Derek Boerboom
Reproduction et endocrinologie
- Professeur titulaire
-
Faculté de médecine vétérinaire - Département de biomédecine vétérinaire
Pavillon 3200, rue Sicotte - Aile A, room 3453
Profile
Research expertise
Étude des rôles des Wnts dans le système reproducteur
Les cancers du système reproducteur
Modélisation animale, trangénèse et génomique fonctionnelle
education
- 2005 — Études postdoctorales — Endocrinologie — Baylor College of Medicine
- 2002 — D.M.V. — — Université de Montréal
- 2000 — Ph.D. — Biologie moléculaire — Université de Montréal
- 1995 — M.Sc. — Biochimie — McGill University
- 1993 — B.Sc. — Biochimie — McGill University
Affiliations and responsabilities
Research affiliations
Teaching and supervision
Student supervision
Theses and dissertation supervision (Papyrus Institutional Repository)
Élucidation des rôles de YAP1 et TAZ dans l'ovaire chez la souris
Cycle : Doctoral
Grade : Ph. D.
Ciblage de la voie Hippo avec les statines pour le traitement des tumeurs mammaires canines
Cycle : Master's
Grade : M. Sc.
Un nouveau rôle de la voie Hippo dans la synthèse des gonadotrophines
Cycle : Master's
Grade : M. Sc.
Comparison of vitrification protocols in immature equine oocytes
Cycle : Master's
Grade : M. Sc.
Élucidation des rôles des voies Wnt et Hippo dans le développement et la fonction du tractus reproducteur femelle chez la souris
Cycle : Doctoral
Grade : Ph. D.
L’efficacité in vitro d'un inhibiteur de VCP de première génération (CB-5083) contre le lymphome canin.
Cycle : Master's
Grade : M. Sc.
Rôle de la voie de signalisation Hippo dans les organes stéroïdiens.
Cycle : Doctoral
Grade : Ph. D.
Élucidation du rôle de la voie Hippo dans l’ovaire chez la souris
Cycle : Doctoral
Grade : Ph. D.
Ciblage thérapeutique de la voie Hippo pour le traitement des cancers mammaires chez la chienne
Cycle : Master's
Grade : M. Sc.
A hypoxia response element in the Vegfa promoter is required for basal Vegfa expression in skin and for optimal granulation tissue formation during wound healing in mice
Cycle : Master's
Grade : M. Sc.
Elucidation of the biological roles of Wnt5a signaling in follicle development
Cycle : Doctoral
Grade : Ph. D.
Evaluation of valosin containing protein (P97) as a cancer biomaker in canine lymphomas
Cycle : Master's
Grade : M. Sc.
Anti-VEGFA therapy reduces tumor growth and extends survival in a murine model of ovarian granulosa cell tumor
Cycle : Master's
Grade : M. Sc.
Régulation de la fonction ovarienne par la voie de signalisation des WNTs
Cycle : Doctoral
Grade : Ph. D.
Contribution de l’hypoxie et du facteur hif1a à la guérison cutanée chez le cheval
Cycle : Doctoral
Grade : Ph. D.
Contribution de l'hypoxie à la cicatrisation cutanée anormale chez le cheval : méthodes physiques d'évaluation
Cycle : Doctoral
Grade : Ph. D.
Études des rôles physiopathologiques de PTEN dans le tractus reproducteur femelle
Cycle : Doctoral
Grade : Ph. D.
Identification and characterization of the transcriptional targets of the WNT/β-catenin signaling pathway in granulosa cells
Cycle : Master's
Grade : M. Sc.
Projects
Research projects
Regulation of gonadotropin action by Slit/Robo signaling in the mammalian orary
Role of development signaling pathways in testicular physiology and spermatogenesis
The Hippo pathway as a regulator of ovarian follicle development
Réseau Québecois en Reproduction (RQR)
Bourse de stage international - Melany Juarez / Réseau Québécois en reproduction (RQR)
Bourse de stage international - Jorge William Franco de Barros Jorge / Réseau Québécois en reproduction (RQR)
MECHANISMS OF GNRH ACTION
Supplément COVID-19 CRSNG_Role of development signaling pathways in testicular physiology and spermatogenesis
Bourse de stage international - Brocher Celia / Réseau Québécois en reproduction (RQR)
Bourse de stage international - Bienvenue-Pariseault Josianne / Réseau Québécois en reproduction (RQR)
TRANSCRIPTIONAL REGULATION OF FOLLICLE STIMULATING HORMONE SYNTHESIS
Transcriptional regulation of follicle stimulating hormone synthesis
Bourse de stage international - Yining Li - Regroupement stratégique Réseau Québécois en reproduction
Bourse de stage international - Raguema, Nozha, Regroupement stratégique Réseau Québécois en reproduction
BASIC RESEARCH EQUIPMENT AND LABORATORY SETUP FOR THE CANADA RESEARCH CHAIR IN OVARIAN MOLECULAR BIOLOGY AND FUNCTIONAL GENOMICS
ELUCIDATION OF THE ROLES OF WNT SIGNALING IN THE MAMMALIAN OVARY
ROLE OF DEVELOPMENTAL SIGNALING PATHWAYS IN TESTICULAR PHYSIOLOGY AND SPERMATOGENESIS
REGROUPEMENT STRATEGIQUE - RESEAU QUEBECOIS EN REPRODUCTION (RQR)
IMPORTANCE FONCTIONNELLE D'UNE DIVERGENCE EVOLUTIVE DE LA STRUCTURE DU RECEPTEUR DE LA GONADOLIBERINE CHEZ LES MAMMIFERES
AMH, PREDICTIVE TOOL OF OVARIAN RESPONSE TO A SUPEROVULATION TREATMENT IN A COW
IMPORTANCE FONCTIONNELLE D'UNE DIVERGENCE ÉVOLUTIVE DE LA STRUCTURE DU RÉCEPTEUR DE LA GONADOLIBÉRINE CHEZ LES MAMMIFÈRES
MECHANISMS OF GNRH ACTION
ASSESSEMENT OF VCP AS A POTENTIAL DIAGNOSTIC MARKER FOR EARLY-STAGE AND RECURRENT OVARIAN CANCER
BIOLOGIE MOLECULAIRE ET GENOMIQUE FONCTIONNELLE DE L'OVAIRE
Valosin containing protein (VCP): a novel therapeutic target for canine lymphoma
Description
Validation in vitro de la protein VCP comme cible thérapeutique dans le lymphome canin.
NOUVELLES VOIES VERS L'EMBRYON SAIN CHEZ LES ANIMAUX DE CONSOMMATION
TRAINING IN REPRODUCTIVE BIOLOGY
TRANSCRIPTIONAL REGULATION OF FOLLICLE STIMULATING HORMONE SYNTHESIS
TRANSCRIPTIONAL REGULATION OF FOLLICLE STIMULATING HORMONE SYNTHESIS
ELUCIDATION OF THE ROLES OF WNT SIGNALING IN THE MAMMALIAN OVARY
REMBOURSEMENT DU CONGÉ PARENTAL D'ÉVELYNE LAPOINTE
Outreach
Publications and presentations
Publications
Boyer A, Girard M, Thimmanahalli DS, Levasseur A, Celeste C, Paquet M, et al. mTOR Regulates Gap Junction Alpha-1 Protein Trafficking in Sertoli Cells and Is Required for the Maintenance of Spermatogenesis in Mice. Biology of reproduction. 2016;95(1):13. Epub 2016/06/10.
Abedini, A., Zamberlam, G., Lapointe, E., Tourigny, C., Boyer, A., Paquet, M., Hayashi, K., Honda, H., Kikuchi, A., Price, C.A. and Boerboom, D. WNT5a is required for normal ovarian follicle development and antagonizes gonadotropin responsiveness in granulosa cells by suppressing canonical WNT signaling. The FASEB Journal Apr;30(4):1534-1547 (2016).
Abedini A, Zamberlam G, Boerboom D, Price CA. Non-canonical WNT5A is a potential regulator of granulosa cell function in cattle. Molecular and cellular endocrinology. 2015;403:39-45. Epub 2015/01/21.
Boerboom D, Kumar V, Boyer A, Wang Y, Lambrot R, Zhou X, et al. beta-catenin stabilization in gonadotropes impairs FSH synthesis in male mice in vivo. Endocrinology. 2015;156(1):323-33. Epub 2014/10/25.
Dong, Y., Wu, H., Rahman, H.N., Liu, Y., Pasula, S., Tessneer, K.L., Cai, X., Liu, X., Chang, B., McManus, J., Hahn, S., Dong, J., Brophy, M.L., Yu, L., Song, K., Silasi-Mansat, R., Saunders, D., Njoku, C., Song, H., Mehta-D'Souza, P., Towner, R., Lupu, F., McEver, R.P., Xia, L., Boerboom, D., Srinivasan, R.S., and Chen, H. Motif mimetic of epsin perturbs tumor growth and metastasis. Journal of Clinical Investigation Dec 1;125(12):4349-4364 (2015).
Nadeau, M.E., Rico, C., Tsoi, M., Vivancos, M., Filimon, S., Paquet, M. and Boerboom, D. Pharmacological targeting of valosin containing protein (VCP) selectively kills canine lymphoma cells by inducing DNA damage. BMC Cancer Jun 24;15:479 (2015).
Rico C, Dodelet-Devillers A, Paquet M, Tsoi M, Lapointe E, Carmeliet P, et al. HIF1 activity in granulosa cells is required for FSH-regulated Vegfa expression and follicle survival in mice. Biology of reproduction. 2014;90(6):135. Epub 2014/05/24.
Tsoi M, Lague MN, Boyer A, Paquet M, Nadeau ME, Boerboom D. Anti-VEGFA Therapy Reduces Tumor Growth and Extends Survival in a Murine Model of Ovarian Granulosa Cell Tumor. Translational oncology. 2013;6(3):226-33. Epub 2013/06/05.
Tran S, Zhou X, Lafleur C, Calderon MJ, Ellsworth BS, Kimmins S, et al. Impaired fertility and FSH synthesis in gonadotrope-specific Foxl2 knockout mice. Molecular endocrinology (Baltimore, Md). 2013;27(3):407-21. Epub 2013/01/24.
Fortin J, Kumar V, Zhou X, Wang Y, Auwerx J, Schoonjans K, et al. NR5A2 regulates Lhb and Fshb transcription in gonadotrope-like cells in vitro, but is dispensable for gonadotropin synthesis and fertility in vivo. PloS one. 2013;8(3):e59058. Epub 2013/03/29.
Lapointe E, Boyer A, Rico C, Paquet M, Franco HL, Gossen J, et al. FZD1 regulates cumulus expansion genes and is required for normal female fertility in mice. Biology of reproduction. 2012;87(5):104. Epub 2012/09/08.
Rico C, Lague MN, Lefevre P, Tsoi M, Dodelet-Devillers A, Kumar V, et al. Pharmacological targeting of mammalian target of rapamycin inhibits ovarian granulosa cell tumor growth. Carcinogenesis. 2012;33(11):2283-92. Epub 2012/08/09.
Richards JS, Fan HY, Liu Z, Tsoi M, Lague MN, Boyer A, et al. Either Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in the ovary and testis. Oncogene. 2012;31(12):1504-20. Epub 2011/08/24.
Lague MN, Romieu-Mourez R, Bonneil E, Boyer A, Pouletty N, Mes-Masson AM, et al. Proteomic profiling of a mouse model for ovarian granulosa cell tumor identifies VCP as a highly sensitive serum tumor marker in several human cancers. PloS one. 2012;7(8):e42470. Epub 2012/08/08.
Deschene K, Celeste C, Boerboom D, Theoret CL. Hypoxia regulates the expression of extracellular matrix associated proteins in equine dermal fibroblasts via HIF1. Journal of dermatological science. 2012;65(1):12-8. Epub 2011/10/18.
Boyer A, Yeh JR, Zhang X, Paquet M, Gaudin A, Nagano MC, et al. CTNNB1 signaling in sertoli cells downregulates spermatogonial stem cell activity via WNT4. PloS one. 2012;7(1):e29764. Epub 2012/01/19.
Disciplines
- Veterinary Sciences
Areas of expertise
- Endocrinologie animale
- Animal Reproduction