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Health Sciences

Jacques Michaud

La différenciation neuronale

Professeur titulaire

Faculté de médecine - Département de pédiatrie

jacques.michaud@umontreal.ca

Professeur titulaire

Faculté de médecine - Département de neurosciences

jacques.michaud@umontreal.ca

Secondary numbers: 514 345-4931 #6900 (Travail 1) 514 345-4801 (Télécopieur)

Profile

Research expertise

The group’s research focuses on the biochemical and cell-based characterization of medically relevant enzymes to uncover the molecular basis of their mechanisms of action, specificities and regulation. We also aim to identify compounds that modulate enzyme activities. This knowledge can provide insight into the precise physiological role of these enzymes, and contribute to the design of potential therapeutic agents. Application of enzyme kinetic techniques to study the molecular basis of the mechanism and specificity of enzymes; structure-function relationships; study of enzyme-inhibitor interactions with the aim of designing new or improved inhibitors of therapeutic importance; modification of enzymes to alter their structural and/or functional properties (stability, specificity, catalytic mechanism); design of experimental protocols in enzyme kinetics; assay development for high-throughput-screening of compound libraries and for functional studies.

Deubiquitinating EnzymesThe modification of cellular proteins by ubiquitin and ubiquitin-like proteins is an essential regulatory mechanism in many biological processes. The isopeptide bond between ubiquitin and a protein, or between ubiquitin molecules in a polyubiquitin chain, can be cleared by deubiquitinating enzymes. The human genome encodes approximately 95 deubiquitinating enzymes, most of them being cysteine proteases, which are relatively poorly characterized. Our group uses detailed biochemical characterization and cell-based studies to provide insights into the molecular mechanisms and physiological roles of these enzymes, in order to elaborate novel molecular therapeutic strategies based on interference with deubiquitinating events.Enzymes from Clostridium difficileStudies are being carried out to characterize at the molecular level cysteine proteases from the bacteria Clostridium difficile, an important human pathogen. In the search for alternative antibiotics for treating bacterial infections, we are also evaluating how these enzymes influence the virulence of Clostridium difficile infections.Other cysteine proteasesIt was demonstrated that a viral papain-like cysteine protease (PLpro) from the Severe Acute Respiratory Syndrome (SARS) coronavirus, previously known to be involved in processing a viral polyprotein precursor and to contribute to the virus replicative cycle, also possesses deubiquitinating activity. This discovery raised provocative hypotheses regarding the ability of the SARS virus to evade cellular defense mechanisms. Our group has also made many important contributions to the study of cathepsin mechanisms, catalysis, specificity and regulation. In addition to general intracellular protein degradation and turnover within the endosomal/lysosomal system, cathepsins (mammalian cysteine proteases) can fulfill specific functions and also play an important role in a variety of pathological processes such as degenerative diseases and malignant tumour development.

Affiliations and responsabilities

Teaching and supervision

Student supervision

Theses and dissertation supervision (Papyrus Institutional Repository)

2016

Implication de Syngap1 dans la transmission GABAergique et la plasticité synaptique

Graduate : Xing, Paul
Cycle : Master's
Grade : M. Sc.
2015

Exploration génomique de la déficience intellectuelle

Graduate : Capo-Chichi, José-Mario
Cycle : Doctoral
Grade : Ph. D.
2015

Genetic Landscape of Joubert syndrome in French Canadians

Graduate : Srour, Myriam
Cycle : Doctoral
Grade : Ph. D.
2011

Régulation transcriptionelle du développement de l'hypothalamus chez l'amphibien

Graduate : Bouyakdan, Khalil
Cycle : Master's
Grade : M. Sc.
2009

Dissection du programme développemental du noyau paraventriculaire de l'hypothalamus.

Graduate : Caqueret, Aurore
Cycle : Doctoral
Grade : Ph. D.
2006

Sim1 function in the developing and adult brain

Graduate : Yang, Chun
Cycle : Doctoral
Grade : Ph. D.
2005

Rôle de Sim1 et Sim2 dans la guidance des axones du corps mammillaire

Graduate : Marion, Jean-François
Cycle : Master's
Grade : M. Sc.

Projects

Research projects

2019 - 2026

Cell analytics infrastructure investment at the Centre Hospitalier Universitaire (CHU) Ste. Justine Research Centre

Lead researcher : Jacques Michaud
Funding sources: Conseil national de recherches du Canada
Grant programs:
2016 - 2023

Bridging the Gap in Paediatric Traumatic Brain Injury: Environmental, biological and clinical markers associated with preschool concussion and TBI

Lead researcher : Miriam Beauchamp
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(FDN) Subvention Fondation
2018 - 2022

Estimating the effect size of rare genomic variants on cognitive and behavioral traits underlying neurodevelopmental disorders

Lead researcher : Sébastien Jacquemont
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet
2019 - 2021

Multilevel analyses of retinoic acid signaling to understand and treat a rare form of progressive motor impairment. (RAinRARE project).

Lead researcher : Jacques Michaud
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-Subvention d'équipe émergente: maladies rares
2018 - 2021

Synaptic dysfunction in intellectual disabiity caused by SYNGAP1. Translational research to develop human models and advanced pharmacological treatments, TREAT SYNGAP.

Lead researcher : Jacques Michaud
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-(ERA-NET Neuron) Québec Europe
2014 - 2020

DE NOVO MUTATIONS IN BIRTH DEFECTS

Lead researcher : Jacques Michaud
Co-researchers : Zoha Kibar
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXX5647-Subvention de fonctionnement incluant les subventions de fonctionnement programmatiques
2018 - 2019

Canadian "Rare Diseases: Models & Mechanisms" Network (RDMM) Réseau Canadien "Maladies Rares: Modèles et Mécanismes" (MRMM)

Lead researcher : Philip A Hieter
Co-researchers : Jacques Michaud
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs:
2018 - 2019

Fondation des étoiles : Neurodéveloppement, santé mentale et maladies rares.

Lead researcher : Jacques Michaud
Funding sources: La Fondation des étoiles
Grant programs:
2013 - 2017

PERSONALIZED MEDICINE IN TREATMENT OF EPILEPSY

Lead researcher : Patrick Cossette
Co-researchers : Béatrice Godard , Jean Lachaine , Marie-Pierre Dubé , Jacques Michaud , Guy Rouleau
Funding sources: Génome Canada
Grant programs:
2012 - 2016

DE NOVO MUTATIONS IN INTELLECTUAL DISABILITY

Lead researcher : Jacques Michaud
Co-researchers : Graziella Di Cristo
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXX5647-Subvention de fonctionnement incluant les subventions de fonctionnement programmatiques
2011 - 2016

DE NOVO MUTATIONS IN INTELLECTUAL DISABILITY

Lead researcher : Jacques Michaud
2008 - 2016

(RESEAUTETE) - THE INTEGRATED RESEARCH NETWORK ON PERINATOLOGY

Lead researcher : William Fraser
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs:
2015

LETTER OF INTENT (LOI) - The POPEYE project: Prevention of ongoing psychological comorbidities through early intervention in youth living with epilepsy. A new transformative model for the management of chronic diseases.

Lead researcher : Lionel Carmant
Co-researchers : Jacques Michaud , Fabrice P. Brunet , Patricia Conrod , Jong Min Rho
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-Stratégie de recherche axée sur le patient (SRAP)
2013 - 2015

PERSONALIZED MEDICINE IN TREATMENT OF EPILEPSY

Lead researcher : Patrick Cossette
Co-researchers : Jacques Michaud , Minassian Berge
Funding sources: Génome Québec
Grant programs:
2009 - 2015

SUBVENTION DE FORMATION DES IRSC-FRSQ EN MEDECINE GENETIQUE APPLIQUEE

Lead researcher : Guy Rouleau
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs:
2009 - 2015

LA FORMATION EN RECHERCHE AU SEIN DU RESEAU DE MEDECINE GENETIQUE APPLIQUEE DU FRSQ

Lead researcher : Guy Rouleau
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Subventions de recherche en partenariat
2012 - 2014

GENETICS OF DEVELOPMENTAL DISORDERS

Lead researcher : Jacques Michaud
Funding sources: Regroupement de compagnies, corporations canadiennes
Grant programs:
2012 - 2014

GENETICS OF DEVELOPMENTAL DISORDERS

Lead researcher : Jacques Michaud
Funding sources: FCI/Fondation canadienne pour l'innovation
Grant programs:
2012 - 2014

GENETICS OF DEVELOPMENTAL DISORDERS

Lead researcher : Jacques Michaud
Funding sources: MSSS/Ministère de la Santé et des Services sociaux
Grant programs:
2010 - 2014

IDENTIFICATION OF AUTOSOMAL RECESSIVE MUTATIONS ASSOCIATED WITH DEVELOPMENTAL ABNORMALITIES THROUGH NEXT-GENERATION RESEQUENCING

Lead researcher : Jacques Michaud
Co-researchers : Mark E. Samuels
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXX5647-Subvention de fonctionnement incluant les subventions de fonctionnement programmatiques
2010 - 2014

GENETIQUE DES MALADIES NEURO-DEVELOPPEMENTALES

Lead researcher : Jacques Michaud
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Bourses - Chercheurs nationaux
2009 - 2014

EMERGING TEAM IN DEVELOPMENT OF STRATEGIES FOR UPTAKE AND ANALYSIS OF NANOSEQUENCING-DERIVED DATA SETS AND LINKING TO DISEASE

Lead researcher : Michel Bouvier
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs:
2011 - 2013

DOSSIER #20289 GENETIQUE DES MALADIES NEURO-DEVELOPPEMENTALES

Lead researcher : Jacques Michaud
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Bourses - Chercheurs nationaux
2010 - 2013

GENETIQUE DES MALADIES NEURO-DEVELOPPEMENTALES

Lead researcher : Jacques Michaud
2010 - 2013

IDENTIFICATION OF AUTOSOMAL RECESSIVE MUTATIONS ASSOCIATED WITH INTELLECTUAL DISABILITY THROUGH NEXT-GENERATION RESEQUENCING

Lead researcher : Jacques Michaud
Funding sources: March of Dimes Birth Defects Foundation
Grant programs:
2010 - 2013

IDENTIFICATION OF AUTOSOMAL RECESSIVE MUTATIONS ASSOCIATED WITH DEVELOPMENTAL ABNORMALITIES THROUGH NEXT-GENERATION RESEQUENCING

Lead researcher : Jacques Michaud
2008 - 2013

EMERGING TEAM IN DEVELOPMENT OF STRATEGIES FOR UPTAKE AND ANALYSIS OF NANOSEQUENCING-DERIVED DATA SETS AND LINKING TO DISEASE

Lead researcher : Guy Rouleau
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs:

Outreach

Publications and presentations

Disciplines

  • Genetics

Areas of expertise

  • Genetic Mapping
  • Chromosomes: Structure / Organization
  • Genetic Screening of Diseases
  • Genomic Damage and Repair
  • Gene Regulation and Expression
  • Genes
  • Susceptibility Genes
  • Applied Genetics
  • Complex Trait Genetics
  • Developmental Genetics
  • Genetics and Ethics
  • Genetics and Heredity
  • Evolutionary Genetics
  • Molecular Genetics
  • Population Genetics
  • Genome
  • Genomics
  • Gene-Environment Interactions
  • Genetic Diseases
  • Genetic Markers
  • DNA and RNA Chips
  • Transgenic Model
  • Mutation (Process)
  • Phenotype
  • Polymorphism
  • Proteins
  • Proteomics
  • Telomeres
  • Gene Therapy