Health Sciences; Medical Sciences
Karl J.L. Fernandes
Cellules souches dans le système nerveux adulte
- Professeur titulaire
-
Faculté de médecine - Département de neurosciences
Secondary number:
514 890-8000 #31279
(Travail 1)
Profile
Research expertise
- Cellules souches du cerveau : régulation pendant le vieillissement et la maladie d’Alzheimer;
- Cellules souches de l’hippocampe : régulation par l’exercice physique et stimulation cognitive;
- Cellules souches de la moelle épinière : identification, caractérisation, et réponses au traumatismes/maladies.
Affiliations and responsabilities
Research affiliations
Research units
Membre
- CRCHUM — Centre de recherche du Centre hospitalier de l’Université de Montréal
- RQRV — Réseau québécois de recherche sur le vieillissement
Affiliated institutions
- Centre hospitalier de l’Université de Montréal (CHUM)
Teaching and supervision
Student supervision
Theses and dissertation supervision (Papyrus Institutional Repository)
2021
Links between abnormal lipid metabolism and inflammation in Alzheimer’s disease
Graduate : Mangahas, Chenicka Lyn
Cycle : Master's
Grade : M. Sc.
Cycle : Master's
Grade : M. Sc.
2021
Identification et activation des cellules souches neurales quiescentes dans le cerveau adulte et durant le vieillissement
Graduate : Cochard, Loïc
Cycle : Doctoral
Grade : Ph. D.
Cycle : Doctoral
Grade : Ph. D.
2018
Mécanismes de régulation de l’activité de la lignée neurale adulte
Graduate : Joppé, Sandra Evelyne
Cycle : Doctoral
Grade : Ph. D.
Cycle : Doctoral
Grade : Ph. D.
2016
Mechanisms underlying activation of neural stem cells in the adult central nervous system
Graduate : Grégoire, Catherine-Alexandra
Cycle : Doctoral
Grade : Ph. D.
Cycle : Doctoral
Grade : Ph. D.
2015
Molecular mechanisms underlying deficient neurogenesis in Alzheimer’s disease
Graduate : Hamilton, Laura
Cycle : Doctoral
Grade : Ph. D.
Cycle : Doctoral
Grade : Ph. D.
2013
Les cytokines inflammatoires modulent la prolifération et la différenciation in vitro des cellules souches/progénitrices de la moelle épinière.
Graduate : Vaugeois, Alexandre
Cycle : Master's
Grade : M. Sc.
Cycle : Master's
Grade : M. Sc.
2010
The regulation of adult hippocampal neurogenesis by wheel running and environmental enrichment
Graduate : Bednarczyk, Matthew
Cycle : Master's
Grade : M. Sc.
Cycle : Master's
Grade : M. Sc.
2010
L’effet du vieillissement sur les cellules souches neurales adultes
Graduate : Bouab, Meriem
Cycle : Master's
Grade : M. Sc.
Cycle : Master's
Grade : M. Sc.
Projects
Research projects
2018
- 2023
Genetic targeting of quiescent adult neural stem cells
Lead researcher :
Karl J.L. Fernandes
Funding sources:
IRSC/Instituts de recherche en santé du Canada
Grant programs:
PVXXXXXX-(PJT) Subvention Projet
2016
- 2022
Mechanisms of experience-dependent hippocampal neurogenesis
Lead researcher :
Karl J.L. Fernandes
Funding sources:
CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs:
PVX20965-(RGP) Programme de subvention à la découverte individuelle ou de groupe
2020
- 2021
Mouse behavioral analysis system
Lead researcher :
Karl J.L. Fernandes
Funding sources:
Fondation du CHUM/Fondation du Centre hospitalier de l'Université de Montréal (CHUM)
Grant programs:
2020
- 2021
Supplément COVID-19 CRSNG_Mechanisms of experience-dependent hippocampal neurogenesis
Lead researcher :
Karl J.L. Fernandes
Funding sources:
CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs:
PVXXXXXX-Supplément à l’appui des étudiants, des stagiaires postdoctoraux et du personnel de soutien à la recherche COVID-19
2016
- 2021
Correction of brain triglyceride metabolism in Alzheimer's disease
Lead researcher :
Karl J.L. Fernandes
Funding sources:
IRSC/Instituts de recherche en santé du Canada
Grant programs:
PVXXXXXX-(PJT) Subvention Projet
2014
- 2020
CHLORIDE HOMEOSTASIS IN NEURAL DEVELOPMENT AND DISEASE
Lead researcher :
Pierre Drapeau
Co-researchers :
Karl J.L. Fernandes
Funding sources:
IRSC/Instituts de recherche en santé du Canada
Grant programs:
PVXX5647-(MOP) Subvention de fonctionnement incluant les subventions de fonctionnement programmatiques (général)
2002
- 2020
SUBVENTION D'INFRASTRUCTURE DU FRSQ POUR LE GRSNC(GROUPE DE RECHERCHE SUR LE SYSTÈME NERVEUX CENTRAL)
Co-researchers :
Serge Rossignol
,
Yoshua Bengio
,
Guy Doucet
,
Gilles Lavigne
,
Allan Smith
,
Pierre J. Blanchet
,
C. Elaine Chapman
,
Laurent Descarries
,
Gary Duncan
,
Arlette Kolta
,
Jean-Claude Lacaille
,
Richard Warren
,
Lionel Carmant
,
Luc DesGroseillers
,
Adriana Di Polo
,
John Francis Kalaska
,
Yves Lamarre
,
Nicole Leclerc
,
Pierre Rainville
,
Jean-Pierre Gossard
,
Pierre Drapeau
,
Hélène Girouard
,
Jannic Boehm
,
Paul Cisek
,
Numa Dancause
,
Karl J.L. Fernandes
,
Florin Amzica
,
Andrea Michelle Green
,
Daniel Lévesque
,
Anne-Noël Samaha
,
Christine Vande Velde
,
Réjean Dubuc
,
Vincent Castellucci
,
Louis St-Amant
,
Wayne Steven Sossin
Funding sources:
FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs:
PVXXXXXX-Subvention de groupe de recherche
2017
- 2019
High performance nucleofection unit for difficult to manipulate cell types
Lead researcher :
Christine Vande Velde
Funding sources:
CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs:
PVXXXXXX-(OIR) Outils et d'instruments de recherche (de 7 001 $ à 150 000 $)
2016
- 2017
Triggers and behavioural consequences of elevated oleic acid in the AD brain.
Lead researcher :
Karl J.L. Fernandes
Funding sources:
Société Alzheimer du Canada
Grant programs:
2014
- 2017
NEURAL STEM CELLS AND THE PROMOTION OF HEALTHY BRAIN AGING
Lead researcher :
Karl J.L. Fernandes
Funding sources:
IRSC/Instituts de recherche en santé du Canada
Grant programs:
PVXX5647-(MOP) Subvention de fonctionnement incluant les subventions de fonctionnement programmatiques (général)
2011
- 2017
PHYSIOLOGICAL REGULATION OF ADULT HIPPOCAMPAL NEUROGENESIS
Lead researcher :
Karl J.L. Fernandes
Funding sources:
CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs:
PVX20965-(RGP) Programme de subvention à la découverte individuelle ou de groupe
2015
- 2016
Development of endogenous stem cell-based strategies for spinal cord repair
Lead researcher :
Karl J.L. Fernandes
Co-researchers :
Steve Lacroix
Funding sources:
IRSC/Instituts de recherche en santé du Canada
Grant programs:
PVXX5647-(MOP) Subvention de fonctionnement incluant les subventions de fonctionnement programmatiques (général)
2014
- 2016
REGULATION OF ENDOGENOUS STEM CELLS DURING SPINAL CORD DISORDERS
Lead researcher :
Karl J.L. Fernandes
Co-researchers :
Steve Lacroix
Funding sources:
IRSC/Instituts de recherche en santé du Canada
Grant programs:
PVXX5647-(MOP) Subvention de fonctionnement incluant les subventions de fonctionnement programmatiques (général)
2011
- 2016
CHAIRE DE RECHERCHE DU CANADA - CELLULES SOUCHES NEURALES
Lead researcher :
Karl J.L. Fernandes
Funding sources:
SPIIE/Secrétariat des programmes interorganismes à l’intention des établissements
Grant programs:
PVX50399-Chaires de recherche du Canada
2014
- 2015
Dichotomous actions of the IL-1 System in MS
Lead researcher :
Steve Lacroix
Co-researchers :
Karl J.L. Fernandes
Funding sources:
Société canadienne de la sclérose en plaques
Grant programs:
2012
- 2015
DICHOTOMOUS ACTIONS OF THE IL-1 SYSTEM IN MS
Lead researcher :
Steve Lacroix
Co-researchers :
Karl J.L. Fernandes
Funding sources:
Société canadienne de la sclérose en plaques
Grant programs:
2011
- 2015
NEURAL STEM CELLS AND THE PROMOTION OF HEALTHY BRAIN AGING
Lead researcher :
Karl J.L. Fernandes
2011
- 2015
PHYSIOLOGICAL REGULATION OF ADULT HIPPOCAMPAL NEUROGENESIS
Lead researcher :
Karl J.L. Fernandes
2013
- 2014
CHLORIDE HOMEOSTASIS IN NEURAL DEVELOPMENT AND DISEASE
Lead researcher :
Pierre Drapeau
Co-researchers :
Karl J.L. Fernandes
Funding sources:
IRSC/Instituts de recherche en santé du Canada
Grant programs:
PVXX5647-(MOP) Subvention de fonctionnement incluant les subventions de fonctionnement programmatiques (général)
2012
- 2014
DICHOTOMOUS ACTIONS OF THE IL-1 SYSTEM IN MS
Lead researcher :
Steve Lacroix
Co-researchers :
Karl J.L. Fernandes
Funding sources:
Société canadienne de la sclérose en plaques
Grant programs:
2011
- 2014
REGULATION OF ENDOGENOUS STEM CELLS DURING SPINAL CORD DISORDERS
Lead researcher :
Karl J.L. Fernandes
Co-researchers :
Steve Lacroix
Funding sources:
IRSC/Instituts de recherche en santé du Canada
Grant programs:
PVXX5647-(MOP) Subvention de fonctionnement incluant les subventions de fonctionnement programmatiques (général)
2010
- 2014
Regulation of Endogenous Stem Cells During Spinal Cord Disorders
Lead researcher :
Karl J.L. Fernandes
Description
Spinal cord injury (SCI) and multiple sclerosis (MS) are just some of the devastating conditions that can affect the adult spinal cord. There are currently few to no treatment options or cures for such disorders. Clinically, they are diverse in terms of functional losses, rate of progression and severity. For example, mild SCI patients can have partial loss of locomotor ability and yet have nearly normal life-spans, whereas MS patients begin with bouts of relatively mild sensori-motor symptoms that recur with increasing intensity and duration. Beyond the motor losses, spinal cord diseases and injury are also associated with important sensory and autonomic consequences that further reduce patient quality of life. The recent discovery of stem cells within the adult spinal cord may offer a novel way for improving the outcome following such diverse spinal cord conditions. We propose to use these spinal cord stem cells to improve the spinal cord's innate self repair capabilities. Before being able to achieve this, however, we must answer fundamental questions about spinal cord stem cells, including: what do they normally do? How do they react during different types of spinal cord diseases? And how are these reactions controlled by processes such as inflammation, a major and complex component of the wound healing process? In this research proposal, we tackle these key questions using animal models of SCI and MS. This project is a novel collaboration between the laboratories of Dr. Karl Fernandes (stem cell and spinal cord researcher, Montreal) and Dr. Steve Lacroix (neuroimmunologist and spinal cord researcher, Quebec City). We hope that this work will ultimately contribute to the development of innovative stem cell-based therapies for spinal cord repair.
Mots-clés : spinal cord injury, cytokines/growth factors, stem cells, ependymal cells, multiple sclerosis, inflammation, oligodendrocytes
2008
- 2014
NEURAL STEM CELLS AND THE PROMOTION OF HEALTHY BRAIN AGING
Lead researcher :
Karl J.L. Fernandes
Funding sources:
IRSC/Instituts de recherche en santé du Canada
Grant programs:
PVXX5647-(MOP) Subvention de fonctionnement incluant les subventions de fonctionnement programmatiques (général)
Outreach
Publications and presentations
Publications
- Paliouras GN, Hamilton LK, Aumont A, Joppé SE, Barnabé-Heider F, Fernandes KJL (2012). mTOR signaling is a key regulator of the transit-amplifying progenitor pool in the adult and aging forebrain. J Neurosci 32(43):15012-26.
- Grégoire CA, Bonenfant D, Le Nguyen A, Aumont A, Fernandes KJL (2014). Untangling the influences of voluntary running, environmental complexity, social housing and stress on adult hippocampal neurogenesis. PLOS One 9(1):e86237.
- Lacroix S, Hamilton LK, Vaugeois A, Beaudoin S, Breault-Dugas C, Pineau I, Lévesque S, Grégoire C-A, Fernandes KJL (2014). Central canal ependymal cells proliferate extensively in response to traumatic spinal cord injury but not demyelinating lesions. PLOS One 9(1):e85916.
- Hamilton LK, Dufresne M, Joppé SE, Petryszyn S, Aumont A, Calon F, Barnabé-Heider F, Furtos A, Parent M, Chaurand P, Fernandes KJL (2015). Aberrant lipid metabolism in the forebrain niche suppresses adult neural stem cell proliferation in an animal model of Alzheimer’s disease. Cell Stem Cell 17(4):397-411.
- Joppé SE, Hamilton LK, Cochard LM, Levros LC, Aumont A, Barnabé-Heider F, Fernandes KJL (2015). BMP impinges on EGFR-induced proliferation signaling to maintain a quiescent neural stem cell pool. Front Neurosci 9:407.
Disciplines
- Neurosciences
Areas of expertise
- Stem Cells and Organogenesis
- Autonomic Nervous System
- Alzheimer’s Disease
- Cognition
- Cognitive Neuropsychology of Aging
- Spinal Cord Diseases
- Cranio-Encephalic and Spinal Cord Trauma
- Neuronal and Synaptic Activity