Passer au contenu

/ Research

Je donne

Rechercher

Natural Sciences and Engineering

Francis Beaudry

Traitement de la douleur chez l'animal

Professeur agrégé

Faculté de médecine vétérinaire - Département de biomédecine vétérinaire

3200, rue Sicotte - Aile A, room 3903

francis.beaudry@umontreal.ca

Secondary numbers: 450 773-8521 #8647 (Travail 1) 450 778-8109 (Télécopieur)

Profile

Research expertise

Les activités de recherche du laboratoire de pharmacologie analytique du Dr Francis Beaudry concernent les axes suivants  :

  1. L'étude systématique de la neuropeptidomique à l'aide de modèles animaux, des organismes modèles (ex. C.elegans) etde la spectrométrie de masse.
  2. Approfondissement des connaissances sur les mécanismes de contrôle protéolytique des neuropeptides endogènes.
  3. Le développement de nouvelles stratégies thérapeutiques pour le traitement de la douleur.
  4. L’étude de la pharmacocinétique et le métabolisme de médicaments utilisés pour le traitement de la douleur et l’anesthésie.

Biography

Le Dr Francis Beaudry a obtenu un baccalauréat en chimie (Université de Sherbrooke) et un doctorat en chimie médicinale (Anglia Ruskin University). Il a poursuivi ses travaux de recherche sur le traitement pharmacologique de la douleur dans le laboratoire du Pr Pascal Vachon. Le Dr Beaudry est entré en fonction en juin 2009 à titre de professeur adjoint au département de biomédecine vétérinaire de l'Université de Montréal. Il fut scientifique de recherche, scientifique principale de recherche, chef de section et directeur associé dans le département de bioanalyse de la compagnie Phoenix International entre 1993 et 2003. Le Dr Beaudry a acquis une vaste expérience dans le domaine de la pharmacocinétique, du métabolisme des médicaments, de la spectrométrie de masse et de la bioanalyse. Le Dr Beaudry est l'auteur ou le coauteur de 124 publications dans des journaux scientifiques à comité de lecture et de 107 affiches présentées lors de congrès scientifiques nationaux et internationaux depuis le début de sa carrière scientifique.

Awards and recognitions

Prix d'excellence en recherche Zoetis 2016 (reçu en février 2017)

Prix pour l'innovation pédagogique 2014 - Membre de l'équipe d'intégration des apprentissages en 1e année du DMV. 

education

  • 2007 — Ph.D. — Chimie, PharmacologieAnglia Ruskin University
  • 1993 — B.Sc. — ChimieUniversité de Sherbrooke

For more information…

Affiliations and responsabilities

Research affiliations

Research units

Membre

  • Le Réseau québécois de recherche sur le medicament (RQRM)
  • Le Réseau québécois de recherche sur la douleur (RQRD)

Affiliated institutions

  • Centre hospitalier de l’Université de Montréal (CHUM)

Professional titles and affiliations

Titles: corporations and professional organizations

Ordre des chimistes du Québec

Teaching and supervision

Student supervision

Theses and dissertation supervision (Papyrus Institutional Repository)

2019

Decoding protein networks during porcine epidemic diarrhea virus (PEDV) infection through proteomics

Graduate : Valle-Tejada, Camila Andrea
Cycle : Master's
Grade : M. Sc.
2018

Effects of fibroblast growth factor 8 and 18 on ovine ovarian granulosa cell function

Graduate : Amin Marashi, Fatemeh
Cycle : Master's
Grade : M. Sc.
2016

The role of protein convertases in bigdynorphin and dynorphin A metabolic pathway

Graduate : Ruiz Orduna, Alberto
Cycle : Master's
Grade : M. Sc.
2015

Interaction entre le virus SRRP et Actinobacillus pleuropneumoniae dans un modèle d'infection en culture cellulaire

Graduate : Ferreira Barbosa, Jérémy A.
Cycle : Master's
Grade : M. Sc.
2010

Étude et modélisation de la cinétique orale de l'amoxicilline chez le porcelet

Graduate : Bernier, Dave
Cycle : Master's
Grade : M. Sc.

Projects

Research projects

2018 - 2023

Improvement of therapeutic and prophylactic measures against porcine reproductive and respiratory syndrome virus (PRRSV) through the discovery of antiviral drugs and the use of antimycotoxins

Lead researcher : Carl A. Gagnon
Co-researchers : Francis Beaudry , Younès Chorfi , Mario Jacques , Tom Hobman
Funding sources: Swine Innovation Porc
Grant programs:
2019 - 2022

Centre de Recherche en infectiologie porcine et avicole (CRIPA) / Regroupements stratégiques

Lead researcher : Carl A. Gagnon
Funding sources: FRQNT/Fonds de recherche du Québec - Nature et technologies (FQRNT)
Grant programs: PVXXXXXX-(RS) Programme de regroupements stratégiques
2018 - 2022

Plateforme de spectrométrie de masse à haute résolution pour l'étude systématique de marqueurs biochimiques d'échantillons biologiques

Lead researcher : Francis Beaudry
Funding sources: FCI/Fondation canadienne pour l'innovation
Grant programs: PVXXXXXX-Fonds d'exploitation des infrastructures (FEI)
2017 - 2021

Nouvelles cibles moléculaires dans le but d’améliorer la fonction ovarienne chez la vache laitière

Lead researcher : Christopher A. Price
Co-researchers : Francis Beaudry , Robert Viger
Funding sources: FRQNT/Fonds de recherche du Québec - Nature et technologies (FQRNT)
Grant programs: PV113724-(PR) Projets de recherche en équipe (et possibilité d'équipement la première année)
2015 - 2021

DECIPHERING CAENORHABDITIS ELEGANS MOLECULAR NOCICEPTION USING MASS SPECTROMETRY-BASED PROTEOMICS AND NETWRK BIOLOGY

Lead researcher : Francis Beaudry
Funding sources: CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs: PVX20965-(RGP) Programme de subvention à la découverte individuelle ou de groupe
2018 - 2019

Qualitative and Quantitative Proteome Profiling ofNavl.8+ and Pax2+ Sensory Neurons / Réseau québecois de recherche sur la douleur (RQRD)

Lead researcher : Reza Sharif Naeini , Philippe Sarret
Co-researchers : Francis Beaudry
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Réseaux thématiques de recherche
2017 - 2019

Plateforme de spectrométrie de masse à haute résolution pour l'étude systématique de marqueurs biochimiques d'échantillons biologiques

Lead researcher : Francis Beaudry
Funding sources: FCI/Fondation canadienne pour l'innovation
Grant programs: PVXXXXXX-Fonds des leaders
2015 - 2016

Preclinical Validation of a Disease-Modifying Osteoarthritis Drug

Lead researcher : Alain Moreau
Co-researchers : Francis Beaudry , Patrick Lavigne , Emile Lévy
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVX97685-(PDP/POP) Programme de démonstration des principes
2010 - 2016

DISCOVERY OF NEUROPROTEOMIC DETERMINANTS OF PAIN TRANSMISSION USING DIFFERENTIAL AND SYSTEMATIC PROTEOME EXPLORATION STRATEGIES

Lead researcher : Francis Beaudry
Funding sources: CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs: PVX20965-(RGP) Programme de subvention à la découverte individuelle ou de groupe
2013 - 2015

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY ELECTROSPRAY TANDEM MASS SPECTROMETRY FOR QUANTITATIVE DETERMINATION OF BIOMARKERS, DRUGS AND METABOLITES AND BIOLOGICAL MATRICES

Lead researcher : Francis Beaudry
Funding sources: CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs: PVXXXXXX-(OIR) Outils et d'instruments de recherche (OIR) -1 -(de 7 001 $ à 150 000 $)
2009 - 2014

DISCOVERY OF NEUROPROTEOMIC DETERMINANTS OF PAIN TRANSMISSION USING DIFFERENTIAL AND SYSTEMATIC PROTEOME EXPLORATION STRATEGIES

Lead researcher : Francis Beaudry

Outreach

Publications and presentations

Publications

Publications (2016-2020)

B. Nakmbeu, J. Ben Salem and F. Beaudry (2020). Capsaicin and its analogues impede nocifensive response of Caenorhabditis elegans to noxious heat. Neuroscience Letters. Manuscript ID: NSL-20121. Available as a preprint on bioRxiv. https://doi.org/10.1101/2020.01.21.914010

L. Sid-Otmane, A. Hamadjida, S.G. Nuara, D. Bédard, F. Gaudette, J.C. Gourdon, V. Michaud, F. Beaudry, M. Panisset and P. Huot (2020). Selective metabotropic glutamate receptor 2 positive allosteric modulation alleviates L-DOPA-induced psychosis-like behaviours and dyskinesia in the MPTP-lesioned marmoset. European Journal of Pharmacology. doi: https:// doi.org/10.1016/j.ejphar.2020.172957 .

S. Leonelli, B. Nkambeu and F.Beaudry (2020). Impaired EAT-4 Vesicular Glutamate Transporter Leads to Defective Nocifensive Response of Caenorhabditis elegans to Noxious Heat. Neurochemical Research. In Press. DOI: 10.1007/s11064-020-02963-x.

C.B. Larouche, R. Johnson, F. Beaudry, C. Mosley, Y.Gu, K.A. Zaman, H. Beaufrère and C. Dutton (2019), Pharmacokinetics of midazolam and its major metabolite 1-hydroxymidazolam in the ball python (Python regius) after intracardiac and intramuscular administrations, Journal of Veterinary Pharmacology and Therapeutics, 42(6):722-731. doi: 10.1111/jvp.12806. 

F. Gaudette, D. Bédard, C. Kwan, I. Frouni, A. Hamadjida, F. Beaudry and P. Huot (2019). Highly sensitive HPLC-MS/MS assay for the quantitation of ondansetron in rat plasma and rat brain tissue homogenate following administration of a very low subcutaneous dose. Journal of Pharmaceutical and Biomedical Analysis. 175:112766, doi: 10.1016/j.jpba.2019.07.014

P. Vogeleer, A.T. Vincent, S. M. Chekabab, S.J. Charette, A. Novikov, M. Caroff, F. Beaudry, M. Jacques, J. Harel (2019). Escherichia coli O157:H7 responds to phosphate starvation by modifying LPS involved in biofilm formation. Journal of Bacteriology. 201(18). pii: e00093-19. doi: 10.1128/JB.00093-19.

I. Frouni, A. Hamadjida, C. Kwan, D. Bédard, V. Nafade, F. Gaudette, S. G. Nuara, J. C. Gourdon, F. Beaudry and Philippe Huot, Activation of mGlu2/3 receptors, a novel therapeutic approach to alleviate dyskinesia and psychosis in experimental parkinsonism. Neuropharmacology, 158:107725. doi: 10.1016/j.neuropharm.2019.107725

M. Saidi, S. Kamali and F. Beaudry (2019). Neuropeptidomics: Comparison of Parallel Reaction Monitoring and Data-Independent Acquisition for the Analysis of Neuropeptides using High-Resolution Mass Spectrometry. Biomedical Chromatography. e4523. doi: 10.1002/bmc.4523

M. Parent-Vachon, F. Beaudry, D. Carrier, G. Di Cristo and P. Vachon (2019). Exercise alleviates pain in female pregnant mice with neuropathic pain and its effects on reproductive performance. Biological Research for Nursing.  21(5):500-509. doi: 10.1177/1099800419857812

C. Otis, M. Guillot, M. Moreau, J.-P. Pelletier, F. Beaudry and E. Troncy (2019). Sensitivity of functional neuropeptidomics in testing pregabalin analgesic efficacy in a rat model of osteoarthritis pain. Clinical and Experimental Pharmacology and Physiology. 46(8):723-733. DOI: 10.1111/1440-1681.13100, In press

M. Kermorgant , J. Ben Salem, J. Santelli J., D. Calise D, A.C. Oster, O. Lairez O, C. Coudret, M. Verelst, C. Gales, J.M. Senard, F. Beaudry, A. Pavy-LeTraon, C. Roux, R. Mauricot and D. Arvanitis (2019). Evaluation of upconverting nanoparticles towards heart theranostics. PLoS One. 14(12):e0225729. doi: 10.1371/journal.pone.0225729

E. Eysseric, F. Beaudry, C. Gagnon and P. Segura (2019). Non-targeted screening of trace organic contaminants in surface waters by a multi-tool approach based on combinatorial analysis of tandem mass spectra and open access databases. Water Research, Manuscript ID: ACA-19-135

I. Frouni, C. Kwan, D. Bedard, S. Belliveau, E. Bourgeois-Cayer, F. Gaudette, F. Beaudry, H. Adjia, P. Huot (2019). Effect of the selective 5-HT2A receptor antagonist EMD-281,014 on L-DOPA induced abnormal involuntary movements in the 6-OHDA-lesioned rat. Experimental Brain Research. 237 (1): 29-36

M. R. Desmarchelier, F. Beaudry, S.T. Ferrell and D. Frank (2019). Determination of the pharmacokinetics of a single oral dose of trazodone and its effect on the activity level of domestic pigeons (Columba livia). American Journal of Veterinary Research.  80(1): 102-109 

J.A. Gervais, C. Otis, B. Lussier, M. Guillot, J. Martel-Pelletier, J.P. Pelletier, F. Beaudry and E. Troncy (2019). Osteoarthritic pain model influences functional outcomes and spinal neuropeptidomics: A pilot study in female rats. Canadian Journal of Veterinary Research. 83 (2): 133-141

J. Ben Salem, B. Nkambeu, D.N. Arvanitis and F. Beaudry (2018). Deciphering the Role of EGL-3 for Neuropeptides Processing in Caenorhabditis elegans using High-Resolution Quadrupole-Orbitrap Mass Spectrometry. Neurochemical Research. 43(11):2121-2131

B. Nkambeu, J. Ben Salem, S. Leonelli, F. Amin Marashi, and F. Beaudry (2019). EGL-3 and EGL-21 are required to trigger nocifensive response of Caenorhabditis elegans to noxious heat. Neuropeptides. 73: 41-48

A. Hamadjida, S. G Nuara, D. Bedard, F. Gaudette, F. Beaudry, J. C. Gourdon and P. Huot (2018). The extremely selective 5-HT2A antagonist EMD-281,014 reduces dyskinesia and psychosis in the parkinsonian marmoset. Neuropharmacology. 139:61-67

J.F. Sicard,  P. Vogeleer, G. Le Bihan,  Y. Rodriguez Olivera, F. Beaudry, M. Jacques and J. Harel, (2018) N-acetyl-glucosamine influences the biofilm formation of Escherichia coli, Gut Pathogens, 10:26.

F. Gaudette, A. Hamadjida, D. Bédard, S. G. Nuara, J. C. Gourdon, V. Michaud, F. Beaudry and P. Huot (2018). Development of a selective and sensitive high-performance liquid chromatography-tandem mass spectrometry assay to support pharmacokinetic studies of LY-487,379 in rat and marmoset. Journal of Chromatography B. 1093-1094:1-7

J. Benito, B. Monteiro, F. Beaudry and P. Steagall (2018), Efficacy and pharmacokinetics of bupivacaine with epinephrine or dexmedetomidine after intraperitoneal administration in cats undergoing ovariohysterectomy. Canadian Journal of Veterinary Research. 82(2): 124-130

J. Ben Salem, B. Nkambeu and F. Beaudry (2018), Characterization of Neuropeptide K Processing in Rat Spinal Cord S9 Fractions using High-Resolution Quadrupole-Orbitrap Mass Spectrometry, Biomedical Chromatography, 32(6):e4204.

C. Yang, G. Ghosh and F. Beaudry (2018), Detection of Gelatin Adulteration using Bio-informatics, Proteomics and High-Resolution Mass Spectrometry. Food Additives and Contaminants. 35(4): 599–608

S.F. Salmin, MC Giroux, P. Vachon and F. Beaudry (2017), In Vitro Metabolism of Specific CYP2D and CYP3A Opioid Substrates using Rat Liver S9 Fractions and Mass Spectrometry Reveal a Severe Metabolic Impairment with Increasing Age. Biomedical Chromatography, 31(2):e3786

E. Eysseric, K. Barry, F. Beaudry, M. Houde, C. Gagnon and P.A. Segura (2017), Application of spectral accuracy to improve the identification of organic compounds in environmental analysis. Analytical Chemistry, 89(18):9805-9813

F. Gaudette, A. Hamadjida, D. Bédard, S. Nuara, F. Beaudry and P. Huot (2017), Development and validation of a high-performance liquid chromatography-tandem mass spectrometry method to quantify LY 354,740 in rat and marmoset plasma, Journal of Chromatography B, 1061-1062:392-398.

M. Rhouma, J.M. Fairbrother, F.Beaudry, and A. Letellier (2017), Post weaning diarrhea in pigs: risk factors and non-colistin-based control strategies, Acta Veterinaria Scandinavica, 59(1):31.

G. Doodnaught, B. Monteiro Steagal, J. Benito, D. Edge, F. Beaudry, L. Pelligand and P. Steagll (2017), Pharmacokinetic and pharmacodynamic modelling after subcutaneous, intravenous and buccal administration of a high-concentration formulation of buprenorphine in conscious cats. PlosOne, 12(4):e0176443. 

G. Le Bihan, P. Garneau, A. Bernalier-Donadille, A. Gobert, A. Garrivier, C. Martin, A. Hay, F. Beaudry, G. Jubelin and J. Harel (2017). N-Acetylglucosamine sensing by NagC contributes to gut colonization by regulating LEE genes in EHEC. Frontiers Microbiology, 7:134.

M. Rhouma, J.M. Fairbrother, W. Thériault, F.Beaudry, N. Bergeron, S. Laurent Lewandowski and A. Letellier (2017), The fecal presence of enterotoxin and F4 genes as an indicator of efficacy of treatment with colistin sulfate in pigs, BMC Microbiology, 17:6

A. Riuz, E. Husby, C, Yang, G. Ghosh and F. Beaudry (2017), Detection of meat species adulteration using high-resolution mass spectrometry and a proteogenomics strategy. Food Additives and Contaminants.  34(7):1110-1120.

M. Saidi and F. Beaudry (2017), Targeted High-Resolution Quadrupole-Orbitrap Mass Spectrometry Analyses Reveal a Significant Reduction of Tachykinin and Opioid Neuropeptides Level in PC1 and PC2 Mutant Mouse Spinal Cords, Neuropeptides, 65:37-44

C. Otis, M. Guillot, M. Moreau, J. Martel-Pelletier, JP Pelletier, F. Beaudry, E. Troncy (2017), Spinal Neuropeptide Modulation and Cartilage Lesions in a Monosodium Iodoacetate Rat Model of Osteoarthritis. Neuropeptides, 65:56-62

M. Rhouma, F. Beaudry, W. Thériault and A. Letellier (2016), Colistin in Pig Production: Chemistry, Mechanism of Antibacterial Action, Microbial Resistance Emergence, and One Health Perspectives. Frontiers in microbiology, 7:1789. 

A. Dodelet-Devillers, C. Zullian , F. Beaudry, J. Gourdon, J. Chevrette, P. Hélie, P. Vachon  (2016)., Physiological and pharmacokinetic effects of multilevel caging on Sprague Dawley rats under ketamine-xylazine anesthesia. Experimental animals. 65(4):383-392

M. RhoumaF. Beaudry, W. Thériault, N. Bergeron, S. L-Lewandowski, J.M. Fairbrother, A. Letellier (2016). In vivo therapeutic efficacy and pharmacokinetics of colistin sulfate in an experimental model of enterotoxigenic Escherichia coli infection in weaned pigs. Veterinary Research, 27;47(1):58

J. Benito, B.P. Monteiro, F. Beaudry, A.M. Lavoie, B.D. Lascelles, P.V. Steagall, (2016). Pharmacokinetics of bupivacaine after intraperitoneal administration to cats undergoing ovariohysterectomy. American Journal of Veterinary Research, 77(6):641-645

C. Otis, J. Gervais, M. Guillot, J.A. Gervais, D. Gauvin, C. Pethel, S. Authier, M.A. Dansereau, P. Sarret, J. Martel-Pelletier, J.P. Pelletier, F.Beaudry, and E. Troncy, (2016). Concurrent validity of different functional and neuroproteomic pain assessment methods in the rat osteoarthritis MIA model. Arthritis Research & Therapy. 18:150

M. RhoumaF.Beaudry and A.Letellier (2016), Resistance to colistin: What is the fate for this antibiotic in pig production, International Journal of Antimicrobial Agents, 48(2):119-126

M. Saidi, S. Kamali and F.Beaudry (2016), Characterization of Substance P Processing in Mouse Spinal Cord S9 Fractions using High-Resolution Quadrupole-Orbitrap Mass Spectrometry, Neuropeptides, 59:47-55.

S. Hathroubi, F. Beaudry, C. Provost, C. A Gagnon and M. Jacques (2016), Impact of Actinobacillus pleuropneumoniae biofilm mode of growth on the lipid A structures and stimulation of immune cells, Innate Immunity, 22(5):353-362

C. Zullian, P. Lema, M. Lavoie, A. Dodelet-Devillers, F. Beaudry and P. Vachon (2016). Plasmatic concentrations of buprenorphine following a single subcutaneous administration of a sustained release formulation of buprenorphine in sheep, Canadian Journal of Veterinary Research, 80(3), 250-253

A.Dodelet-Devillers, C.Zullian, P. Vachon, F. Beaudry (2016), Formulation Stability Assessment of Ketamine-Xylazine Preparations using High Performance Liquid Chromatography Mass Spectrometry" Canadian Journal of Veterinary Research. 80(1):86-89

J.S. Mort, F. Beaudry, K. Théroux, A. A. Emmott, H. Richard, W. D. Fisher, E. R. Lee, A. R. Poole and S. Laverty (2016). Early cathepsin K degradation of type II collagen in vitro and in vivo in articular cartilage. Osteoarthritis and Cartilage, 24(8):1461-1469

A. Orduna RuizF. Beaudry (2016), Characterization of Endoproteolytic Processing of Dynorphins by Proprotein Convertases using Mouse Spinal Cord S9 Fractions and Mass Spectrometry, Neuropeptides, 57:85-94

M-C. Giroux, R. Santamaria, P. Hélie, P. Burns, F. Beaudry and P. Vachon (2016), Physiological, biochemical and pharmacokinetic comparisons between 3, 6, 12 and 18 month old male Sprague Dawley rats following ketamine-xylazine anesthesia, Experimental Animals. 65(1):63-75

Disciplines

  • Chemistry
  • Pharmacology
  • Biochemistry
  • Biomedical Sciences

Areas of expertise

  • Chimie analytique et médicinale