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Medical Sciences

Marcio Costa

L'interaction entre les animaux domestiques et leur microbiome.

Professeur adjoint

Faculté de médecine vétérinaire - Département de biomédecine vétérinaire

3200, rue Sicotte - Aile A, room 3980

514 343-6111 #37397

Secondary number: 450 773-8521 #37397 (Travail 1)


Awards and recognitions

XXIX World Buiatrics Congress Scholarship (2016)

Best research abstract ACVIM Forum (2013)

ESCMID Travel Grant (2010)

OVC PhD Fellowship (2010)

Best research abstract ACVIM Forum (2009)

XXV World Buiatrics Congress Scholarship (2008)

OVC'49 and Dr. Ray Cormack Graduate Entrance Scholarship (2008)

CNPq Master’s Fellowship (2006)


  • 2014 — PhD — — University of Guelph
  • 2010 — DVSc — — University of Guelph
  • 2003 — DVM — Médecine vétérinaireUniversity of Londrina

Affiliations and responsabilities

Professional titles and affiliations

Titles: corporations and professional organizations

Morris Animal Foundation (Large Animal Scientific Advisory Board)

Teaching and supervision


Research projects

2018 - 2024

Microbiota manipulation used to improve animal production

Lead researcher : Marcio Costa
Funding sources: CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs: PVXXXXXX-(DGECR) Tremplin vers la découverte
2018 - 2024

Microbiota manipulation used to improve animal production

Lead researcher : Marcio Costa
Funding sources: CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs: PVX20965-(RGP) Programme de subvention à la découverte individuelle ou de groupe
2019 - 2022

Centre de Recherche en infectiologie porcine et avicole (CRIPA) / Regroupements stratégiques

Lead researcher : Carl A. Gagnon
Funding sources: FRQNT/Fonds de recherche du Québec - Nature et technologies (FQRNT)
Grant programs: PVXXXXXX-(RS) Programme de regroupements stratégiques
2017 - 2020

Characterization of the anal sac microbiota in dog with sacculitis

Lead researcher : Marcio Costa
Funding sources: AKC Canine Health Foundation
Grant programs:


Publications and presentations


  1. GOMEZ DE, GALVAO KN, RODRIGUEZ-LECOMPTE JC, COSTA MC. The cattle microbiota and the immune system: an evolving field. Veterinary Clinics of North America: Food Animal Practice, 2019, 35(3): 485-505. doi: 10.1016/j.cvfa.2019.08.002.
  2. COSTA MC, WESSE JS. Methods and Basic Concepts for Microbiota Assessment. The Veterinary Journal, 2019; 249: 10-15.
  3. ROMANA F, CLARK A, RUET A, COSTA MC, MACH N. Inter-breed diversity and temporal dynamics of the gut microbiota in healthy horses Journal of Animal Breeding and Genetics, 2019, doi: 10.1111/jbg.12441.
  4. KAMUS LJ, THEORET C, COSTA MC. Use of high throughput sequencing to investigate the microbiota of experimentally induced wounds and the effect of bandaging in horses. PlosOne. 2018 Nov 26;13(11):e0206989. doi: 10.1371/journal.pone.0206989
  5. COSTA MC, WESSE JS. Understanding the intestinal microbiome in health and disease. Veterinary Clinics of North America. Equine Practice. Advances in the Diagnosis and Management of Equine Gastrointestinal Disease, 2018, pii: S0749-0739(17)30918-5. doi: 10.1016/j.cveq.2017.11.005.
  6. PEREIRA, GQ, GOMES, LA, SANTOS, IF, ALFIERI, AF, WEESE, JS, COSTA, MC. Fecal Microbiota Transplantation in Puppies with Canine Parvovirus Infection. Journal of Veterinary Internal Medicine, 2018, published ahead. DOI: 10.1111/jvim.15072.
  7. ISHIKAWA AT, WEESE JS, BRACARENSE APFRL, ALFIERI AA, OLIVEIRA GG, KAWAMURA O, HIROOKA EY, ITANO EN, COSTA MC. Single aflatoxin B1 exposure induces changes in gut microbiota community in C57Bl/6 mice. World Mycotoxin Journal, 2017, v.10 (3) p.249-254. DOI:10.3920/WMJ2017.2190.
  8. ISHIKAWA AT, HIROOKA EY, ALVARES E SILVA PL, BRACARENSE APFRL, FLAIBAN KKMDC, AKAGI CY, KAWAMURA O, COSTA MC, ITANO EN. Impact of a Single Oral Acute Dose of Aflatoxin B₁ on Liver Function/Cytokines and the Lymphoproliferative Response in C57Bl/6 Mice. Toxins (Basel). 2017, v.9(11): E374. doi: 10.3390/toxins9110374.
  9. BESSEGATTO JA, PAULINO LR, LISBÔA JAN, ALFIERI AA, MONTEMOR CH, MEDEIROS LP, KOBAYASHI RKT, WEESE JS, COSTA MC Changes in the Fecal Microbiota of Beef Cattle Caused by Confinement and the Use of Virginiamycin as Growth Promoter. Research in Veterinary Science 2017, v.114, p.355-362.
  10. COSTA, MC; BESSEGATTO, JA; ALFIERI, AA; WEESE, JS; FILHO, JAB; OBA, A. Different antibiotic growth promoters induce specific changes in the cecal microbiota membership of broiler chicken. Plos One. 2017, v.12, e0171642
  11. ARROYO LG, COSTA MC, GUEST BB, PLATTNER BL, LILLIE BN, WEESE JS Experimental Model of Duodenitis-Proximal Jejunitis in Horses Inoculated with Clostridium difficile Toxins. Journal of Veterinary Internal Medicine, 2017; 31(1):158-163.
  12. GOMEZ, DE; ARROYO, LG; COSTA, MC; VIEL, L; WEESE, JS. Characterization of the Fecal Bacterial Microbiota of Healthy and Diarrheic Dairy Calves. Journal of Veterinary Internal Medicine, 2017 published ahead.
  13. ALMEIDA, MLM, FERINGER, WH, … COSTA, MC, FERRAZ, GC. Effects of Intense Exercise and Aerobic Conditioning Associated with Chromium or Carnitine Supplementation on the Fecal Microbiota of Fillies. Plos One 2016, v.11, e0167108.
  14. COSTA, MC, STÄMPFLI, HR, ALLEN-VERCOE, E, WEESE, JS. Development of the faecal microbiota in foals. Equine Veterinary Journal. 2015. doi: 10.1111/evj.12532.
  15. COSTA, MC, STÄMPFLI, HR, ARROYO, LG, ALLEN-VERCOE, E, GOMES, RG, WEESE, JS. Changes in the equine fecal microbiota associated with the use of systemic antimicrobial drugs. BMC Veterinary Research, 2015, v.11, e19.
  16. COSTA, MC, SILVA, G, RAMOS, RV, STÄMPFLI, HENRY R, ARROYO, LUIS G, WEESE, JS. Characterization and comparison of the bacterial microbiota in different gastrointestinal tract compartments in horses. The Veterinary Journal, 2015, v.205, 74-80.
  17. GORGIC, H., COSTA, MC, FRIENDSHIP R, CARMAN S, NAGY E. Genetic Characterization of H1N1 and H1N2 Influenza A Viruses Circulating in Ontario Pigs in 2012. Plos One, 2015, v.10, e0127840.
  18. GORGIC, H., COSTA, MC, FRIENDSHIP R, CARMAN S, NAGY E, WIDEMAN, G., WEESE, JS, POJAC, Z. Molecular characterization of H3N2 influenza A viruses isolated from Ontario swine in 2011 and 2012. Virology Journal, 2014, v.11, 194.
  19. STURGEON, A STULL, JW, COSTA, MC, WEESE, JS. Metagenomic analysis of the canine oral cavity as revealed by high-throughput pyrosequencing of the 16S rRNA gene In Veterinary Microbiology, 2013, v.162, 891-898.
  20. COSTA, MC, REID-SMITH, R, GOW, S., HANNON, S, BENEDICT, KM, MORLEY, PS, WEESE, JS. Prevalence and molecular characterization of Clostridium difficile isolated from feedlot beef cattle upon arrival and mid-feeding period. BMC Veterinary Research, 2012, v.8, e38.
  21. VETTORATO, ED, COSTA, MC, FLAIBAN, KKMC, VIDOTTO, O, BALARIN, MRS, LISBÔA, JAN. Serum proteins variation in Nelore and Holstein calves from birth to six months. Semina. Ciências Agrárias, 2012, v.33, 3181-3190.
  22. COSTA, MC, ARROYO, LG, ALLEN-VERCOE, E, STAEMPFLI, H, STURGEON, A., KIM, P, WEESE, JS. Comparison of the Fecal Microbiota of Healthy Horses and Horses with Colitis by High Throughput Sequencing of the V3-V5 Region of the 16S rRNA Gene. Plos One, 2012, v.7, e41484.
  23. COSTA, MC, WEESE, JS. The equine intestinal microbiome. Animal Health Research Reviews, 2012, v.1, 1-8.
  24. RUSH, S, PINDER, S, COSTA, MC, KIM, P. A Microbiology Primer for Pyrosequencing. Quantitative Bio-Science, 2012, v.31, 53-81.
  25. PARREIRA VR, COSTA, MC, EIKMEYER, F, BLOM, J, PRESCOTT, JF. Sequence of Two Plasmids from Clostridium perfringens Chicken Necrotic Enteritis Isolates and Comparison with C. perfringens Conjugative Plasmids. Plos One, 2012, v.7, e49753.
  26. STURGEON, A., PINDER SL, COSTA, MC, WEESE, JS. Characterization of the oral microbiota of healthy cats using next-generation sequencing. The Veterinary Journal, 2012, v.201, 223-229.
  27. ISERNHAGEN, AJ, CONSENZA, M, COSTA, MC, MÉDICI, KC, BALARIN, MRS, BRACARENSE, APFRL, ALFIERI, AA, LISBÔA, JAN. Asymptomatic encephalitis in calves experimentally infected with bovine herpesvirus-5. Canadian Veterinary Journal, 2011, v.52, 1312-1318.
  28. COSTA, MC, STAEMPFLI, H, ARROYO, LG, PEARL, DL, WEESE, JS. Epidemiology of Clostridium difficile on a veal farm: Prevalence, molecular characterization and tetracycline resistance. Veterinary Microbiology, 2011, v.152, 379-384.
  29. METCALF, D, COSTA, MC, DEW, WM, WEESE, JS. Clostridium difficile in vegetables, Canada. Letters in Applied Microbiology, 2010, v.51, 600-602.
  30. SANTOS, GMG, SILVA, KCF, CASIMIRO, TR, COSTA, MC, MORI, RM, MIZUBUTI, IY, MOREIRA, FB, SENEDA, MM. Reproductive performance of ewes mated in the spring when given nutritional supplements to enhance energy levels. Animal Reproduction, 2009, v.6, 422-427.
  31. COSTA, MC, FLAIBAN, KKMC, CONEGLIAN, MM, FEITOSA, FLF, BALARIN, MRS, LISBÔA, JAN. Passive transfer of immunity in Nelore and Limousin calves and serum proteinogram in the first four months of life. Brazilian Journal of Veterinary Research, 2008, v.28, 410-416.
  32. COSTA, MC, FLAIBAN, KKMC, CONEGLIAN, MM, DOGNANI, R, VETTORATO, ED, BALARIN, MRS, LISBÔA, JAN. Neutrophil oxidative burst in Nelore and Limousin calves in the first four months of life. Brazilian Journal of Veterinary Research, 2008, v.28, 431-436.
  33. COSTA, MC, ISERNHAGEN, AJ, MORAES, FLZ, DEARO, ACO, SAMPAIO, AJSA, REICHMANN, P, LISBÔA, JAN.. Absence of diarrhea in horses treated with oxytetracycline. Semina Ciência Agrárias, 2004, v.25, 245-248.


  • Veterinary Sciences
  • Biomedical Sciences

Areas of expertise

  • Microbiology
  • Bactériologie
  • Médecine interne des grands animaux
  • Animaux de la ferme
  • Animaux de compagnie