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André Tremblay

Biologie moléculaire et cellulaire des récepteurs nucléaires

Professeur titulaire

Faculté de médecine - Département d'obstétrique-gynécologie

andre.tremblay.1@umontreal.ca

Professeur accrédité

Faculté de médecine - Département de biochimie et médecine moléculaire

Secondary numbers: 514 345-4931 #2830 (Travail 1) 514 345-4988 (Télécopieur)
Secondary email: andre.tremblay@recherche-ste-justine.qc.ca (Travail)

Profile

Research expertise

Nuclear receptors are part of a multigenic family of hormone-activated transcription factors that regulate target gene expression. Of interest is also their inherent ability of undergoing post-translational modifications in response to cellular kinase pathways.

Two classes of receptors are studied in the laboratory:
  1. The estrogen receptors ERα and ERβ mediate hormone responsiveness of reproductive and peripheral tissues, and are involved in diverse aspects of human reproduction, embryonic development, and physiology. Our interest relates to the role of upstream cellular signals that regulate ER functions.
  2. The PPARs (α, β, and g) are nuclear receptors involved in lipid homeostasis and energy metabolism. The regulation of lipogenic/thermogenic target gene expression, the role of other nuclear receptors, such as LXR and FXR, and the mitochondrial activity and biogenesis are among the various aspects studied in the lab.

Awards and recognitions

  • Subvention Projet, Instituts de recherche en santé du Canada (IRSC), 2017-2020
  • Bourse salariale pour nouveau chercheur, Instituts de recherche en santé du Canada (IRSC), 2000-2005

Teaching and supervision

Student supervision

Theses and dissertation supervision (Papyrus Institutional Repository)

2016

SUMOylation atypique du récepteur nucléaire Nor-1

Graduate : Gagnon, Jonathan
Cycle : Master's
Grade : M. Sc.
2014

Rôle de la ghréline dans la régulation du coactivateur transcriptionnel PGC-1alpha

Graduate : Keil, Sarah
Cycle : Master's
Grade : M. Sc.
2013

Étude fonctionnelle du couplage chimiokine-estrogène dans les tissus reproducteurs

Graduate : Benhadjeba, Samira A.
Cycle : Master's
Grade : M. Sc.
2011

Regulation of lipid metabolism in adipocytes and hepatocytes by hexarelin through scavenger receptor CD36

Graduate : Rodrigue-Way, Amélie
Cycle : Doctoral
Grade : Ph. D.
2006

Sim1 function in the developing and adult brain

Graduate : Yang, Chun
Cycle : Doctoral
Grade : Ph. D.
2004

Régulation protéasome-dépendante de l'activité transcriptionnelle des récepteurs des estrogènes

Graduate : Charbonneau, Catherine
Cycle : Master's
Grade : M. Sc.

Projects

Research projects

2019 - 2025

The role of a novel SUMO conjugation process on nuclear receptor function and gene transcription

Lead researcher : André Tremblay
Funding sources: CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs: PVX20965-(RGP) Programme de subvention à la découverte individuelle ou de groupe
2020 - 2022

Multimode determination of gene transcription and metabolic labeling

Lead researcher : André Tremblay
Funding sources: CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs: PVXXXXXX-(OIR) Outils et d'instruments de recherche (OIR) -1 -(de 7 001 $ à 150 000 $)
2017 - 2022

Peripheral regulation of PPAR Nuclear Receptors in energy metabolism

Lead researcher : André Tremblay
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet
2013 - 2021

THE ROLE OF A NOVEL SUMO CONGUGATION PROCESS ON ESTROGEN RECEPTOR FUNCTION AND GENE TRANSCRIPTION

Lead researcher : André Tremblay
Funding sources: CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs: PVX20965-(RGP) Programme de subvention à la découverte individuelle ou de groupe
2011 - 2018

REGROUPEMENT STRATEGIQUE - RESEAU QUEBECOIS EN REPRODUCTION (RQR)

Lead researcher : Bruce D. Murphy
Funding sources: FRQNT/Fonds de recherche du Québec - Nature et technologies (FQRNT)
Grant programs: PVXXXXXX-(RS) Programme de regroupements stratégiques
2012 - 2015

THE ROLE OF A NOVEL KINASE-REGULATED SUMO CONJUGATION PROTEIN PROCESS ON ESTROGEN RECEPTOR FUNCTION AND GENE TRANSCRIPTION

Lead researcher : André Tremblay
Funding sources: CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs: PVX20965-(RGP) Programme de subvention à la découverte individuelle ou de groupe
2012 - 2015

ROLE OF THE CD36-PPAR PATHWAY IN LIPID AND ENERGY METABOLISM IN FAT

Lead researcher : André Tremblay
Funding sources: Association canadienne du diabète
Grant programs:
2009 - 2015

ROLE OF GHRELIN SIGNALING ON PERIPHERAL NUCLEAR RECEPTORS AND THE REGULATION OF LIPID AND ENERGY METABOLISM

Lead researcher : André Tremblay
Co-researchers : Grant Mitchell
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXX5647-Subvention de fonctionnement incluant les subventions de fonctionnement programmatiques
2009 - 2014

ROLE OF GHRELIN SIGNALING ON PERIPHERAL NUCLEAR RECEPTORS AND THE REGULATION OF LIPID AND ENERGY METABOLISM

Lead researcher : André Tremblay

Outreach

Publications and presentations

Publications

  • Sanchez, M., Sauvé, K., Picard, N., Tremblay, A. (2010) Challenging estrogen receptor b with phosphorylation. Trends Endo Met (in press)
  • Demers, A., Caron, V., Rodrigue-Way, A., Wahli, W., Ong, H., Tremblay, A. (2009) A Concerted Kinase Interplay Identifies PPARg as a Molecular Target of Ghrelin Signaling in Macrophages. PLoS ONE 4(11): e7728.
  • Sauvé, K., Lepage, J., Sanchez, M., Heveker, N., Tremblay, A. (2009) Positive feedback activation of estrogen receptors by the SDF1-CXCR4 pathway. Cancer Research 69: 5793-5800.
  • Picard, N., Charbonneau, C., Sanchez, M., Licznar, A., Busson, M., Lazennec, G., Tremblay, A. (2008) Phosphorylation of AF-1 regulates proteasome-dependent nuclear mobility and E6-AP ubiquitin ligase recruitment to the estrogen receptor β. Molecular Endocrinology 22: 317-330.
  • Demers, A., Rodrigue-Way, A., Tremblay, A. (2008). Hexarelin signaling to PPARgamma in metabolic disease. Special Issue on Cardiovascular Physiology and Disease. PPAR Research Jan. 2008:1-9.
  • Rodrigue-Way, A., Demers, A., Ong, H., Tremblay, A. (2007) A Growth Hormone-Releasing Peptide Promotes Mitochondrial Biogenesis And A Fat Burning-like Phenotype Through Scavenger Receptor CD36 in White Adipocytes Endocrinology. 148:1009-1018.
  • Sanchez, M., Sauvé, K., Picard, N., Tremblay, A. (2007) Transcriptional repression of the estrogen receptor β by the PI3K/Akt pathway involves a phosphorylation-dependent release of CBP. J. Biol. Chem. 282:4830-4840.
  • Avallone, R., Demers, A., Rodrigue-Way, A., Anghel, S., Wahli, W., Marleau, S., Ong, H., Tremblay, A. (2006) A Growth Hormone-Releasing Peptide that Binds Scavenger Receptor CD36 and Ghrelin Receptor Upregulates ABC Sterol Transporters and Cholesterol Efflux in Macrophages Through a PPARg-dependent Pathway. Molecular Endocrinology, 20(12):3165-3178.

Disciplines

  • Molecular Biology
  • Oncology
  • Endocrinology

Areas of expertise

  • Cell
  • Metabolic Disorders
  • Gene Regulation and Expression
  • Gene (Living Organisms)
  • Hormone Replacement Therapy
  • Immune Mediators: Cytokines and Chemokines
  • Receptors and Carriers
  • Hormonal Regulation
  • Endocrine Regulation
  • Cell Signaling and Cancer
  • Endocrine System