Christopher A. Price
fertility, ovary, cattle, sheep, ovulation
- Professeur titulaire
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Faculté de médecine vétérinaire - Département de biomédecine vétérinaire
Pavillon 3200, rue Sicotte - Aile A, room 1429
Profile
Research expertise
The long-term goals of my lab are to understand better the endocrine and paracrine factor that control ocarian follicle development, for a better control of fertility in cattle.
To do so, we use mainly in-vitro appoaches with ruminant granulosa and theca cell cultures to investigate the mechanisms of action of various hormines and growth factors on cell health and function.
Biography
BSc, University of Nottingham
PhD, University of Edinburgh
Post-doc: Wallaceville Animal Research Centre, New Zealand.
Affiliations and responsabilities
Research affiliations
Teaching and supervision
Student supervision
Theses and dissertation supervision (Papyrus Institutional Repository)
Phosphatases à double spécificité dans l’ovaire : rôle et régulation par les facteurs de croissance chez la vache et la brebis
Cycle : Doctoral
Grade : Ph. D.
Comparison of vitrification protocols in immature equine oocytes
Cycle : Master's
Grade : M. Sc.
Regulation of thecal endothelial cell function by growth factors in ruminants
Cycle : Master's
Grade : M. Sc.
Effects of deoxynivalenol and deepoxy-deoxynivalenol on bovine ovarian theca cell function
Cycle : Master's
Grade : M. Sc.
Effects of the mycotoxin, deoxynivalenol, and its major metabolite, de-epoxy deoxynivalenol, on bovine reproduction
Cycle : Doctoral
Grade : Ph. D.
Elucidation of the biological roles of Wnt5a signaling in follicle development
Cycle : Doctoral
Grade : Ph. D.
Expression et effets des WNTs sur l’expansion du cumulus et la maturation de l’ovocyte chez la vache
Cycle : Master's
Grade : M. Sc.
The involvement of nitric oxide in bovine follicular development and ovulation
Cycle : Doctoral
Grade : Ph. D.
Differential regulation of early response genes by fibroblast growth factor (FGF) 8 and FGF18 in bovine granulosa cells in vitro
Cycle : Master's
Grade : M. Sc.
La régulation du gène CYP19A1 dans les cellules de granulosa bovine in vitro
Cycle : Doctoral
Grade : Ph. D.
Purification and identification of specific RNA-binding protein that binds to the 3'UTR region of cytochrome P450aromatase mRNA in bovine granulosa cells
Cycle : Master's
Grade : M. Sc.
Expression and regulation of protease nexin-1 and plasminogen activators in bovine ovarian follicles
Cycle : Doctorat / Doctoral
Grade : Ph. D.
La régulation du gène P450aromatase dans les cellules de granulosa bovine in vitro
Cycle : Doctoral
Grade : Ph. D.
Projects
Research projects
Novel mechanisms of theca cell growth in the ovarian follicle of cattle
Réseau Québecois en Reproduction (RQR)
Nouvelles cibles moléculaires dans le but d’améliorer la fonction ovarienne chez la vache laitière
THE ROLE OF THECA CELLS IN OVARIAN FOLLICLE ATRESIA IN CATTLE
The role of theca cells in ovarian follicle atresia in cattle - Supplément d'accélération
REGROUPEMENT STRATEGIQUE - RESEAU QUEBECOIS EN REPRODUCTION (RQR)
EFFECT OF FUNGAL TOXINS ON FERTILITY IN DAIRY CATTLE
NOVEL REGULATORS OF GRANULOSA CELL FUNCTION
LIQUID SCINTILLATION COUNTER
NOUVELLES VOIES VERS L'EMBRYON SAIN CHEZ LES ANIMAUX DE CONSOMMATION
NOVEL REGULATORS OF GRANULOSA CELL FUNCTION
NOUVELLES VOIES VERS L'EMBRYON SAIN CHEZ LES ANIMAUX DE CONSOMMATION
SAFETY OF ESTRADIOL USE DURING SUPEROVULATION IN LACTATING DAIRY COWS
INCUBATOR SUITE
Outreach
Publications and presentations
Publications
Jaton C, Koeck A, Sargolzaei M, Malchiodi F, Price CA, Schenkel FS, et al. Genetic analysis of superovulatory response of Holstein cows in Canada. J Dairy Sci. 2016;99(5):3612-23.
Abedini A, Zamberlam G, Lapointe E, Tourigny C, Boyer A, Paquet M, Hayashi K, Honda H, Kikuchi A, Price C, Boerboom D. (2016) WNT5a is required for normal ovarian follicle development and antagonizes gonadotropin responsiveness in granulosa cells by suppressing canonical WNT signaling. FASEB Journal DOI:10.1096/fj.15-280313.
Price CA (2016) Invited review: Mechanisms of fibroblast growth factor signaling in the ovarian follicle. Journal of Endocrinology 228: R31-R43.
Castilho ACS, Price CA, Dalanezi F, Ereno RL, Machado MF, Barros CM, Gasperin BG, Gonçalves PBD, Buratini J (2015) Evidence that fibroblast growth factor 10 plays a role in follicle selection in cattle. Reproduction, Fertility and Development in press.
de Souza LB, Paradis M, Zamberlam G, Benoit-Biancamano MO, Price C (2015) Identification of 5α-reductase isoenzymes in canine skin. Veterinary Dermatology 26: 363-e81.
Machado MF, Caixeta ES, Sudiman J, Gilchrist RB, Thompson JG, Lima PF, Price CA, Buratini J. (2015) Fibroblast growth factor 17 and bone morphogenetic protein 15 enhance cumulus expansion and improve quality of in vitro-produced embryos in cattle. Theriogenology 84: 390-398.
Guerrero-Netro HM, Chorfi Y, Price CA (2015) Effects of the mycotoxin deoxynivalenol on steroidogenesis and apoptosis in granulosa cells. Reproduction 149: 555-561.
de Souza LB, Dupras R, Mills L, Chorfi Y, Price CA. Effect of synchronization of follicle-wave emergence with estradiol and progesterone and superstimulation with follicle-stimulating hormone on milk estrogen concentrations in dairy cattle. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire. 2013;77(1):75-8.
Sahmi F, Nicola E, Price CA. Bioassay for follicle stimulating activity of equine gonadotropic hormone in mare serum using frozen/thawed transiently transfected reporter cells. Theriogenology. 2012;78(4):724-30.
Disciplines
- Veterinary Sciences
- Biology and Related Sciences
- Endocrinology
- Physiology
Areas of expertise
- Physiologie de la reproduction