Daniel Lévesque
- Professeur titulaire
-
Faculté de pharmacie
Pavillon Jean Coutu, room local 3216
Profile
education
- 1995 — Stage postdoctoral — Neurosciences — INSERM U109
- 1991 — Doctorat — Pharmacie — Université Laval
Affiliations and responsabilities
Teaching and supervision
Student supervision
Theses and dissertation supervision (Papyrus Institutional Repository)
Caractérisation de la modulation de l’activité du récepteur nucléaire orphelin NUR77 (NR4A1) par ses modifications post-traductionnelles et son interactome
Cycle : Doctoral
Grade : Ph. D.
Caractérisation neurochimique de la dyskinésie tardive dans un modèle primate non humain.
Cycle : Master's
Grade : M. Sc.
Caractérisation de l’activité Nur77 et de ses complexes en essais BRET par complémentation
Cycle : Doctoral
Grade : Ph. D.
Caractérisation pharmacologique et moléculaire des dyskinésies tardives chez un modèle de primate non humain
Cycle : Doctoral
Grade : Ph. D.
Nur77 au sein des désordres dopaminergiques inhérents à la schizophrénie, la maladie de Parkinson ou la dépendance aux drogues d'abus
Cycle : Doctoral
Grade : Ph. D.
La modulation transcriptionnelle du neuropeptide enképhaline par les récepteurs nucléaires Nur77 et RXRγ
Cycle : Master's
Grade : M. Sc.
Mécanismes cellulaires de l'induction du facteur de transcription Nur77 après un traitement aux antipsychotiques
Cycle : Doctoral
Grade : Ph. D.
Projects
Research projects
Soutien Médicament Québec
Identification of lead compounds for modulation of Nur77 /RXR receptor complex activity in the management of L-Dopa-induced dyskinesia in Parkinson's disease
THE ROLE OF TRANSCRIPTION FACTORS NUR77 AND RETINOID X RECEPTOR (RXR) IN THE EFFECT OF ANTIPSYCHOTIC DRUG
SUBVENTION D'INFRASTRUCTURE DU FRSQ POUR LE GRSNC(GROUPE DE RECHERCHE SUR LE SYSTÈME NERVEUX CENTRAL)
Neural mechanisms that sub-serve sensitization to the behavioral effects of psychostimulant drugs.
NUR77 and RXR : New Targets in Drug-Induced Dyskinesia.
NUR77 and RXR : New Targets in Drug-Induced Dyskinesia.
Identification of Nurrl / RXR complex agonists for neuroprotection
NEUROTENSIN MODULATION OF LIMBIC NEUROTRANSMISSION
RESEAU DE RECHERCHE EN SANTE BUCCODENTAIRE ET OSSEUSE (RSBO) GROUPE DE RECHERCHE INTERDISCIPLINAIRE SUR LA DYSKINESIE (GRID): NOUVELLES APPROCHES MOLECULAIRES ET PHARMACOLOGIQUES VERS LA PREVENTION ET LE TRAITEMENT D
NUCLEAR RECEPTORS AND DOPAMINE NEUROTRANSMISSION: A YIN-YANG RELATIONSHIP
NUCLEAR RECEPTORS AND DOPAMINE NEUROTRANSMISSION: A YIN-YANG RELATIONSHIP
IN SITU-FORMING IMPLANTS OF RIVASTIGMINE IN THE TREATMENT OF ALZHEIMER'S DISEASE
IN SITU-FORMING IMPLANTS OF RIVASTIGMINE IN THE TREATMENT OF ALZHEIMER'S DISEASE
ANALYSES MOLECULAIRES ET CELLULAIRES DE L'EFFET DES AGENTS ANTIPSYCHOTIQUES SUR LE FACTEUR DE TRANSCRIPTION NUR77
Outreach
Publications and presentations
Publications
Publications récentes:
Schweizer N, T Viereckel, C Smith-Anttila, K Nordenankar, E Arvisson, S Mahmoudi, A Zampera, H Warner Jonsson, J Bergquist, D Lévesque, A Konradsson-Geuken, M Andersson, S Dumas and A Wallen-Mackenzie, Reduced sugar consumption and altered size of subtalamic nucleus identify a role for Pitx2/Vglut2 co-expressing neurons in action selection, eNeuro, 3(5) e0264-16, 2016.
Fakhoury M, D Voyer, D Lévesque and PP Rompré, Effect of electrolytic lesions of the dorsal diencephalic conduction system on the distribution of Fos-like immunoreactivity induced by rewarding electrical stimulation, Neuroscience, 334: 214-225, 2016.
Voyer D, Lévesque D and PP Rompré, Repeated ventral midbrain neurotensin injections sensitize to amphetamine-induced locomotion and ERK activation: a role for NMDA receptors, Neuropharmacology, 112: 150-163, 2016.
Giner X, D Cotnoir-White, S Mader and D. Lévesque, Selective ligand activity at Nur/retinoid X receptor complexes revealed by dimer-specific bioluminescence resonance energy transfer-based sensors, FASEB J, 29: 4256-4267 2015.
Hernandez G, A Khodami-Pour, D Lévesque and PP Rompré, Reduction in ventral midbrain NMDA receptors reveals two opposite modulatory roles for glutamate on reward, Neuropsychopharmacology, 40: 1682-1691, 2015.
Rocchetti J, Isingrini E, Dal Bo G, Sagheby S, Menagaux A, Tronche F, Lévesque D, Moquin L, Gratton A, Wong TP, Rubinstein M and Giros B, Presynaptic D2 dopamine receptors control LTD expression and memory processes in the temporal hippocampus, Biol. Psychiatry, 77: 513-525, 2015.
Mahmoudi S, Lévesque D and Blanchet PJ, Upregulation of dopamine D3, but not D2, receptors correlates with tardive dyskinesia in primate model, Mov. Disorders, 29: 1125-1133, 2014. This paper was highlighted in the journal’s editorial section, Jenner P, A late appearance by the dopamine D-3 receptor, Mov. Disorders, 29: 1094-1096, 2014.
Schweizer N, Pupe S, Arvidsson E, Nordenankar K, Smith-Anttila CJA, Mahmoudi S, Andren A, Dumas S, Rajagopalan A, Lévesque D, Leao RN and Wallen-Mackenzie A, Limiting glutamatergic transmission in a Vglut2-expressing subpopulation of the subtalamic nucleus is sufficient to cause hyperlocomotion, Proc. Natl. Acad. Sci. USA, 111: 7837-7842, 2014.
Bouayad-Gervais K, Minogianis EA, Lévesque D and Samaha AN, The self administration of rapidly delivered cocaine promotes increased motivation to take the drug: contributions of prior levels of operant responding and cocaine intake, Psychopharmacology (Berlin), 231: 4241-4252, 2014.
Mahmoudi S, PJ Blanchet and D Lévesque, Haloperidol-induced Nur77 expression in non-human primate model is associated with tardive dyskinesia, Eur. J. Neurosci., 38: 2192-2198, 2013.
Minogianis EA, D Lévesque and AN Samaha, The speed of cocaine delivery determines the subsequent motivation to self-administer the drug, Neuropsychopharmacology, 38: 2644-2656, 2013.
Bédard AM, J Maheux, D Lévesque and AN Samaha, Prior haloperidol, but not olanzapine, exposure augments the pursuit of reward cues: implications for substance abuse in schizophrenia, Schizophrenia Bull., 39: 692-702, 2013.
Samadi P, Boutet A, Rymar V, Rewal K, Maheux J, Chakrya-Kvann J, Tomaszewski M, Beaubien F, Cloutier JF, Lévesque D and Sadikot A, Relationship between BDNF expression in major striatal afferents, striatum morphology and motor behavior in the R6/2 mouse model of Huntington’s disease, Genes, Brain and Behav., 12: 108-124, 2013.
Disciplines
- Neurosciences
- Pharmacology
Areas of expertise
- Axe : Découverte et validation de cibles thérapeutiques
- Pharmacothérapie (système nerveux central)