
Health Sciences; Natural Sciences and Engineering
Zoha Kibar
- Professeure sous octroi agrégée
-
Faculté de médecine - Département d'obstétrique-gynécologie
- Professeure sous octroi agrégée
-
Faculté de médecine - Département de neurosciences
Secondary numbers:
514 345-4931 #3984
(Travail 1)
514 345-4801
(Télécopieur)
Secondary email:
zoha.kibar@recherche-ste-justine.qc.ca
(Travail)
Profile
Research expertise
We use the tools of genetics, genomics and molecular biology to identify and characterize the genes predisposing to congenital malformations of the central nervous system (CNS) and the associated axial skeletal structures. Our laboratory is particularly interested in understanding the genetic and biological basis of two such malformations: neural tube defects (NTDs) and Chiari I malformation (CMI). These anomalies have a multifactorial etiology involving genetic and environmental factors that remain largely unknown.
Neural tube defects (NTDs), including spina bifida and anencephaly, represent a group of very common congenital malformations in humans, affecting 1-2 infants per 1000 births. They are caused by a partial or complete failure of the neural tube to close during embryogenesis. During my postdoctoral studies, I identified the gene mutated in Loop-tail, a well-established model for the study of NTDs in humans. This gene, designated as Vangl2, forms part of the non-canonical Frizzled (Fz)/Dishevelled (Dvl) membrane signaling pathway controlling the morphogenetic process of convergent extension (CE) that is central to gastrulation and neural tube closure. We recently identified mutations in a human homolog called VANGL1 that are associated with neural tube defects in humans, representing the first report of pathogenic mutations in a specific gene in human NTDs. For identification of novel genes involved in NTDs, we are pursuing three major approaches: (1) molecular genetic investigation of VANGL1, VANGL2 and other members of the non-canonical Fz/Dvl pathway in human NTDs, (2) molecular genetic studies of other novel chemically-induced mouse models and (3) whole-genome analysis of copy number variants using the array Comparative Genomic Hybridization technology.Chiari I malformation (CMI) is a common abnormality of the craniocerebral junction characterized by a caudal descent of the cerebellar tonsils into the spinal canal. CMI in humans is similar to a common condition in the Cavalier King Charles Spaniels (CKCS) and Brussels Griffon dog breeds. We will identify the gene(s) defective in CMI in the dog using linkage and association studies followed by a positional candidate gene approach. We will next investigate the human ortholog(s) of the dog CMI gene(s) to identify and characterize the gene(s) defective in CMI in humans.Our studies of NTDs and CMI will help better understand the underlying pathological mechanisms and are crucial for studying and characterizing the gene-environment interactions in these diseases. Gene-environment studies will help design novel preventive strategies and better counseling for couples at risk. Furthermore, these studies will help elucidate some of the molecular and cellular mechanisms underlying the early development of the neural tube and its derivatives.Affiliations and responsabilities
Research affiliations
Teaching and supervision
Teaching
Courses taught (current session only)
Programs
Student supervision
Theses and dissertation supervision (Papyrus Institutional Repository)
2018
Le rôle du gène de la polarité apico-basale SCRIBBLE1 dans les anomalies de tube neural
Graduate : Kharfallah, Fares
Cycle : Doctoral
Grade : Ph. D.
Cycle : Doctoral
Grade : Ph. D.
2018
Caractérisation moléculaire et fonctionnelle d'un nouvel allèle du gène de la polarité cellulaire planaire (PCP) Vangl2
Graduate : El-Hassan, Abdul-Rahman
Cycle : Master's
Grade : M. Sc.
Cycle : Master's
Grade : M. Sc.
2018
Anomalies du tube neural : mieux comprendre les causes génétiques de cette pathologie complexe
Graduate : Lemay, Philippe
Cycle : Doctoral
Grade : Ph. D.
Cycle : Doctoral
Grade : Ph. D.
2016
Role of the Protein Tyrosine Kinase 7 gene in human neural tube defects
Graduate : Wang, Mingqin
Cycle : Master's
Grade : M. Sc.
Cycle : Master's
Grade : M. Sc.
2015
Études génétiques moléculaires des gènes de la polarité planaire cellulaire dans les anomalies du tube neural chez l’Homme
Graduate : Allache, Redouane
Cycle : Doctoral
Grade : Ph. D.
Cycle : Doctoral
Grade : Ph. D.
2013
Identification et caractérisation d’une souris mutante Skam26Jus comme un nouveau modèle des anomalies du tube neural
Graduate : Lachance, Stéphanie
Cycle : Master's
Grade : M. Sc.
Cycle : Master's
Grade : M. Sc.
2012
Analyse génétique moléculaire du gène de la voie non-canonique Frizzled/Dishevelled PRICKLE1 dans les anomalies du tube neural chez l’humain
Graduate : Bosoi, Marius Ciprian
Cycle : Master's
Grade : M. Sc.
Cycle : Master's
Grade : M. Sc.
2012
Malformation Chiari-Like : l’investigation d’une maladie complexe par l’utilisation d’un modèle canin
Graduate : Lemay, Philippe
Cycle : Master's
Grade : M. Sc.
Cycle : Master's
Grade : M. Sc.
2012
Études génétiques moléculaires du gène de la polarité planaire SCRIBBLE1 chez les anomalies du tube neural
Graduate : Kharfallah, Fares
Cycle : Master's
Grade : M. Sc.
Cycle : Master's
Grade : M. Sc.
Projects
Research projects
2018
- 2024
Molecular crosstalk between apicalbasal polarity and planar cell polarity in axon guidance
Lead researcher :
Zoha Kibar
Funding sources:
CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs:
PVX20965-(RGP) Programme de subvention à la découverte individuelle ou de groupe
2020
- 2022
Multimode determination of gene transcription and metabolic labeling
Lead researcher :
André Tremblay
Funding sources:
CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs:
PVXXXXXX-(OIR) Outils et d'instruments de recherche (OIR) -1 -(de 7 001 $ à 150 000 $)
2020
- 2021
Supplément COVID-19 CRSNG_Molecular crosstalk between apicalbasal polarity and planar cell polarity in axon guidance
Lead researcher :
Zoha Kibar
Funding sources:
CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs:
PVXXXXXX-Supplément à l’appui des étudiants, des stagiaires postdoctoraux et du personnel de
soutien à la recherche COVID-19
2018
- 2020
Investigating the role of planar cell polarity signaling in cell migration and invasion in acute myeloid leukemia.
Lead researcher :
Zoha Kibar
Funding sources:
Fondation Charles Bruneau
Grant programs:
2014
- 2020
DE NOVO MUTATIONS IN BIRTH DEFECTS
Lead researcher :
Jacques Michaud
Co-researchers :
Zoha Kibar
Funding sources:
IRSC/Instituts de recherche en santé du Canada
Grant programs:
PVXX5647-Subvention de fonctionnement incluant les subventions de fonctionnement programmatiques
2013
- 2020
IDENTIFICATION AND CHARACTERIZATION OF GENES PREDISPOSING TO NEURAL TUBE DEFECTS IN HUMANS
Lead researcher :
Zoha Kibar
Funding sources:
IRSC/Instituts de recherche en santé du Canada
Grant programs:
PVXX5647-Subvention de fonctionnement incluant les subventions de fonctionnement programmatiques
2013
- 2019
MOLECULAR CROSSTALK BETWEEN APICAL-BASAL POLARITY AND PLANAR CELL POLARITY IN AXON GUIDANCE
Lead researcher :
Zoha Kibar
Funding sources:
CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs:
PVX20965-(RGP) Programme de subvention à la découverte individuelle ou de groupe
2017
- 2018
Canadian "rare diseases: models & mechanisms" network (RDMM) / Réseau canadien "maladies rares : modèles et mécanismes" (MRMM).
Lead researcher :
Philip A Hieter
Co-researchers :
Zoha Kibar
Funding sources:
IRSC/Instituts de recherche en santé du Canada
Grant programs:
PVXXXXXX-Subvention de réseau
2016
- 2017
Études génétiques moléculaires et fonctionnelles du syndrome PDAC
Lead researcher :
Zoha Kibar
Funding sources:
Fondation du Grand défi Pierre Lavoie
Grant programs:
2014
- 2017
Identification of gene(s) predisposing to syringomyelia associated with Chiari-like malformation in the Cavalier King Charles spaniels.
Lead researcher :
Zoha Kibar
Funding sources:
Dogs Trust
Grant programs:
2008
- 2016
(RESEAUTETE) - THE INTEGRATED RESEARCH NETWORK ON PERINATOLOGY
Lead researcher :
William Fraser
Co-researchers :
Marie-Pierre Dubé
,
Bryn Williams-Jones
,
Béatrice Godard
,
Jean-Claude Tardif
,
Mira Johri
,
Isaac-Jacques Kadoch
,
François Audibert
,
Nils Chaillet
,
Jacques Lacroix
,
Zhong-Cheng Luo
,
Gregor Andelfinger
,
Mark E. Samuels
,
Patricia Monnier
,
Zoha Kibar
,
François Bissonnette
,
Maryse Lassonde
,
Marie-Josée Bédard
,
Franco Lepore
,
Sylvain Chemtob
,
Marie Hatem
,
Guy Rouleau
,
Luc Laurier Oligny
,
Jean Séguin
,
Anick Bérard
,
Anne Monique Nuyt
,
Jacques Michaud
,
Helen Trottier
,
Emmanuelle Lemyre
,
Richard Ernest Tremblay
,
Éric Dewailly
,
Pierre Julien
,
Jean-Marie Moutquin
,
Bruno Piedboeuf
,
Pierre Ayotte
,
Gina Muckle
,
Yves Tremblay
,
Isabelle Marc-Series
,
Margaret Somerville
,
Michal Abrahamowicz
,
Jacquetta M Trasler
,
Togas Tulandi
,
Seang Lin Tan
,
Normand Brassard
,
Ri-Cheng Chian
,
Catherine Limperopoulos
,
Haim Arie Abenhaim
,
Richard Brown
,
Patricia Monnier
,
Andrew Grant
,
Jean-Charles Pasquier
,
Daria Pereg
,
Rhian Touyz
,
Mark Walker
,
Rosana Weksberg
,
Shi Wu
,
Elisabeth Winsor
,
Lise Dubois
,
Tye Arbuckle
,
Germaine Buck Louis
,
Regen Drouin
,
Patricke Eydoux
,
Warren Foster
,
Sonya Kashyap
,
Elena Kolomietz
Funding sources:
IRSC/Instituts de recherche en santé du Canada
Grant programs:
2009
- 2015
(RESEAUTETE) CIHR - QUEBEC TRAINING NETWORK IN PERINATAL RESEARCH
Lead researcher :
William Fraser
Co-researchers :
Jacques Viens
,
Bryn Williams-Jones
,
Patricia Monnier
,
Bruce D. Murphy
,
Denise Avard
,
Nils Chaillet
,
Zhong-Cheng Luo
,
Zoha Kibar
,
Marie Hatem
,
Jean Séguin
,
Anick Bérard
,
Anne Monique Nuyt
,
Helen Trottier
,
Richard Ernest Tremblay
,
Sylvana Côté
,
Pierre Julien
,
Jean-Marie Moutquin
,
Bruno Piedboeuf
,
Gina Muckle
,
Yves Tremblay
,
Jean-François Bilodeau
,
Jacques J. Tremblay
,
Isabelle Marc-Series
,
Haim Arie Abenhaim
,
Robert Gagnon
,
Emmanuel Bujold
,
Patricia Monnier
,
William Fisher
,
Roger Pierson
,
Mark Walker
Funding sources:
FRQS/Fonds de recherche du Québec - Santé (FRSQ)
,
IRSC/Instituts de recherche en santé du Canada
Grant programs:
PVXXXXXX-Subventions de recherche en partenariat
,
2007
- 2015
IDENTIFICATION DES GENES PREDISPOSANT AUX ANOMALIES DES STRUCTURES DORSOMEDIALES DES SYSTEMES NERVEUX CENTRAL ET SQUELETTIQUE
Lead researcher :
Zoha Kibar
Funding sources:
FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs:
PVXXXXXX-Bourse de chercheurs-boursiers: junior I et II et senior
2011
- 2014
IDENTIFICATION DES GÈNES PRÉDISPOSANT AUX ANOMALIES DES STRUCTURES DORSOMÉDIALES DES SYSTÈMES NERVEUX CENTRAL ET SQUELETTIQUE
2010
- 2014
IDENTIFICATION OF THE GENE(S) PREDISPOSING TO CHIARI MALFORMATION I USING THE GRIFFON BRUXELLOIS DOG MODEL
Lead researcher :
Zoha Kibar
Co-researchers :
Clare Rusbridge
Funding sources:
IRSC/Instituts de recherche en santé du Canada
Grant programs:
PVXX5647-Subvention de fonctionnement incluant les subventions de fonctionnement programmatiques
2010
- 2013
PLATEFORME D'INNOVATION EN GENOMIQUE DES SCOLIOSES PEDIATRIQUES (GSP): DES GENES AUX TESTS DIAGNOSTIQUES COMPLETS
Lead researcher :
Alain Moreau
Funding sources:
Génome Québec
Grant programs:
2010
- 2013
IDENTIFICATION OF THE GENE(S) PREDISPOSING TO CHIARI MALFORMATION I USING THE GRIFFON BRUXELLOIS DOG MODEL
Lead researcher :
Zoha Kibar
2008
- 2009
IDENTIFICATION DES GENES PREDISPOSANT AUX ANOMALIES DES STRUCTURES DORSOMEDIALES DES SYSTEMES NERVEUX CENTRAL ET SQUELETTIQUE.
Lead researcher :
Zoha Kibar
2008
IDENTIFICATION AND CHARACTERIZATION OF GENES PREDISPOSING TO NEURAL TUBE DEFECTS IN HUMANS
Lead researcher :
Zoha Kibar
Outreach
Publications and presentations
Disciplines
- Neurosciences
- Biochemistry