The work of Dr Séguin bears on the cognitive and emotional aspects of the development of mental health, while taking into account risk and protective factors for substance use and cardiovascular health. His clinical training allows him to work as much with cognitive schemas, information processing approaches and underlying neural functions. His doctoral work (McGill University, 1995) aimed largely at neuropsychological aspects of physical aggression. Subsequent work broadened that conceptual basis to encompass hyperactivity, other externalised and internalised problems as well as cognitive development. A longitudinal study of a birth cohort allowed to examine the eraly development of self-regulation from a cognitive point of view. More recent studies, include pregnancy cohorts. One important hypothesis suggests that self regulation is partly acquired through socialisation. This research investigates the physiological, genetic and both physical and social environnemental bases of that learning from pregnancy. Child characteristics of interest include neuropsychological function as well as early temperament and personality. A key question for rpevention is what are the challenges and resources that affect that development? How does early self regulation lead to mental health? Can early interventions which aim to support families have an imppact on self-regulation?

1. **Chaput-Langlois, S., Parent, S., Castellanos-Ryan, N., Vitaro, F., Séguin, J.R. (2022). Friends, attachment and substance use in adolescence. Journal of Applied Developmental Psychology, 83, 101457. https://doi.org/10.1016/j.appdev.2022.101457.
2. **Pocuca, N., Parent, S., Côté, S.M., Boivin, M., Tremblay, R.E., Séguin, J.R., Castellanos-Ryan, N. (2022). The moderating role of sex and self-, teacher-, and father-reported ADHD-hyperactivity-impulsivity symptoms on the association between early adolescent internalizing symptoms and substance use. Addictive Behaviors, 135, 107437. https://doi.org/10.1016/j.addbeh.2022.107437.
3. **El Hourani, M. Zadra, A., Castellanos-Ryan, N., Parent, S., Renaud, J., Séguin, J.R. (2022). Longitudinal associations throughout adolescence: suicidal ideation, disturbing dreams, and internalizing symptoms. Sleep Medicine. 98, 89-97. https://doi.org/10.1016/j.sleep.2022.06.012
4. **Pocuca, N., London-Nadeau, K., Geoffroy, M. C., Chadi, N., Séguin, J. R., Parent, S. Boivin, M., Tremblay, R.E., Côté, S.M., Castellanos-Ryan, N. (2022). Changes in Emerging Adults' Alcohol and Cannabis Use from Before to During the COVID-19 Pandemic: Evidence from a Prospective Birth Cohort. Psychology of Addictive Behaviors, 36(7), 786–797. https://doi.org/10.1037/adb0000826
5. **Leblond, M., Parent, S., Castellanos-Ryan, N., Lupien, S., Fraser, W.D., Séguin, J.R. (2022). Transition from Preschool to School: Children’s Pattern of Change in Morning Cortisol Concentrations. Psychoneuroendocrinology, 105724. https://doi.org/10.1016/j.psyneuen.2022.105724 Preprint : https://psyarxiv.com/6g8xp/
6. **Dumont, É., Castellanos-Ryan, N., Parent, S., Jacques, S., Séguin, J.R., Zelazo, P.D. (2021). Transactional Longitudinal Relations between Accuracy and Reaction Time on a Measure of Cognitive Flexibility: The Transition from Kindergarten to Grade School. Developmental Science, e13254. http://doi.org/10.1111/desc.13254
7. *Armitage, J.M., *Morneau-Vaillancourt, G., Pingault, J.-B., Andlauer, T.F.M., Paquin, S., Langevin, S., Brendgen, M., Dionne, G., Séguin, J.R., Rouleau, G., Vitaro, F., Ouellet-Morin, I., Boivin, M. (2022). A multi-informant and multi-polygenic approach to understanding predictors of peer victimisation in childhood and adolescence. Journal of Child Psychology and Psychiatry – Advances, 2(1), e12063. https://doi.org/10.1002/jcv2.12063
8. *Thaw, A., Herba, C.M., Paquin, S., Orri, M., Séguin, J.R., Berthoz, S., Kim-Cohen, J., Tremblay, R.E., Côté, S.M. (2022). Parent affective personality and children's self-reported internalising and externalising behaviour. Social Development, 31(4), 1001-1019. https://doi.org/10.1111/sode.12594
9. *Thébault-Dagher, F., Robles, M., Herba, Catherine M., Saint-Pierre, J., Brochen, C., Muckle, G., Lupien, S.J., Séguin, J.R., Fraser, W.D., Vaillancourt, C., Lippé, S. (2022). Febrile seizure incidence and age at first occurrence are associated with changes in placental normalized gene expression: the ‘3D’ pregnancy cohort study. Journal of Neuroendocrinology, 33(10), e13046. https://onlinelibrary.wiley.com/doi/10.1111/jne.13046 https://doi.org/10.1111/jne.13046
10. *Vergunst, F., Chadi, N., Orri, M.; Brousseau-Paradis, C., Castellanos-Ryan, N., Séguin, J.R., Vitaro, F., Nagin, D., Tremblay, R.E., Côté, S.M. (2022). Trajectories of adolescent poly-substance use and their long-term social and economic outcomes for males from low-income backgrounds. European Child and Adolescent Psychiatry, 31(11), 1729-1738. htpps://doi.org/10.1007/s00787-021-01810-w
11. *Iqbal, M., Cox, S.M.L., *Jaworska, N., Tippler, M., Castellanos-Ryan, N., Parent, S., Dagher, A., Vitaro, F., Brendgen, M.R., Boivin, M., Pihl, R.O., Côté, S.M., Tremblay, R.E., Séguin, J.R., Leyton, M. (2022). A Three-Factor Model of Common Early Onset Psychiatric Disorders: Temperament, Adversity, and Dopamine. Neuropsychopharmacology 47, 752–758.
12. **Rioux, C., **Huet, A-S., Castellanos-Ryan, N., *Fortier, L., **Le Blanc, M., **Hamaoui, S., Geoffroy, M-C., Renaud, J. & Séguin, J. R. (2021). The direction of the association between substance use disorders and suicidality in youth: A meta-analysis. PloS One, 16(8), e0255799. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0255799
13. **Rioux, C., Parent, S., Castellanos-Ryan, N., Archambault, I., Boivin, M., Herba, C.M., Lupien, S.J., Marc, I., Muckle, G., Fraser, W.D., Séguin, J.R. (2021). The 3D-Transition Study: Objectives, Methods, and Implementation of an Innovative Planned Missing Data Design. American Journal of Epidemiology, 190(11), 2262-2274. https://doi.org/10.1093/aje/kwab141
14. *Morneau-Vaillancourt, G., Andlauer, T., Ouellet-Morin, I., Paquin, S., Brendgen, M., Vitaro, F., Gouin, J.-P., Séguin, J.R., Gagnon, É., Cheesman, R., Tremblay, R.E. Côté, S.M., Dionne, G., & Boivin, M. (2021). Polygenic scores differently predict developmental trajectories of subtypes of social withdrawal in middle childhood. Journal of Child Psychology and Psychiatry, 62(11), 1320-1329. https://doi.org/10.1111/jcpp.13459, https://acamh.onlinelibrary.wiley.com/doi/full/10.1111/jcpp.13459
15. *Laporte, C., Pereira, B., Orri, M., Chadi, N., Castellanos-Ryan, N., Brousse, G., Séguin, J.R., Xu, Q., Vitaro, F., Tremblay, R.E., Boivin, M., Côté, S.M. (2021). Associations of childhood sociability and responsibility with cannabis use trajectories during adolescence: results from a prospective population-based birth cohort study. European Child & Adolescent Psychiatry. https://doi.org/10.1007/s00787-021-01730-9; https://link.springer.com/article/10.1007/s00787-021-01730-9
16. *London-Nadeau, K., Rioux, C., Parent, S., Vitaro, F., Côté, S.M., Boivin, M., Tremblay, R.E., Séguin, J.R., Castellanos-Ryan, N. (2021). Longitudinal associations of cannabis, depression and anxiety in heterosexual and LGB adolescents. Journal of Abnormal Psychology, 130(4), 333-345. https://psycnet.apa.org/fulltext/2021-60300-001.pdf https://doi.org/10.1037/abn0000542
17. **Gauchat, A., Zadra, A., **El Hourani, M., Parent, S., Renaud, J., Tremblay, R.E., & Séguin, J.R. (2021). Association between recurrent dreams, disturbing dreams and suicidal ideation in adolescents. Dreaming, 31(1), 32-43. https://doi.org/10.1037/drm0000157
18. Orri, M., Chadi, N., Ahun, M. N., Séguin, J. R., Tremblay, R. E., Boivin, M., Turecki, G., Geoffroy, M.C., Côté, S.M. (2021). Suicidal ideation and attempt in adolescents exposed to maternal smoking across pregnancy and childhood: a 20-year prospective cohort study. Journal of Affective Disorders, 286, 10-18. https://www.sciencedirect.com/science/article/pii/S0165032721001737
19. Cox, S.M.L., Castellanos-Ryan, N., Parent, S., Benkelfat, C., Vitaro, F., Pihl, R.O., Boivin, M., Tremblay, R.E., Leyton, M., Séguin, J.R. (2021). Externalizing risk pathways for adolescent substance use and its developmental onset: A Canadian birth cohort study. Canadian Journal of Psychiatry, 66(10), 887-896. https://doi.org/10.1177/0706743720982429
20. *Suffren, S., *La Buissonière-Ariza, V., Tucholka, A., Nassim, M., Séguin, J.R., Boivin, M., Singh, M.K., Foland-Ross, L.R., Lepore, F., Gotlib, I.H., Tremblay, R.E., Maheu, F.S. (2021). Prefrontal cortex and amygdala anatomy in youth with persistent levels of harsh parenting practices and subclinical anxiety symptoms over time during childhood. Development and Psychopathology. https://doi.org/10.1017/S0954579420001716
21. *Azar, N., Booij, L., Muckle, G., Arbuckle, T.E., Séguin, J.R., Asztalos, E., Fraser, W.D., Lanphear, B.P., Bouchard, M.F. (2021). Prenatal Exposure to Polybrominated Diphenyl Ethers (PBDEs) and Cognitive Ability in Early Childhood. Environment International, 146 https://doi.org/10.1016/j.envint.2020.106296
22. *Orri, M., Séguin, J. R., Castellanos-Ryan, N., Tremblay, R. E., Côté, S. M., Turecki, G., Geoffroy, M.-C. (2021). A genetically informed study on the association of cannabis, alcohol, and tobacco smoking with suicide attempt. Molecular Psychiatry, 26, 5061–5070. https://doi.org/10.1038/s41380-020-0785-6
23. **Gauchat, A., Zadra, A., **El Hourani, M., Parent, S., Tremblay, R.E., and Séguin, J.R. (2020). The relation between disturbing dreams and psychosocial maladjustment in children: A prospective study of the moderating role of early negative emotionality. Frontiers in Neurology, 11:762, 1-11. https://www.frontiersin.org/articles/10.3389/fneur.2020.00762/
24. Cox, S.M.L., Tippler, M., *Jaworska, N., Smart, K., Castellanos-Ryan, N., Durand, F., Allard, D., Benkelfat, C., Parent, S., Dagher, A., Vitaro, F., Boivin, M., Pihl, R.O., Côté, S.M., Tremblay, R.E., Séguin, J.R., Leyton, M. (2020). mGlu5 receptor availability in youth at risk for addictions: Effects of vulnerability traits and cannabis use. Neuropsychopharmacology, 45(11), 1817-1825. https://www.nature.com/articles/s41386-020-0708-x.pdf
25. *Orri, M., *Scardera, S., *Perret, L.C., **Bolanis, D., Temcheff, C., Séguin, J.R., Boivin, M., Turecki, G., Tremblay, R.E., Côté, S.M., Geoffroy, M.C. (2020). Mental health problems and risk of suicidal ideation and attempts in adolescents. Pediatrics, 146(1), e20193823. https://doi.org/10.1542/peds.2019-3823
26. *Jaworska, N., Cox, S.M.L., Tippler, M., Castellanos-Ryan, N., Benkelfat, C., Parent, S., Dagher, A., Vitaro, F., Boivin, M., Pihl, R.O., Côté, S.M., Tremblay, R.E., Séguin, J.R., Leyton, M. (2020). Extra-striatal D2/3 receptor availability in youth at risk for addiction. Neuropsychopharmacology, 45(9), 1498-1505. https://www.nature.com/articles/s41386-020-0662-7
27. **Bolanis, D., Orri, M., Castellanos-Ryan, N., Renaud, J., Montreuil, T., Boivin, M., Vitaro, F., Tremblay, R.E., Turecki, G., Côté, S.M., Séguin, J.R., Geoffroy, M.C. (2020). Cannabis use, depression and suicidal ideation in Canadian adolescents: Comorbidity and direction of associations. Journal of Affective Disorders, 274, 1076-1083. https://doi.org/10.1016/j.jad.2020.05.136.
28. *Afzali, M. H., Stewart, S. H., Séguin, J. R., & Conrod, P. J. (2020). The network constellation of personality and substance use: Evolution from early to late adolescence. European Journal of Personality, 34(6), 1109-1139. https://doi.org/10.1002/per.2245https://doi.org/10.1002/per.2245
29. Oulhote, Y., Lanphear, B., Braun, J.M., Webster, G.M., Arbuckle, T.E., Etzel, T., Forget-Dubois, N., Séguin, J.R., Bouchard, M.F., MacFarlane, A., Ouellet, E., Fraser, W.D., Muckle, G. (2020). Gestational exposures to phthalates and folic acid, and autistic traits in Canadian children. Environmental Health Perspectives, 128, 2, https://ehp.niehs.nih.gov/doi/10.1289/EHP5621.
30. *Paquin, C., Côté, S.M., Tremblay, R.E., Séguin, J.R., Boivin, M., Herba, C.M. (2020). Maternal depressive symptoms and children’s cognitive development: Does early childcare and child’s sex matter? PLoS One, 15, e0227179. https://doi.org/10.1371/journal.pone.0227179.