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Natural Sciences and Engineering

Francis Beaudry

Traitement de la douleur chez l'animal

Professeur agrégé

Faculté de médecine vétérinaire - Département de biomédecine vétérinaire

3200, rue Sicotte - aile A, room 3903

francis.beaudry@umontreal.ca

Secondary numbers: 450 773-8521 #8647 (Travail 1) 450 778-8109 (Télécopieur)

Profile

Research expertise

Les activités de recherche du laboratoire de pharmacologie analytique du Dr Francis Beaudry concernent les axes suivants  :

  1. L'étude systématique de la neuropeptidomique à l'aide de modèles animaux, des organismes modèles (ex. C.elegans) etde la spectrométrie de masse.
  2. Approfondissement des connaissances sur les mécanismes de contrôle protéolytique des neuropeptides endogènes.
  3. Le développement de nouvelles stratégies thérapeutiques pour le traitement de la douleur.
  4. L’étude de la pharmacocinétique et le métabolisme de médicaments utilisés pour le traitement de la douleur et l’anesthésie.

Biography

Le Dr Francis Beaudry a obtenu un baccalauréat en chimie (Université de Sherbrooke) et un doctorat en chimie médicinale (Anglia Ruskin University). Il a poursuivi ses travaux de recherche sur le traitement pharmacologique de la douleur dans le laboratoire du Pr Pascal Vachon. Le Dr Beaudry est entré en fonction en juin 2009 à titre de professeur adjoint au département de biomédecine vétérinaire de l'Université de Montréal. Il fut scientifique de recherche, scientifique principale de recherche, chef de section et directeur associé dans le département de bioanalyse de la compagnie Phoenix International entre 1993 et 2003. Le Dr Beaudry a acquis une vaste expérience dans le domaine de la pharmacocinétique, du métabolisme des médicaments, de la spectrométrie de masse et de la bioanalyse. Le Dr Beaudry est l'auteur ou le coauteur de 101 publications dans des journaux scientifiques à comité de lecture et de 95 affiches présentées lors de congrès scientifiques nationaux et internationaux depuis le début de sa carrière scientifique.

Awards and recognitions

Prix d'excellence en recherche Zoetis 2016

Prix pour l'innovation pédagogique 2014 - Membre de l'équipe d'intégration des apprentissages en 1e année du DMV. 

education

  • 2007 — Ph.D. — Chimie, PharmacologieAnglia Ruskin University
  • 1993 — B.Sc. — ChimieUniversité de Sherbrooke

For more information…

Affiliations and responsabilities

Research affiliations

Research units

Membre

  • Le Réseau québécois de recherche sur le medicament (RQRM)
  • Le Réseau québécois de recherche sur la douleur (RQRD)

Affiliated institutions

  • Centre hospitalier de l’Université de Montréal (CHUM)

Professional titles and affiliations

Titles: corporations and professional organizations

Ordre des chimistes du Québec

Teaching and supervision

Student supervision

Theses and dissertation supervision (Papyrus Institutional Repository)

2018

Effects of fibroblast growth factor 8 and 18 on ovine ovarian granulosa cell function

Graduate : Amin Marashi, Fatemeh
Cycle : Master's
Grade : M. Sc.
2016

The role of protein convertases in bigdynorphin and dynorphin A metabolic pathway

Graduate : Ruiz Orduna, Alberto
Cycle : Master's
Grade : M. Sc.
2015

Interaction entre le virus SRRP et Actinobacillus pleuropneumoniae dans un modèle d'infection en culture cellulaire

Graduate : Ferreira Barbosa, Jérémy A.
Cycle : Master's
Grade : M. Sc.
2010

Étude et modélisation de la cinétique orale de l'amoxicilline chez le porcelet

Graduate : Bernier, Dave
Cycle : Master's
Grade : M. Sc.

Projects

Research projects

2018 - 2023

Improvement of therapeutic and prophylactic measures against porcine reproductive and respiratory syndrome virus (PRRSV) through the discovery of antiviral drugs and the use of antimycotoxins

Lead researcher : Carl A. Gagnon
Co-researchers : Francis Beaudry , Mario Jacques , Younès Chorfi , Tom Hobman
Funding sources: Swine Innovation Porc
Grant programs:
2019 - 2022

Centre de Recherche en infectiologie porcine et avicole (CRIPA) / Regroupements stratégiques

Lead researcher : Carl A. Gagnon
Funding sources: FRQNT/Fonds de recherche du Québec - Nature et technologies (FQRNT)
Grant programs: PVXXXXXX-(RS) Programme de regroupements stratégiques
2018 - 2022

Plateforme de spectrométrie de masse à haute résolution pour l'étude systématique de marqueurs biochimiques d'échantillons biologiques

Lead researcher : Francis Beaudry
Funding sources: FCI/Fondation canadienne pour l'innovation
Grant programs: PVXXXXXX-Fonds d'exploitation des infrastructures (FEI)
2017 - 2021

Nouvelles cibles moléculaires dans le but d’améliorer la fonction ovarienne chez la vache laitière

Lead researcher : Christopher A. Price
Co-researchers : Francis Beaudry , Robert Viger
Funding sources: FRQNT/Fonds de recherche du Québec - Nature et technologies (FQRNT)
Grant programs: PV113724-(PR) Projets de recherche en équipe (et possibilité d'équipement la première année)
2015 - 2021

DECIPHERING CAENORHABDITIS ELEGANS MOLECULAR NOCICEPTION USING MASS SPECTROMETRY-BASED PROTEOMICS AND NETWRK BIOLOGY

Lead researcher : Francis Beaudry
Funding sources: CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs: PVX20965-(RGP) Programme de subvention à la découverte individuelle ou de groupe
2018 - 2019

Qualitative and Quantitative Proteome Profiling ofNavl.8+ and Pax2+ Sensory Neurons / Réseau québecois de recherche sur la douleur (RQRD)

Lead researcher : Francis Beaudry
Co-researchers : Reza Sharif Naeini , Philippe Sarret
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Réseaux thématiques de recherche
2017 - 2019

Plateforme de spectrométrie de masse à haute résolution pour l'étude systématique de marqueurs biochimiques d'échantillons biologiques

Lead researcher : Francis Beaudry
Funding sources: FCI/Fondation canadienne pour l'innovation
Grant programs: PVXXXXXX-Fonds des leaders
2015 - 2016

Preclinical Validation of a Disease-Modifying Osteoarthritis Drug

Lead researcher : Alain Moreau
Co-researchers : Francis Beaudry , Patrick Lavigne , Emile Lévy
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVX97685-(PDP/POP) Programme de démonstration des principes
2010 - 2016

DISCOVERY OF NEUROPROTEOMIC DETERMINANTS OF PAIN TRANSMISSION USING DIFFERENTIAL AND SYSTEMATIC PROTEOME EXPLORATION STRATEGIES

Lead researcher : Francis Beaudry
Funding sources: CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs: PVX20965-(RGP) Programme de subvention à la découverte individuelle ou de groupe
2013 - 2015

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY ELECTROSPRAY TANDEM MASS SPECTROMETRY FOR QUANTITATIVE DETERMINATION OF BIOMARKERS, DRUGS AND METABOLITES AND BIOLOGICAL MATRICES

Lead researcher : Francis Beaudry
Funding sources: CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs: PVXXXXXX-(OIR) Outils et d'instruments de recherche (OIR) -1 -(de 7 001 $ à 150 000 $)
2009 - 2014

DISCOVERY OF NEUROPROTEOMIC DETERMINANTS OF PAIN TRANSMISSION USING DIFFERENTIAL AND SYSTEMATIC PROTEOME EXPLORATION STRATEGIES

Lead researcher : Francis Beaudry

Outreach

Publications and presentations

Publications

Publications récenttes (2013-2017)

98- E. Eysseric, K. Barry, F. Beaudry, M. Houde, C. Gagnon and P.A. Segura (2017), Application of spectral accuracy to improve the identification of organic compounds in environmental analysis. Analytical Chemistry, Submitted in May 2017, Manuscript ID: ac-2017-017616

97- F. Gaudette, A. Hamadjida, D. Bédard, S. Nuara, F. Beaudry and P. Huot (2017), Development and validation of a high-performance liquid chromatography-tandem mass spectrometry method to quantify LY 354,740 in rat and marmoset plasma, Journal of Chromatography B, Submitted in March 2017, Manuscript ID: CHROMB_2017_283

96- M. Rhouma, J.M. Fairbrother, F.Beaudry, and A. Letellier Factors of post weaning diarrhea and alternative strategies to colistin for the control of this disease in pigs, Acta Veterinaria Scandinavica, Manuscript ID: AVSC-D-16-00206, Accepted and In Press

95- C. Otis, M. Guillot, M. Moreau, F.Beaudry and E. Troncy (2017). Testing pregabalin analgesic efficacy in a rat model of osteoarthritis pain: Interest in functional neuropeptidomics. Neuropharmacology. Submitted april 16th.

94- G. Doodnaught, B. Monteiro Steagal, J. Benito, D. Edge, F. Beaudry, L. Pelligand and P. Steagll (2017), Pharmacokinetic and pharmacodynamic modelling after subcutaneous, intravenous and buccal administration of a high-concentration formulation of buprenorphine in conscious cats. PLOS ONE, PONE-D-16-49428, In Press

93- G. Le Bihan, P. Garneau, A. Bernalier-Donadille, A. Gobert, A. Garrivier, C. Martin, A. Hay, F. Beaudry, G. Jubelin and J. Harel (2016). N-Acetylglucosamine sensing by NagC contributes to gut colonization by regulating LEE genes in EHEC. Frontiers Microbiology, Manuscript ID: 257203, Accepted and In Press

92- M. Rhouma, J.M. Fairbrother, W. Thériault, F.Beaudry, N. Bergeron, S. Laurent Lewandowski and A. Letellier (2017), The fecal presence of enterotoxin and F4 genes as an indicator of efficacy of treatment with colistin sulfate in pigs, BMC Microbiology, 17:6

91- A. Riuz, E. Husby, C, Yang, G. Ghosh and F. Beaudry (2017), Meat Species Determination and Adulteration Detection can be Performed using High-Resolution Mass Spectrometry and a Proteogenomics Strategy, Food Additives and Contaminants, Submitted in March 2017 Manuscript ID: TFAC-2017-147

90- M. Saidi and F. Beaudry (2017), Targeted High-Resolution Quadrupole-Orbitrap Mass Spectrometry Analyses Reveal a Significant Reduction of Tachykinin and Opioid Neuropeptides Level in PC1 and PC2 Mutant Mouse Spinal Cords, Neuropeptides, Submited in November 2016, Manuscript ID: NPEP_2016_128

89- C. Otis, M. Guillot, M. Moreau, J. Martel-Pelletier, JP Pelletier, F. Beaudry, E. Troncy (2017), Spinal Neuropeptide Modulation and Cartilage Lesions in a Monosodium Iodoacetate Rat Model of Osteoarthritis. Neuropeptides, Submitted in March 2017

88- M. Rhouma, F. Beaudry, W. Thériault and A. Letellier (2016), Colistin in Pig Production: Chemistry, Mechanism of Antibacterial Action, Microbial Resistance Emergence, and One Health Perspectives. Frontiers in microbiology, 7:1789. doi: 10.3389/fmicb.2016.01789

87- A. Dodelet-Devillers, C. Zullian , F. Beaudry, J. Gourdon, J. Chevrette, P. Hélie, P. Vachon  (2016)., Physiological and pharmacokinetic effects of multilevel caging on Sprague Dawley rats under ketamine-xylazine anesthesia. Experimental animals. 65(4):383-392

86- M. Rhouma, F. Beaudry, W. Thériault, N. Bergeron, S. L-Lewandowski, J.M. Fairbrother, A. Letellier (2016). In vivo therapeutic efficacy and pharmacokinetics of colistin sulfate in an experimental model of enterotoxigenic Escherichia coli infection in weaned pigs. Veterinary Research, 27;47(1):58

85- J. Benito, B.P. Monteiro, F. Beaudry, A.M. Lavoie, B.D. Lascelles, P.V. Steagall, (2016). Pharmacokinetics of bupivacaine after intraperitoneal administration to cats undergoing ovariohysterectomy. American Journal of Veterinary Research, 77(6):641-645

84- C. Otis, J. Gervais, M. Guillot, J.A. Gervais, D. Gauvin, C. Pethel, S. Authier, M.A. Dansereau, P. Sarret, J. Martel-Pelletier, J.P. Pelletier, F.Beaudry, and E. Troncy, (2016). Concurrent validity of different functional and neuroproteomic pain assessment methods in the rat osteoarthritis MIA model. Arthritis Research & Therapy. 18:150

83- M. Rhouma, F.Beaudry and A.Letellier (2016), Resistance to colistin: What is the fate for this antibiotic in pig production, International Journal of Antimicrobial Agents, 48(2):119-126

82- M. Saidi, S. Kamali and F.Beaudry (2016), Characterization of Substance P Processing in Mouse Spinal Cord S9 Fractions using High-Resolution Quadrupole-Orbitrap Mass Spectrometry, Neuropeptides, 59:47-55. 10.1016/j.npep.2016.06.002, In Press

81- S.F. Salmin, MC Giroux, P. Vachon and F. Beaudry (2017), In Vitro Metabolism of Specific CYP2D and CYP3A Opioid Substrates using Rat Liver S9 Fractions and Mass Spectrometry Reveal a Severe Metabolic Impairment with Increasing Age. Biomedical Chromatography, 31(2):e3786

80- S. Hathroubi, F. Beaudry, C. Provost, C. A Gagnon and M. Jacques (2016), Impact of Actinobacillus pleuropneumoniae biofilm mode of growth on the lipid A structures and stimulation of immune cells, , Innate Immunity, 22(5):353-362

79- C. Zullian, P. Lema, M. Lavoie, A. Dodelet-Devillers, F. Beaudry and P. Vachon (2016). Plasmatic concentrations of buprenorphine following a single subcutaneous administration of a sustained release formulation of buprenorphine in sheep, Canadian Journal of Veterinary Research, 80(3), 250-253

78- A.Dodelet-Devillers, C.Zullian, P. Vachon, F. Beaudry (2016), Formulation Stability Assessment of Ketamine-Xylazine Preparations using High Performance Liquid Chromatography Mass Spectrometry" Canadian Journal of Veterinary Research. 80(1):86-89

77- J.S. Mort, F. Beaudry, K. Théroux, A. A. Emmott, H. Richard, W. D. Fisher, E. R. Lee, A. R. Poole and S. Laverty (2016). Early cathepsin K degradation of type II collagen in vitro and in vivo in articular cartilage. Osteoarthritis and Cartilage, 24(8):1461-1469

76- A. Benoit, T. Mustafy, I. Londono, F. Beaudry, P. Vachon, G. Grimard, C.-E. Aubin and I. Villemure (2015).  Histomorphometry of the newly formed bone after its growth modulation by static and dynamic compression using a rat tail model, Computer Methods in Biomechanics and Biomedical Engineering, 2015;18(S1):1884-5

75- M. Saidi, S. Kamali, A. Orduna Ruiz, F. Beaudry (2015), Tachykinins Processing is Significantly Impaired in PC1 and PC2 Mutant Mouse Spinal Cord S9 Fractions, Neurochemical Research, 40(11):2304-2316,

74- A. Orduna Ruiz, F. Beaudry (2016), Characterization of Endoproteolytic Processing of Dynorphins by Proprotein Convertases using Mouse Spinal Cord S9 Fractions and Mass Spectrometry, Neuropeptides, 57:85-94

73-  A. L. Ménard, G. Grimard, I. Londono, F. Beaudry, P. Vachon, F. Moldovan, I. Villemure (2015), Bone Growth Resumption Following In vivo Static and Dynamic Compression Removal on Rats. BONE, 81:662-668. http://dx.doi.org/10.1016/j.bone.2015.09.013

72- J. Ferreira Barbosa, J. Labrie, F. Beaudry, C. Gagnon, and M. Jacques (2015). Actinobacillus pleuropneumoniae induces SJPL cell cycle arrest in G2/M-phase and inhibits porcine reproductive and respiratory syndrome virus replication. Journal of Virology, 12:188 DOI 10.1186/s12985-015-0404-3

71-  A. Riuz, E. Husby, C, Yang, G. Ghosh and F. Beaudry (2015), Assessment of meat authenticity using bioinformatics, targeted peptide biomarkers and high-resolution mass spectrometry, Food Additives and Contaminants. 32(10):1709-1717.  http://dx.doi.org/10.1080/19440049.2015.1064173

70- M. Rhouma, F. Beaudry, W. Thériault, N. Bergeron, S. Laurent-Lewandowski, J. M. Fairbrother, A. Letellier (2015), Gastric stability and oral bioavailability of colistin sulfate in pigs challenged or not with Escherichia coli F4 (K88), Research in Veterinary Science, 102:173–181

69- M. Saidi and F. Beaudry (2015), Liquid Chromatography-Electrospray Linear Ion Trap Mass Spectrometry Analysis of Targeted Neuropeptides in Tac1-/- Mouse Spinal Cords Reveal Significant Lower Concentration of Opioid Peptides. Neuropeptides, 52:79-87 http://dx.doi.org/10.1016/j.npep.2015.05.005

68- F. Gaudette, J. Benito, P. Steagall and F. Beaudry (2015), Assessment of Tandem Mass Spectrometry and High Resolution Mass Spectrometry for the Analysis of Bupivacaine in Plasma, Biomedical Chromatography, 29(11):1724-1730.

67-M-C. Giroux, R. Santamaria, P. Hélie, P. Burns, F. Beaudry and P. Vachon (2016), Physiological, biochemical and pharmacokinetic comparisons between 3, 6, 12 and 18 month old male Sprague Dawley rats following ketamine-xylazine anesthesia, Experimental Animals. 65(1):63-75

66- L. Jafari, P. Vachon, F. Beaudry and E. Langelier (2015), Histopathological, biomechanical and behavioural pain findings of Achilles tendinopathy using an animal model of overuse injury, Physiological Reports, 3(1): e12265

65- Rialland P, Otis C, Moreau M, Pelletier JP, Martel-Pelletier J, Beaudry F, Del Castillo JR, Bertaim T, Gauvin D, Troncy E (2014), Association between sensitisation and pain-related behaviours in an experimental canine model of osteoarthritis. Pain, 155(10):2071-2079

64- R. Santamaria, F. Pailleux and F. Beaudry (2014), In Vitro Ketamine CYP3A Mediated Metabolism Study using Mammalian Liver S9 Fractions, cDNA Expressed Enzymes and Liquid Chromatography Tandem Mass Spectrometry, Biomedical Chromatography, 28(12):1660-1669

63- F. Pailleux and F. Beaudry (2014), Evaluation of Multiple Reaction Monitoring Cubed for the Analysis of Tachykinin Related Peptides in Rat Spinal Cord using a Hybrid Triple Quadrupole–Linear Ion Trap Mass Spectrometer, Journal of Chromatography B. 947-948:164-167

62- G. Le Bihan, G.Jubelin, P. Garneau, A. Bernalier-Donadille; C. Martin, F. Beaudry and J. Harel (2014), Transcriptome analysis of Escherichia coli O157:H7 grown in vitro in the cecal content of humanized rats reveals an adaptive expression of metabolic and virulence genes, Microbes Infect. 2015;17(1):23-33. doi: 10.1016/j.micinf.2014.09.008

61- P. Rialland, C. Otis, M.L. de Courval, P-Y. Mulon, D. Harvey, S. Bichot, D. Gauvin, A. Livingston, F. Beaudry, D. Frank, J.R.E. del Castillo, E. Troncy (2014), Assessing experimental visceral pain in dairy cattle: a pilot, prospective, blinded, randomized and controlled study focusing on spinal pain proteomics, Journal of Dairy Science, 97(4):2118-2134

60- F. Pailleux, P. Vachon, J. Lemoine and F. Beaudry (2013), Targeted Liquid Chromatography Quadrupole Ion Trap Mass Spectrometry Analysis of Tackykinin Related Peptides Reveals Significant Expression Differences in a Rat Model of Neuropathic Pain, Neuropeptides, 47(4):261-271

59- D. Veilleux-Lemieux, A. Castel, D. Carrier, F. Beaudry and P.Vachon (2013), Comparative pharmacokinetics of ketamine and xylazine in young and old Sprague Dawley rats, Journal of the American Association for Laboratory Animal Science, 52(5):567-570.

58- D. St-Germain Lavoie, P. Pailleux, P.Vachon and F. Beaudry (2013), Characterization of xylazine metabolism in rat liver microsomes using liquid chromatography-hybrid triple quadrupole-linear ion trap-mass spectrometry, Biomedical Chromatography, 27: 882–888

57- A. Castel, P. Hélie, F. Beaudry and P. Vachon (2013), Bilateral central pain sensitization in rats following a unilateral thalamic lesion can be treated with high doses of ketamine, BMC Veterinary Research, 9:59.

56- P. Rialland, S. Bichot, B. Lussier, M. Moreau, F. Beaudry, JRE del Castillo, D Gauvin, E Troncy (2013), Effect of a diet enriched with green-lipped mussel on pain behavior and functioning in dogs with clinical osteoarthritis, The Canadian Journal of Veterinary Research, 77(1):66-74

55- ML. Gauthier, F. Beaudry and P.Vachon (2013), Intrathecal [6]-Gingerol Administration Alleviates Peripherally-induced Neuropathic Pain in Male Sprague-Dawley Rats, Phytotherapy Research, 27(8):1251-1254

54- F. Pailleux, J. Lemoine, F. Beaudry (2013) Investigation of the Metabolic Biotransformation of Substance P in Liver Microsomes by Liquid Chromatography Quadrupole Ion Trap Mass Spectrometry, Biomedical Chromatography, 27:39-47 

53- P. Vachon, M. Millecamps, L. A. Low, S. J. Thompson, F. Pailleux, F. Beaudry, M. Catherine Bushnell, and L.S. Stone (2013), Reversal of chronic neuropathic pain by environmental enrichment in mice, Behavioral and Brain Functions, 9:22 (www.behavioralandbrainfunctions.com/content/9/1/22)

52- M. Rhouma, A. de Oliveira El Warrak, E. Troncy, F. Beaudry, Y. Chorfi (2013) Anti-inflammatory response of dietary vitamin E during early stages of surgically-induced osteoarthritis in dogs and its consequences on pain and joint structures, Canadian Journal of Veterinary Research, 77(3):191-198.

Disciplines

  • Chemistry
  • Pharmacology
  • Biochemistry
  • Biomedical Sciences

Areas of expertise

  • Chimie analytique et médicinale