management 2025;1:5556400.
  7. Badie, SR, Mujtaba M, Williamson D, Burry L. Pharmacology of sedatives. Crit Care Clinics 2025;41:625-39.
  8. Groguhé S, Landry O, Sirmalis C, Williamson D, Stortini A, Fortier M. Eco-responsible Awareness Raising interventions To reduce the use of long-acting MDIs and carbon footprint in a university Hospital center (EARTH). Ann Pharmacother 2025;ePub June 3rd.
  9. Girard Pepin R, Seyfzadeh F, Williamson D, Gosseries O, Duclos C. Pharmacological therapies for early and long-term recovery in disorders of consciousness: current knowledge and promising avenues. Expert Review of Neurotherapeutics 2025;25 :613-633.
  10. Williamson DR, Dryden L, Cheng W, Hutton B, Skidmore B, Mehta S, Golan E, Turgeon AF, Adhikari NKJ, Rose L, Burry L. Sedation for moderate-to-severe traumatic brain injury in adults (Protocol). Cochrane Database of Systematic Reviews 2025;;5:CD012639.
  11. Deane AM, Lauzier F, Adhikari NKJ, Lamontagne F, Heels-Ansdell D, Thabane L, Williamson D, Kanji S, Barletta JF, Finfer S, Arabi Y, Ostermann M, Marshall J, Zytaruk N, Hardie M, Hammond N, Gyatt G, White K, Burns K, Dionne J, Young P, Cook D. Risk Factors for Patient-Important Upper Gastrointestinal Bleeding. Am J Resp Crit Care 2025;211;1671-80.
  12. Martineau J, Bernard F, Gagnon A, Williams V, Araujo de Franca S, Williamson D, Cavayas YA. Variation in carbon dioxide is a stronger determinant of the brain tissue oxygenation than its synchronous value in critically ill patients with acute brain injury. Crit Care Explorations 2025;7:e1241.
  13. Azimdadeh D, Lapierre A, Bouaouina Z, Williamson D, Mailhot T, Arbour C. ICU nurses’ perspectives on family involvement in delirium care for postoperative cardiac surgery patients. Intensive Crit Care Nursing 2025;88:104001.
  14. St-Jean I, Hachemi D, Friciu M, Forest JM, Belliveau M, Williamson D, Leclair G. Stability of dexmedetomidine, ketamine and lidocaine combined injectable solution. Eur J Hosp Pharm 2025;ePub 5 mars.
  15. Beaucage-Charron J, Rinfret J, Trottier G, Sevigny MM, Burry L, Marsot A, Williamson D. Pharmacokinetics of opioid infusions in the intensive care unit setting – A systematic review. Clin Pharmacokinetics 2025;64;323-34.
  16. Brazeau D, Deshaies AA, Williamson DR, Bernard F, Arbour C, Lavigne G, Pinard AM, Rouleau D, de Beaumont L. Impact of an acute 1-month cannabidiol treatment on pain and inflammation after a long bone fracture: a triple-blind randomized, placebo controlled, clinical trial protocol. BMJ Open 2025;15:e092919.
  17. Saavedra-Mitjans M, David PM, Arbour C, Perreault M, Roux M, Frenette AJ, Khwaja K, Bernard F, Williamson DR. EXperienceS and percepTions towards Agitated behaviours in Tbi ICu patients: qualitative interviews with nurses. Brain Injury 2025;39: 598-609
  18. Burry LD, Williamson DR, Detsky M, Bernard F, Mehta S, Scales D, Rose L. Feasibility of melatonin for prevention of delirium in critically ill patients. Chest 2025;167:1397-1407.
  19. Daoust R, Paquet J, Williamson D, Huard V, Arbour C, Perry JJ, Emond M, Berthelot S, Archambault P, Rouleau D, Morris J, Cournoyer. Impact of Vitamin C on the Reduction of Opioid Consumption for Acute Musculoskeletal Pain: A Double-Blind Randomized Control Pilot Study. Plos One 2024;19:e0316450.
  20. Massé O, Mercurio CM, Dupuis S, Arruda A, Desforges K, Dugré N, Dallaire G, Williamson DR. Calcium and/or vitamin D to prevent fractures and falls in older adults: Protocol for a systematic review and meta-analysis. BMJ Open 2024;14:e085902.
  21. Lapierre, A., Bérubé, M., Giroux, M., Tardif, P.-A., Turcotte, V., Mercier, É., Richard-Denis, A., Williamson, D., & Moore, L. Interprofessional interventions that impact collaboration and quality of care across inpatient trauma care continuum: A scoping review. Injury 2024;55(11):111873.
  22. Mohktari KW, Wong A, Nguyen M, Giard A, Ly B, Wazzan D, Williamson D, Dagenais-Beaulé V. Post-discharge opioid prescription and consumption in surgical inpatients: the POPCORN observational Study. Can J Hosp Pharmacy 2024;77:e3574.
  23. Dahel H, Burry L, Tabbara N, Williamson D, Hornstein G, Wang HT. Optimizing Subsequent CARdiovascular Medication Re-introduction in the Intensive Care Unit (OSCAR-ICU). Can J Kidney Disease 2024;11: 20543581241276361.
  24. Daoust R, Paquet J, Emond M, Iseppon M, Williamson D, Yan J, Perry JJ, Huard V, Lavigne G, Lee J, Lessard J, Lang E, Cournoyer A. Opioids for acute pain: how much to prescribe to minimize unused medication? (OPUM Study). CMAJ 2024;196:E866-E874.
  25. De Koninck B, Brazeau D, Apinis-Deshaies A, Briand MM, Maschke C, Williams V, Arbour C, Williamson D, Duclos C, Bernard F, Blain-Moraes S, De Beaumont L. Modulation of brain activity in brain-injured patients with a disorder of consciousness in intensive care with repeated 10-Hz transcranial alternating current stimulation (tACS): a randomised controlled trial protocol. BMJ Open 2024;14:e07828.
  26. Wang Y, Parpia S, Ge L, Heels-Ansdell D, Lai H, Esfahani MA, Pan E, Alhazzani W, Schandelmaier S, Lauzier F, Arabi Y, Barletta J, Deane A, Finfer S, Williamson D, Kanji S, Moller MH, Perner A, Krag M, Young PJ, Dionne JC, Hammond N, Ye Z, Ibrahim Q, Cook, D. Proton Pump Inhibitors for Prophylaxis Against Gastrointestinal Bleeding in Critically Ill Patients: A Systematic Review with Meta-Analysis. NEJM evidence 2024:3:EVIDoa2400134.
  27. Cook D, Dean A, Lauzier F, Zytaruk N, Guyatt G, Saunders L, Hardie M, Heels-Ansdell D, Alhazzani W, Marshall J, Muscedere J, Myburgh J, English S, Arabi Y, Ostermann M, Knowles S, Hammond N, Byrne KM, Chapman M, Venkatesh B, Young P, Rajbhandari D, Poole A, Al Fares A, Reis G, Johnson D, Iqbal M, Hall R, Meade M, Hand L, Duan E, Clarke F, Dionne JC, Tsang JLY, Rochwerg B, Karachi T, Lamontagne F, D’Aragon F, St-Arnauld C, Reeve B, Geagea A, Niven F, Vasquez-Grande G, Zarychanski R, Ovakim D, Wood G, Burns K, Goffi A, Wilcox E, Henderson W, Forrest D, Fowler R, Adhikari N, Ball I, Mele T, Binnie A, Trop S, Mehta S, Morgan I, Loubani O, Vanstone M, Fiest K, Charbonney E, Cavayas A, Archambault P, Rewa O, Lau V, Kristoff AS, Khwaja K, Williamson D, Kanji S, Sy E, Dennis B, Reynolds S, Marquis F, Lellouche F, Rahman A, Hosek P, Barletta J, Cirone R, Tutschka M, Xie F, Billot L, Thabane L, Finfer S, for the REVISE Trial Investigators. Stress Ulcer Prophylaxis for Invasively Ventilated Patients: A Randomized Trial. N Engl J Med 2024;391:9-20
  28. Burry LD, Bell C, Hill A, Pinto R, Scales D, Bronskill S,Rose L, Williamson D, Fowler R, Wunsch H. Trends in Sedative Prescription Among Older Adults after Critical Illness: A Population-Based Cohort Study. Am J Resp Crit Care 2024;210:680-683.
  29. Lapierre A, Proulx A, Gélinas C, Dollé S, Alexander S, Williamson D, Bernard F, Arbour C. Association between pupil light reflex measurements during mechanical ventilation and post-extubation delirium in adults with traumatic brain injury: Preliminary findings. J Neuroscience Nursing 2024:10:1097.
  30. Saavedra-Mitjans M, Van der Maren S, Gosselin N, Duclos C, Frenette AJ, Arbour C, Burry L, Williams V, Bernard F, Williamson D. Use of actigraphy for monitoring agitation in patients with Acute Traumatic Brain Injury in the Intensive Care Unit. Brain injury 2024;38:692-698
  31. Cataford G, Monton LA, Livernoche-Leduc C, Karzon S, Saavedra-Mitjans M, Potvin MJ, Bernard F, Burry L, Arbour C, Williamson DR.Cognitive and motor function effects of antipsychotics in traumatic brain injury: a systematic review of preclinical studies. Neurotrauma Reports 2024;5:181-193.
  32. El-Hattaf I, Marsot A, Hachemi D, Pesout T, Williams V, Smith MA, Albert M, Williamson D. Exposure Levels and Target Attainment of Piperacillin/Tazobactam in Intensive Care Unit Adult Patients: a Prospective Observational Study. Can J Anesth 2024; 71:511-522.
  33. Saavedra-Mitjans M, Frenette AJ, McCredie V, Arbour C, Charbonney E, Albert M, Mehta S, Wang HT, Burry L, Bernard F, Williamson D. ICU physicians’ beliefs and perceived importance of agitation in TBI patients: A survey of Canadian intensivists. Can J Anesth 2024;71:264-73.
  34. White G, Adessky N, Chen FW, Regazzoni A, Tourian L, Chagnon M, Gursahaney A, Roux M, Alharbi M, Williamson D, Perreault. Impact Of Valproic Acid For Agitation In The Intensive Care Unit: a Retrospective Analysis Of Psychiatric Consults. Int J Clin Pharm 2024;46:177-185
  35. Leclerc C, Gervais C, Hjeij D, Briand MM, Williamson D, Bernard F, Duclos C, Arbour C. Sleep in hospitalized adults sustaining a traumatic brain injury: A scoping review. J Head Trauma Rehab 2024;39:E201-E215
  36. D’Amours M, Ettis F, Ginefri L, Lim J, Lin Poo Yuan A-S, Fontaine J, Wazzan D, Williamson D, Dagenais-Beaulé V. A pilot study to improve geriatric care through a pharmacist-led psychotropic stewardship program. Drugs and Aging 2023; 40:1037-1045.
  37. El-Hattaf I, Laverdière J, Albert M, Marsot A, Williamson D. Potential Benefits of Therapeutic Drug Monitoring for Beta-lactam Antibiotics in Augmented Renal Clearance Patients: A Case Report. Canadian Journal of Physiology and Pharmacology 2023;102:69-74.
  38. Daoust R, Paquet J, Marquis M, Williamson D, Fontaine G, Chauny JM, Frégeau A, Orkin A, Cournoyer A. Efficacy and Safety of Prescribed Opioids for Acute Pain after Being Discharged from the Emergency Department: A Systematic Review. Acad Emerg Med 2023;30:1253-1263.
  39. Duceppe MA, Kanji S, Ruo N, Do A, Cavayas YA, Robert-Halabi M, Albert M, Zavalkoff S, Samoukovic G, Williamson DR. Alterations in the pharmacokinetics and pharmacodynamics of commonly used antimicrobials in pediatric critical care patients during extracorporeal membrane oxygenation: A systematic review. Pediatric Drugs 2023;25:515-535
  40. Daoust R, Paquet J, Chauny JM, Williamson D, Huard V, Arbour C, Emond M, Rouleau D, Cournoyer A. Impact of Vitamin C on the Reduction of Opioid Consumption After an Emergency Department Visit for Acute Musculoskeletal Pain: A Double-Blind Randomized Control Trial Protocol. BMJ Open 2023;13:e699230.
  41. Kanji S, Williamson D, Hartwick M. Pharmacological confounders in the setting of brain death declaration. Can J Anesth 2023;70:713-23.
  42. Beaucage-Charron J, Rinfret J, Coveney R, Williamson D. Melatonin and Ramelteon in the Treatment of Delirium: A Systematic Review and Meta-analysis. J Psychomatic Res 2023;170:111345.
  43. Ouerd S, Frenette AJ, Williamson D, Serri K, D’Aragon F, Meade M, Bichet D, Charbonnney E. Vasopressin use in organ donors: a narrative review of the literature and evidences. Crit Care Explorations 2023;5:e0907
  44. Flynn F, Dobrescu MA, Richard G, Hassan C, Pigeon M, Chagnon M, Charbonney E, Serri K, D’Aragon F, Weiss MJ, Williamson DR, Frenette AJ. Self-perceived role and knowledge of community pharmacists in organ donation. Int J Clin Pharm 2023;45:748-57.
  45. Duquet-Armand M, Bouziane A, Arruda A, Denault JS, Routhier A, Cusson T, Halwagi A, Williamson D, Perreault M, Lordkipanidzé, Létourneau-Guillon L, Thiboutot Z. Spontaneous intracranial hemorrhage and oral anticoagulation: a retrospective study. Can Journ Gen Int Med 2023;18:54-65.
  46. Duong A, Simard C, Williamson D, Marsot A. Tobramycin a priori dosing regimens based on PopPK model’s simulations in critically ill patients: are they transferable? Ther Drug Monit 2023;45:616-622
  47. Dionne JC, Johnstone J, Heels-Ansdell D, Duan E, Lauzier F, Arabi YM, Adhikari NKJ, Sligl W, Dodek P, Rochwerg B, Marshall JC, Niven DJ, Williamson DR, Reynolds S, Zytaruk N, Cook D.Clostridioides Difficile Infection in Mechanically Ventilated Critically Ill Patients: A Nested Cohort Study. J Crit Care 2023; 75:154254.
  48. Burry LD, Bell C, Hill A, Pinto R, Scales DC, Bronskill SE, Williamson D, Rose L, Fu L, Fowler R, Martin CM, Dolovich L, Wunsch H. New and persistent sedative prescription after critical illness among older adults: A population-based cohort study. Chest 2023;163:1425-36.
  49. Hardy A, Beetz G, Chamali K, Courgeon M, Sandman E, Williamson D, Goetti P, Leduc S, de Beaumont L, Rouleau DM. Traumatic Brain Injuries in Proximal Humeral or Clavicle Fractures Studies: The Missing Link – A Systematic Review. International Orthopedics 2023;47:17-50.

Areas of expertise

  • Pharmacothérapie (soins critiques)
  • Clinical research
  • Recherche épidémiologique