Jean Séguin
Développement de la santé mentale de la grossesse à l'âge adulte
- Professeur titulaire
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Faculté de médecine - Département de psychiatrie et d’addictologie
Profile
Research expertise
The work of Dr Séguin bears on the cognitive and emotional aspects of the development of mental health, while taking into account risk and protective factors for substance use and cardiovascular health. His clinical training allows him to work as much with cognitive schemas, information processing approaches and underlying neural functions. His doctoral work (McGill University, 1995) aimed largely at neuropsychological aspects of physical aggression. Subsequent work broadened that conceptual basis to encompass hyperactivity, other externalised and internalised problems as well as cognitive development. A longitudinal study of a birth cohort allowed to examine the eraly development of self-regulation from a cognitive point of view. More recent studies, include pregnancy cohorts. One important hypothesis suggests that self regulation is partly acquired through socialisation. This research investigates the physiological, genetic and both physical and social environnemental bases of that learning from pregnancy. Child characteristics of interest include neuropsychological function as well as early temperament and personality. A key question for rpevention is what are the challenges and resources that affect that development? How does early self regulation lead to mental health? Can early interventions which aim to support families have an imppact on self-regulation?
Awards and recognitions
- 2016-2017 Bourse du Fonds Monique-Gaumond pour la recherche en maladies affectives
Affiliations and responsabilities
Research affiliations
Research units
Membre
- GRIP — Groupe de recherche sur l’inadaptation psychosociale chez l’enfant
- Centre de recherche Azrieli du CHU Sainte-Justine
- Cundill Center for Adolescent Depression, CAMH, Toronto
Affiliated institutions
- Centre hospitalier universitaire Sainte-Justine (CHU Sainte-Justine)
Teaching and supervision
Student supervision
Theses and dissertation supervision (Papyrus Institutional Repository)
Évolution des profils de comportements sociaux et de victimisation par les pairs des garçons et des filles au début du primaire : corrélats cognitifs, comportementaux et relationnels
Cycle : Doctoral
Grade : Ph. D.
Rêves dysphoriques, adversité précoce et adaptation psychosociale : étude longitudinale chez les enfants et les adolescents
Cycle : Doctoral
Grade : Ph. D.
L'examen de la fonction exécutive à 5, 6 et 7 ans et de son rôle dans le lien entre l'inhibition comportementale et les symptômes anxieux à 7 ans
Cycle : Doctoral
Grade : Ph. D.
Le rôle de la mémoire de travail et de l’impulsivité dès l’enfance dans la prédiction de la consommation de substances à travers l’adolescence.
Cycle : Master's
Grade : M. Sc.
De la sensibilité différentielle à la diathèse-stress dans la prédiction de la consommation de substances à l’adolescence : interactions entre l’environnement familial et le tempérament au cours du développement
Cycle : Doctoral
Grade : Ph. D.
Le rôle de la méthylation de l’ADN dans les fonctions cérébrales fronto-limbiques et la réactivité au stress quotidien
Cycle : Master's
Grade : M. Sc.
Rêves dysphoriques et rêves récurrents chez les enfants et les adolescents : corrélats psychosociaux et implications cliniques.
Cycle : Doctoral
Grade : Ph. D.
Habileté de mentalisation chez les mères présentant un trouble de personnalité limite : orientation mentale maternelle lors d’interactions mère-bébé.
Graduate : Marcoux, Andrée-Anne
Cycle : Master's
Grade : M. Sc.
Modèle de mélange de lois multinormales appliqué à l'analyse de comportements et d'habiletés cognitives d'enfants.
Graduate : Giguère, Charles-Édouard
Cycle : Master's
Grade : M. Sc.
Le rôle de la sérotonine sur le développement de traits anxieux : une étude de trajectoire longitudinale
Graduate : Farshadgohar, Tina
Cycle : Master's
Grade : M. Sc.
Negative affect mediates the relationship between the Cortisol Awakening Response and Conduct Problems in boys
Graduate : Walsh, Anthony
Cycle : Master's
Grade : M. Sc.
Le rôle de la garde non-maternelle sur le développement cognitif et la sécrétion cortisolaire des enfants : investigations longitudinales populationnelles et méta-analytiques
Graduate : Geoffroy, Marie-Claude
Cycle : Doctoral
Grade : Ph. D.
Projects
Research projects
Pubertal development and mental health in the 3D Cohort Study: Key biological, sociocultural and environmental correlates of puberty and their longitudinal association with mental health outcomes in boys and girls
Longitudinal associations between cannabis and polysubstance use and neurocognition across youth (13-27 years): Evidence from two prospective birth cohorts
Groupe de recherche sur l'inadaptation psychosociale chez l'enfant (GRIP). ( GRIPSYENF )
From birth to adulthood: The role of age of cannabis use onset in the individual and environmental developmental pathways leading to substance use problems.
The role of age of cannabis use onset in the developmental pathways leading to substance use problems by early adulthood: key mediators and moderators.
Estimating the effect size of rare genomic variants on cognitive and behavioral traits underlying neurodevelopmental disorders
Talking at home and at school: The developmental trajectory of oral language among young children who speak minority languages
Temporal effects of alcohol and polysubstance use on neurocognition across youth (13-25 years): Evidence from a prospective birth cohort
Canabis and brain maturation: A population-based study
Challenges to the vulnerable child in the transitions from preschool to grade school in a pregnancy cohort
The predective brain: a sensitive biomaker of neurodevelopment
Exploring cannabis use and mental health in sexually and gender diverse youth: A qualitative, community-based study
Réseau RQSHA/A prospective study of mental health change across Québec children linked to COVID-19
Shared and specific risk factors for early onset cannabis and other substance use and later substance use disorders: can we predict who will initiate cannabis use early and who will develop future substance use problems?
Dopamine and Risk for Addictions
EFFECTS OF DELAYING AGE OF ONSET OF BINGE DRINKING ON ADOLESCENT BRAIN DEVELOPMENT : A PROPOSAL TO ADD NEUROIMAING MEASURES TO THE CO-VENTURE TRIAL.
Targeting impulsivity in early childhood in the prevention of externalizing psychopathology: Using RCT to test developmental models of individual (biology/dispositional) factors by environment interaction
JEUX DE HASARD ET D'ARGENT A L'ADOLESCENCE: PROFILS-TYPE, FACTEURS PREDICTIFS ET REUSSITE SCOLAIRE
A CLUSTER RANDOMISED TRIAL INVESTIGATING THE EFFECTS OF DELAYING ONSET OF SUBSTANCE USE ON ADOLESCENT COGNITIVE DEVELOPMENT
Maternal stress, depression and anxiety during pregnancy and associations with biomarkers of stress in a Canadian pregnancy cohort.
Maternal stress, depression and anxiety during pregnancy and early child development: A study of psychosocial and biological mechanisms
MATURATION AND PSYCHOSOCIAL FACTORS' RELATION TO SUBSTANCE USE IN ADOLESCENCE FOR CHILDREN WIHT EARLY PHYSICAL AGGRESSION AND HYPERACTIVITY
MATERNAL DEPRESSION AND CHILD MENTAL HEALTH : ROLE OF EMOTION-PROCESSING AND CHILDCARE
FROM BIRTH TO ADOLESCENCE : THE DEVELOPMENTAL TRAJECTORIES LEADING TO MENTAL HEALTH PROBLEMS IN A REPRESENTATIVE POPULATION SAMPLE
(RESEAUTETE) - THE INTEGRATED RESEARCH NETWORK ON PERINATOLOGY
LONG-TERM CONSEQUENCES OF PRENATAL EXPOSURE TO MATERNAL CIGARETTE SMOKING ON BRAIN STRUCTURE, FUNCTION AND MENTAL HEALTH IN ADOLESCENCE : ROLE OF GENES AND ENVIRONNEMENT IN BRAIN DEVELOPMENT
MATERNAL DEPRESSION AND CHILD MENTAL HEALTH : ROLE OF EMOTION-PROCESSING AND NON-MATERNAL CARE
LES PRECURSEURS DES PROBLEMES DE JEU A L'ADOLESCENCE : UN MODELE DEVELOPPEMENTAL INTEGRE - PHASE 2
(RESEAUTETE) CIHR - QUEBEC TRAINING NETWORK IN PERINATAL RESEARCH
HARSH PARENTING CONDITIONS AND FEAR CIRCUITRY FUNCTION IN ANXIOUS AND HEALTH YOUTHS
GROUPE DE RECHERCHE SUR L'INADAPTATION PSYCHOSOCIALE CHEZ L'ENFANT (GRIP)
MATURATION AND PSYCHOSOCIAL FACTORS' RELATION TO SUBSTANCE USE IN ADOLESCENCE FOR CHILDREN WIHT EARLY PHYSICAL AGGRESSION AND HYPERACTIVITY
THE INTERACTION OF FETAL DEVELOPMENT AND GENOTYPE IN DETERMINING NEUROCOGNITIVE DEVELOPMENT
AMELIORATION DE LA SANTE MENTALE PAR LES SERVICES PERINATAUX ET PRESCOLAIRES: PERSPECTIVE INTERGENERATIONNELLE DES MECANISMES BIO-PSYCHO-SOCIAUX
PEER INFLUENCES ON ADOLESCENT SUBSTANCE USE
Outreach
Publications and presentations
Publications
- **Gauchat, A., Zadra, A., **El Hourani, M., Parent, S., Renaud, J., Tremblay, R.E., & Séguin, J.R. (2021). Association between recurrent dreams, disturbing dreams and suicidal ideation in adolescents. Dreaming
- *London-Nadeau, K., Rioux, C., Vitaro, F., Côté, S.M., Boivin, M., Tremblay, R.E., Séguin, J.R., Castellanos-Ryan, N. (2021). Longitudinal associations of cannabis, depression and anxiety in heterosexual and LGB adolescents. Journal of Abnormal Psychology.
- Cox, S.M.L., Castellanos-Ryan, N., Parent, S., Benkelfat, C., Vitaro, F., Pihl, R.O., Boivin, M., Tremblay, R.E., Leyton, M., Séguin, J.R. (2021). Externalizing risk pathways for adolescent substance use and its developmental onset: A Canadian birth cohort study. Canadian Journal of Psychiatry.
- *Suffren, S., *La Buissonière-Ariza, V., Tucholka, A., Nassim, M., Séguin, J.R., Boivin, M., Singh, M.K., Foland-Ross, L.R., Lepore, F., Gotlib, I.H., Tremblay, R.E., Maheu, F.S. (2021). Prefrontal cortex and amygdala anatomy in youth with persistent levels of harsh parenting practices and subclinical anxiety symptoms over time during childhood. Development and Psychopathology.
- *Azar, N., Booij, L., Muckle, G., Arbuckle, T.E., Séguin, J.R., Asztalos, E., Fraser, W.D., Lanphear, B.P., Bouchard, M.F. (2021). Prenatal Exposure to Polybrominated Diphenyl Ethers (PBDEs) and Cognitive Ability in Early Childhood. Environment International, 146 https://doi.org/10.1016/j.envint.2020.106296
- **Gauchat, A., Zadra, A., **El Hourani, M., Parent, S., Tremblay, R.E., and Séguin, J.R. (2020). The relation between disturbing dreams and psychosocial maladjustment in children: A prospective study of the moderating role of early negative emotionality. Frontiers in Neurology, 11:762, 1-11. https://www.frontiersin.org/articles/10.3389/fneur.2020.00762/
- Cox, S.M.L., Tippler, M., *Jaworska, N., Smart, K., Castellanos-Ryan, N., Durand, F., Allard, D., Benkelfat, C., Parent, S., Dagher, A., Vitaro, F., Boivin, M., Pihl, R.O., Côté, S.M., Tremblay, R.E., Séguin, J.R., Leyton, M. (2020). mGlu5 receptor availability in youth at risk for addictions: Effects of vulnerability traits and cannabis use. Neuropsychopharmacology. https://www.nature.com/articles/s41386-020-0708-x.pdf
- *Orri, M., Séguin, J. R., Castellanos-Ryan, N., Tremblay, R. E., Côté, S. M., Turecki, G., Geoffroy, M.-C. (2020). A genetically informed study on the association of cannabis, alcohol, and tobacco smoking with suicide attempt. Molecular Psychiatry. https://doi.org/10.1038/s41380-020-0785-6
- *Orri, M., *Scardera, S., *Perret, L.C., **Bolanis, D., Temcheff, C., Séguin, J.R., Boivin, M., Turecki, G., Tremblay, R.E., Côté, S.M., Geoffroy, M.C. (2020). Mental health problems and risk of suicidal ideation and attempts in adolescents. Pediatrics, 146(1), e20193823. https://doi.org/10.1542/peds.2019-3823
- *Jaworska, N., Cox, S.M.L., Tippler, M., Castellanos-Ryan, N., Benkelfat, C., Parent, S., Dagher, A., Vitaro, F., Boivin, M., Pihl, R.O., Côté, S.M., Tremblay, R.E., Séguin, J.R., Leyton, M. (2020). Extra-striatal D2/3 receptor availability in youth at risk for addiction. Neuropsychopharmacology, 45(9), 1498-1505. https://www.nature.com/articles/s41386-020-0662-7
- **Bolanis, D., Orri, M., Castellanos-Ryan, N., Renaud, J., Montreuil, T., Boivin, M., Vitaro, F., Tremblay, R.E., Turecki, G., Côté, S.M., Séguin, J.R., Geoffroy, M.C. (2020). Cannabis use, depression and suicidal ideation in Canadian adolescents: Comorbidity and direction of associations. Journal of Affective Disorders, 274, 1076-1083. https://doi.org/10.1016/j.jad.2020.05.136.
- *Afzali, M. H., Stewart, S. H., Séguin, J. R., & Conrod, P. J. (2020). The network constellation of personality and substance use: Evolution from early to late adolescence. European Journal of Personality. https://doi.org/10.1002/per.2245
- Oulhote, Y., Lanphear, B., Braun, J.M., Webster, G.M., Arbuckle, T.E., Etzel, T., Forget-Dubois, N., Séguin, J.R., Bouchard, M.F., MacFarlane, A., Ouellet, E., Fraser, W.D., Muckle, G. (2020). Gestational exposures to phthalates and folic acid, and autistic traits in Canadian children. Environmental Health Perspectives, 128, 2, https://ehp.niehs.nih.gov/doi/10.1289/EHP5621.
- *Paquin, C., Côté, S.M., Tremblay, R.E., Séguin, J.R., Boivin, M., Herba, C.M. (2020). Maternal depressive symptoms and children’s cognitive development: Does early childcare and child’s sex matter? PLoS One, 15, e0227179. https://doi.org/10.1371/journal.pone.0227179.
- Krzeczkowski, J. E., Boylan, K., Arbuckle, T. E., Muckle, G., Poliakova, N., Séguin, J. R., Favotto, L.A., Savoy, C., Amani, B., Mortaji, N.; Van Lieshout, R.J. (2020). Maternal pregnancy diet quality is directly associated with autonomic nervous system function in 6-month-old offspring. The Journal of Nutrition, 150, 267-275 https://doi.org/10.1093/jn/nxz228
- *Paquin, C., Castellanos-Ryan, N., Vitaro, F., Côté, S.M., Tremblay, R.E., Séguin, J.R., Boivin, M., Herba, C.M. (2020). Maternal depression symptoms, child behavior problems and their transactional relations: Probing the role of formal childcare. Development and Psychopathology, 32(3), 831-844. https://doi.org/10.1017/S0954579419000956
- *Charrois, J., Côté, S.M., Paquin, S., Séguin, J.R., Japel, C., Vitaro, F., Kim-Cohen, J., Tremblay, R.E., Herba, C.M. (2019). Maternal depression in early childhood and child emotional and behavioral outcomes at school-age: Examining the roles of preschool childcare quality and current maternal depression symptomatology. European Child and Adolescent Psychiatry, 29(5), 637-648. https://link.springer.com/article/10.1007%2Fs00787-019-01385-7
- Rioux,C., *Murray,J., Castellanos-Ryan,N., Séguin,J.R., Tremblay,R.E., Parent,S. (2020). Moderation of parenting by inhibitory control in the prediction of the common and unique variance of hyperactivity-impulsivity and inattention. Development and Psychopathology, 32(3), 909-921. https://doi.org/10.1017/S0954579419000774
- Arbuckle, T.E., MacPherson, S., Barrett, E., Muckle, G., Séguin, J.R., Foster, W.G., Sathyanarayana, S., Dodds, L., Fisher, M., Agarwal, A., Monnier, P., Walker, M., Fraser, W.D. (2019). Do stressful life events during pregnancy modify associations between phthalates and anogenital distance in newborns? Environmental Research, 177, 108593. http://www.sciencedirect.com/science/article/pii/S0013935119303901, https://doi.org/10.1016/j.envres.2019.108593
- *La Buissonnière-Ariza V., Séguin, J.R., Nassim, M., Boivin, M., Pine, D.S., Lepore, F., Tremblay, R.E., Maheu, F.S. (2019). Chronic Harsh Parenting and Anxiety Associations with Fear Circuitry Function in Healthy Adolescents: A Preliminary Study. Biological Psychology, 145, 198-210. http://www.sciencedirect.com/science/article/pii/S0301051118301248 https://doi.org/10.1016/j.biopsycho.2019.03.019
- *Gorin, H. M., Kosson, D. S., Miller, S. A., Fontaine, N. M. G., Vitaro, F., Séguin, J. R., Boivin, M., Côté, S. & Tremblay, R. E. (2019). Psychopathic Traits in Middle Childhood: Evidence of a Hierarchical Three-Factor Structure. Journal of Psychopathology and Behavioral Assessment, 41, 341-352. https://doi.org/10.1007/s10862-019-09733-2
- *Farooqi, N. A. I., *Scotti, M., Yu, A., Lew, J., Monnier, P., Botteron, K. N., Campbell, B.C., Booij, L., Herba, C.M., Séguin, J.R., Castellanos-Ryan, N., McCracken, J.T., Nguyen, T.V. (2019). Sex-specific contribution of DHEA-cortisol ratio to prefrontal-hippocampal structural development, cognitive abilities and personality traits. Journal of Neuroendocrinology, 31, e12682. https://doi.org/10.1111/jne.12682
- *Smart, K., Cox, S. M. L., Kostikov, A., Shalai, A., Scala, S. G., Tippler, M., *Jaworska, N., Boivin, M., Séguin, J. R., Benkelfat, C., Leyton, M. (2019). Effect of (z)-isomer content on [¹¹C]ABP688 binding potential in humans. European Journal of Nuclear Medicine and Molecular Imaging, 46 (5), 1175-1178. https://link.springer.com/article/10.1007/s00259-018-4237-3
- *Smart, K., Cox, S. M. L., Scala, S. G., Tippler, M., *Jaworska, N., Boivin, M., Séguin, J. R., Benkelfat, C., Leyton, M. (2019). Sex differences in [11C]ABP688 Binding A positron emission tomography study of mGlu5 receptors. European Journal of Nuclear Medicine and Molecular Imaging, 46 (5), 1179-1183. https://link.springer.com/article/10.1007/s00259-018-4252-4
- *Afzali, M. H., Sunderland, M., Stewart, S. H., Mâsse, B., Séguin, J. R., Newton, N., Teeson, M., Conrod, P. J. (2019). Machine-learning prediction of adolescent alcohol use: A cross-study, cross-cultural validation. Addiction, 114(4), 662-671. https://onlinelibrary.wiley.com/doi/epdf/10.1111/add.14504
- **Rioux, C., Castellanos-Ryan, N. Vitaro, F., Séguin, J.R. (2019). The interactive effects of parental knowledge with impulsivity and sensation seeking in adolescent substance use. Child Psychiatry and Human Development, 50, 95-107. https://link.springer.com/article/10.1007/s10578-018-0825-5
- **Rioux, C., & Séguin, J. R. (2019). Commentary on Otten et al. (2019): Moderators and person-environment interactions in developmental cascade models. Addiction, 114(2), 335-336.
- *Sharkey, R.J., *Bourque, J, Larcher, K., Misic, B., Zhang, Y., Altinkaya, A., Sadikot, A., Conrod, P.J., Evans, A.C., Garavan, H., Leyton, M., Séguin, J.R., Pihl, R.O., Dagher, A. (2019). Early adolescent striatal and midbrain resting state connectivity correlate with impulsivity, sensation-seeking, and body weight. Appetite, 132, 25-36. https://www.sciencedirect.com/science/article/pii/S0195666318306184?via%3Dihub
- Li, N., Arbuckle, T.E., Muckle, G., Lanphear, B.P., Boivin, M., Chen, A., Dodds, L., Fraser, W.D., Ouellet, E., Séguin, J.R., Vélez, M.P., Yolton, K., Braun, J.M. (2019). Associations of cord blood leptin and adiponectin with children’s cognitive abilities. Psychoneuroendocrinology, 99, 257-264. https://www.sciencedirect.com/science/article/pii/S0306453018308187?via%3Dihub https://doi.org/10.1016/j.psyneuen.2018.10.021
- Parent, S., Lupien, S., Herba, C., Dupéré, V., Gunnar, M., and Séguin, J.R. (2019). Children’s cortisol response to the transition from preschool to formal schooling: A review. Psychoneuroendocrinology, 99, 196-205. https://doi.org/10.1016/j.psyneuen.2018.09.013.
- *Morin, J.-F. G., *Afzali, M. H., *Bourque, J., Stewart, S. H., Séguin, J. R., *O'Leary-Barrett, M. & Conrod, P. J. (2019) A population-based analysis of the relationship between substance use and adolescent cognitive development. American Journal of Psychiatry, 176, 98-106. https://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2018.18020202#
- **Rioux, C., Séguin, J.R., Paris, J. (2018). Perspective: Differential susceptibility to the environment and Borderline Personality Disorder. Harvard Psychiatry Review, 26(6), 374-383. https://doi.org/10.1097/HRP.0000000000000182.
- Etzel, T., Muckle, G., Arbuckle, T. E., Fraser, W. D., Ouellet, E., Séguin, J. R., Lanphear, B., Braun, J.M. (2018). Prenatal urinary triclosan concentrations and child neurobehavior. Environment International, 114, 152-159. https://www.sciencedirect.com/science/article/pii/S0160412017319979
Disciplines
- Psychology
- Psychiatry
- Psychoeducation
Areas of expertise
- Learning and Memory (Psychology - Biological Aspects)
- Cognition and Language
- Life Cycles ( Childhood, Adolescence, Adulthood, etc.)
- Affective and Emotional Development
- Cognitive Development
- Motivation, Emotions and Rewards
- Socialization
- Drug Abuse
- Behavioral Disorders in Children and Adolescents