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Je donne

Rechercher

Natural Sciences and Engineering; Health Sciences; Medical Sciences

Christopher A. Price

fertility, ovary, cattle, sheep, ovulation

Professeur titulaire

Faculté de médecine vétérinaire - Département de biomédecine vétérinaire

Pavillon 3200, rue Sicotte - Aile A, room 1429

514 343-6111 #8383

christopher.price@umontreal.ca

Secondary number: 450 773-8521 #8261 (Travail 1)

Profile

Research expertise

The long-term goals of my lab are to understand better the endocrine and paracrine factor that control ocarian follicle development, for a better control of fertility in cattle.

To do so, we use mainly in-vitro appoaches with ruminant granulosa and theca cell cultures to investigate the mechanisms of action of various hormines and growth factors on cell health and function.

Biography

BSc, University of Nottingham

PhD, University of Edinburgh

Post-doc: Wallaceville Animal Research Centre, New Zealand.

Affiliations and responsabilities

Teaching and supervision

Student supervision

Theses and dissertation supervision (Papyrus Institutional Repository)

2023

The involvement of Hippo Pathway in the physiology and pathophysiology of ovulation in cows

Graduate : Corrêa Dos Santos, Esdras
Cycle : Doctoral
Grade : Ph. D.
2021

Comparison of vitrification protocols in immature equine oocytes

Graduate : Herrera-Hidalgo, Karla Elena
Cycle : Master's
Grade : M. Sc.
2019

Regulation of thecal endothelial cell function by growth factors in ruminants

Graduate : Ben Koura, Morad
Cycle : Master's
Grade : M. Sc.
2017

Effects of deoxynivalenol and deepoxy-deoxynivalenol on bovine ovarian theca cell function

Graduate : Torabi, Mohammad Ali
Cycle : Master's
Grade : M. Sc.
2017

Effects of the mycotoxin, deoxynivalenol, and its major metabolite, de-epoxy deoxynivalenol, on bovine reproduction

Graduate : Guerrero Netro, Hilda Morayma
Cycle : Doctoral
Grade : Ph. D.
2016

Elucidation of the biological roles of Wnt5a signaling in follicle development

Graduate : Abedini Najafabadi, Atefeh
Cycle : Doctoral
Grade : Ph. D.
2014

The involvement of nitric oxide in bovine follicular development and ovulation

Graduate : Zamberlam, Gustavo
Cycle : Doctoral
Grade : Ph. D.
2014

La régulation du gène CYP19A1 dans les cellules de granulosa bovine in vitro

Graduate : Sahmi, Fatiha
Cycle : Doctoral
Grade : Ph. D.
2005

Expression and regulation of protease nexin-1 and plasminogen activators in bovine ovarian follicles

Graduate : Cao, Mingju
Cycle : Doctorat / Doctoral
Grade : Ph. D.
2004

La régulation du gène P450aromatase dans les cellules de granulosa bovine in vitro

Graduate : Sahmi, Malha
Cycle : Doctoral
Grade : Ph. D.
1999

La sécrétion de l'inhibine dimère par les cellules de granulosa bovine antrales et murales in vitro

Graduate : Boudjemaa, Mohamed Lotfi
Cycle : Master's
Grade : M. Sc.

Projects

Research projects

2021 - 2029

Novel mechanisms of theca cell growth in the ovarian follicle of cattle

Lead researcher : Christopher A. Price
Funding sources: CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs: PVX20965-(RGP) Programme de subvention à la découverte individuelle ou de groupe
2023 - 2025

The role of 'FNDC' adipokines in ovarian function in cattle.

Lead researcher : Christopher A. Price
Funding sources: CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs: PVXXXXXX-Subventions Alliance - International Catalyseur
2017 - 2025

Réseau Québecois en Reproduction (RQR)

Lead researcher : Derek Boerboom
Funding sources: FRQNT/Fonds de recherche du Québec - Nature et technologies (FQRNT)
Grant programs: PVXXXXXX-(RS) Programme de regroupements stratégiques
2017 - 2022

Nouvelles cibles moléculaires dans le but d’améliorer la fonction ovarienne chez la vache laitière

Lead researcher : Christopher A. Price
Co-researchers : Francis Beaudry , Robert Viger
Funding sources: FRQNT/Fonds de recherche du Québec - Nature et technologies (FQRNT)
Grant programs: PV113724-(PR) Projets de recherche en équipe (et possibilité d'équipement la première année)
2015 - 2022

THE ROLE OF THECA CELLS IN OVARIAN FOLLICLE ATRESIA IN CATTLE

Lead researcher : Christopher A. Price
Funding sources: CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs: PVX20965-(RGP) Programme de subvention à la découverte individuelle ou de groupe
2015 - 2019

The role of theca cells in ovarian follicle atresia in cattle - Supplément d'accélération

Lead researcher : Christopher A. Price
Funding sources: CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs: PV118029-(RGPAS) Programme de suppléments d'accélération à la découverte
2011 - 2018

REGROUPEMENT STRATEGIQUE - RESEAU QUEBECOIS EN REPRODUCTION (RQR)

Lead researcher : Bruce D. Murphy
Funding sources: FRQNT/Fonds de recherche du Québec - Nature et technologies (FQRNT)
Grant programs: PVXXXXXX-(RS) Programme de regroupements stratégiques
2012 - 2016

EFFECT OF FUNGAL TOXINS ON FERTILITY IN DAIRY CATTLE

Lead researcher : Christopher A. Price
Co-researchers : Younès Chorfi
Funding sources: CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG) , Medivet Inc.
Grant programs: PVX20973-(RDC-CRD) Partenariat de recherche / Subvention de recherche et développement coopérative ,
1994 - 2016

NOVEL REGULATORS OF GRANULOSA CELL FUNCTION

Lead researcher : Christopher A. Price
Funding sources: CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs: PVX20965-(RGP) Programme de subvention à la découverte individuelle ou de groupe
2013 - 2015

LIQUID SCINTILLATION COUNTER

Lead researcher : Christopher A. Price
Funding sources: CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs: PVXXXXXX-(OIR) Outils et d'instruments de recherche (OIR) -1 -(de 7 001 $ à 150 000 $)
2011 - 2015

NOUVELLES VOIES VERS L'EMBRYON SAIN CHEZ LES ANIMAUX DE CONSOMMATION

Lead researcher : Christopher A. Price
Co-researchers : Derek Boerboom , François Richard
Funding sources: FRQNT/Fonds de recherche du Québec - Nature et technologies (FQRNT)
Grant programs: PV113724-(PR) Projets de recherche en équipe (et possibilité d'équipement la première année)
2009 - 2014

NOVEL REGULATORS OF GRANULOSA CELL FUNCTION

Lead researcher : Christopher A. Price
2011 - 2013

NOUVELLES VOIES VERS L'EMBRYON SAIN CHEZ LES ANIMAUX DE CONSOMMATION

2010

SAFETY OF ESTRADIOL USE DURING SUPEROVULATION IN LACTATING DAIRY COWS

Lead researcher : Christopher A. Price
2009

INCUBATOR SUITE

Lead researcher : Christopher A. Price

Outreach

Publications and presentations

Publications

Buratini J, Dellaqua TT, Lima PF, Renzini MM, Canto MD, Price CA. Oocyte secreted factors control genes regulating FSH signaling and the maturation cascade in cumulus cells: the oocyte is not in a hurry. JARG doi.org/10.1007/s10815-023-02822-y

Reyes-Perea AD,  Guerrero-Netro HM, Meza-Serrano E, Estienne A, Price CA (2023) The mycotoxin de-epoxy-deoxynivalenol (DOM-1) increases endoplasmic reticulum stress in ovarian theca cells. Toxins 15: 228. doi.org/10.3390/toxins15030228

Daudon M, Ramé C, Price CA*, Dupont J* (2023) Irisin modulates glucose metabolism and inhibits steroidogenesis in bovine granulosa cells. Reproduction 165:533-542. https://doi.org/10.1530/REP-22-0404

Wang S, Yao Q, Zhao F, Cui W, Price CA, Wang Y, Lv J, Tang H, Jiang Z (2023). 1α,25(OH)2D3 promotes the autophagy of porcine ovarian granulosa cells as a protective mechanism against ROS through BNIP3/PINK1 pathway. Int J Mol Sci 24: 4364. doi.org/10.3390/ijms24054364

Biolková M, Moore T, Schindler K, Swann K, Vail A, Flook L, Dick H, Fitzharris G, Price C*, Spears N* (2023). Investigation of potential gender bias in the peer review system at Reproduction. Learned Publishing 36: 25-30. https://doi.org/10.1002/leap.1537.

Relav L, dos Santos, EC, Zamberlam G, Price CA. Abundance of dual specificity phosphatase (DUSP) 1 and DUSP6 mRNA is regulated by Hippo signaling in bovine pre-ovulatory granulosa cells.  Reproductive Sciences. https://doi.org/10.1007/s43032-022-01142-3.

Goetten ALF, Koch J, Rocha CC, Mezzalira A, Price CA, Portela VM, Barreta MH. (2023) Expression profile of key genes involved in DNA repair mechanisms in bovine cumulus cells cultured with bovine serum albumin or fetal calf serum. Reproductive Biology 23: 100709.

Daudon M, Rame C, Estienne A, Price CA*, Dupont J*. (2022) Impact of Fibronectin type III Domain-Containing Family in the changes in metabolic and hormonal profiles during peripartum period in dairy cows.  Frontiers in Vet Sci 9:960778. DOI 10.3389/fvets.2022.960778.

Daudon M, Bigot Y, Dupont J*, Price CA* (2022) Irisin and the fibronectin type III domain-containing family: Structure, signalling and role in female reproduction. Reproduction 164: R1-R9.

Estienne AE, Relav L, Benkoura M, Monniaux D, Morin F, Fabre S, Price CA (2022) Endothelial cell-derived fibroblast growth factor-18 regulates ovarian function in sheep. J Cell Physiol. 237:2528-2538. http://doi.org/10.1002/jcp.30718

Liu N, Wang S, Yao Q, Li Y, Hu H, Xiaorong T, Ran H, Price C, Jiang ZL (2022) Activin A attenuates apoptosis of granulosa cells in atretic follicles through ERβ-induced autophagy. Reprod Dom Anim. 57:625-634.

Dos Santos EC, Lalonde-Larue A, Antoniazzi AQ, Barreta MH, Price CA, Gonçalves PBD, Portela VM, Zamberlam GO (2022) YAP signaling in preovulatory granulosa cells is critical for the functioning of the EGF network during ovulation. Mol Cell Endo 541:111524

Relav L, Price CA (2021) Regulation of Dual Specificity Phosphatases by Fibroblast Growth Factor signaling pathways in bovine granulosa cells. Reproduction 162: 367-374. (http://dx.doi.org/10.1530/REP-21-0270)

Juengel JL, Cushman RA, Dupont J, Fabre S, Lea RG, Martin GB, Mossa F, Pitman JL, Price CA, Smith P (2021) The ovarian follicle of ruminants: the path from conceptus to adult. Reprod Fertil Devel. 33: 621-642. https://doi.org/10.1071/RD21086

Relav L, Estienne A, Price CA (2021) Dual-specificity phosphatase 6 (DUSP6) mRNA and protein abundance is regulated by fibroblast growth factor 2 in sheep granulosa cells and inhibits c-Jun N-terminal kinase (MAPK8) phosphorylation. Mol Cell Endo 531: 111297. https://doi.org/10.1016/j.mce.2021.111297

Guerro-Netro H, Barreta M, Costa E, Goetten A, Dupras R, Mills L, Koch J, Portela VM, Price CA, Chorfi Y (2021) Effects of the mycotoxin metabolite de-epoxy-deoxynivalenol (DOM-1) on embryo development and sperm motility in cattle. J Appl Toxicol 41:1180-1187.  DOI: 10.1002/jat.4102

Han P, Relav L, Price CA (2020) Regulation of the early growth response-1 binding protein NAB2 in bovine granulosa cells and effect on connective tissue growth factor expression. Mol Cell Endo 518: 111041.   doi.org/10.1016/j.mce.2020.111041

Jaton C, Schenkel FS, Chud TCS, Malchiodi F, Sargolzaei M, Price CA, Cánovas A,, Baes C, Miglior F. (2020) Genetic and genomic analyses of embryo production in dairy cattle. Reproduction, Fertility and Development 32, 50–55. doi.org/10.1071/RD19275

Sahmi F, Sahmi M, Gévry N, Sahadevan P, Allen BG, Price CA. (2019) A putative protein:RNA complex regulates post-transcriptional processing of cytochrome P450 aromatase (CYP19A1) in bovine granulosa cells. Mol Reprod Develop 86:1901-1908. https://doi.org/10.1002/mrd.23289

Zhang N, Wang L, Juo G, Tang X, Ma L, Zheng Y, Liu S, Price CA, Jiang Z (2019) Arachidonic acid regulation of intracellular signaling pathways and target gene expression in bovine ovarian granulosa cells. Animals 9: 374.

Estienne A, Portela VM, Choi Y, Zamberlam G, Boerboom D, Roussel V, Meinsohn MC, Brännström M, Curry TE, Jo M, Price CA. (2019) The endogenous hydrogen sulfide generating system regulates ovulation. Free Rad Biol Med 138:43-52. doi.org/10.1016/j.freeradbiomed.2019.03.028

Disciplines

  • Veterinary Sciences
  • Biology and Related Sciences
  • Endocrinology
  • Physiology
  • Gynecologic Reproductive Endocrinology and Infertility

Areas of expertise

  • Physiologie de la reproduction
  • Bovins
  • Génomique bovine