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Health Sciences; Medical Sciences

Florina Moldovan

Étude et meilleurs traitements des déformations du rachis et maladies musculosquelettiques

Professeure titulaire

Faculté de médecine dentaire - Département de stomatologie

Roger-Gaudry, room C506

514 343-7129

florina.moldovan@umontreal.ca

Secondary numbers: 514 345-4931 #5746 (Travail 1) 514 345-4801 (Télécopieur)

Profile

Research expertise

  • Arthrose et arthrite;
  • Scoliose idiopathique de l’adolescence;
  • Ankylose dentaire;
  • Douleur inflammatoire;  
  • Biologie cellulaire;
  • Cytokines;
  • Endothélium et endothéline;
  • Hybridation in situ;
  • Immunoanalyse et immunohistochimie;
  • Métalloprotéases;
  • Récepteurs membranaires.

Awards and recognitions

  • Prix Grammer, European Spine Journal, 2014.
  • Lauréat, recherche fondamentale, Fondation Yves Cotrel - Institut de France, 2006, 2010, 2012, 2016.
  • Prix Carroll-A.-Laurin, recherche fondamentale en orthopédie, Fondation canadienne d'orthopédie, 2004.
  • Chercheur-boursier Junior 2, Fonds de la recherche en santé du Québec, 2004.
  • Chercheur-boursier, Instituts de recherche en santé du Canada, 2001.
  • Fellow en recherche bioclinique, Association Claude Bernard, France, 1995.

For more information…

Affiliations and responsabilities

Research affiliations

Research units

Membre

Affiliated institutions

  • Centre hospitalier universitaire Sainte-Justine (CHU Sainte-Justine)

Teaching and supervision

Student supervision

Theses and dissertation supervision (Papyrus Institutional Repository)

2012

Rôle du facteur de transcription PITX1 dans la pathogenèse de l'arthrose.

Graduate : Picard, Cynthia
Cycle : Doctoral
Grade : Ph. D.
2008

Rôle des estrogênes dans la scoliose idiopathique adolescente

Graduate : Letellier, Kareen
Cycle : Master's
Grade : M. Sc.
2008

Profil d'expression de l'ET-1, de l'ostéocrine, de la PARP-1 et de l'ezrine dans l'ostéosarcome humain

Graduate : Guyot, Marie-Claude
Cycle : Master's
Grade : M. Sc.
2006

Le rôle de l'endothéline-1 dans l'invasion tumorale des ostéosarcomes due aux métalloprotéases

Graduate : Felx, Mélanie
Cycle : Master's
Grade : M. Sc.
2005

Mécanisme d'action de l'endothéline-1 (ET-1) dans les chondrocytes articulaires des patients arthrosiques

Graduate : Manacu, Cristina Alexandra
Cycle : Master's
Grade : M. Sc.
2004

Effet de l'ET-1 sur le système MMP/TIMP dans les chondrocytes arthrosiques

Graduate : Roy-Beaudry, Marjolaine
Cycle : Master's
Grade : M. Sc.

Projects

Research projects

2018 - 2023

Role of fibronectin mutations in spondylometaphyseal dysplasia and idiopathic scoliosis.

Lead researcher : Philippe Campeau
Co-researchers : Stefan Parent , Florina Moldovan , Dieter Reinhardt
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet
2018 - 2021

Mise au point, validation et étude fonctionnelle d'un modèle murin de la scoliose idiopathique basé sur l'expression d'une forme mutée du gène POC5.

Lead researcher : Florina Moldovan
Funding sources: Fondation Yves Cotrel
Grant programs:
2017 - 2021

Investigation de la biocompatibilité de nanostructures élaborées à partir de biopolymères pour des usages médicaux et diagnostiques

Lead researcher : Florina Moldovan
Funding sources: FRQNT/Fonds de recherche du Québec - Nature et technologies (FQRNT)
Grant programs: PV113724-(PR) Projets de recherche en équipe (et possibilité d'équipement la première année)
2017 - 2020

Approche biomimétique pour la lubrification et la régénération des joints articulaires

Lead researcher : Xavier Banquy
Co-researchers : Florina Moldovan , Laurent David , Guillaume Sudre
Funding sources: FRQNT/Fonds de recherche du Québec - Nature et technologies (FQRNT)
Grant programs: PVXXXXXX-(FQ) Programme Samuel-De Champlain (volet Recherche)
2017 - 2019

Functional role of gene variants in adolescent idiopathic scoliosis.

Lead researcher : Florina Moldovan
Funding sources: Scoliosis Research Society
Grant programs:
2016 - 2018

FEI Sans Restriction Florina Moldovan

Lead researcher : Florina Moldovan
Funding sources: Université de Montréal
Grant programs:
2015 - 2018

Biomimetic polymers for the treatment of articular joint diseases.

Lead researcher : Xavier Banquy
Co-researchers : Florina Moldovan
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-Subvention de fonctionnement transitoire
2012 - 2018

A NEW APPROACH TO THE TREATMENT OF CHRONIC JOINT PAIN

Lead researcher : Florina Moldovan
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXX5647-Subvention de fonctionnement incluant les subventions de fonctionnement programmatiques
2015 - 2016

Effects on exogenous retinoic acid and corticotomy on inflammatory process and bone remodeling during tooth movement

Lead researcher : Clarice Nishio
Co-researchers : Florina Moldovan
Funding sources: American Association of Orthodontists Foundation 
Grant programs:
2015 - 2016

Réseau provincial de recherche en adaptation-réadaptation (REPAR) - Cortical sensorimotor information processing associated with postural control in adolescents with idiopathic scoliosis and in healthy adolescents.

Lead researcher : Martin Simoneau
Co-researchers : Stefan Parent , Cyril Duclos , Sarah Lippé , Florina Moldovan , Carole Fortin
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Réseaux thématiques de recherche
2014 - 2016

The risk of community-acquired pneumonia among immunosuppressive opioids users.

Co-researchers : Florina Moldovan , Igor Karp
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PV125458-Subvention de fonctionnement : des connaissances à la pratique
2014 - 2016

Réseau québécois de recherche sur les médicaments (RQRM) / Nanohydrogel/peptide conjugates for the treatment of arthritic joints.

Co-researchers : Florina Moldovan
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Réseaux thématiques de recherche
2009 - 2015

SUBVENTION DE FORMATION DES IRSC EN EVALUATION ET TRAITEMENT DES TROUBLES DE LA MOBILITE ET DE LA POSTURE (PROGRAMME MENTOR)

Lead researcher : Hubert Labelle
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs:
2013 - 2014

RESEAU DE RECHERCHE EN SANTE BUCCODENTAIRE ET OSSEUSE (RSBO) - SCOLIOSE IDIOPATHIQUE : DU GENE A A COHERENCE CORTICO-MUSCULAIRE

Lead researcher : Florina Moldovan
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Réseaux thématiques de recherche
2008

THERAPEUTIC POTENTIAL OF ETA SELECTIVE ANTAGONIST IN OA

Lead researcher : Florina Moldovan

Outreach

Publications and presentations

Publications

Patten SA, Margaritte-Jeannin P, Bernard JC, Alix E, Labalme A, Besson A, Girard SL, Fendri K, Fraisse N, Biot B, Poizat C, Campan-Fournier A, Abelin-Genevois K, Cunin V, Zaouter C, Liao M, Lamy R, Lesca G, Menassa R, Marcaillou C, Letexier M, Sanlaville D, Berard J, Rouleau GA, Clerget-Darpoux F, Drapeau P, Moldovan F, Edery P. Functional variants of POC5 identified in patients with idiopathic scoliosis. J Clin Invest. 2015 Mar 2;125(3):1124-8. doi: 10.1172/JCI77262. Epub 2015 Feb 2

Shi Q, Abusarah J, Zaouter C, Moldovan F, Fernandes JC, Fahmi H, Benderdou M. New evidence implicating 4-hydroxynonenal in the pathogenesis of osteoarthritis in vivo. Arthritis Rheumatol. 2014 May 16.

Ménard AL, Grimard G, Valteau B, Londono I, Moldovan F, Villemure I.In vivo dynamic loading reduces bone growth without histomorphometric changes of the growth plate.J Orthop Res. 2014 Sep;32(9):1129-36. doi: 10.1002/jor.22664. Epub 2014 Jun 6.

Londono D, Kou I, Johnson TA, Sharma S, Ogura Y, Tsunoda T, Takahashi A, Matsumoto M, Herring JA, Lam TP, Wang X, Tam EM, Song YQ, Fan YH, Chan D, Cheah KS, Qiu X, Jiang H, Huang D; Japanese Scoliosis Clinical Research Group, TSRHC IS Clinical Group, the International Consortium for Scoliosis Genetics (including Moldovan F), Su P, Sham P, Cheung KM, Luk KD, Gordon D, Qiu Y, Cheng J, Tang N, Ikegawa S, Wise CA. A meta-analysis identifies adolescent idiopathic scoliosis association with LBX1 locus in multiple ethnic groups. Med Genet. 2014 Jun;51(6):401-6.

Feldman DE, Beausejour M, Sosa JF, Goulet L, Parent S, Labelle H and the members of the Québec Scoliosis Society and the Canadian Pediatric Spinal Deformities Group. Cost effectiveness of school screening for scoliosis: A systematic review. Int J Child Adolesc Health 2014:7(1):1-7.

Beausejour M, Goulet L, Parent S, Feldman DE, Turgeon I, Roy-Beaudry M, Sosa JF, Labelle H and Members of the Québec Scoliosis Society and of the Canadian Paediatric Spinal Deformities Study Group (including Moldovan F). The effectiveness of scoliosis screening programs: methods for systematic review and expert panel recommendations formulation. Scoliosis 2013 Jul 24;8(1):12.

Fendri K, Patten SA, Kaufman GN, Zaouter C, Parent S, Grimard G, Edery P, Moldovan FMicroarray expression profiling identifies genes with altered expression in Adolescent Idiopathic Scoliosis. Eur Spine J. 2013 Jun;22(6):1300-11. doi: 10.1007/s00586-013-2728-2.

Moldovan F, Villemure I, Fendri K, Grimard G, Zaouter C, Parent S, Moreau A, Labelle H, Patten SA. Adolescent Idiopathic Scoliosis (AIS): Metabolic Factors, Biomechanical Stress and Estrogen Impact. Stud Health Technol Inform. 2012;176:452

Moldovan F, Patten SA, Fendri K, Girard S, Zaouter C, Edery P. Exome sequencing identifies novel candidate mutations in idiopathic. Stud Health Technol Inform. 2012; 176:453.

Menard AL, Valteau B, Londono I, Moldovan F, Grimard G, Villemure I. Influence of dynamic loading parameters on bone growth modulation. Stud Health Technol Inform. 2012; 176:469.

Bentz M, Zaouter C, Shi Q, Fahmi H, Moldovan F, Fernandes JC, Benderdour M. Inhibition of inducible nitric oxide synthase prevents lipid peroxidation in osteoarthritic chondrocytes. J. Cell. Biochem. 2012. Jul; 113(7):2256-67.

Feldman DE, Beausejour M, Sosa JF, Goulet L, Parent S, Labelle H and the members of the Québec Scoliosis Society and the Canadian Pediatric Spinal Deformities Group. Cost effectiveness of school screening for scoliosis: A systematic review. Int J Child Adolesc Health 2014:7(1):1-7.

Moldovan F, Villemure I, Fendri K, Grimard G, Zaouter C, Parent S, Moreau A, Labelle H, Patten SA. Adolescent Idiopathic Scoliosis (AIS): Metabolic Factors, Biomechanical Stress and Estrogen Impact. Stud Health Technol Inform. 2012;176:452

Moldovan F, Patten SA, Fendri K, Girard S, Zaouter C, Edery P. Exome sequencing identifies novel candidate mutations in idiopathic. Stud Health Technol Inform. 2012; 176:453.

Patten S, Jacobs NL, Zaouter C, Drapeau P, Albertson CR, Moldovan F. Novel Role of Chd7 in retinal organization and vertebral mineralization in a zebrafish model of charge syndrome. PLoS One. 2012; 7(2):e31650. Epub 2012 Feb 20

Acaroglu E, Moldovan F, Moreau A, Marcucio R, Enouf J, Bobe R. The metabolic basis of Adolescent Idiopathic Scoliosis 2011 report of the metabolic workgroup of the Foundation Yves CotrelEur Spine J. 2012 Mar 9. [Epub ahead of print].

Valteau B, Grimard G, Londono I, Moldovan F, Villemure I. In Vivo dynamic bone growth modulation is less detrimental but as effective as static growth modulation, Bone. 2011 Nov; 49(5):996-1004.

Kaufman GN, Zaouter C, Valteau B, Sirois P, Moldovan F. Nociceptive tolerance is improved by bradykinin receptor B1 antagonism and joint morphology in a surgical model of osteoarthritis, Arthritis & Res Therapy2011 May 16;13(3):R76.

Edery P, Margaritte-Jeannin P, Biot B, Labalme A, Bernard JC, Chastang J, Kassai B, Plays MH, Moldovan F, Clerget-Darpoux F. New disease gene location and high genetic heterogeneity in Idiopathic Scoliosis. Eur J Hum Genet. 2011 Aug; 19(8):865-9.

Fendri K, Moldovan F. Potential role of COMP as a biomarker for idiopathic scoliosis. Med Hypotheses, 2011 May;76(5):762-3.

Patten S, Moldovan F. Could genetic determinants of inner ear anomalies be a factor for the development of idiopathic scoliosisis? Med Hypotheses. 2011 Mar; 76(3) :438-40.

Sergerie K, Parent S, Londono I, Moldovan F, Villemure I. Growth plate explants respond differently to in vitro static and dynamic loadings.J Orthop Res. 2011 Apr;29(4) :473-80

Leboeuf D, Letellier K, Alos N, Edery P, Moldovan F. Do estrogens impact adolescent idiopathic scoliosis? Trends in Endocrinology and Metabolism (IF 7.1) 2009 Apr 4. [Epub ahead of print]

Cancel, M., Grimard, G., Thuillard-Crisinel, D., Moldovan F. & Villemure, I. (2009) Effects of in vivo static compressive loading on aggrecan and type II and X collagens in the rat growth plate extracellular matrix. Bone, 44(2), 306-15. Epub 2008 Sep 24.

Quintero, M., Riera, H., Colantuoni, G., Khatib, A. M., Attalah HL, Moldovan F, Mitrovic, D. R. & Lomri, A. (2008) Granulocyte-macrophage colony stimulating factor is anabolic and interleukin-1beta is catabolic for rat articular chondrocytes. Cytokine. 2008 Dec;44(3):366-72. Epub 2008 Nov 20.

Letellier K, Azeddine, B., Parent, S., Labelle, H., Rompre, P. H., Moreau, A. & Moldovan F. (2008) Estrogen cross-talk with the melatonin signaling pathway in human osteoblasts derived from adolescent idiopathic scoliosis patients. J Pineal Res, 45(4), 383-93. Epub 2008 May 26.

Letellier K, Azeddine B, Blain S, Turgeon I, Wang DS, Samba Boiro M, Moldovan F, Labelle H, Poitras B, Rivard C-H, Grimard G, Parent S, Ouellet J, Lacroix G, and Moreau A. Récents progrès dans l’étiopathogenèse de la scoliose idiopathique de l’adolescent et nouveaux concepts moléculaires. Médecine/Sciences. 2007 Nov:23(11) :910-916.

Calin Lungu, Jenny  Pena Dias, Camilla Estevão de França, Brice Ongali,  Domenico Regoli, Moldovan F, Réjean Couture. Involvement of kinin B1 receptor and oxidative stress in sensory abnormalities and arterial hypertension in an experimental rat model of insulin resistance. Neuropeptides. 2007 Dec:41(6):375-87

Khatib AM, Lomri A, Mitrovic RD, Moldovan F. Articular chondrocyte aging and endothelin-1. Articular chondrocyte aging and endothelin-1. Cytokine. 2007 Jan;37(1):6-13.

Azeddine B, Letellier K, Wang DS, Moldovan F and Moreau A. Molecular determinants of melatonin signalling dysfunction in in Adolescent Idiopathic Scoliosis. Clin Orthop Relat Res. 2007 Jun 7

Picard C, Azeddine B, Moldovan F, Martel-Pelletier J, Fernandes J, and Moreau A. New Emerging Role of Pitx1 Transcription Factor in Osteoarthritis Pathogenesis. Clin Orthop Relat Res. 2007 May 31

Felx M, Guyot MC, Isler M, Turcotte RE, Doyon J, Khatib AM, Leclerc S, Moreau A, Moldovan F. Entotheline-1 (ET-1) promotes MMP-2 and MMP-9 induction involving transcription factor NF-kappaB in human osteosarcoma. Clin Sci (Lond) 2006, 110 (6): 645-654

Korban T, Landreville V,  Leclerc S, Kauzman A, Mason AM, Moreau A, F. Moldovan Osteoarthritic lesions in temporo-mandibular joints of STR/ort mice. Journal of the Canadian Dental Association (JCDA) , October 2006 Vol72, No 8, page 693

Lévesque M, Guimond JC, Pilote M, Leclerc S, Moldovan F, Roy S. Expression of heat-shock protein 70 during limb development and regeneration in the axolotl. Dev Dynamics 2005;  233(4): 1525-1534.

Manacu CA, Martel-Pelletier J, Pelletier J-P, Shipkolye F, Fernandes JC, Mitrovic DR, Moldovan F. Endothelin-1 in osteoarthritic chondrocytes triggers nitric oxide production and up-regulates collagenases production. Arthritis Research Therapy 7:R324-32, 2005.

Roy-Beaudry M, Martel-Pelletier J, Pelletier J-P, Nait M’Barek K, Christgau S, Shipkolye F, Moldovan F. Endothelin-1 promotes osteoarthritic cartilage degradation via MMP-1 and MMP-13 induction. Arthritis Rheum 48(10):2855-64.2003

Pelletier J-P, Fernandes JC, Moldovan F, Schrier D, Flory C, Martel-Pelletier J. In vivo inhibition of MEK1/2 in rabbit experimental osteoarthritis is associated with a reduction in the development of structural changes. Arthritis Rheum. 48(6):1582-93, 2003.

Boileau C, Martel-Pelletier J, Moldovan F, Jouzeau JY, Netter P, Manning PT,  Pelletier JP.  The in situ up-regulation of chondrocyte interleukin-1-converting enzyme and interleukin-18 levels in experimental osteoarthritis is mediated by nitric oxide. Arthritis Rheum. 2002, 46(10):2637-47.

Boileau C, Martel-Pelletier J, Jouzeau JY, Netter P, Moldovan F, Laufer S, Tries S, Pelletier JP.  Licofelone (ML-3000), a dual inhibitor of 5-lipoxygenase and cyclooxygenase, reduces the level of cartilage chondrocyte death in vivo in experimental dog osteoarthritis: inhibition of pro-apoptotic factors. J Rheumatol. 2002 Jul;29(7):1446-53.

Khatib AM, Siegfried G, Messai H, Moldovan F, Mitrovic DR.  Mechanism of inhibition of endothelin-1-stimulated proteoglycan and collagen synthesis in rat articular chondrocytes. Cytokine. 2002 Mar 7;17(5):254-61.

Moldovan F, Pelletier JP, Mineau F, Dupuis M, Cloutier JM, Martel-Pelletier J.  Modulation of collagenase 3 in human osteoarthritic cartilage by activation of extracellular transforming growth factor beta: role of furin convertase. Arthritis Rheum. 2000 Sep;43(9):2100-9.

Moldovan F, Pelletier JP, Jolicoeur FC, Cloutier JM, Martel-Pelletier J.  Diacerhein and rhein reduce the ICE-induced IL-1beta and IL-18 activation in human osteoarthritic cartilage. Osteoarthritis Cartilage. 2000 May;8(3):186-96.

Publications majeures avant 2000

Moldovan F, Martel-Pelletier J, Hambour J, Cloutier JM, Pelletier JP. Collagenase-3 (MMP13) is preferentially localized in the deeper layer of human arthritic cartilage. In vitro mimicking effect by TGF-beta. Arthritis & Rheum. 40: 1653-61, 1997.

Moldovan F, Bennani H, Fiet J, Cussenot O, Dumas J, Darbord C, Soliman HR. Establishment of permanent human endothelial cells achieved by transfection with SV40 large T antigen which retains typical phenotypic and functional characteristics. In vitro Cell. Dev. Biol. Anim. 32: 16-23, 1996.

Disciplines

  • Stomatology
  • Physical Medicine & Rehabilitation
  • General Pathology

Areas of expertise

  • COVID-19
  • COVID19